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Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes.

Publication ,  Journal Article
Ji, KSY; Frank-Ito, D; Abi Hachem, R; Issa, K; Johnson, C; Mohamedaly, O; Goldstein, BJ; Jang, DW
Published in: Am J Rhinol Allergy
May 2022

BACKGROUND: Endoscopic sinus surgery is a well-established treatment for chronic rhinosinusitis in patients with cystic fibrosis, though its benefits seem to be limited to improving sinonasal symptoms rather than affecting lung function. OBJECTIVE: This study aims to identify clinical and demographic factors that may influence sinonasal and pulmonary outcomes after surgery. METHODS: This is a six-year retrospective analysis of adult cystic fibrosis patients who underwent endoscopic sinus surgery at a tertiary care center. 22-Item Sino-Nasal Outcomes Test scores and mean forced expiratory volume data at baseline and three to six months after surgery were analyzed using t-test and stepwise regression with the following covariates: age, gender, lung transplant, revision surgery, and pseudomonas on sinus culture. RESULTS: 119 surgeries were performed on 88 patients, with 69% on patients with transplant. The overall mean (Standard Deviation) improvement in 22-Item Sino-Nasal Outcomes Test score was 9.42 (18.15) for the entire cohort (P < .001). Pseudomonas on culture was associated with less improvement in sinonasal scores (P = .002). There was no significant change in forced expiratory volume after surgery (P = .94). Revision surgery (P = .004) and older age (P = .007) were associated with less favorable change of pulmonary function on stepwise regression (P = .002). There was no correlation between change in sinonasal scores and pulmonary function. CONCLUSION: Although surgery was associated with a clinically and statistically significant improvement in sinonasal scores in cystic fibrosis patients, patients with pseudomonas may experience less benefit. Revision surgery and older age may be associated with less favorable pulmonary outcomes. Awareness of such variables may help when deciding which cystic fibrosis patients should undergo surgery.

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Published In

Am J Rhinol Allergy

DOI

EISSN

1945-8932

Publication Date

May 2022

Volume

36

Issue

3

Start / End Page

307 / 312

Location

United States

Related Subject Headings

  • Sinusitis
  • Rhinitis
  • Retrospective Studies
  • Otorhinolaryngology
  • Lung
  • Humans
  • Endoscopy
  • Cystic Fibrosis
  • Chronic Disease
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
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Ji, K. S. Y., Frank-Ito, D., Abi Hachem, R., Issa, K., Johnson, C., Mohamedaly, O., … Jang, D. W. (2022). Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes. Am J Rhinol Allergy, 36(3), 307–312. https://doi.org/10.1177/19458924211059606
Ji, Keven S. Y., Dennis Frank-Ito, Ralph Abi Hachem, Khalil Issa, Carrie Johnson, Omar Mohamedaly, Bradley J. Goldstein, and David W. Jang. “Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes.Am J Rhinol Allergy 36, no. 3 (May 2022): 307–12. https://doi.org/10.1177/19458924211059606.
Ji KSY, Frank-Ito D, Abi Hachem R, Issa K, Johnson C, Mohamedaly O, et al. Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes. Am J Rhinol Allergy. 2022 May;36(3):307–12.
Ji, Keven S. Y., et al. “Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes.Am J Rhinol Allergy, vol. 36, no. 3, May 2022, pp. 307–12. Pubmed, doi:10.1177/19458924211059606.
Ji KSY, Frank-Ito D, Abi Hachem R, Issa K, Johnson C, Mohamedaly O, Goldstein BJ, Jang DW. Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes. Am J Rhinol Allergy. 2022 May;36(3):307–312.

Published In

Am J Rhinol Allergy

DOI

EISSN

1945-8932

Publication Date

May 2022

Volume

36

Issue

3

Start / End Page

307 / 312

Location

United States

Related Subject Headings

  • Sinusitis
  • Rhinitis
  • Retrospective Studies
  • Otorhinolaryngology
  • Lung
  • Humans
  • Endoscopy
  • Cystic Fibrosis
  • Chronic Disease
  • Adult