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Analyses on the influence of normal nasal morphological variations on odorant transport to the olfactory cleft.

Publication ,  Journal Article
Sicard, RM; Shah, R; Frank-Ito, DO
Published in: Inhal Toxicol
2022

OBJECTIVE: Olfaction requires a combination of sensorineural components and conductive components, but conductive mechanisms have not typically received much attention. This study investigates the role of normal nasal vestibule morphological variations in ten healthy subjects on odorant flux in the olfactory cleft. MATERIALS AND METHODS: Computed tomography images were used to create subject-specific nasal models. Each subject's unilateral nasal cavity was classified according to its nasal vestibule shape as Standard or Notched. Inspiratory airflow simulations were performed at 15 L/min, simulating resting inspiration using computational fluid dynamics modeling. Odorant transport simulations for three odorants (limonene, 2,4-dinitrotoluene, and acetaldehyde) were then performed at concentrations of 200 ppm for limonene and acetaldehyde, and 0.2 ppm for dinitrotoluene. Olfactory cleft odorant flux was computed for each simulation. RESULTS AND DISCUSSION AND CONCLUSION: Simulated results showed airflow in the olfactory cleft was greater in the Standard phenotype compared to the Notched phenotype. For Standard, median airflow was greatest in the anterior region (0.5006 L/min) and lowest in the posterior region (0.1009 L/min). Median airflow in Notched was greatest in the medial region (0.3267 L/min) and lowest in the posterior region (0.0756 L/min). Median olfactory odorant flux for acetaldehyde and limonene was greater in Standard (Acetaldehyde: Standard = 140.45 pg/cm2-s; Notched = 122.20 pg/cm2-s. Limonene: Standard = 0.67 pg/cm2-s; Notched = 0.65 pg/cm2-s). Median dinitrotoluene flux was greater in Notched (Standard = 2.86 × 10-4pg/cm2-s; Notched = 4.29 × 10-4 pg/cm2-s). The impact of nasal vestibule morphological variations on odorant flux at the olfactory cleft may have implications on individual differences in olfaction, which should be investigated further.

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Published In

Inhal Toxicol

DOI

EISSN

1091-7691

Publication Date

2022

Volume

34

Issue

11-12

Start / End Page

350 / 358

Location

England

Related Subject Headings

  • Toxicology
  • Smell
  • Odorants
  • Nasal Cavity
  • Limonene
  • Dinitrobenzenes
  • Acetaldehyde
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Chicago
ICMJE
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Sicard, R. M., Shah, R., & Frank-Ito, D. O. (2022). Analyses on the influence of normal nasal morphological variations on odorant transport to the olfactory cleft. Inhal Toxicol, 34(11–12), 350–358. https://doi.org/10.1080/08958378.2022.2115175
Sicard, Ryan M., Reanna Shah, and Dennis O. Frank-Ito. “Analyses on the influence of normal nasal morphological variations on odorant transport to the olfactory cleft.Inhal Toxicol 34, no. 11–12 (2022): 350–58. https://doi.org/10.1080/08958378.2022.2115175.
Sicard RM, Shah R, Frank-Ito DO. Analyses on the influence of normal nasal morphological variations on odorant transport to the olfactory cleft. Inhal Toxicol. 2022;34(11–12):350–8.
Sicard, Ryan M., et al. “Analyses on the influence of normal nasal morphological variations on odorant transport to the olfactory cleft.Inhal Toxicol, vol. 34, no. 11–12, 2022, pp. 350–58. Pubmed, doi:10.1080/08958378.2022.2115175.
Sicard RM, Shah R, Frank-Ito DO. Analyses on the influence of normal nasal morphological variations on odorant transport to the olfactory cleft. Inhal Toxicol. 2022;34(11–12):350–358.

Published In

Inhal Toxicol

DOI

EISSN

1091-7691

Publication Date

2022

Volume

34

Issue

11-12

Start / End Page

350 / 358

Location

England

Related Subject Headings

  • Toxicology
  • Smell
  • Odorants
  • Nasal Cavity
  • Limonene
  • Dinitrobenzenes
  • Acetaldehyde
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences