Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine.
A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.
Duke Scholars
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Related Subject Headings
- Viral Hepatitis Vaccines
- Vaccines, Combined
- Vaccination
- Microbiology
- Male
- Humans
- Hepatovirus
- Hepatitis B virus
- Hepatitis B Vaccines
- Hepatitis B Surface Antigens
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Viral Hepatitis Vaccines
- Vaccines, Combined
- Vaccination
- Microbiology
- Male
- Humans
- Hepatovirus
- Hepatitis B virus
- Hepatitis B Vaccines
- Hepatitis B Surface Antigens