Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina - Chapel Hill 1995
  • B.S., North Carolina State University 1990
• 

  Previous Appointments & Affiliations

  • Professor of Biochemistry, Biochemistry, Basic Science Departments 2010 - 2022
• Recognition
• 

  In the News

  • JUN 18, 2014

    Chris Podracky: Undergraduate Explores Mechanisms of Bacterial Disease

  • JUN 16, 2014

    Lindsey Olivere: Student Seeks Alternative Pathway for Parkinson's Treatment
• 

  Awards & Honors

  • Eli Lilly Award in Biological Chemistry. American Chemical Society. 2005
• Research
• 

  Selected Grants

  • Chemical Biology of the E3 Ubiqutin Ligase Nedd4 awarded by National Institutes of Health 2023 - 2027
  • Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
  • Non-Opioid Post-Operative Pain Management Using Bupivicaine-loaded Poly(ester urea) Mesh awarded by 21MedTech, LLC 2021 - 2023
  • Chemical Biology of Ubiquitin- and Neddylation-Protein Ligases in Neurodegeneration awarded by National Institutes of Health 2019 - 2022
  • Nedd4 E3 Ubiquitin Ligase as a Target for the Alleviation of Mutant Alpha-Synuclein Toxicity awarded by Michael J. Fox Foundation for Parkinson's Research 2019 - 2020
  • Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
  • Enzymology of Chlamydial Pathogenesis awarded by National Institutes of Health 2013 - 2020
  • Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
  • BC123577: Targeting Epigenetics Therapy for Estrogen Receptor Negative Breast Cancers awarded by United States Army Medical Research and Materiel Command 2013 - 2016
  • Chemical Biology Approaches to Combat Parkinson's Disease and Dyskinesia awarded by National Institutes of Health 2013 - 2016
  • Automated detection of protein crystals in high-throughput crystallography experiments awarded by North Carolina Biotechnology Center 2014 - 2015
  • Structural and Biochemical Studies of LpxC Inhibition awarded by National Institutes of Health 2003 - 2014
  • Bioorganic Mechanisms of Chromatin Modifying Enzymes awarded by National Institutes of Health 2009 - 2011
  • Bioorganic Mechanisms of Peptide Antibiotics awarded by National Institutes of Health 2006 - 2011
  • Mechanistic Analyses of Protein Deacetylation awarded by National Institutes of Health 2006 - 2008
  • RSF: Properties and Dependence Upon Histone Modifications awarded by National Institutes of Health 2006 - 2007
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Hatstat, A Katherine, Baiyi Quan, Morgan A. Bailey, Michael C. Fitzgerald, Michaela C. Reinhart, and Dewey G. McCafferty. “Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity.” Rsc Chemical Biology 3, no. 1 (January 2022): 96–111. https://doi.org/10.1039/d1cb00103e.
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    • Dudiak, Brianne M., Tri M. Nguyen, David Needham, Taylor C. Outlaw, and Dewey G. McCafferty. “Inhibition of the futalosine pathway for menaquinone biosynthesis suppresses Chlamydia trachomatis infection.” Febs Letters 595, no. 24 (December 2021): 2995–3005. https://doi.org/10.1002/1873-3468.14223.
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    • Hatstat, A Katherine, Michael D. Pupi, Michaela C. Reinhart, and Dewey G. McCafferty. “Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration.” Acs Chemical Neuroscience 12, no. 21 (November 2021): 3972–84. https://doi.org/10.1021/acschemneuro.1c00524.
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    • Stariha, Lydia M., and Dewey G. McCafferty. “Discovery of the Class I Antimicrobial Lasso Peptide Arcumycin.” Chembiochem : A European Journal of Chemical Biology 22, no. 16 (August 2021): 2632–40. https://doi.org/10.1002/cbic.202100132.
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    • Hatstat, A Katherine, Hannah D. Ahrendt, Matthew W. Foster, Leland Mayne, M Arthur Moseley, S Walter Englander, and Dewey G. McCafferty. “Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade.” Cell Chem Biol 28, no. 1 (January 21, 2021): 14-25.e9. https://doi.org/10.1016/j.chembiol.2020.10.008.
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    • Hatstat, A Katherine, Michael D. Pupi, and Dewey G. McCafferty. “Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases.” Plos One 16, no. 10 (January 2021): e0258315. https://doi.org/10.1371/journal.pone.0258315.
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    • Morgan, Kelsey T., Jeffrey Zheng, and Dewey G. McCafferty. “Discovery of Six Ramoplanin Family Gene Clusters and the Lipoglycodepsipeptide Chersinamycin*.” Chembiochem : A European Journal of Chemical Biology 22, no. 1 (January 2021): 176–85. https://doi.org/10.1002/cbic.202000555.
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    • Hatstat, A Katherine, and Dewey G. McCafferty. “Robust and facile purification of full-length, untagged human Nedd4 as a recombinant protein from Escherichia coli.” Protein Expression and Purification 173 (September 2020): 105649. https://doi.org/10.1016/j.pep.2020.105649.
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    • Dudiak, Brianne M., Kenneth R. Maksimchuk, Maria M. Bednar, Christopher J. Podracky, Jonathan M. Burg, Tri M. Nguyen, Felix O. Nwogbo, Raphael H. Valdivia, and Dewey G. McCafferty. “Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF.” Biochemistry 58, no. 33 (August 20, 2019): 3527–36. https://doi.org/10.1021/acs.biochem.9b00522.
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    • Biniossek, Martin L., Melanie Niemer, Ken Maksimchuk, Bettina Mayer, Julian Fuchs, Pitter F. Huesgen, Dewey G. McCafferty, et al. “Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics.” Molecular & Cellular Proteomics : Mcp 15, no. 7 (July 2016): 2515–24. https://doi.org/10.1074/mcp.o115.056671.
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    • Burg, Jonathan M., Julie J. Gonzalez, Kenneth R. Maksimchuk, and Dewey G. McCafferty. “Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones.” Biochemistry 55, no. 11 (March 2016): 1652–62. https://doi.org/10.1021/acs.biochem.5b01135.
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    • Maksimchuk, Kenneth R., Katherine A. Alser, Rui Mou, Raphael H. Valdivia, and Dewey G. McCafferty. “The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins.” Plos One 11, no. 2 (2016): e0147233. https://doi.org/10.1371/journal.pone.0147233.
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    • Burg, Jonathan M., Alan T. Makhoul, Charles W. Pemble, Jennifer E. Link, Frederick J. Heller, and Dewey G. McCafferty. “A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity.” Febs Letters 589, no. 18 (August 2015): 2340–46. https://doi.org/10.1016/j.febslet.2015.07.028.
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    • Burg, Jonathan M., Jennifer E. Link, Brittany S. Morgan, Frederick J. Heller, Amanda E. Hargrove, and Dewey G. McCafferty. “KDM1 class flavin-dependent protein lysine demethylases.” Biopolymers 104, no. 4 (July 2015): 213–46. https://doi.org/10.1002/bip.22643.
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    • Snavely, Emily A., Marcela Kokes, Joe Dan Dunn, Hector A. Saka, Bidong D. Nguyen, Robert J. Bastidas, Dewey G. McCafferty, and Raphael H. Valdivia. “Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches.” Pathog Dis 71, no. 3 (August 2014): 336–51. https://doi.org/10.1111/2049-632X.12179.
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    • McCafferty, D. G., and J. A. Melvin. “Sortases” 2 (August 29, 2013): 2459–65. https://doi.org/10.1016/B978-0-12-382219-2.00549-4.
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    • Qi, Yizhi, Miriam Amiram, Weiping Gao, Dewey G. McCafferty, and Ashutosh Chilkoti. “Sortase-catalyzed initiator attachment enables high yield growth of a stealth polymer from the C terminus of a protein.” Macromolecular Rapid Communications 34, no. 15 (August 2013): 1256–60. https://doi.org/10.1002/marc.201300460.
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    • Bellucci, Joseph J., Miriam Amiram, Jayanta Bhattacharyya, Dewey McCafferty, and Ashutosh Chilkoti. “Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides.” Angewandte Chemie (International Ed. in English) 52, no. 13 (March 2013): 3703–8. https://doi.org/10.1002/anie.201208292.
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    • Folk, Drew S., Justin C. Torosian, Sunhee Hwang, Dewey G. McCafferty, and Katherine J. Franz. “Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.” Angewandte Chemie (International Ed. in English) 51, no. 43 (October 2012): 10795–99. https://doi.org/10.1002/anie.201206673.
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    • Pollock, Julie A., Michelle D. Larrea, Jeff S. Jasper, Donald P. McDonnell, and Dewey G. McCafferty. “Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.” Acs Chem Biol 7, no. 7 (July 20, 2012): 1221–31. https://doi.org/10.1021/cb300108c.
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    • Weinberg, David R., Christopher J. Gagliardi, Jonathan F. Hull, Christine Fecenko Murphy, Caleb A. Kent, Brittany C. Westlake, Amit Paul, Daniel H. Ess, Dewey Granville McCafferty, and Thomas J. Meyer. “Proton-coupled electron transfer.” Chemical Reviews 112, no. 7 (July 2012): 4016–93. https://doi.org/10.1021/cr200177j.
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    • Hoertz, Amanda J., James B. Hamburger, David M. Gooden, Maria M. Bednar, and Dewey G. McCafferty. “Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2.” Bioorganic & Medicinal Chemistry 20, no. 2 (January 2012): 859–65. https://doi.org/10.1016/j.bmc.2011.11.062.
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    • Bednar, Maria M., Ine Jorgensen, Raphael H. Valdivia, and Dewey G. McCafferty. “Chlamydia protease-like activity factor (CPAF): characterization of proteolysis activity in vitro and development of a nanomolar affinity CPAF zymogen-derived inhibitor.” Biochemistry 50, no. 35 (September 6, 2011): 7441–43. https://doi.org/10.1021/bi201098r.
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    • Melvin, Jeffrey A., Christine F. Murphy, Laura G. Dubois, J Will Thompson, M Arthur Moseley, and Dewey G. McCafferty. “Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation.” Biochemistry 50, no. 35 (September 6, 2011): 7591–99. https://doi.org/10.1021/bi200844h.
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    • Jorgensen, Ine, Maria M. Bednar, Vishar Amin, Beckley K. Davis, Jenny P. Y. Ting, Dewey G. McCafferty, and Raphael H. Valdivia. “The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence.” Cell Host Microbe 10, no. 1 (July 21, 2011): 21–32. https://doi.org/10.1016/j.chom.2011.06.008.
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    • Cropp, T Ashton, and Dewey G. McCafferty. “Found in translation: applications of protein and peptide molecular diversity.” Current Opinion in Chemical Biology 15, no. 3 (June 2011): 347–49. https://doi.org/10.1016/j.cbpa.2011.04.013.
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    • Hwang, Sunhee, Allison A. Schmitt, Andrea E. Luteran, Eric J. Toone, and Dewey G. McCafferty. “Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST.” Biochemistry 50, no. 4 (February 2011): 546–57. https://doi.org/10.1021/bi101776t.
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    • Hu, Xiangqian, Hao Hu, Jeffrey A. Melvin, Kathleen W. Clancy, Dewey G. McCafferty, and Weitao Yang. “Autocatalytic intramolecular isopeptide bond formation in gram-positive bacterial pili: a QM/MM simulation.” Journal of the American Chemical Society 133, no. 3 (January 2011): 478–85. https://doi.org/10.1021/ja107513t.
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    • Schmidt, John W., Adrienne Greenough, Michelle Burns, Andrea E. Luteran, and Dewey G. McCafferty. “Generation of ramoplanin-resistant Staphylococcus aureus.” Fems Microbiology Letters 310, no. 2 (September 2010): 104–11. https://doi.org/10.1111/j.1574-6968.2010.02051.x.
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    • Clancy, Kathleen W., Jeffrey A. Melvin, and Dewey G. McCafferty. “Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.” Biopolymers 94, no. 4 (January 2010): 385–96. https://doi.org/10.1002/bip.21472.
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    • Hamburger, James B., Amanda J. Hoertz, Amy Lee, Rachel J. Senturia, Dewey G. McCafferty, and Patrick J. Loll. “A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface.” Proceedings of the National Academy of Sciences of the United States of America 106, no. 33 (August 2009): 13759–64. https://doi.org/10.1073/pnas.0904686106.
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    • Gaweska, Helena, Michelle Henderson Pozzi, Dawn M. Z. Schmidt, Dewey G. McCafferty, and Paul F. Fitzpatrick. “Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1.” Biochemistry 48, no. 23 (June 2009): 5440–45. https://doi.org/10.1021/bi900499w.
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    • Kudryavtsev, Konstantin V., Matthew L. Bentley, and Dewey G. McCafferty. “Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform.” Bioorganic & Medicinal Chemistry 17, no. 7 (April 2009): 2886–93. https://doi.org/10.1016/j.bmc.2009.02.008.
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    • Deshmukh, Hitesh S., James B. Hamburger, Sun Hee Ahn, Dewey G. McCafferty, Suxiao R. Yang, and Vance G. Fowler. “Critical role of NOD2 in regulating the immune response to Staphylococcus aureus.” Infect Immun 77, no. 4 (April 2009): 1376–82. https://doi.org/10.1128/IAI.00940-08.
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    • Race, Paul R., Matthew L. Bentley, Jeff A. Melvin, Allister Crow, Richard K. Hughes, Wendy D. Smith, Richard B. Sessions, Michael A. Kehoe, Dewey G. McCafferty, and Mark J. Banfield. “Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism.” The Journal of Biological Chemistry 284, no. 11 (March 2009): 6924–33. https://doi.org/10.1074/jbc.m805406200.
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    • Bentley, Matthew L., Erin C. Lamb, and Dewey G. McCafferty. “Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus.” The Journal of Biological Chemistry 283, no. 21 (May 2008): 14762–71. https://doi.org/10.1074/jbc.m800974200.
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    • Gooden, David M., Dawn M. Z. Schmidt, Julie A. Pollock, Ami M. Kabadi, and Dewey G. McCafferty. “Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.” Bioorganic & Medicinal Chemistry Letters 18, no. 10 (May 2008): 3047–51. https://doi.org/10.1016/j.bmcl.2008.01.003.
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    • Frankel, Brenda A., Yan Tong, Matthew L. Bentley, Michael C. Fitzgerald, and Dewey G. McCafferty. “Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA.” Biochemistry 46, no. 24 (June 2007): 7269–78. https://doi.org/10.1021/bi700448e.
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    • Schmidt, Dawn M. Z., and Dewey G. McCafferty. “trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.” Biochemistry 46, no. 14 (April 2007): 4408–16. https://doi.org/10.1021/bi0618621.
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    • Bentley, Matthew L., Helena Gaweska, Joseph M. Kielec, and Dewey G. McCafferty. “Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA.” The Journal of Biological Chemistry 282, no. 9 (March 2007): 6571–81. https://doi.org/10.1074/jbc.m610519200.
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    • McCafferty, Dewey G. “Crossing a biological velvet rope.” Acs Chemical Biology 1, no. 6 (July 2006): 339–40. https://doi.org/10.1021/cb6002948.
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    • Lee, Min Gyu, Christopher Wynder, Dawn M. Schmidt, Dewey G. McCafferty, and Ramin Shiekhattar. “Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.” Chemistry & Biology 13, no. 6 (June 2006): 563–67. https://doi.org/10.1016/j.chembiol.2006.05.004.
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    • Frankel, Brenda A., Ryan G. Kruger, Dana E. Robinson, Neil L. Kelleher, and Dewey G. McCafferty. “Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism.” Biochemistry 44, no. 33 (August 2005): 11188–200. https://doi.org/10.1021/bi050141j.
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    • Barkallah, S., S. L. Schneider, and D. G. McCafferty. “Facile syntheses of conformationally constrained analogues of lysine and homoglutamic acid.” Tetrahedron Letters 46, no. 30 (July 25, 2005): 4985–87. https://doi.org/10.1016/j.tetlet.2005.05.093.
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    • Gaweska, Helena, Joseph Kielec, and Dewey McCafferty. “A suppression strategy for antibiotic discovery.” Chemistry & Biology 11, no. 10 (October 2004): 1330–32. https://doi.org/10.1016/j.chembiol.2004.09.007.
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    • Kruger, Ryan G., Salim Barkallah, Brenda A. Frankel, and Dewey G. McCafferty. “Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics.” Bioorganic & Medicinal Chemistry 12, no. 13 (July 2004): 3723–29. https://doi.org/10.1016/j.bmc.2004.03.066.
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    • Striplin, Durwin R., Steven Y. Reece, Dewey G. McCafferty, Craig G. Wall, Duane A. Friesen, Bruce W. Erickson, and Thomas J. Meyer. “Solvent dependence of intramolecular electron transfer in a helical oligoproline assembly.” Journal of the American Chemical Society 126, no. 16 (April 2004): 5282–91. https://doi.org/10.1021/ja0304289.
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    • Frankel, Brenda A., Matthew Bentley, Ryan G. Kruger, and Dewey G. McCafferty. “Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus.” Journal of the American Chemical Society 126, no. 11 (March 2004): 3404–5. https://doi.org/10.1021/ja0390294.
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    • Frankel, Brenda A., and Dewey G. McCafferty. “Profiling natural product biosynthesis.” Chemistry & Biology 11, no. 3 (March 2004): 290–91. https://doi.org/10.1016/j.chembiol.2004.03.007.
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    • Kruger, Ryan G., Patrick Dostal, and Dewey G. McCafferty. “Development of a high-performance liquid chromatography assay and revision of kinetic parameters for the Staphylococcus aureus sortase transpeptidase SrtA.” Analytical Biochemistry 326, no. 1 (March 2004): 42–48. https://doi.org/10.1016/j.ab.2003.10.023.
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    • Kruger, Ryan G., Balint Otvos, Brenda A. Frankel, Matthew Bentley, Patrick Dostal, and Dewey G. McCafferty. “Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA.” Biochemistry 43, no. 6 (February 2004): 1541–51. https://doi.org/10.1021/bi035920j.
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    • Loyola, Alejandra, Shu He, Santaek Oh, Dewey G. McCafferty, and Danny Reinberg. “Techniques used to study transcription on chromatin templates.” Methods in Enzymology 377 (January 2004): 474–99. https://doi.org/10.1016/s0076-6879(03)77031-1.
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    • He, Shu, David Bauman, Jamaine S. Davis, Alejandra Loyola, Kenichi Nishioka, Jennifer L. Gronlund, Danny Reinberg, Fanyu Meng, Neil Kelleher, and Dewey G. McCafferty. “Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis.” Proceedings of the National Academy of Sciences of the United States of America 100, no. 21 (October 2003): 12033–38. https://doi.org/10.1073/pnas.2035256100.
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    • Kapustin, Galina V., György Fejér, Jennifer L. Gronlund, Dewey G. McCafferty, Edward Seto, and Felicia A. Etzkorn. “Phosphorus-based SAHA analogues as histone deacetylase inhibitors.” Organic Letters 5, no. 17 (August 2003): 3053–56. https://doi.org/10.1021/ol035056n.
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    • Huang, C. Y., S. He, W. F. DeGrado, D. G. McCafferty, and F. Gai. “Light-induced helix formation.” Journal of the American Chemical Society 124, no. 43 (October 30, 2002): 12674–75. https://doi.org/10.1021/ja028084u.
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    • Kruger, Ryan G., Patrick Dostal, and Dewey G. McCafferty. “An economical and preparative orthogonal solid phase synthesis of fluorescein and rhodamine derivatized peptides: FRET substrates for the Staphylococcus aureus sortase SrtA transpeptidase reaction.” Chemical Communications (Cambridge, England), no. 18 (September 2002): 2092–93. https://doi.org/10.1039/b206303d.
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    • Cudic, Predrag, Douglas C. Behenna, James K. Kranz, Ryan G. Kruger, A Joshua Wand, Yuri I. Veklich, John W. Weisel, and Dewey G. McCafferty. “Functional analysis of the lipoglycodepsipeptide antibiotic ramoplanin.” Chemistry & Biology 9, no. 8 (August 2002): 897–906. https://doi.org/10.1016/s1074-5521(02)00191-6.
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    • Cudic, Predrag, James K. Kranz, Douglas C. Behenna, Ryan G. Kruger, Hellina Tadesse, A Joshua Wand, Yuri I. Veklich, John W. Weisel, and Dewey G. McCafferty. “Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation.” Proceedings of the National Academy of Sciences of the United States of America 99, no. 11 (May 2002): 7384–89. https://doi.org/10.1073/pnas.102192099.
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    • Kruger, R. G., P. Dostal, and D. G. McCafferty. “An economical and preparative orthogonal solid phase synthesis of fluorescein and rhodamine derivatized peptides: FRET substrates for the Staphylococcus aureus sortase SrtA transpeptidase reaction.” Chemical Communications, no. 18 (2002): 2092–93.
    • McCafferty, Dewey G., Predrag Cudic, Brenda A. Frankel, Salim Barkallah, Ryan G. Kruger, and Wenkai Li. “Chemistry and biology of the ramoplanin family of peptide antibiotics.” Biopolymers 66, no. 4 (January 2002): 261–84. https://doi.org/10.1002/bip.10296.
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    • Cudic, P., D. C. Behenna, M. K. Yu, R. G. Kruger, L. M. Szewczuk, and D. G. McCafferty. “Synthesis of P(1)-Citronellyl-P(2)-alpha-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG.” Bioorganic & Medicinal Chemistry Letters 11, no. 24 (December 2001): 3107–10. https://doi.org/10.1016/s0960-894x(01)00653-9.
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    • Bishop, B. M., D. G. McCafferty, and B. W. Erickson. “4'-Aminomethyl-2,2'-bipyridyl-4-carboxylic acid (Abc) and related derivatives: Novel bipyridine amino acids for the solid-phase incorporation of a metal coordination site within a peptide backbone.” Tetrahedron 56, no. 27 (June 30, 2000): 4629–38. https://doi.org/10.1016/S0040-4020(00)00367-7.
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    • McCafferty, D. G., P. Cudic, M. K. Yu, D. C. Behenna, and R. Kruger. “Synergy and duality in peptide antibiotic mechanisms.” Current Opinion in Chemical Biology 3, no. 6 (December 1999): 672–80. https://doi.org/10.1016/s1367-5931(99)00025-3.
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    • Lessard, I. A., S. D. Pratt, D. G. McCafferty, D. E. Bussiere, C. Hutchins, B. L. Wanner, L. Katz, and C. T. Walsh. “Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function.” Chemistry & Biology 5, no. 9 (September 1998): 489–504. https://doi.org/10.1016/s1074-5521(98)90005-9.
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    • McCafferty, D. G., I. A. Lessard, and C. T. Walsh. “Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX.” Biochemistry 36, no. 34 (August 1997): 10498–505. https://doi.org/10.1021/bi970543u.
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    • McCafferty, D. G., D. A. Friesen, E. Danielson, C. G. Wall, M. J. Saderholm, B. W. Erickson, and T. J. Meyer. “Photochemical energy conversion in a helical oligoproline assembly.” Proceedings of the National Academy of Sciences of the United States of America 93, no. 16 (August 1996): 8200–8204. https://doi.org/10.1073/pnas.93.16.8200.
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    • McCafferty, D. G., B. M. Bishop, C. G. Wall, S. G. Hughes, S. L. Mecklenberg, T. J. Meyer, and B. W. Erickson. “Synthesis of redox derivatives of lysine and their use in solid-phase synthesis of a light-harvesting peptide.” Tetrahedron 51, no. 4 (January 23, 1995): 1093–1106. https://doi.org/10.1016/0040-4020(94)01018-U.
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    • McCafferty, D. G., C. A. Slate, B. M. Nakhle, H. D. Graham, T. L. Austell, R. W. Vachet, B. H. Mullis, and B. W. Erickson. “Engineering of a 129-residue tripod protein by chemoselective ligation of proline-II helices.” Tetrahedron 51, no. 36 (January 1, 1995): 9859–72. https://doi.org/10.1016/0040-4020(95)00592-V.
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    • Mecklenburg, S. L., D. G. McCafferty, J. R. Schoonover, B. M. Peek, B. W. Erickson, and T. J. Meyer. “Spectroscopic Study of Electron Transfer in a Trifunctional Lysine with Anthraquinone as the Electron Acceptor.” Inorganic Chemistry 33, no. 13 (June 1, 1994): 2974–83. https://doi.org/10.1021/ic00091a042.
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    • Mecklenburg, S. L., B. M. Peek, J. R. Schoonover, D. G. McCafferty, C. G. Wall, B. W. Erickson, and T. J. Meyer. “Photoinduced Electron Transfer in Amino Acid Assemblies.” Journal of the American Chemical Society 115, no. 13 (June 1, 1993): 5479–95. https://doi.org/10.1021/ja00066a017.
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• Teaching & Mentoring
• 

  Recent Courses

  • CHEM 201DL: Organic Chemistry I 2023
  • CHEM 393: Research Independent Study 2023
  • CHEM 394: Research Independent Study 2023
  • CHEM 493: Research Independent Study 2023
  • CHEM 494: Research Independent Study 2023
  • BIOCHEM 536: Bioorganic Chemistry 2022
  • BIOCHEM 593: Research Independent Study 2022
  • CHEM 91: Chemistry, Technology, and Society 2022
  • CHEM 393: Research Independent Study 2022
  • CHEM 394: Research Independent Study 2022
  • CHEM 493: Research Independent Study 2022
  • CHEM 494: Research Independent Study 2022
  • CHEM 536: Bioorganic Chemistry 2022
  • BIOCHEM 536: Bioorganic Chemistry 2021
  • BIOCHEM 593: Research Independent Study 2021
  • CHEM 91: Chemistry, Technology, and Society 2021
  • CHEM 393: Research Independent Study 2021
  • CHEM 394: Research Independent Study 2021
  • CHEM 493: Research Independent Study 2021
  • CHEM 494: Research Independent Study 2021
  • CHEM 536: Bioorganic Chemistry 2021
• Scholarly, Clinical, & Service Activities
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  Presentations & Appearances

  • National ACS conference. January 15, 2008  2008

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