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Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.

Publication ,  Journal Article
Russel, SM; Chiang, H; Finlay, JB; Shah, R; Marcus, JR; Jang, DW; Abi Hachem, R; Goldstein, BJ; Frank-Ito, DO
Published in: Facial Plast Surg Aesthet Med
2023

Background: Unilateral cleft lip nasal deformity (uCLND) is associated with olfactory dysfunction, but the underlying etiology remains poorly understood. Objective: To investigate the etiology of uCLND-associated olfactory dysfunction using clinical, computational, and histologic assessments. Methods: Inclusion criteria: uCLND patients >16 years undergoing septorhinoplasty. Exclusion criteria: prior septoplasty or rhinoplasty, pregnancy, sinusitis. Measured outcomes: patient-reported scores, rhinomanometry, smell identification and threshold tests, computational fluid dynamics (CFD) airflow simulations, and histologic analysis of olfactory epithelium. Results: Five uCLND subjects were included: 18-23 years, three male and two female, four left-sided cleft and one right-sided cleft. All subjects reported moderate to severe nasal obstruction. Smell identification and threshold tests showed varying degrees of hyposmia. Nasal resistance was higher on the cleft side versus noncleft side measured by rhinomanometry (median 3.85 Pa-s/mL, interquartile range [IQR] = 21.96, versus 0.90 Pa-s/mL, IQR = 5.17) and CFD (median 1.04 Pa-s/mL, IQR = 0.94 vs. 0.11 Pa-s/mL, IQR = 0.12). Unilateral olfaction varied widely and was dependent on unilateral percentage olfactory airflow. Biopsies revealed intact olfactory neuroepithelium. Conclusions: uCLND-associated olfactory dysfunction appears to be primarily conductive in etiology and highly susceptible to variations in nasal anatomy. Clinical Trial Registration number: NCT04150783.

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Published In

Facial Plast Surg Aesthet Med

DOI

EISSN

2689-3622

Publication Date

2023

Volume

25

Issue

6

Start / End Page

457 / 465

Location

United States

Related Subject Headings

  • Smell
  • Olfaction Disorders
  • Nose
  • Nasal Obstruction
  • Male
  • Humans
  • Female
  • Cleft Lip
 

Citation

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Russel, S. M., Chiang, H., Finlay, J. B., Shah, R., Marcus, J. R., Jang, D. W., … Frank-Ito, D. O. (2023). Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities. Facial Plast Surg Aesthet Med, 25(6), 457–465. https://doi.org/10.1089/fpsam.2022.0367
Russel, Sarah M., Harry Chiang, John B. Finlay, Reanna Shah, Jeffrey R. Marcus, David W. Jang, Ralph Abi Hachem, Bradley J. Goldstein, and Dennis Onyeka Frank-Ito. “Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.Facial Plast Surg Aesthet Med 25, no. 6 (2023): 457–65. https://doi.org/10.1089/fpsam.2022.0367.
Russel SM, Chiang H, Finlay JB, Shah R, Marcus JR, Jang DW, et al. Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities. Facial Plast Surg Aesthet Med. 2023;25(6):457–65.
Russel, Sarah M., et al. “Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.Facial Plast Surg Aesthet Med, vol. 25, no. 6, 2023, pp. 457–65. Pubmed, doi:10.1089/fpsam.2022.0367.
Russel SM, Chiang H, Finlay JB, Shah R, Marcus JR, Jang DW, Abi Hachem R, Goldstein BJ, Frank-Ito DO. Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities. Facial Plast Surg Aesthet Med. 2023;25(6):457–465.

Published In

Facial Plast Surg Aesthet Med

DOI

EISSN

2689-3622

Publication Date

2023

Volume

25

Issue

6

Start / End Page

457 / 465

Location

United States

Related Subject Headings

  • Smell
  • Olfaction Disorders
  • Nose
  • Nasal Obstruction
  • Male
  • Humans
  • Female
  • Cleft Lip