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Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care.

Publication ,  Journal Article
Clements, DA; Langdon, L; Bland, C; Walter, E
Published in: Arch Pediatr Adolesc Med
October 1995

OBJECTIVE: To determine if the use of influenza vaccine in children in day care decreases the incidence of otitis media during the influenza season. DESIGN: Prospective cohort study. SETTING: Eight day-care centers in North Carolina. PARTICIPANTS: One hundred eighty-six children aged 6 to 30 months. INTERVENTION: Half the participants received trivalent subvirion influenza virus vaccine. MEASUREMENTS: Acute otitis media (AOM) and serous otitis media (SOM) were assessed biweekly from mid-November 1993 to mid-March 1994 by visual and tympanometric examinations performed by "blinded" observers. The winter season was divided into three periods-before, during, and after influenza season--and the number of children with AOM or SOM during each period was determined. Unadjusted and adjusted odds ratios (ORs) were computed, while controlling for race and sex using logistic regression methods. RESULTS: Influenza vaccine was protective against AOM (OR = 0.69, 95% CI, 0.49-0.98) during the influenza season. Although there may have been some protection against SOM (OR = 0.75, 95% CI, 0.54-1.02) statistical significance was not achieved. Myringotomy tubes were also significantly protective against AOM and SOM during all three time periods, with ORs between 0.34 and 0.52, but the greatest protection was seen during the influenza period. CONCLUSIONS: Influenza vaccination of 6- to 30-month-old children in day care was associated with a decreased incidence of otitis media during the influenza season. Myringotomy tubes protected against AOM and SOM during all 16 weeks monitored.

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Published In

Arch Pediatr Adolesc Med

DOI

ISSN

1072-4710

Publication Date

October 1995

Volume

149

Issue

10

Start / End Page

1113 / 1117

Location

United States

Related Subject Headings

  • Single-Blind Method
  • Seasons
  • Prospective Studies
  • Pediatrics
  • Otitis Media
  • Middle Ear Ventilation
  • Male
  • Logistic Models
  • Influenza Vaccines
  • Influenza A virus
 

Citation

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Clements, D. A., Langdon, L., Bland, C., & Walter, E. (1995). Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care. Arch Pediatr Adolesc Med, 149(10), 1113–1117. https://doi.org/10.1001/archpedi.1995.02170230067009
Clements, D. A., L. Langdon, C. Bland, and E. Walter. “Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care.Arch Pediatr Adolesc Med 149, no. 10 (October 1995): 1113–17. https://doi.org/10.1001/archpedi.1995.02170230067009.
Clements DA, Langdon L, Bland C, Walter E. Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care. Arch Pediatr Adolesc Med. 1995 Oct;149(10):1113–7.
Clements, D. A., et al. “Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care.Arch Pediatr Adolesc Med, vol. 149, no. 10, Oct. 1995, pp. 1113–17. Pubmed, doi:10.1001/archpedi.1995.02170230067009.
Clements DA, Langdon L, Bland C, Walter E. Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care. Arch Pediatr Adolesc Med. 1995 Oct;149(10):1113–1117.

Published In

Arch Pediatr Adolesc Med

DOI

ISSN

1072-4710

Publication Date

October 1995

Volume

149

Issue

10

Start / End Page

1113 / 1117

Location

United States

Related Subject Headings

  • Single-Blind Method
  • Seasons
  • Prospective Studies
  • Pediatrics
  • Otitis Media
  • Middle Ear Ventilation
  • Male
  • Logistic Models
  • Influenza Vaccines
  • Influenza A virus