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A computational analysis of nasal vestibule morphologic variabilities on nasal function.

Publication ,  Journal Article
Ramprasad, VH; Frank-Ito, DO
Published in: J Biomech
February 8, 2016

Although advances in computational modeling have led to increased understanding of nasal airflow, not much is known about the effects of normal sinonasal anatomic variabilities on nasal function. In this study, three distinct variations in the human nasal vestibule airspace that have not been previously described were identified. Computational fluid dynamics modeling of nasal airflow profile in each identified variation of nasal vestibule phenotype was conducted to assess the role of these phenotypes on nasal physiology. Three-dimensional reconstructions of the nasal geometry in sixteen subjects with normal radiographic sinonasal images were created and each respective unilateral nasal cavity was classified as Notched, Standard, or Elongated phenotype based nasal vestibule morphology. Steady state, laminar and incompressible flow simulations were performed in the nasal geometries under physiological, pressure-driven conditions with constant inspiratory pressure. Results showed that at localized regions of the unilateral nasal cavity, average resistance was significantly different among nasal vestibule phenotypes. However, global comparison from nostril to choana showed that average resistance was not significantly different across phenotypes; suggesting that with normal anatomic variations, the nose has a natural compensatory mechanism that modulates localized airflow in order to achieve a desired amount of global airflow.

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Published In

J Biomech

DOI

EISSN

1873-2380

Publication Date

February 8, 2016

Volume

49

Issue

3

Start / End Page

450 / 457

Location

United States

Related Subject Headings

  • Young Adult
  • Tomography, X-Ray Computed
  • Respiration
  • Pressure
  • Phenotype
  • Nose
  • Nasal Cavity
  • Middle Aged
  • Male
  • Imaging, Three-Dimensional
 

Citation

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Ramprasad, V. H., & Frank-Ito, D. O. (2016). A computational analysis of nasal vestibule morphologic variabilities on nasal function. J Biomech, 49(3), 450–457. https://doi.org/10.1016/j.jbiomech.2016.01.009
Ramprasad, Vaibhav H., and Dennis O. Frank-Ito. “A computational analysis of nasal vestibule morphologic variabilities on nasal function.J Biomech 49, no. 3 (February 8, 2016): 450–57. https://doi.org/10.1016/j.jbiomech.2016.01.009.
Ramprasad VH, Frank-Ito DO. A computational analysis of nasal vestibule morphologic variabilities on nasal function. J Biomech. 2016 Feb 8;49(3):450–7.
Ramprasad, Vaibhav H., and Dennis O. Frank-Ito. “A computational analysis of nasal vestibule morphologic variabilities on nasal function.J Biomech, vol. 49, no. 3, Feb. 2016, pp. 450–57. Pubmed, doi:10.1016/j.jbiomech.2016.01.009.
Ramprasad VH, Frank-Ito DO. A computational analysis of nasal vestibule morphologic variabilities on nasal function. J Biomech. 2016 Feb 8;49(3):450–457.
Journal cover image

Published In

J Biomech

DOI

EISSN

1873-2380

Publication Date

February 8, 2016

Volume

49

Issue

3

Start / End Page

450 / 457

Location

United States

Related Subject Headings

  • Young Adult
  • Tomography, X-Ray Computed
  • Respiration
  • Pressure
  • Phenotype
  • Nose
  • Nasal Cavity
  • Middle Aged
  • Male
  • Imaging, Three-Dimensional