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Intranasal Spray Characteristics for Best Drug Delivery in Patients With Chronic Rhinosinusitis.

Publication ,  Journal Article
Popper, C; Martin, H; Shah, R; Sicard, R; Hodges, K; Frank-Ito, DO
Published in: Laryngoscope
May 2023

OBJECTIVES: To determine parameter combinations for effective drug delivery of intranasal spray steroids to the ostiomeatal complex (OMC) and maxillary sinus (MS) in patients with chronic rhinosinusitis (CRS). METHODS: Each patient's sinonasal cavity was reconstructed from computed tomography scans. Intranasal airflow and drug particle transport were simulated using computational fluid dynamic modeling. Airflow simulations were performed at 15 Pascal inhalation pressure. Intranasal spray particles of 1-100 μm were simulated at release speeds of 1, 5, and 10 m/s from 6 release locations (Bottom, Center, Top, Lateral, Lateral-Bottom, and Lateral-Top) at a nozzle insertion depth of 15 mm. Drug delivery simulations were performed in the head tilted forward position. RESULTS: Maximal OMC deposition was 0.78%-12.44%, while maximal MS deposition was 0.02%-1.03% across all simulations. In general, particles between 6 and 10 μm had the best OMC (at 1 m/s particle velocity) and MS (at 10 m/s particle velocity) deposition. Particles ranging from 21 to 30 μm also had superior OMC deposition. The lateral and lateral-top spray release locations produced maximum OMC deposition, but no one release location demonstrated an increase in MS deposition. CONCLUSION: This preliminary study suggests that it is challenging to determine a common set of intranasal spray parameter combinations for effective drug delivery to the OMC and MSs. Although drug particle size and spray particle velocity seem to impact particle deposition patterns, spray release location appears to vary with anatomical differences between subjects, particularly when the MS is the target location for particle deposition. Laryngoscope, 133:1036-1043, 2023.

Duke Scholars

Published In

Laryngoscope

DOI

EISSN

1531-4995

Publication Date

May 2023

Volume

133

Issue

5

Start / End Page

1036 / 1043

Location

United States

Related Subject Headings

  • Sinusitis
  • Respiratory Aerosols and Droplets
  • Pharmaceutical Preparations
  • Particle Size
  • Otorhinolaryngology
  • Maxillary Sinus
  • Humans
  • Computer Simulation
  • Chronic Disease
  • Administration, Intranasal
 

Citation

APA
Chicago
ICMJE
MLA
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Popper, C., Martin, H., Shah, R., Sicard, R., Hodges, K., & Frank-Ito, D. O. (2023). Intranasal Spray Characteristics for Best Drug Delivery in Patients With Chronic Rhinosinusitis. Laryngoscope, 133(5), 1036–1043. https://doi.org/10.1002/lary.30155
Popper, Carson, Hannah Martin, Reanna Shah, Ryan Sicard, Katrina Hodges, and Dennis Onyeka Frank-Ito. “Intranasal Spray Characteristics for Best Drug Delivery in Patients With Chronic Rhinosinusitis.Laryngoscope 133, no. 5 (May 2023): 1036–43. https://doi.org/10.1002/lary.30155.
Popper C, Martin H, Shah R, Sicard R, Hodges K, Frank-Ito DO. Intranasal Spray Characteristics for Best Drug Delivery in Patients With Chronic Rhinosinusitis. Laryngoscope. 2023 May;133(5):1036–43.
Popper, Carson, et al. “Intranasal Spray Characteristics for Best Drug Delivery in Patients With Chronic Rhinosinusitis.Laryngoscope, vol. 133, no. 5, May 2023, pp. 1036–43. Pubmed, doi:10.1002/lary.30155.
Popper C, Martin H, Shah R, Sicard R, Hodges K, Frank-Ito DO. Intranasal Spray Characteristics for Best Drug Delivery in Patients With Chronic Rhinosinusitis. Laryngoscope. 2023 May;133(5):1036–1043.
Journal cover image

Published In

Laryngoscope

DOI

EISSN

1531-4995

Publication Date

May 2023

Volume

133

Issue

5

Start / End Page

1036 / 1043

Location

United States

Related Subject Headings

  • Sinusitis
  • Respiratory Aerosols and Droplets
  • Pharmaceutical Preparations
  • Particle Size
  • Otorhinolaryngology
  • Maxillary Sinus
  • Humans
  • Computer Simulation
  • Chronic Disease
  • Administration, Intranasal