Dennis Onyeka Frank-Ito

Journal Article Ann Otol Rhinol Laryngol · June 2026 INTRODUCTION: The role of conductive factors on olfactory acuity has received little attention. The relationships between nasal anatomy, inspiratory airflow and olfaction remain unclear, including if nasal anatomic and functional factors account for some v ... Full text Link to item Cite

Preliminary Analysis to Quantify Sinonasal Airspace Changes in Chronic Rhinosinusitis.

Journal Article Ann Otol Rhinol Laryngol · March 2026 PURPOSE: Chronic rhinosinusitis (CRS), marked by nasal mucosal inflammation, is a common condition often assessed via computed tomography (CT). However, the extent of airway opacification due to CRS-related inflammation remains incompletely quantified rela ... Full text Link to item Cite

Effects of Elexacaftor/Tezacaftor/Ivacaftor on the Sinonasal Airspace in Cystic Fibrosis.

Journal Article Laryngoscope · February 2026 OBJECTIVES: People with Cystic Fibrosis (CF) experience significant sinonasal airway opacification, leading to chronic airway-related conditions. The triple combination therapy Elexacaftor/Tezacaftor/Ivacaftor (ETI) has emerged as a therapeutic option for ... Full text Link to item Cite

Investigating the Challenges of Managing Coexisting Subglottic Stenosis and Bronchopulmonary Diseases Medically Using Computational Modeling.

Journal Article Otolaryngol Head Neck Surg · February 2026 OBJECTIVE: Subglottic stenosis (SGS) coexists with bronchopulmonary disease, complicating topical therapy given the distinct anatomical targets. Optimizing inhaled medication delivery to both regions remain a therapeutic challenge. This study evaluates the ... Full text Link to item Cite

Nasal cycling effects in intranasal drug delivery efficiency to the olfactory cleft.

Journal Article Respir Physiol Neurobiol · January 2026 BACKGROUND: Optimizing olfactory cleft drug delivery remains a significant challenge due to the anatomical complexity of the nasal cavity and olfactory cleft location. While various strategies have been explored to improve targeting, the influence of nasal ... Full text Link to item Cite

Embedded FEM with strongly-enforced interface conditions for incompressible flow with moving boundaries

Journal Article Computer Methods in Applied Mechanics and Engineering · October 1, 2025 We present an embedded finite element method for solving the incompressible Navier–Stokes equations on complex or moving domains while using a fixed structured background mesh. The key component of our approach is a ghost node framework that modifies basis ... Full text Cite

A Human-Centered Design Approach to SOVTE Straw Phonation Instruction.

Journal Article J Voice · July 2025 OBJECTIVES: Extensive research has demonstrated that straw/tube phonation exercises produce positive effects on the voice quality of the user. The purpose of this study was to explore pedagogical practices employed by a range of voice professionals when us ... Full text Link to item Cite

Functional Septorhinoplasty in Unilateral and Bilateral Nasal Obstruction: A Comparison of Patient-Reported Outcomes.

Journal Article Ann Otol Rhinol Laryngol · May 2025 PURPOSE: Functional septorhinoplasty is an effective treatment for nasal airway obstruction. Little distinction exists between bilaterally and unilaterally obstructed patients in literature. Our study evaluates outcomes in patients with unilateral nasal ai ... Full text Link to item Cite

Olfaction and drug delivery to the human olfactory airspace: current challenges and recent advances.

Journal Article Expert Opin Drug Deliv · April 2025 INTRODUCTION: Olfactory function, despite its critical role in human survival and quality of life, is often underappreciated. This could be associated with the fact that symptoms of olfactory dysfunction rarely occur in isolation as they are frequently con ... Full text Link to item Cite

Comparative Analysis of Spreader Grafts and Spreader Flaps on Intranasal Drug Delivery Efficiency to Posterolateral Nasal Wall

Journal Article Face · March 1, 2025 Background: This study compared the impact of spreader grafts (SG) and spreader flaps (SF) on the transport of intranasal drug delivery to target the posterolateral nasal wall. Method: SG and SF were each performed in sequence on two cadaveric specimens af ... Full text Open Access Cite

Comparing Patient-Reported Outcomes with Computational Fluid Dynamics-Derived Nasal Airflow After Nasal Airway Surgery: Prioritizing the Patient's Perception of Nasal Obstruction.

Journal Article Facial Plast Surg Aesthet Med · 2025 Background: Some patients report persistent nasal obstruction after surgical treatment despite objective improvement. Objective: To compare patients' perceptions of nasal obstruction after surgery with objective nasal airflow as determined by computational ... Full text Open Access Link to item Cite

Impact of Intra-Phenotypic Nasal Vestibular Variation on Local Airflow Dynamics.

Journal Article Laryngoscope · January 2025 OBJECTIVES: Many individuals with healthy normal nasal anatomy and function exhibit a prominent notch indentation at the junction of the ala and sidewall, specifically around the anterior-superior region of the unilateral nasal vestibule up to the internal ... Full text Link to item Cite

Nasal airway obstruction in patients with cleft lip nasal deformity: A systematic review.

Journal Article Journal of plastic, reconstructive & aesthetic surgery : JPRAS · May 2024 BackgroundCleft lip nasal deformity (CLND)-associated nasal airway obstruction (CL-NAO) may be inadequately characterized, with its functional implications subsequently underappreciated and neglected. The purpose of this systematic review is to (1 ... Full text Open Access Cite

Limitations in Faculty Advancement for Underrepresented Groups in Academic Otolaryngology.

Journal Article Laryngoscope · April 2024 OBJECTIVE: Despite the increasing racial diversity of the United States, representation in academic medicine faculty does not reach concordance with the general population and worsens with higher rank. Few studies have examined this within academic Otolary ... Full text Link to item Cite

Parameter characteristics in intranasal drug delivery: A key to targeting medications to the olfactory airspace.

Journal Article Clin Biomech (Bristol) · April 2024 BACKGROUND: The nose is a viable pathway for topical drug delivery to the olfactory cleft for treatment of obstructive smell loss and nose-to-brain drug delivery. This study investigates how variations in nasal vestibule morphology influence intranasal spr ... Full text Link to item Cite

Finding the Potholes in Academic Career Pathways for Underrepresented Groups in Otolaryngology.

Journal Article Otolaryngol Head Neck Surg · February 2024 OBJECTIVE: To assess inequities in representation among ranks and odds of promotion by race in academic otolaryngology. STUDY DESIGN: Cross-sectional study. SETTING: US academic medical centers. METHODS: Demographic data was collected for medical students, ... Full text Link to item Cite

Insights into exercise-induced rhinitis based on nasal aerodynamics induced by airway morphology.

Journal Article Respir Physiol Neurobiol · January 2024 BACKGROUND: Exercise-induced rhinitis (EIR) is a poorly understood phenomenon that may be related to increased inspiratory airflow. Characterization of the development of EIR is important to understand contributing factors. OBJECTIVE: To characterize how d ... Full text Link to item Cite

Olfactory drug delivery with intranasal sprays after nasal midvault reconstruction.

Journal Article Int J Pharm · September 25, 2023 Conductive olfaction and nose to brain drug delivery are important processes that remain limited by inadequate odorant or drug delivery to the olfactory airspace. Primary challenges include anatomic barriers and poor targeting to the olfactory region. This ... Full text Open Access Link to item Cite

Nasal Airflow Dynamics Before and After Septorhinoplasty for Correction of Cleft Lip Nasal Deformity: A Single Patient Case Report

Journal Article Face · September 1, 2023 Background: Unilateral cleft lip nasal deformity (uCLND) creates multiple sites of nasal airway obstruction, impacting patients’ quality of life. Surgical restoration of function remains technically challenging and complex. Objectives: This is a single pat ... Full text Open Access Cite

Intranasal Spray Characteristics for Best Drug Delivery in Patients With Chronic Rhinosinusitis.

Journal Article Laryngoscope · May 2023 OBJECTIVES: To determine parameter combinations for effective drug delivery of intranasal spray steroids to the ostiomeatal complex (OMC) and maxillary sinus (MS) in patients with chronic rhinosinusitis (CRS). METHODS: Each patient's sinonasal cavity was r ... Full text Link to item Cite

Computational Analyses of Physiologic Effects After Midvault Repair Techniques in Rhinoplasty

Journal Article Face · March 1, 2023 Background: Midvault reconstruction is an essential element of functional rhinoplasty. An improved understanding of airflow patterns after spreader graft (SG) or spreader flap (SF) techniques can inform surgical techniques based on individual anatomy. Obje ... Full text Open Access Cite

Comparison of Inhaled Drug Delivery in Patients With One- and Two-level Laryngotracheal Stenosis.

Journal Article Laryngoscope · February 2023 OBJECTIVES/HYPOTHESIS: Laryngotracheal stenosis (LTS) is a functionally devastating condition with high respiratory morbidity and mortality. This preliminary study investigates airflow dynamics and stenotic drug delivery in patients with one- and two-level ... Full text Link to item Cite

Gender Differences in Nasal Anatomy and Function Among Caucasians.

Journal Article Facial Plast Surg Aesthet Med · 2023 Background: Anatomical variations influence nasal physiology, yet sex differences in physiology remains unclear. Objective: To investigate sex differences among Caucasians using computational fluid dynamics. Methods: Adult subjects were selected with norma ... Full text Link to item Cite

A computational analysis on the impact of multilevel laryngotracheal stenosis on airflow and drug particle dynamics in the upper airway.

Journal Article Exp Comput Multiph Flow · 2023 Laryngotracheal stenosis (LTS) is a type of airway narrowing that is frequently caused by intubation-related trauma. LTS can occur at one or multiple locations in the larynx and/or trachea. This study characterizes airflow dynamics and drug delivery in pat ... Full text Link to item Cite

Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.

Journal Article Facial Plast Surg Aesthet Med · 2023 Background: Unilateral cleft lip nasal deformity (uCLND) is associated with olfactory dysfunction, but the underlying etiology remains poorly understood. Objective: To investigate the etiology of uCLND-associated olfactory dysfunction using clinical, compu ... Full text Open Access Link to item Cite

Opioid and non-opioid analgesic prescribing practices for pediatric adenotonsillectomy in a tertiary care center.

Journal Article Int J Pediatr Otorhinolaryngol · December 2022 IMPORTANCE: The U.S. is in an opioid epidemic with greater than 40,000 deaths annually. Pediatric adenotonsillectomy is one of the most common and painful otolaryngology surgeries performed, often associated with opioid prescriptions. OBJECTIVE: To underst ... Full text Link to item Cite

Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes.

Journal Article Am J Rhinol Allergy · May 2022 BACKGROUND: Endoscopic sinus surgery is a well-established treatment for chronic rhinosinusitis in patients with cystic fibrosis, though its benefits seem to be limited to improving sinonasal symptoms rather than affecting lung function. OBJECTIVE: This st ... Full text Link to item Cite

The role of normal nasal morphological variations from race and gender differences on respiratory physiology.

Journal Article Respir Physiol Neurobiol · March 2022 This study identifies anatomical and airflow-induced relationships based on nasal morphological variations due to inter- and intra-racial differences and gender. Subject-specific nasal airway reconstruction was created from computed tomography images in 16 ... Full text Link to item Cite

A systematic analysis of surgical interventions for the airway in the mature unilateral cleft lip nasal deformity: a single case study.

Journal Article Int J Comput Assist Radiol Surg · January 2022 PURPOSE: Individuals with unilateral cleft lip nasal deformity (uCLND) often require rhinoplasty in adolescence to correct nasal obstruction. The intent of this study is to identify sites of greatest nasal obstruction and evaluate the effects of isolated a ... Full text Link to item Cite

Analyses on the influence of normal nasal morphological variations on odorant transport to the olfactory cleft.

Journal Article Inhal Toxicol · 2022 OBJECTIVE: Olfaction requires a combination of sensorineural components and conductive components, but conductive mechanisms have not typically received much attention. This study investigates the role of normal nasal vestibule morphological variations in ... Full text Link to item Cite

Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity.

Journal Article Cleft Palate Craniofac J · October 2021 OBJECTIVES: To evaluate the magnitude of olfactory recess opacity in patients with unilateral cleft lip nasal deformity (uCLND). DESIGN: Subject-specific 3-dimensional reconstruction of the nasal airway anatomy was created from computed tomography images i ... Full text Link to item Cite

Analysis of nasal air conditioning in subjects with unilateral cleft lip nasal deformity.

Journal Article Respir Physiol Neurobiol · September 2021 This study evaluated the impact of unilateral cleft lip nasal deformity (uCLND) on the ability of the nasal passages to warm and humidify inspired environmental air using computational fluid dynamics (CFD) modeling. Nasal air conditioning was simulated at ... Full text Link to item Cite

Orally Inhaled Drug Particle Transport in Computerized Models of Laryngotracheal Stenosis.

Journal Article Otolaryngol Head Neck Surg · April 2021 OBJECTIVE: Adjuvant management for laryngotracheal stenosis (LTS) may involve inhaled corticosteroids, but metered dose inhalers are designed for pulmonary drug delivery. Comprehensive analyses of drug particle deposition efficiency for orally inhaled cort ... Full text Link to item Cite

Role of nasal vestibule morphological variations on olfactory airflow dynamics.

Journal Article Clin Biomech (Bristol) · February 2021 BACKGROUND: The conductive mechanisms of olfaction are typically given little priority in the evaluation of olfactory function. The objective of this study is to investigate the role of nasal vestibule morphological variations on airflow volume at the olfa ... Full text Link to item Cite

Numerical evaluation of spray position for improved nasal drug delivery.

Journal Article Sci Rep · June 29, 2020 Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques. In this study, ... Full text Link to item Cite

Virtual septoplasty: a method to predict surgical outcomes for patients with nasal airway obstruction.

Journal Article Int J Comput Assist Radiol Surg · April 2020 PURPOSE: A deviated nasal septum is the most common etiology for nasal airway obstruction (NAO), and septoplasty is the most common surgical procedure performed by ear-nose-throat surgeons in adults. However, quantitative criteria are rarely adopted to sel ... Full text Link to item Cite

Normative ranges of nasal airflow variables in healthy adults.

Journal Article Int J Comput Assist Radiol Surg · January 2020 PURPOSE: Virtual surgery planning based on computational fluid dynamics (CFD) simulations of nasal airflow has the potential to improve surgical outcomes for patients with nasal airway obstruction (NAO). Virtual surgery planning requires normative ranges o ... Full text Link to item Cite

Impact of endoscopic craniofacial resection on simulated nasal airflow and heat transport.

Journal Article Int Forum Allergy Rhinol · August 2019 BACKGROUND: Endoscopic craniofacial resections (CFR) are performed for extensive anterior skull base lesions. This surgery involves removal of multiple intranasal structures, potentially leading to empty nose syndrome (ENS). However, many patients remain a ... Full text Link to item Cite

Geometry and airflow dynamics analysis in the nasal cavity during inhalation.

Journal Article Clin Biomech (Bristol) · June 2019 BACKGROUND: A major issue among computational respiratory studies is the wide variety of nasal morphologies being studied, caused by both inter-population and inter-subject variations. METHOD: Six nasal cavity geometries exhibiting diverse geometry variati ... Full text Link to item Cite

A COMPUTATIONAL ANALYSIS OF AEROSOL DEPORTATION IN LARYNGOTRACHEAL STENOSIS

Conference JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY · June 1, 2019 Link to item Cite

Computational Analysis of the Mature Unilateral Cleft Lip Nasal Deformity on Nasal Patency.

Journal Article Plast Reconstr Surg Glob Open · May 2019 BACKGROUND: Nasal airway obstruction (NAO) due to nasal anatomic deformities is known to be more common among cleft patients than the general population, yet information is lacking regarding severity and variability of cleft-associated nasal obstruction re ... Full text Open Access Link to item Cite

A computational fluid dynamics analysis of the effects of size and shape of anterior nasal septal perforations.

Journal Article Rhinology · April 1, 2019 BACKGROUND: Nasal septal perforations (NSPs) often cause bleeding, crusting, obstruction, and/or whistling. The objective was to analyze the impact of anterior NSP size and shape on nasal physiology using computational fluid dynamics (CFD). METHODS: A 3-di ... Full text Link to item Cite

Multimodal Characterization of the Mature Septal Deformity and Airspace Associated with Unilateral Cleft Lip and Palate.

Journal Article Plast Reconstr Surg · March 2019 BACKGROUND: The nasal deformity that accompanies cleft conditions is often acknowledged as the most difficult obstacle to restoring facial balance in affected children. Despite considerable progress in the treatment of cleft lip and palate, the outcomes of ... Full text Link to item Cite

Upper airway reconstruction using long-range optical coherence tomography: Effects of airway curvature on airflow resistance.

Journal Article Lasers Surg Med · February 2019 OBJECTIVES: Adenotonsillectomy (AT) is commonly used to treat upper airway obstruction in children, but selection of patients who will benefit most from AT is challenging. The need for diagnostic evaluation tools without sedation, radiation, or high costs ... Full text Link to item Cite

A hierarchical stepwise approach to evaluate nasal patency after virtual surgery for nasal airway obstruction.

Journal Article Clin Biomech (Bristol) · January 2019 BACKGROUND: Despite advances in medicine and expenditures associated in treatment of nasal airway obstruction, 25-50% of patients undergoing nasal surgeries complain of persistent obstructive symptoms. Our objective is to develop a "stepwise virtual surger ... Full text Link to item Cite

Air conditioning analysis among human nasal passages with anterior anatomical variations.

Journal Article Med Eng Phys · July 2018 A major functional role of the nasal cavity is air conditioning of the inspired environmental air to near alveolar conditions. It is well known that the anatomical disparities among nasal passages can change airflow patterns to a great extent. However, its ... Full text Link to item Cite

Detailed nanoparticle exposure analysis among human nasal cavities with distinct vestibule phenotypes

Journal Article Journal of Aerosol Science · July 1, 2018 Despite human exposure to inhaled nanoparticles has been intensively studied, the effect of nasal cavity morphology on the distribution patterns of inhaled particles remains less investigated. This paper compared the total and regional deposition patterns ... Full text Cite

Investigating the effects of laryngotracheal stenosis on upper airway aerodynamics.

Journal Article Laryngoscope · April 2018 OBJECTIVE: Very little is known about the impact of laryngotracheal stenosis (LTS) on inspiratory airflow and resistance, especially in air hunger states. This study investigates the effect of LTS on airway resistance and volumetric flow across three diffe ... Full text Link to item Cite

On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation.

Journal Article Int J Numer Method Biomed Eng · April 2018 Generating anatomically realistic 3-dimensional (3D) models of the human sinonasal cavity for numerical investigations of sprayed drug transport presents a host of methodological ambiguities. For example, subject-specific radiographic images used for 3D re ... Full text Link to item Cite

A Pilot Study to Investigate the Relationship Between Interaural Differences in Temporal Bone Anatomy and Normal Variations in Caloric Asymmetry.

Journal Article Am J Audiol · March 8, 2018 PURPOSE: This study assesses interaural differences in temporal bone anatomy in subjects with normal caloric findings. METHOD: Eligible patients included those referred to the Duke University Medical Center otology clinic complaining of dizziness, with a h ... Full text Link to item Cite

Reevaluating Order Effects in the Binaural Bithermal Caloric Test.

Journal Article Am J Audiol · March 8, 2018 PURPOSE: The purpose of this study was to determine whether a significant order effect exists in the binaural bithermal caloric test. METHOD: Fifteen volunteers (mean age = 24.3 years, range = 18-38 years) with no history of vestibular disorder, hearing lo ... Full text Link to item Cite

Virtual Surgery for the Nasal Airway: A Preliminary Report on Decision Support and Technology Acceptance.

Journal Article JAMA Facial Plast Surg · January 1, 2018 IMPORTANCE: Nasal airway obstruction (NAO) is a common problem that affects patient quality of life. Surgical success for NAO correction is variable. Virtual surgery planning via computational fluid dynamics (CFD) has the potential to improve the success r ... Full text Link to item Cite

Personalized mathematical model of endotoxin-induced inflammatory responses in young men and associated changes in heart rate variability

Journal Article Mathematical Modelling of Natural Phenomena · January 1, 2018 The objective of this study was to develop a personalized inflammatory model and estimate subject-specific parameters that could be related to changes in heart rate variability (HRV), a measure that can be obtained non-invasively in real time. An inflammat ... Full text Cite

Temporal bone anatomy characteristics in superior semicircular canal dehiscence.

Journal Article J Otol · December 2017 INTRODUCTION: Superior semicircular canal dehiscence (SCD) remains difficult to diagnose despite advances in high-resolution computed tomography (HRCT) imaging. We hypothesize possible associations between gross temporal bone anatomy and sub-millimeter pat ... Full text Link to item Cite

The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation.

Journal Article J Otol · September 2017 OBJECTIVES: Recent studies have introduced middle ear volume (MEV) as a novel determinant of perforation-induced conductive hearing loss (CHL) in a mechanism driven by trans-tympanic membrane pressure differences. The primary aims of this preliminary repor ... Full text Link to item Cite

Numerical air conditioning performance assessment of nasal models with morphologic variations

Conference Proceedings International Symposium on Biomedical Imaging · June 15, 2017 A major functional role of the nasal cavity is air conditioning of the inspired environmental air to nearly alveolar conditions in order to protect the moist and warm alveolar lining where gas exchange takes place. It is well known that the morphological d ... Full text Cite

Disagreement in middle ear volume estimation between tympanometry and three-dimensional volume reconstruction in the context of tympanic membrane perforation.

Journal Article J Otol · June 2017 INTRODUCTION: Middle ear volume (MEV) is a clinically relevant parameter across middle ear diseases. MEV values between these techniques have never before been tested for agreement in ears with perforated tympanic membranes (TMs). METHODS: Middle ears were ... Full text Link to item Cite

Creation of an idealized nasopharynx geometry for accurate computational fluid dynamics simulations of nasal airflow in patient-specific models lacking the nasopharynx anatomy.

Journal Article Int J Numer Method Biomed Eng · May 2017 Virtual surgery planning based on computational fluid dynamics (CFD) simulations has the potential to improve surgical outcomes for nasal airway obstruction patients, but the benefits of virtual surgery planning must outweigh the risks of radiation exposur ... Full text Link to item Cite

Characterizing human nasal airflow physiologic variables by nasal index.

Journal Article Respir Physiol Neurobiol · October 2016 Although variations in nasal index (NI) have been reported to represent adaptation to climatic conditions, assessments of NI with airflow variables have not been rigorously investigated. This study uses computational fluid dynamics modeling to investigate ... Full text Link to item Cite

Mechanical Nasal Dilators for the Management of Nasal Obstruction.

Journal Article JAMA Facial Plast Surg · September 1, 2016 Full text Link to item Cite

Anatomic Variations in Temporal Bones Affect the Intensity of Nystagmus During Warm Caloric Irrigation.

Journal Article Otol Neurotol · September 2016 HYPOTHESIS: Anatomic variables within the mastoid will correlate with intensity of caloric responses. BACKGROUND: During caloric irrigation, heat is transferred from the external auditory canal to the lateral semicircular canal (LSCC) through aerated masto ... Full text Link to item Cite

A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups.

Journal Article J Aerosol Med Pulm Drug Deliv · April 2016 BACKGROUND: Very little is known about the role of nasal morphology due to ethnic variation on particle deposition pattern in the sinonasal cavity. This preliminary study utilizes computational fluid dynamics (CFD) modeling to investigate sinonasal airway ... Full text Link to item Cite

A computational analysis of nasal vestibule morphologic variabilities on nasal function.

Journal Article J Biomech · February 8, 2016 Although advances in computational modeling have led to increased understanding of nasal airflow, not much is known about the effects of normal sinonasal anatomic variabilities on nasal function. In this study, three distinct variations in the human nasal ... Full text Link to item Cite

Influence of Mesh Density on Airflow and Particle Deposition in Sinonasal Airway Modeling.

Journal Article J Aerosol Med Pulm Drug Deliv · February 2016 BACKGROUND: There are methodological ambiguities in the literature on mesh refinement analysis for computational fluid dynamics (CFD) modeling of physiologically realistic airflow dynamics and particle transport in the human sinonasal cavity. To investigat ... Full text Link to item Cite

Characterizing airflow profile in the postoperative maxillary sinus by using computational fluid dynamics modeling: A pilot study.

Journal Article Am J Rhinol Allergy · 2016 BACKGROUND: Maxillary antrostomy is commonly performed during endoscopic sinus surgery. Little is known about the association surrounding recalcitrant maxillary sinusitis, antrostomy size, and intranasal airflow changes. Furthermore, the interaction betwee ... Full text Link to item Cite

Response to Dr Chung's Question on Simulating the Nasal Cycle with Computational Fluid Dynamics.

Other Otolaryngol Head Neck Surg · August 2015 Full text Link to item Cite

A computational study of functional endoscopic sinus surgery and maxillary sinus drug delivery.

Journal Article Rhinology · March 2015 BACKGROUND: Topical medication is increasingly used following functional endoscopic sinus surgery (FESS). Information on particle sizes that maximise maxillary sinus (MS) delivery is conflicting, and the effect of antrostomy size on delivery is unclear. Th ... Full text Link to item Cite

Simulating the nasal cycle with computational fluid dynamics.

Journal Article Otolaryngol Head Neck Surg · February 2015 OBJECTIVES: (1) To develop a method to account for the confounding effect of the nasal cycle when comparing preoperative and postoperative objective measures of nasal patency. (2) To illustrate this method by reporting objective measures derived from compu ... Full text Link to item Cite

Changes in aerodynamics during vocal cord dysfunction.

Journal Article Comput Biol Med · February 2015 BACKGROUND: Changes in laryngeal airflow dynamics during episodes of vocal cord dysfunction (VCD) have not been well described. Very little is known about how inspiratory airflow is impacted when the vocal cords transition from normal inhalation state to a ... Full text Link to item Cite

Modeling alterations in sinonasal physiology after skull base surgery.

Journal Article Am J Rhinol Allergy · 2015 BACKGROUND: Endonasal endoscopic skull base surgery (EESBS) often requires significant alterations in intranasal anatomy. For example, posterior septectomy (PS) with middle turbinate resection (MTR) is frequently performed to provide access to large sellar ... Full text Link to item Cite

Predicting postsurgery nasal physiology with computational modeling: current challenges and limitations.

Journal Article Otolaryngol Head Neck Surg · November 2014 INTRODUCTION: High failure rates for surgical treatment of nasal airway obstruction (NAO) indicate that better diagnostic tools are needed to improve surgical planning. This study evaluates whether computer models based on a surgeon's edits of presurgery s ... Full text Link to item Cite

In reference to Regional peak mucosal cooling predicts the perception of nasal patency.

Other Laryngoscope · May 2014 Full text Link to item Cite

Perception of better nasal patency correlates with increased mucosal cooling after surgery for nasal obstruction.

Journal Article Otolaryngol Head Neck Surg · January 2014 OBJECTIVES: To (1) quantify mucosal cooling (ie, heat loss) spatially in the nasal passages of nasal airway obstruction (NAO) patients before and after surgery using computational fluid dynamics (CFD) and (2) correlate mucosal cooling with patient-reported ... Full text Link to item Cite

A systematic review of patient-reported nasal obstruction scores: defining normative and symptomatic ranges in surgical patients.

Journal Article JAMA Facial Plast Surg · 2014 IMPORTANCE A gold standard objective measure of nasal airway obstruction (NAO) does not currently exist, so patient-reported measures are commonly used, particularly the Nasal Obstruction Symptom Evaluation (NOSE) scale and the visual analog scale (VAS). H ... Full text Link to item Cite

Characterization of postoperative changes in nasal airflow using a cadaveric computational fluid dynamics model: supporting the internal nasal valve.

Journal Article JAMA Facial Plast Surg · 2014 IMPORTANCE: Collapse or compromise of the internal nasal valve (INV) results in symptomatic nasal obstruction; thus, various surgical maneuvers are designed to support the INV. OBJECTIVE: To determine the effect on nasal airflow after various surgical tech ... Full text Link to item Cite

Changes in nasal airflow and heat transfer correlate with symptom improvement after surgery for nasal obstruction.

Journal Article J Biomech · October 18, 2013 Surgeries to correct nasal airway obstruction (NAO) often have less than desirable outcomes, partly due to the absence of an objective tool to select the most appropriate surgical approach for each patient. Computational fluid dynamics (CFD) models can be ... Full text Link to item Cite

Quantification of airflow into the maxillary sinuses before and after functional endoscopic sinus surgery.

Journal Article Int Forum Allergy Rhinol · October 2013 BACKGROUND: The effects of increases in maxillary sinus (MS) airflow following functional endoscopic sinus surgery (FESS) are unknown. The goal of this study was to quantify the effects of FESS on airflow into the MS in a cohort of patients with chronic rh ... Full text Link to item Cite

A COMPUTATIONAL MESH DESIGN FOR AIRFLOW AND NEBULIZED PARTICLE TRANSPORT SIMULATION IN A SINONASAL MODEL AFTER FUNCTIONAL ENDOSCOPIC SINUS SURGERY (FESS)

Conference JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY · April 1, 2013 Link to item Cite

Modeling nasal physiology changes due to septal perforations.

Journal Article Otolaryngol Head Neck Surg · March 2013 OBJECTIVE: To use computational fluid dynamics (CFD) technology to help providers understand (1) how septal perforations may alter nasal physiology and (2) how these alterations are influenced by perforation size and location. STUDY DESIGN: Computer simula ... Full text Link to item Cite

Computed intranasal spray penetration: comparisons before and after nasal surgery.

Journal Article Int Forum Allergy Rhinol · January 2013 BACKGROUND: Quantitative methods for comparing intranasal drug delivery efficiencies pre- and postoperatively have not been fully utilized. The objective of this study is to use computational fluid dynamics techniques to evaluate aqueous nasal spray penetr ... Full text Link to item Cite

Deviated nasal septum hinders intranasal sprays: a computer simulation study.

Journal Article Rhinology · September 2012 BACKGROUND: This study investigates how deviated nasal septum affects the quantity and distribution of spray particles, and examines the effects of inspiratory airflow and head position on particle transport. METHODS: Deposition of spray particles was anal ... Full text Link to item Cite

Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: A preliminary report.

Journal Article Am J Rhinol Allergy · May 1, 2012 BACKGROUND: Nasal airway obstruction (NAO) is a common health condition impacting mood, energy, recreation, sleep, and overall quality of life. Nasal surgery often addresses NAO but the results are sometimes unsatisfactory. Evaluating surgical treatment ef ... Full text Link to item Cite

Effects of anatomy and particle size on nasal sprays and nebulizers.

Journal Article Otolaryngol Head Neck Surg · February 2012 OBJECTIVE: To study the effects of nasal deformity on aerosol penetration past the nasal valve (NV) for varying particle sizes using sprays or nebulizers. STUDY DESIGN: Computed mathematical nasal airway model. SETTING: Department computer lab. SUBJECTS AN ... Full text Link to item Cite

Computed nasal resistance compared with patient-reported symptoms in surgically treated nasal airway passages: a preliminary report.

Journal Article Am J Rhinol Allergy · 2012 BACKGROUND: Nasal airway obstruction (NAO) is a common health condition impacting mood, energy, recreation, sleep, and overall quality of life. Nasal surgery often addresses NAO but the results are sometimes unsatisfactory. Evaluating surgical treatment ef ... Full text Link to item Cite

Role of virtual surgery in preoperative planning: assessing the individual components of functional nasal airway surgery.

Journal Article Arch Facial Plast Surg · 2012 OBJECTIVES: To demonstrate the effect of individual components of functional nasal airway surgery in a patient with multifactorial obstruction and to discuss the potential benefit of computational fluid dynamics (CFD)–aided virtual surgery. METHODS: A 53-y ... Full text Link to item Cite