Scholars@Duke
Diana Remy Dou

Diana Remy Dou

Assistant Professor of Integrative Immunobiology
Integrative Immunobiology

Selected Publications

Xist ribonucleoproteins promote female sex-biased autoimmunity.

Journal Article Cell · February 1, 2024 Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-coding RNA (lncRNA) is expressed only in females to randomly inactivate one of ... Full text Link to item Cite

Structural modularity of the XIST ribonucleoprotein complex.

Journal Article Nat Commun · December 2, 2020 Long noncoding RNAs are thought to regulate gene expression by organizing protein complexes through unclear mechanisms. XIST controls the inactivation of an entire X chromosome in female placental mammals. Here we develop and integrate several orthogonal s ... Full text Link to item Cite

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation.

Journal Article Elife · May 7, 2020 The Xist lncRNA mediates X chromosome inactivation (XCI). Here we show that Spen, an Xist-binding repressor protein essential for XCI , binds to ancient retroviral RNA, performing a surveillance role to recruit chromatin silencing machinery to these parasi ... Full text Link to item Cite

Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells.

Journal Article Exp Hematol · September 2018 Hematopoietic stem cells (HSCs) are multipotent cells responsible for the maintenance of the hematopoietic system throughout life. Dysregulation of the balance in HSC self-renewal, death, and differentiation can have serious consequences such as myelodyspl ... Full text Link to item Cite

Interferon Stimulated Gene Expression in HIV/HCV Coinfected Patients Treated with Nitazoxanide/Peginterferon-Alfa-2a and Ribavirin.

Journal Article AIDS Res Hum Retroviruses · July 2016 A combination of nitazoxanide (NTZ), peginterferon (PegIFN), and ribavirin (RBV) may result in higher sustained virologic response (SVR) rates in hepatitis C virus (HCV) monoinfected patients. This study evaluated the effect of NTZ on interferon-stimulated ... Full text Link to item Cite

Medial HOXA genes demarcate haematopoietic stem cell fate during human development.

Journal Article Nat Cell Biol · June 2016 Pluripotent stem cells (PSCs) may provide a potential source of haematopoietic stem/progenitor cells (HSPCs) for transplantation; however, unknown molecular barriers prevent the self-renewal of PSC-HSPCs. Using two-step differentiation, human embryonic ste ... Full text Link to item Cite

High interferon-stimulated gene ISG-15 expression affects HCV treatment outcome in patients co-infected with HIV and HCV.

Journal Article J Med Virol · June 2013 Increased baseline expression and lack of induction of interferon-stimulated genes (ISG) are strong negative predictors of therapeutic response to PegIFN/RBV in patients co-infected with HIV and hepatitis C virus (HCV). This study specifically addressed wh ... Full text Link to item Cite