Scholars@Duke publication: Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia.

Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia.

Publication , Journal Article

Woods, CW; Bressler, AM; LiPuma, JJ; Alexander, BD; Clements, DA; Weber, DJ; Moore, CM; Reller, LB; Kaye, KS

Published in: Clin Infect Dis

May 1, 2004

The Burkholderia cepacia complex includes 9 genomovars. The relative virulence of each is unknown. Host and pathogen features associated with mortality were evaluated among patients with B. cepacia complex bacteremia. Cases were ascertained through review of blood culture results for the period of May 1996 through May 2002. Isolates were identified to species level with 16S rDNA and recA-based species-specific polymerase chain reaction analyses and recA restriction fragment-length polymorphism. Strain typing was performed with pulsed-field gel electrophoresis. Fifty-three patients with B. cepacia complex bacteremia were identified; only 9 (17%) had cystic fibrosis. Twenty-five patients (47%) died within 14 days of bacteremia. After controlling for comorbid conditions and therapeutic interventions, 2 outbreak-related strains of Burkholderia cenocepacia (genomovar III) were associated with 14-day mortality (odds ratio, 5.5; 95% confidence interval, 1.20-25.02). B. cenocepacia is an emerging nosocomial pathogen. Certain strains are associated with an enhanced capacity for interpatient spread and poor outcome.

Duke Scholars

Author Christopher Wildrick Woods Medicine, Infectious Diseases

Author Barbara Dudley Alexander Medicine, Infectious Diseases

Author Dennis Alfred Clements III Pediatrics, General Pediatrics and Adolescent Health

Author Lyman Barth Reller Pathology

Published In

Clin Infect Dis

DOI

10.1086/383313

EISSN

1537-6591

Publication Date

May 1, 2004

Volume

Issue

Start / End Page

1243 / 1250

Location

United States

Related Subject Headings

Survival Analysis
RNA, Ribosomal, 16S
Middle Aged
Microbiology
Male
Infant, Newborn
Infant
Humans
Female
Disease Outbreaks

Citation

APA

Chicago

ICMJE

MLA

NLM

Woods, C. W., Bressler, A. M., LiPuma, J. J., Alexander, B. D., Clements, D. A., Weber, D. J., … Kaye, K. S. (2004). Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia. Clin Infect Dis, 38(9), 1243–1250. https://doi.org/10.1086/383313

Woods, Christopher W., Adam M. Bressler, John J. LiPuma, Barbara D. Alexander, Dennis A. Clements, David J. Weber, Christopher M. Moore, L Barth Reller, and Keith S. Kaye. “Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia.” Clin Infect Dis 38, no. 9 (May 1, 2004): 1243–50. https://doi.org/10.1086/383313.

Woods CW, Bressler AM, LiPuma JJ, Alexander BD, Clements DA, Weber DJ, et al. Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia. Clin Infect Dis. 2004 May 1;38(9):1243–50.

Woods, Christopher W., et al. “Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia.” Clin Infect Dis, vol. 38, no. 9, May 2004, pp. 1243–50. Pubmed, doi:10.1086/383313.

Woods CW, Bressler AM, LiPuma JJ, Alexander BD, Clements DA, Weber DJ, Moore CM, Reller LB, Kaye KS. Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia. Clin Infect Dis. 2004 May 1;38(9):1243–1250.