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Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity.

Publication ,  Journal Article
Shah, R; Marcus, JR; Frank-Ito, DO
Published in: Cleft Palate Craniofac J
October 2021

OBJECTIVES: To evaluate the magnitude of olfactory recess opacity in patients with unilateral cleft lip nasal deformity (uCLND). DESIGN: Subject-specific 3-dimensional reconstruction of the nasal airway anatomy was created from computed tomography images in 11 (4 males and 7 females) subjects with uCLND and 7 (3 males, and 4 females) normal subjects. The volume and surface area of each subject's unilateral and bilateral olfactory airspace was quantified to assess the impact of opacification. Qualitatively speaking, patients with 75% to 100% olfactory recess opacification were classified as extreme, 50% to 75% as severe, 25% to 50% as moderate, and 0% to 25% as mild. RESULTS: Of the 11 subjects with uCLND, 5 (45%) were classified as having extreme olfactory recess opacification, 3 (27%) subjects had severe opacification, and 3 (27%) subjects had moderate opacification. Mean (±SD) bilateral olfactory recess volume was significantly greater in normal subjects than in subjects with uCLND (0.9668 cm3 ± 0.4061 cm3 vs 0.3426 cm3 ± 0.1316 cm3; P < .001). Furthermore, unilateral olfactory airspace volumes for the cleft and non-cleft sides in subjects with uCLND were considerably less than unilateral olfactory volume in subjects with normal anatomy (uCLND cleft side = 0.1623 cm3 ± 0.0933 cm3; uCLND non-cleft side = 0.1803 cm3 ± 0.0938 cm3; normal = 0.4834 cm3 ± 0.2328 cm3; P < .001). CONCLUSIONS: Our findings indicate a high prevalence of olfactory recess opacification among subjects with uCLND when compared to subjects with normal anatomy. The majority of subjects with uCLND had extreme olfactory recess opacity, which will likely influence their sense of smell.

Duke Scholars

Published In

Cleft Palate Craniofac J

DOI

EISSN

1545-1569

Publication Date

October 2021

Volume

58

Issue

10

Start / End Page

1242 / 1250

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Smell
  • Nasopharynx
  • Male
  • Humans
  • Female
  • Dentistry
  • Cleft Lip
  • 3203 Dentistry
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shah, R., Marcus, J. R., & Frank-Ito, D. O. (2021). Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity. Cleft Palate Craniofac J, 58(10), 1242–1250. https://doi.org/10.1177/1055665620982754
Shah, Reanna, Jeffrey R. Marcus, and Dennis O. Frank-Ito. “Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity.Cleft Palate Craniofac J 58, no. 10 (October 2021): 1242–50. https://doi.org/10.1177/1055665620982754.
Shah R, Marcus JR, Frank-Ito DO. Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity. Cleft Palate Craniofac J. 2021 Oct;58(10):1242–50.
Shah, Reanna, et al. “Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity.Cleft Palate Craniofac J, vol. 58, no. 10, Oct. 2021, pp. 1242–50. Pubmed, doi:10.1177/1055665620982754.
Shah R, Marcus JR, Frank-Ito DO. Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity. Cleft Palate Craniofac J. 2021 Oct;58(10):1242–1250.

Published In

Cleft Palate Craniofac J

DOI

EISSN

1545-1569

Publication Date

October 2021

Volume

58

Issue

10

Start / End Page

1242 / 1250

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Smell
  • Nasopharynx
  • Male
  • Humans
  • Female
  • Dentistry
  • Cleft Lip
  • 3203 Dentistry
  • 3202 Clinical sciences