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On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation.

Publication ,  Journal Article
Basu, S; Frank-Ito, DO; Kimbell, JS
Published in: Int J Numer Method Biomed Eng
April 2018

Generating anatomically realistic 3-dimensional (3D) models of the human sinonasal cavity for numerical investigations of sprayed drug transport presents a host of methodological ambiguities. For example, subject-specific radiographic images used for 3D reconstructions typically exclude spray bottles. Subtracting a bottle contour from the 3D airspace and dilating the anterior nasal vestibule for nozzle placement augment the complexity of model building. So we explored the question: how essential are these steps to adequately simulate nasal airflow and identify the optimal delivery conditions for intranasal sprays? In particular, we focused on particle deposition patterns in the maxillary sinus, a critical target site for chronic rhinosinusitis. The models were reconstructed from postsurgery computed tomography scans for a 39-year-old Caucasian male, with chronic rhinosinusitis history. Inspiratory airflow patterns during resting breathing are reliably tracked through computational fluid dynamics-based steady-state laminar-viscous modeling, and such regimes portray relative lack of sensitivity to inlet perturbations. Consequently, we hypothesized that the posterior airflow transport and the particle deposition trends should not be radically affected by the nozzle subtraction and vestibular dilation. The study involved 1 base model and 2 derived models; the latter 2 with nozzle contours (2 different orientations) subtracted from the dilated anterior segment of the left vestibule. We analyzed spray transport in the left maxillary sinus for multiple release conditions. Similar release points, localized on an approximately 2 mm × 4.5 mm contour, facilitated improved maxillary deposition in all 3 test cases. This suggests functional redundancy of nozzle insertion in a 3D numerical model for identifying the optimal spray release locations.

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Published In

Int J Numer Method Biomed Eng

DOI

EISSN

2040-7947

Publication Date

April 2018

Volume

34

Issue

4

Start / End Page

e2946

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Pharmaceutical Preparations
  • Paranasal Sinuses
  • Numerical Analysis, Computer-Assisted
  • Nasal Sprays
  • Nasal Cavity
  • Models, Biological
  • Male
  • Hydrodynamics
  • Humans
 

Citation

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Basu, S., Frank-Ito, D. O., & Kimbell, J. S. (2018). On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation. Int J Numer Method Biomed Eng, 34(4), e2946. https://doi.org/10.1002/cnm.2946
Basu, Saikat, Dennis O. Frank-Ito, and Julia S. Kimbell. “On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation.Int J Numer Method Biomed Eng 34, no. 4 (April 2018): e2946. https://doi.org/10.1002/cnm.2946.
Basu, Saikat, et al. “On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation.Int J Numer Method Biomed Eng, vol. 34, no. 4, Apr. 2018, p. e2946. Pubmed, doi:10.1002/cnm.2946.
Journal cover image

Published In

Int J Numer Method Biomed Eng

DOI

EISSN

2040-7947

Publication Date

April 2018

Volume

34

Issue

4

Start / End Page

e2946

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Pharmaceutical Preparations
  • Paranasal Sinuses
  • Numerical Analysis, Computer-Assisted
  • Nasal Sprays
  • Nasal Cavity
  • Models, Biological
  • Male
  • Hydrodynamics
  • Humans