Dennis Onyeka Frank-Ito | Scholars@Duke

Dennis Onyeka Frank-Ito
Assistant Professor of Surgery

My research interests include modeling the effects of human airway anatomy on respiratory airflow patterns, deposition of inhaled gases and particle transport using computational fluid dynamics.

Current Appointments & Affiliations

Assistant Professor of Surgery, Surgery, Head and Neck Surgery and Communication Sciences, Surgery 2014
Assistant Professor in the Department of Mechanical Engineering and Materials Science, Mechanical Engineering and Materials Science, Pratt School of Engineering 2016

Contact Information

40 Duke Medicine Circle, DUMC 3805, 3576 White Zone, Durham, NC 27710
dennis.frank@duke.edu (919) 681-7247
Frank-Ito Computational Modeling Research Lab

Background
Education, Training, & Certifications
- Postdoctoral Research Fellow, University of North Carolina at Chapel Hill 2010 - 2013
- Ph.D., North Carolina State University 2010
Duke Appointment History
- Instructor, Temporary in the Department ofSurgery, Surgery, Head and Neck Surgery and Communication Sciences, Surgery 2013 - 2014
Recognition
In the News
- MAY 8, 2017 ENTtoday
  
  Computational Modeling Shows Promise for Otolaryngology Use
Expertise
Subject Headings
Research
Selected Grants
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Improving Topical Drug Delivery for Treatment of Chronic Rhinosinusitis awarded by University of North Carolina - Chapel Hill 2015 - 2019
- Creating Virtual Surgery Targets and Methods to Improve Outcomes of Nasal Airway Surgery awarded by Medical College of Wisconsin 2014 - 2018
- Modeling the Pediatric Upper Airway Using A-OCT and DNS CFD awarded by University of California - Irvine 2013 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kimbell, JS, Basu, S, Garcia, GJM, Frank-Ito, DO, Lazarow, F, Su, E, Protsenko, D, Chen, Z, Rhee, JS, and Wong, BJ. "Upper airway reconstruction using long-range optical coherence tomography: Effects of airway curvature on airflow resistance." Lasers in Surgery and Medicine (July 26, 2018). Full Text
  - Dong, J, Ma, J, Shang, Y, Inthavong, K, Qiu, D, Tu, J, and Frank-Ito, D. "Detailed nanoparticle exposure analysis among human nasal cavities with distinct vestibule phenotypes." Journal of Aerosol Science 121 (July 2018): 54-65. Full Text
  - Ma, J, Dong, J, Shang, Y, Inthavong, K, Tu, J, and Frank-Ito, DO. "Air conditioning analysis among human nasal passages with anterior anatomical variations." Medical Engineering & Physics 57 (July 2018): 19-28. Full Text
  - Basu, S, Frank-Ito, DO, and Kimbell, JS. "On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation." International Journal for Numerical Methods in Biomedical Engineering 34, no. 4 (April 2018): e2946-null. Full Text
  - Cheng, T, Carpenter, D, Cohen, S, Witsell, D, and Frank-Ito, DO. "Investigating the effects of laryngotracheal stenosis on upper airway aerodynamics." The Laryngoscope 128, no. 4 (April 2018): E141-E149. Full Text
  - Burnette, E, Piker, EG, and Frank-Ito, D. "Reevaluating Order Effects in the Binaural Bithermal Caloric Test." American Journal of Audiology 27, no. 1 (March 2018): 104-109. Full Text
  - Carpenter, D, Kaylie, D, Piker, E, and Frank-Ito, D. "A Pilot Study to Investigate the Relationship Between Interaural Differences in Temporal Bone Anatomy and Normal Variations in Caloric Asymmetry." American Journal of Audiology 27, no. 1 (March 2018): 110-120. Full Text
  - Brady, R, Frank-Ito, DO, Tran, HT, Janum, S, Møller, K, Brix, S, Ottesen, JT, Mehlsen, J, and Olufsen, MS. "Personalized mathematical model of endotoxin-induced inflammatory responses in young men and associated changes in heart rate variability." Mathematical Modelling of Natural Phenomena 13, no. 5 (January 1, 2018). Full Text
  - Vanhille, DL, Garcia, GJM, Asan, O, Borojeni, AAT, Frank-Ito, DO, Kimbell, JS, Pawar, SS, and Rhee, JS. "Virtual Surgery for the Nasal Airway: A Preliminary Report on Decision Support and Technology Acceptance." Jama Facial Plastic Surgery 20, no. 1 (January 2018): 63-69. Full Text
  - de Jong, MA, Carpenter, DJ, Kaylie, DM, Piker, EG, and Frank-Ito, DO. "Temporal bone anatomy characteristics in superior semicircular canal dehiscence." Journal of Otology 12, no. 4 (December 2017): 185-191. Full Text
  - Inthavong, K, Ma, J, Shang, Y, Dong, J, Chetty, ASR, Tu, J, and Frank-Ito, D. "Geometry and airflow dynamics analysis in the nasal cavity during inhalation." Clinical Biomechanics (October 2017). Full Text
  - Carpenter, DJ, Tucci, DL, Kaylie, DM, and Frank-Ito, DO. "The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation." Journal of Otology 12, no. 3 (September 2017): 125-131. Full Text
  - Carpenter, DJ, Tucci, DL, Kaylie, DM, and Frank-Ito, DO. "Disagreement in middle ear volume estimation between tympanometry and three-dimensional volume reconstruction in the context of tympanic membrane perforation." Journal of Otology 12, no. 2 (June 2017): 74-79. Full Text
  - A T Borojeni, A, Frank-Ito, DO, Kimbell, JS, Rhee, JS, and Garcia, GJM. "Creation of an idealized nasopharynx geometry for accurate computational fluid dynamics simulations of nasal airflow in patient-specific models lacking the nasopharynx anatomy." International Journal for Numerical Methods in Biomedical Engineering 33, no. 5 (May 2017). Full Text
  - Patki, A, and Frank-Ito, DO. "Characterizing human nasal airflow physiologic variables by nasal index." Respiratory Physiology & Neurobiology 232 (October 2016): 66-74. Full Text
  - Kimbell, JS, and Frank-Ito, DO. "Mechanical Nasal Dilators for the Management of Nasal Obstruction." Jama Facial Plastic Surgery 18, no. 5 (September 2016): 389-390. Full Text
  - Patki, AU, Ronen, O, Kaylie, DM, Frank-Ito, DO, and Piker, EG. "Anatomic Variations in Temporal Bones Affect the Intensity of Nystagmus During Warm Caloric Irrigation." Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology 37, no. 8 (September 2016): 1111-1116. Full Text
  - Keeler, JA, Patki, A, Woodard, CR, and Frank-Ito, DO. "A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups." Journal of Aerosol Medicine and Pulmonary Drug Delivery 29, no. 2 (April 2016): 153-166. Full Text
  - Ramprasad, VH, and Frank-Ito, DO. "A computational analysis of nasal vestibule morphologic variabilities on nasal function." Journal of Biomechanics 49, no. 3 (February 2016): 450-457. Full Text
  - Choi, KJ, Jang, DW, Ellison, MD, and Frank-Ito, DO. "Characterizing airflow profile in the postoperative maxillary sinus by using computational fluid dynamics modeling: A pilot study." American Journal of Rhinology & Allergy 30, no. 1 (January 2016): 29-36. Full Text
  - Frank-Ito, DO, Wofford, M, Schroeter, JD, and Kimbell, JS. "Influence of Mesh Density on Airflow and Particle Deposition in Sinonasal Airway Modeling." Journal of Aerosol Medicine and Pulmonary Drug Delivery (June 11, 2015). Full Text
  - Frank-Ito, DO, Sajisevi, M, Solares, CA, and Jang, DW. "Modeling alterations in sinonasal physiology after skull base surgery." American Journal of Rhinology & Allergy 29, no. 2 (March 2015): 145-150. Full Text
  - Wofford, MR, Kimbell, JS, Frank-Ito, DO, Dhandha, V, McKinney, KA, Fleischman, GM, Ebert, CS, Zanation, AM, and Senior, BA. "A computational study of functional endoscopic sinus surgery and maxillary sinus drug delivery." Rhinology 53, no. 1 (March 2015): 41-48. Full Text
  - Frank-Ito, DO, Schulz, K, Vess, G, and Witsell, DL. "Changes in aerodynamics during vocal cord dysfunction." Computers in Biology and Medicine 57 (February 2015): 116-122. Full Text
  - Patel, RG, Garcia, GJM, Frank-Ito, DO, Kimbell, JS, and Rhee, JS. "Simulating the nasal cycle with computational fluid dynamics." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 152, no. 2 (February 2015): 353-360. Full Text
  - Frank-Ito, DO, Kimbell, JS, Laud, P, Garcia, GJM, and Rhee, JS. "Predicting postsurgery nasal physiology with computational modeling: current challenges and limitations." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 151, no. 5 (November 2014): 751-759. Full Text
  - Shadfar, S, Shockley, WW, Fleischman, GM, Dugar, AR, McKinney, KA, Frank-Ito, DO, and Kimbell, JS. "Characterization of postoperative changes in nasal airflow using a cadaveric computational fluid dynamics model: supporting the internal nasal valve." Jama Facial Plastic Surgery 16, no. 5 (September 2014): 319-327. Full Text
  - Rhee, JS, Sullivan, CD, Frank, DO, Kimbell, JS, and Garcia, GJM. "A systematic review of patient-reported nasal obstruction scores: defining normative and symptomatic ranges in surgical patients." Jama Facial Plastic Surgery 16, no. 3 (May 2014): 219-232. (Review) Full Text
  - Sullivan, CD, Garcia, GJM, Frank-Ito, DO, Kimbell, JS, and Rhee, JS. "Perception of better nasal patency correlates with increased mucosal cooling after surgery for nasal obstruction." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 150, no. 1 (January 2014): 139-147. Full Text
  - Frank, DO, Zanation, AM, Dhandha, VH, McKinney, KA, Fleischman, GM, Ebert, CS, Senior, BA, and Kimbell, JS. "Quantification of airflow into the maxillary sinuses before and after functional endoscopic sinus surgery." International Forum of Allergy & Rhinology 3, no. 10 (October 2013): 834-840. Full Text
  - Kimbell, JS, Frank, DO, Laud, P, Garcia, GJM, and Rhee, JS. "Changes in nasal airflow and heat transfer correlate with symptom improvement after surgery for nasal obstruction." Journal of Biomechanics 46, no. 15 (October 2013): 2634-2643. Full Text
  - Cannon, DE, Frank, DO, Kimbell, JS, Poetker, DM, and Rhee, JS. "Modeling nasal physiology changes due to septal perforations." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 148, no. 3 (March 2013): 513-518. Full Text
  - Frank, DO, Kimbell, JS, Cannon, D, and Rhee, JS. "Computed intranasal spray penetration: comparisons before and after nasal surgery." International Forum of Allergy & Rhinology 3, no. 1 (January 2013): 48-55. Full Text
  - Frank, DO, Kimbell, JS, Cannon, D, Pawar, SS, and Rhee, JS. "Deviated nasal septum hinders intranasal sprays: a computer simulation study." Rhinology 50, no. 3 (September 2012): 311-318. Full Text
  - Rhee, JS, Cannon, DE, Frank, DO, and Kimbell, JS. "Role of virtual surgery in preoperative planning: assessing the individual components of functional nasal airway surgery." Archives of Facial Plastic Surgery 14, no. 5 (September 2012): 354-359. Full Text
  - Kimbell, JS, Garcia, GJM, Frank, DO, Cannon, DE, Pawar, SS, and Rhee, JS. "Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: a preliminary report." American Journal of Rhinology & Allergy 26, no. 3 (May 2012): e94-e98. Full Text
  - Frank, DO, Kimbell, JS, Pawar, S, and Rhee, JS. "Effects of anatomy and particle size on nasal sprays and nebulizers." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 146, no. 2 (February 2012): 313-319. Full Text
- Other Articles
  - Garcia, GJM, Patel, RG, Frank-Ito, DO, Kimbell, JS, and Rhee, JS. "Response to Dr Chung's Question on Simulating the Nasal Cycle with Computational Fluid Dynamics." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 153, no. 2 (August 2015): 308-309. (Letter) Full Text
  - Garcia, GJM, Kimbell, JS, and Frank-Ito, DO. "In reference to Regional peak mucosal cooling predicts the perception of nasal patency." The Laryngoscope 124, no. 5 (May 2014): E210-null. (Letter) Full Text
- Conference Papers
  - Ma, J, Dong, J, Shang, Y, Inthavong, K, Tu, J, and Frank-Ito, DO. "Numerical air conditioning performance assessment of nasal models with morphologic variations." June 15, 2017. Full Text
  - Wofford, M, Kimbell, JS, Frank, DO, Schroeter, JD, Dhandha, V, Ebert, CS, Zanation, AM, and Senior, BA. "A COMPUTATIONAL MESH DESIGN FOR AIRFLOW AND NEBULIZED PARTICLE TRANSPORT SIMULATION IN A SINONASAL MODEL AFTER FUNCTIONAL ENDOSCOPIC SINUS SURGERY (FESS)." : MARY ANN LIEBERT INC, April 1, 2013. Link to Item

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Education, Training, & Certifications

Duke Appointment History

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Other Articles

Conference Papers