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Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine.

Publication ,  Journal Article
Frey, S; Dagan, R; Ashur, Y; Chen, XQ; Ibarra, J; Kollaritsch, H; Mazur, MH; Poland, GA; Reisinger, K; Walter, E; Van Damme, P; Braconier, JH ...
Published in: J Infect Dis
December 1999

A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.

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Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

December 1999

Volume

180

Issue

6

Start / End Page

2018 / 2022

Location

United States

Related Subject Headings

  • Viral Hepatitis Vaccines
  • Vaccines, Combined
  • Vaccination
  • Microbiology
  • Male
  • Humans
  • Hepatovirus
  • Hepatitis B virus
  • Hepatitis B Vaccines
  • Hepatitis B Surface Antigens
 

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Frey, S., Dagan, R., Ashur, Y., Chen, X. Q., Ibarra, J., Kollaritsch, H., … Gress, J. O. (1999). Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine. J Infect Dis, 180(6), 2018–2022. https://doi.org/10.1086/315119
Frey, S., R. Dagan, Y. Ashur, X. Q. Chen, J. Ibarra, H. Kollaritsch, M. H. Mazur, et al. “Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine.J Infect Dis 180, no. 6 (December 1999): 2018–22. https://doi.org/10.1086/315119.
Frey S, Dagan R, Ashur Y, Chen XQ, Ibarra J, Kollaritsch H, et al. Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine. J Infect Dis. 1999 Dec;180(6):2018–22.
Frey, S., et al. “Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine.J Infect Dis, vol. 180, no. 6, Dec. 1999, pp. 2018–22. Pubmed, doi:10.1086/315119.
Frey S, Dagan R, Ashur Y, Chen XQ, Ibarra J, Kollaritsch H, Mazur MH, Poland GA, Reisinger K, Walter E, Van Damme P, Braconier JH, Uhnoo I, Wahl M, Blatter MM, Clements D, Greenberg D, Jacobson RM, Norrby SR, Rowe M, Shouval D, Simmons SS, van Hattum J, Wennerholm S, Gress JO. Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine. J Infect Dis. 1999 Dec;180(6):2018–2022.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

December 1999

Volume

180

Issue

6

Start / End Page

2018 / 2022

Location

United States

Related Subject Headings

  • Viral Hepatitis Vaccines
  • Vaccines, Combined
  • Vaccination
  • Microbiology
  • Male
  • Humans
  • Hepatovirus
  • Hepatitis B virus
  • Hepatitis B Vaccines
  • Hepatitis B Surface Antigens