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Computed intranasal spray penetration: comparisons before and after nasal surgery.

Publication ,  Journal Article
Frank, DO; Kimbell, JS; Cannon, D; Rhee, JS
Published in: Int Forum Allergy Rhinol
January 2013

BACKGROUND: Quantitative methods for comparing intranasal drug delivery efficiencies pre- and postoperatively have not been fully utilized. The objective of this study is to use computational fluid dynamics techniques to evaluate aqueous nasal spray penetration efficiencies before and after surgical correction of intranasal anatomic deformities. METHODS: Ten three-dimensional models of the nasal cavities were created from pre- and postoperative computed tomography scans in 5 subjects. Spray simulations were conducted using a particle size distribution ranging from 10 μm to 110 μm, a spray speed of 3 m/second, plume angle of 68 degrees, and with steady state, resting inspiratory airflow present. Two different nozzle positions were compared. Statistical analysis was conducted using Student t test for matched pairs. RESULTS: On the obstructed side, posterior particle deposition after surgery increased by 118% and was statistically significant (p = 0.036), while anterior particle deposition decreased by 13% and was also statistically significant (p = 0.020). The fraction of particles that bypassed the airways either pre- or postoperatively was less than 5%. Posterior particle deposition differences between obstructed and contralateral sides of the airways were 113% and 30% for pre- and postsurgery, respectively. Results showed that nozzle positions can influence spray delivery. CONCLUSION: Simulations predicted that surgical correction of nasal anatomic deformities can improve spray penetration to areas where medications can have greater effect. Particle deposition patterns between both sides of the airways are more evenly distributed after surgery. These findings suggest that correcting anatomic deformities may improve intranasal medication delivery. For enhanced particle penetration, patients with nasal deformities may explore different nozzle positions.

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Published In

Int Forum Allergy Rhinol

DOI

EISSN

2042-6984

Publication Date

January 2013

Volume

3

Issue

1

Start / End Page

48 / 55

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Nasal Surgical Procedures
  • Nasal Sprays
  • Nasal Cavity
  • Models, Biological
  • Models, Anatomic
  • Middle Aged
  • Male
  • Imaging, Three-Dimensional
 

Citation

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Frank, D. O., Kimbell, J. S., Cannon, D., & Rhee, J. S. (2013). Computed intranasal spray penetration: comparisons before and after nasal surgery. Int Forum Allergy Rhinol, 3(1), 48–55. https://doi.org/10.1002/alr.21070
Frank, Dennis O., Julia S. Kimbell, Daniel Cannon, and John S. Rhee. “Computed intranasal spray penetration: comparisons before and after nasal surgery.Int Forum Allergy Rhinol 3, no. 1 (January 2013): 48–55. https://doi.org/10.1002/alr.21070.
Frank DO, Kimbell JS, Cannon D, Rhee JS. Computed intranasal spray penetration: comparisons before and after nasal surgery. Int Forum Allergy Rhinol. 2013 Jan;3(1):48–55.
Frank, Dennis O., et al. “Computed intranasal spray penetration: comparisons before and after nasal surgery.Int Forum Allergy Rhinol, vol. 3, no. 1, Jan. 2013, pp. 48–55. Pubmed, doi:10.1002/alr.21070.
Frank DO, Kimbell JS, Cannon D, Rhee JS. Computed intranasal spray penetration: comparisons before and after nasal surgery. Int Forum Allergy Rhinol. 2013 Jan;3(1):48–55.
Journal cover image

Published In

Int Forum Allergy Rhinol

DOI

EISSN

2042-6984

Publication Date

January 2013

Volume

3

Issue

1

Start / End Page

48 / 55

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Nasal Surgical Procedures
  • Nasal Sprays
  • Nasal Cavity
  • Models, Biological
  • Models, Anatomic
  • Middle Aged
  • Male
  • Imaging, Three-Dimensional