Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Research Fellow, University of North Carolina at Chapel Hill 2010 - 2013
  • Ph.D., North Carolina State University 2010
• 

  Duke Appointment History

  • Instructor, Temporary in the Department ofSurgery, Surgery, Head and Neck Surgery and Communication Sciences, Surgery 2013 - 2014
• Recognition
• 

  In the News

  • MAY 8, 2017

    ENTtoday

    Computational Modeling Shows Promise for Otolaryngology Use
• Expertise
• 

  Subject Headings

  • Adolescent
  • Aerosols
  • Airway Resistance
  • Body Temperature Regulation
  • Computational fluid dynamics
  • Computer Simulation
  • Endoscopy
  • Female
  • Humans
  • Hydrodynamics
  • Male
  • Maxillary Sinus
  • Models, Biological
  • Models, Theoretical
  • Monitoring, Physiologic
  • Nasal Cartilages
  • Nasal Cavity
  • Nasal Mucosa
  • Nasal Obstruction
  • Nasal Septum
  • Nasal Surgical Procedures
  • Nebulizers and Vaporizers
  • Nose
  • Particle Size
  • Perception
  • Pilot Projects
  • Postoperative Care
  • Postoperative Period
  • Posture
  • Preoperative Care
  • Prospective Studies
  • Pulmonary Ventilation
  • Quality of Life
  • Questionnaires
  • Recovery of Function
  • Rhinitis
  • Rhinoplasty
  • Self Report
  • Severity of Illness Index
  • Sinusitis
  • Suture Techniques
  • Tomography, X-Ray Computed
  • Treatment Outcome
• Research
• 

  Selected Grants

  • Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
  • Improving Topical Drug Delivery for Treatment of Chronic Rhinosinusitis awarded by University of North Carolina - Chapel Hill 2015 - 2019
  • Creating Virtual Surgery Targets and Methods to Improve Outcomes of Nasal Airway Surgery awarded by Medical College of Wisconsin 2014 - 2018
  • Modeling the Pediatric Upper Airway Using A-OCT and DNS CFD awarded by University of California - Irvine 2013 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Frank-Ito, DO, Kimbell, JS, Borojeni, AAT, Garcia, GJM, and Rhee, JS. "A hierarchical stepwise approach to evaluate nasal patency after virtual surgery for nasal airway obstruction." Clinical Biomechanics (Bristol, Avon) 61 (December 19, 2018): 172-180.  Full Text
    • Kimbell, JS, Basu, S, Garcia, GJM, Frank-Ito, DO, Lazarow, F, Su, E, Protsenko, D, Chen, Z, Rhee, JS, and Wong, BJ. "Upper airway reconstruction using long-range optical coherence tomography: Effects of airway curvature on airflow resistance." Lasers in Surgery and Medicine (July 26, 2018).  Full Text
    • Dong, J, Ma, J, Shang, Y, Inthavong, K, Qiu, D, Tu, J, and Frank-Ito, D. "Detailed nanoparticle exposure analysis among human nasal cavities with distinct vestibule phenotypes." Journal of Aerosol Science 121 (July 1, 2018): 54-65.  Full Text
    • Ma, J, Dong, J, Shang, Y, Inthavong, K, Tu, J, and Frank-Ito, DO. "Air conditioning analysis among human nasal passages with anterior anatomical variations." Medical Engineering & Physics 57 (July 2018): 19-28.  Full Text
    • Basu, S, Frank-Ito, DO, and Kimbell, JS. "On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation." International Journal for Numerical Methods in Biomedical Engineering 34, no. 4 (April 2018): e2946-null.  Full Text
    • Cheng, T, Carpenter, D, Cohen, S, Witsell, D, and Frank-Ito, DO. "Investigating the effects of laryngotracheal stenosis on upper airway aerodynamics." The Laryngoscope 128, no. 4 (April 2018): E141-E149.  Full Text
    • Burnette, E, Piker, EG, and Frank-Ito, D. "Reevaluating Order Effects in the Binaural Bithermal Caloric Test." American Journal of Audiology 27, no. 1 (March 2018): 104-109.  Full Text
    • Carpenter, D, Kaylie, D, Piker, E, and Frank-Ito, D. "A Pilot Study to Investigate the Relationship Between Interaural Differences in Temporal Bone Anatomy and Normal Variations in Caloric Asymmetry." American Journal of Audiology 27, no. 1 (March 2018): 110-120.  Full Text
    • Brady, R, Frank-Ito, DO, Tran, HT, Janum, S, Møller, K, Brix, S, Ottesen, JT, Mehlsen, J, and Olufsen, MS. "Personalized mathematical model of endotoxin-induced inflammatory responses in young men and associated changes in heart rate variability." Mathematical Modelling of Natural Phenomena 13, no. 5 (January 1, 2018).  Full Text
    • Vanhille, DL, Garcia, GJM, Asan, O, Borojeni, AAT, Frank-Ito, DO, Kimbell, JS, Pawar, SS, and Rhee, JS. "Virtual Surgery for the Nasal Airway: A Preliminary Report on Decision Support and Technology Acceptance." Jama Facial Plastic Surgery 20, no. 1 (January 2018): 63-69.  Full Text
    • de Jong, MA, Carpenter, DJ, Kaylie, DM, Piker, EG, and Frank-Ito, DO. "Temporal bone anatomy characteristics in superior semicircular canal dehiscence." Journal of Otology 12, no. 4 (December 2017): 185-191.  Full Text
    • Carpenter, DJ, Tucci, DL, Kaylie, DM, and Frank-Ito, DO. "The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation." Journal of Otology 12, no. 3 (September 2017): 125-131.  Full Text
    • Carpenter, DJ, Tucci, DL, Kaylie, DM, and Frank-Ito, DO. "Disagreement in middle ear volume estimation between tympanometry and three-dimensional volume reconstruction in the context of tympanic membrane perforation." Journal of Otology 12, no. 2 (June 2017): 74-79.  Full Text
    • A T Borojeni, A, Frank-Ito, DO, Kimbell, JS, Rhee, JS, and Garcia, GJM. "Creation of an idealized nasopharynx geometry for accurate computational fluid dynamics simulations of nasal airflow in patient-specific models lacking the nasopharynx anatomy." International Journal for Numerical Methods in Biomedical Engineering 33, no. 5 (May 2017).  Full Text
    • Inthavong, K, Ma, J, Shang, Y, Dong, J, Chetty, ASR, Tu, J, and Frank-Ito, D. "Geometry and airflow dynamics analysis in the nasal cavity during inhalation(Accepted)." Clinical Biomechanics (January 1, 2017).  Full Text
    • Patki, A, and Frank-Ito, DO. "Characterizing human nasal airflow physiologic variables by nasal index." Respiratory Physiology & Neurobiology 232 (October 2016): 66-74.  Full Text
    • Kimbell, JS, and Frank-Ito, DO. "Mechanical Nasal Dilators for the Management of Nasal Obstruction." Jama Facial Plastic Surgery 18, no. 5 (September 2016): 389-390.  Full Text
    • Patki, AU, Ronen, O, Kaylie, DM, Frank-Ito, DO, and Piker, EG. "Anatomic Variations in Temporal Bones Affect the Intensity of Nystagmus During Warm Caloric Irrigation." Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology 37, no. 8 (September 2016): 1111-1116.  Full Text
    • Keeler, JA, Patki, A, Woodard, CR, and Frank-Ito, DO. "A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups." Journal of Aerosol Medicine and Pulmonary Drug Delivery 29, no. 2 (April 2016): 153-166.  Full Text
    • Ramprasad, VH, and Frank-Ito, DO. "A computational analysis of nasal vestibule morphologic variabilities on nasal function." Journal of Biomechanics 49, no. 3 (February 2016): 450-457.  Full Text
    • Choi, KJ, Jang, DW, Ellison, MD, and Frank-Ito, DO. "Characterizing airflow profile in the postoperative maxillary sinus by using computational fluid dynamics modeling: A pilot study." American Journal of Rhinology & Allergy 30, no. 1 (January 2016): 29-36.  Full Text
    • Frank-Ito, DO, Wofford, M, Schroeter, JD, and Kimbell, JS. "Influence of Mesh Density on Airflow and Particle Deposition in Sinonasal Airway Modeling." Journal of Aerosol Medicine and Pulmonary Drug Delivery (June 11, 2015).  Full Text
    • Frank-Ito, DO, Sajisevi, M, Solares, CA, and Jang, DW. "Modeling alterations in sinonasal physiology after skull base surgery." American Journal of Rhinology & Allergy 29, no. 2 (March 2015): 145-150.  Full Text
    • Wofford, MR, Kimbell, JS, Frank-Ito, DO, Dhandha, V, McKinney, KA, Fleischman, GM, Ebert, CS, Zanation, AM, and Senior, BA. "A computational study of functional endoscopic sinus surgery and maxillary sinus drug delivery." Rhinology 53, no. 1 (March 2015): 41-48.  Full Text
    • Frank-Ito, DO, Schulz, K, Vess, G, and Witsell, DL. "Changes in aerodynamics during vocal cord dysfunction." Computers in Biology and Medicine 57 (February 2015): 116-122.  Full Text
    • Patel, RG, Garcia, GJM, Frank-Ito, DO, Kimbell, JS, and Rhee, JS. "Simulating the nasal cycle with computational fluid dynamics." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 152, no. 2 (February 2015): 353-360.  Full Text
    • Frank-Ito, DO, Kimbell, JS, Laud, P, Garcia, GJM, and Rhee, JS. "Predicting postsurgery nasal physiology with computational modeling: current challenges and limitations." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 151, no. 5 (November 2014): 751-759.  Full Text
    • Shadfar, S, Shockley, WW, Fleischman, GM, Dugar, AR, McKinney, KA, Frank-Ito, DO, and Kimbell, JS. "Characterization of postoperative changes in nasal airflow using a cadaveric computational fluid dynamics model: supporting the internal nasal valve." Jama Facial Plastic Surgery 16, no. 5 (September 2014): 319-327.  Full Text
    • Rhee, JS, Sullivan, CD, Frank, DO, Kimbell, JS, and Garcia, GJM. "A systematic review of patient-reported nasal obstruction scores: defining normative and symptomatic ranges in surgical patients." Jama Facial Plastic Surgery 16, no. 3 (May 2014): 219-232. (Review)  Full Text
    • Sullivan, CD, Garcia, GJM, Frank-Ito, DO, Kimbell, JS, and Rhee, JS. "Perception of better nasal patency correlates with increased mucosal cooling after surgery for nasal obstruction." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 150, no. 1 (January 2014): 139-147.  Full Text
    • Frank, DO, Zanation, AM, Dhandha, VH, McKinney, KA, Fleischman, GM, Ebert, CS, Senior, BA, and Kimbell, JS. "Quantification of airflow into the maxillary sinuses before and after functional endoscopic sinus surgery." International Forum of Allergy & Rhinology 3, no. 10 (October 2013): 834-840.  Full Text
    • Kimbell, JS, Frank, DO, Laud, P, Garcia, GJM, and Rhee, JS. "Changes in nasal airflow and heat transfer correlate with symptom improvement after surgery for nasal obstruction." Journal of Biomechanics 46, no. 15 (October 2013): 2634-2643.  Full Text
    • Cannon, DE, Frank, DO, Kimbell, JS, Poetker, DM, and Rhee, JS. "Modeling nasal physiology changes due to septal perforations." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 148, no. 3 (March 2013): 513-518.  Full Text
    • Frank, DO, Kimbell, JS, Cannon, D, and Rhee, JS. "Computed intranasal spray penetration: comparisons before and after nasal surgery." International Forum of Allergy & Rhinology 3, no. 1 (January 2013): 48-55.  Full Text
    • Frank, DO, Kimbell, JS, Cannon, D, Pawar, SS, and Rhee, JS. "Deviated nasal septum hinders intranasal sprays: a computer simulation study." Rhinology 50, no. 3 (September 2012): 311-318.  Full Text
    • Rhee, JS, Cannon, DE, Frank, DO, and Kimbell, JS. "Role of virtual surgery in preoperative planning: assessing the individual components of functional nasal airway surgery." Archives of Facial Plastic Surgery 14, no. 5 (September 2012): 354-359.  Full Text
    • Kimbell, JS, Garcia, GJM, Frank, DO, Cannon, DE, Pawar, SS, and Rhee, JS. "Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: a preliminary report." American Journal of Rhinology & Allergy 26, no. 3 (May 2012): e94-e98.  Full Text
    • Frank, DO, Kimbell, JS, Pawar, S, and Rhee, JS. "Effects of anatomy and particle size on nasal sprays and nebulizers." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 146, no. 2 (February 2012): 313-319.  Full Text

  • Other Articles

    • Garcia, GJM, Patel, RG, Frank-Ito, DO, Kimbell, JS, and Rhee, JS. "Response to Dr Chung's Question on Simulating the Nasal Cycle with Computational Fluid Dynamics." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 153, no. 2 (August 2015): 308-309. (Letter)  Full Text
    • Garcia, GJM, Kimbell, JS, and Frank-Ito, DO. "In reference to Regional peak mucosal cooling predicts the perception of nasal patency." The Laryngoscope 124, no. 5 (May 2014): E210-null. (Letter)  Full Text

  • Conference Papers

    • Ma, J, Dong, J, Shang, Y, Inthavong, K, Tu, J, and Frank-Ito, DO. "Numerical air conditioning performance assessment of nasal models with morphologic variations." June 15, 2017.  Full Text
    • Wofford, M, Kimbell, JS, Frank, DO, Schroeter, JD, Dhandha, V, Ebert, CS, Zanation, AM, and Senior, BA. "A COMPUTATIONAL MESH DESIGN FOR AIRFLOW AND NEBULIZED PARTICLE TRANSPORT SIMULATION IN A SINONASAL MODEL AFTER FUNCTIONAL ENDOSCOPIC SINUS SURGERY (FESS)." : MARY ANN LIEBERT INC, April 1, 2013.  Link to Item

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