Anna Mae Diehl
Florence McAlister Distinguished Professor of Medicine
Our lab
has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).
Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.
Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.
Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.
Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.
Current Appointments & Affiliations
- Florence McAlister Distinguished Professor of Medicine, Medicine, Gastroenterology, Medicine 2005
- Professor of Medicine, Medicine, Gastroenterology, Medicine 2004
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2004
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
- Ste 1073, GSRB 1, 595 Lasalle Street, Durham, NC 27710
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diehl004@mc.duke.edu
(919) 684-2366
- Background
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Education, Training, & Certifications
- Fellow in Gastroenterology, Medicine, Johns Hopkins University 1981 - 1984
- Medical Resident, Medicine, Johns Hopkins University 1978 - 1981
- M.D., Georgetown University 1978
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Previous Appointments & Affiliations
- Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2014 - 2020
- Chief, Division of Gastroenterology in the Department of Medicine, Medicine, Gastroenterology, Medicine 2004 - 2014
- Instructor, Temporary in the Department of Medicine, Medicine, Gastroenterology, Medicine 2004
- Recognition
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In the News
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OCT 29, 2018
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Awards & Honors
- Research
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Selected Grants
- Duke Training Grant in Digestive Diseases and Nutrition awarded by National Institutes of Health 1988 - 2027
- Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2027
- Prediction and Prevention of Hepatic Decompensation in Patients with Cirrhosis awarded by National Institutes of Health 2021 - 2026
- Inventiva NATiV3 awarded by Inventiva 2022 - 2025
- Madrigal 3196-18 A 52-Week, Phase 3 Open-Label Extension Study, with a Resmetirom (MGL-3196) in Patients with Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension awarded by Madrigal Pharmaceuticals, Inc. 2022 - 2025
- Hippo-Yap Pathway, Ferroptosis of Hepatic Stellate Cells and Liver Fibrosis awarded by American Association for the Study of Liver Diseases 2021 - 2024
- A multidisciplinary study of biological disparities in NASH progression and response to statins to inform personalized liver cancer chemoprevention in NAFLD awarded by Department of Defense 2020 - 2024
- TNF Alpha and Recovery from Alcoholic Liver Injury awarded by National Institutes of Health 2014 - 2024
- Vitamin E Dosing Study (VEDS): A dose finding clinical trial of vitamin E for the treatment of adult NAFLD awarded by Johns Hopkins University 2022 - 2024
- Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) awarded by National Institutes of Health 2004 - 2024
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2024
- Ancillary Studies of NAFLD and NASH in HIV infected Adults (R01) awarded by Indiana University 2020 - 2024
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- Is Heart Failure with Preserved Edection Fraction the Symptomatic Manifestation of Liver Disease awarded by American Heart Association 2021 - 2022
- Hedgehog Signaling and Adult Liver Regeneration awarded by National Institutes of Health 2016 - 2022
- Transmission electron microscope (TEM) awarded by National Institutes of Health 2019 - 2021
- Pathophysiological Role of Glutaminolysis in Human NAFLD Progression awarded by American Association for the Study of Liver Diseases 2018 - 2020
- TAIWANJ JKB 121-001 awarded by TaiwanJ Pharmaceuticals Co. Ltd 2015 - 2020
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease awarded by American Association for the Study of Liver Diseases 2018 - 2020
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease awarded by American College of Gastroenterology 2015 - 2019
- Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma awarded by Fibrolamellar Cancer Foundation 2016 - 2019
- Submucosal esophageal structures as a progenitor niche for esophageal repair awarded by National Institutes of Health 2013 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- Impact of IMM-124E on Innate Immune and Fibrogenic Responses in Preclinical Mouse Model of NASH awarded by Immuron, Ltd 2016 - 2018
- Impact of Fructose on Metabolism, Energy Homeostasis and MR biomarkers in NAFLD awarded by National Institutes of Health 2012 - 2016
- Pathogenesis of NASH Cirrhosis awarded by National Institutes of Health 2015 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Liver Disease in Obesity awarded by National Institutes of Health 1999 - 2015
- TNF Alpha and Recovery from Alchoholic Liver Injury awarded by National Institutes of Health 1994 - 2014
- Rac1 Promotes Hepatic Stellate Accumulation/Activation in Liver Injury awarded by National Institutes of Health 2009 - 2014
- Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
- Hyperinsulimia and Insulin Resistance in Nonalcoholic Fatty Liver Disease awarded by National Institutes of Health 2006 - 2010
- Cholesterol, Hedgehog Signaling & Fetal Alcohol Syndrome awarded by National Institutes of Health 2007 - 2010
- Drug Abuse: Discovering Ligands for Pertinent GPCRs awarded by National Institutes of Health 2006 - 2010
- Innovative Assays for Oncogenic Hedgehog Signaling awarded by National Institutes of Health 2006 - 2010
- Liver Derived Microparticles In Cirrhosis Pathogenesis awarded by National Institutes of Health 2008 - 2009
- Metabolic Profiling to Identify Alcohol Biomarker Signature awarded by National Institutes of Health 2006 - 2009
- Bioenergetics and Alcoholic Liver Disease Pathogenesis awarded by National Institutes of Health 2000 - 2006
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External Relationships
- Aria Pharmaceuticals
- Avolynt
- Boehringer Ingleheim
- Filtricine
- Merck
- Panbela Therapeutics
- Viking Therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Pan, Christopher C., Raquel Maeso-Díaz, Tylor R. Lewis, Kun Xiang, Lianmei Tan, Yaosi Liang, Liuyang Wang, et al. “Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing.” Cell Res, May 11, 2023. https://doi.org/10.1038/s41422-023-00820-4.Full Text Link to Item
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Barzi, Mercedes, Collin G. Johnson, Tong Chen, Ramona M. Rodriguiz, Madeline Hemmingsen, Trevor J. Gonzalez, Alan Rosales, et al. “Rescue of glutaric aciduria type I in mice by liver-directed therapies.” Sci Transl Med 15, no. 692 (April 19, 2023): eadf4086. https://doi.org/10.1126/scitranslmed.adf4086.Full Text Link to Item
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Sanyal, Arun J., Stephen A. Williams, Joel E. Lavine, Brent A. Neuschwander-Tetri, Leigh Alexander, Rachel Ostroff, Hannah Biegel, et al. “Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in non-alcoholic fatty liver disease.” J Hepatol 78, no. 4 (April 2023): 693–703. https://doi.org/10.1016/j.jhep.2022.11.029.Full Text Link to Item
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Wegermann, K., A. M. Diehl, and C. A. Moylan. “Challenges and barriers in hepatocellular carcinoma (HCC) surveillance for patients with non-alcoholic fatty liver disease (NAFLD).” Hepatoma Research 9 (January 1, 2023). https://doi.org/10.20517/2394-5079.2022.92.Full Text
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Heinemann, Fabian, Peter Gross, Svetlana Zeveleva, Hu Sheng Qian, Jon Hill, Anne Höfer, Danny Jonigk, et al. “Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies.” Sci Rep 12, no. 1 (November 10, 2022): 19236. https://doi.org/10.1038/s41598-022-23905-3.Full Text Link to Item
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Moylan, Cynthia A., Alisha M. Mavis, Dereje Jima, Rachel Maguire, Mustafa Bashir, Jeongeun Hyun, Melanie N. Cabezas, et al. “Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children.” Epigenetics 17, no. 11 (November 2022): 1446–61. https://doi.org/10.1080/15592294.2022.2039850.Full Text Link to Item
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Baptissart, Marine, Christine M. Bradish, Brie S. Jones, Evan Walsh, Jesse Tehrani, Vicmarie Marrero-Colon, Sanya Mehta, et al. “Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.” Hepatology 76, no. 4 (October 2022): 1090–1104. https://doi.org/10.1002/hep.32363.Full Text Link to Item
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Sahoo, Sarthak, Ashutosh Mishra, Anna Mae Diehl, and Mohit Kumar Jolly. “Dynamics of hepatocyte-cholangiocyte cell-fate decisions during liver development and regeneration.” Iscience 25, no. 9 (September 16, 2022): 104955. https://doi.org/10.1016/j.isci.2022.104955.Full Text Link to Item
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Zhou, Jin, Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, et al. “Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.” Nat Commun 13, no. 1 (September 3, 2022): 5202. https://doi.org/10.1038/s41467-022-32788-x.Full Text Link to Item
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Pailhoriès, Hélène, Jerome Boursier, and Anna Mae Diehl. “Determinants of the severity of fatty liver diseases: Need all the pieces to solve the puzzle.” Hepatology 75, no. 4 (April 2022): 782–84. https://doi.org/10.1002/hep.32282.Full Text Link to Item
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Woreta, Tinsay A., Mark L. Van Natta, Mariana Lazo, Arunkumar Krishnan, Brent A. Neuschwander-Tetri, Rohit Loomba, Anna Mae Diehl, et al. “Validation of the accuracy of the FAST™ score for detecting patients with at-risk nonalcoholic steatohepatitis (NASH) in a North American cohort and comparison to other non-invasive algorithms.” Plos One 17, no. 4 (2022): e0266859. https://doi.org/10.1371/journal.pone.0266859.Full Text Link to Item
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Fudim, Marat, Lin Zhong, Kershaw V. Patel, Rohan Khera, Manal F. Abdelmalek, Anna Mae Diehl, Robert W. McGarrah, et al. “Nonalcoholic Fatty Liver Disease and Risk of Heart Failure Among Medicare Beneficiaries.” J Am Heart Assoc 10, no. 22 (November 16, 2021): e021654. https://doi.org/10.1161/JAHA.121.021654.Full Text Link to Item
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Salah, Husam M., Ambarish Pandey, Anzhela Soloveva, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan, Kara Wegermann, et al. “Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction.” Jacc Basic Transl Sci 6, no. 11 (November 2021): 918–32. https://doi.org/10.1016/j.jacbts.2021.07.010.Full Text Link to Item
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Sanyal, Arun J., Mark L. Van Natta, Jeanne Clark, Brent A. Neuschwander-Tetri, AnnaMae Diehl, Srinivasan Dasarathy, Rohit Loomba, et al. “Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease.” N Engl J Med 385, no. 17 (October 21, 2021): 1559–69. https://doi.org/10.1056/NEJMoa2029349.Full Text Link to Item
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Alexopoulos, Anastasia-Stefania, Matthew J. Crowley, Ying Wang, Cynthia A. Moylan, Cynthia D. Guy, Ricardo Henao, Dawn L. Piercy, et al. “Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease.” Hepatology 74, no. 3 (September 2021): 1220–33. https://doi.org/10.1002/hep.31806.Full Text Open Access Copy Link to Item
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Dalton, George D., Seh-Hoon Oh, Linda Tang, Stephanie Zhang, Amanda L. Brown, Venkateshwari Varadharajan, Camelia Baleanu-Gogonea, et al. “Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice.” Iscience 24, no. 9 (September 2021): 103089. https://doi.org/10.1016/j.isci.2021.103089.Full Text
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Du, Kuo, Seh Hoon Oh, Rajesh K. Dutta, Tianai Sun, Wen-Hsuan Yang, Jen-Tsan Chi, and Anna Mae Diehl. “Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury.” Liver Int 41, no. 9 (September 2021): 2214–27. https://doi.org/10.1111/liv.14945.Full Text Link to Item
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Hyun, Jeongeun, Muthana Al Abo, Rajesh Kumar Dutta, Seh Hoon Oh, Kun Xiang, Xiyou Zhou, Raquel Maeso-Díaz, et al. “Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease.” Journal of Hepatology 75, no. 3 (September 2021): 623–33. https://doi.org/10.1016/j.jhep.2021.04.033.Full Text
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Chen, Tianyi, and Anna Mae Diehl. “A Beautiful Day in the Neighborhood: Application of Single-Cell Transcriptomics to Unravel Liver Cell Heterogeneity in Diseased Human Livers.” Hepatology 74, no. 2 (August 2021): 547–49. https://doi.org/10.1002/hep.31827.Full Text Link to Item
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Chen, Yong, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Hui-Ping Ding, Xin Zhang, et al. “Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.” Gastroenterology 161, no. 1 (July 2021): 301-317.e16. https://doi.org/10.1053/j.gastro.2021.03.049.Full Text Link to Item
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Allende, Daniela S., Samer Gawrieh, Oscar W. Cummings, Patricia Belt, Laura Wilson, Mark Van Natta, Cynthia A. Behling, et al. “Glycogenosis is common in nonalcoholic fatty liver disease and is independently associated with ballooning, but lower steatosis and lower fibrosis.” Liver Int 41, no. 5 (May 2021): 996–1011. https://doi.org/10.1111/liv.14773.Full Text Link to Item
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Peters, Anthony E., Ambarish Pandey, Colby Ayers, Kara Wegermann, Robert W. McGarrah, Justin L. Grodin, Manal F. Abdelmalek, et al. “Association of liver fibrosis risk scores with clinical outcomes in patients with heart failure with preserved ejection fraction: findings from TOPCAT.” Esc Heart Fail 8, no. 2 (April 2021): 842–48. https://doi.org/10.1002/ehf2.13250.Full Text Link to Item
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Wegermann, Kara, Ayako Suzuki, Alisha M. Mavis, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia A. Moylan. “REPLY.” Hepatology 73, no. 4 (April 2021): 1625. https://doi.org/10.1002/hep.31593.Full Text Link to Item
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Canivet, Clemence M., Norma David, Helene Pailhoriès, Martial Briand, Cynthia D. Guy, Olivier Bouchez, Gilles Hunault, et al. “Cross-linkage between bacterial taxonomy and gene functions: a study of metagenome-assembled genomes of gut microbiota in adult non-alcoholic fatty liver disease.” Aliment Pharmacol Ther 53, no. 6 (March 2021): 722–32. https://doi.org/10.1111/apt.16262.Full Text Link to Item
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Wegermann, Kara, Ayako Suzuki, Alisha M. Mavis, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia A. Moylan. “Tackling Nonalcoholic Fatty Liver Disease: Three Targeted Populations.” Hepatology 73, no. 3 (March 2021): 1199–1206. https://doi.org/10.1002/hep.31533.Full Text Link to Item
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Wegermann, Kara, Jeongeun Hyun, and Anna Mae Diehl. “Molecular Mechanisms Linking Nonalcoholic Steatohepatitis to Cancer.” Clin Liver Dis (Hoboken) 17, no. 1 (January 2021): 6–10. https://doi.org/10.1002/cld.1006.Full Text Link to Item
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Friedersdorf, Matthew, and Anna Mae Diehl. “Inflammation Writes the Fibrogenic Code.” Cell Mol Gastroenterol Hepatol 12, no. 3 (2021): 1147–48. https://doi.org/10.1016/j.jcmgh.2021.06.012.Full Text Link to Item
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Chen, Tianyi, Sehhoon Oh, Simon Gregory, Xiling Shen, and Anna Mae Diehl. “Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration.” Jci Insight 5, no. 22 (November 19, 2020). https://doi.org/10.1172/jci.insight.141024.Full Text Link to Item
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Loomba, Rohit, Brent A. Neuschwander-Tetri, Arun Sanyal, Naga Chalasani, Anna Mae Diehl, Norah Terrault, Kris Kowdley, et al. “Multicenter Validation of Association Between Decline in MRI-PDFF and Histologic Response in NASH.” Hepatology 72, no. 4 (October 2020): 1219–29. https://doi.org/10.1002/hep.31121.Full Text Link to Item
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Hyun, Jeongeun, Zhaoli Sun, Ali Reza Ahmadi, Sushant Bangru, Ullas V. Chembazhi, Kuo Du, Tianyi Chen, et al. “Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.” J Clin Invest 130, no. 4 (April 1, 2020): 2129–45. https://doi.org/10.1172/JCI132691.Full Text Link to Item
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Liu, Xue-Jing, Li Xie, Kuo Du, Chang Liu, Ning-Ping Zhang, Chen-Jian Gu, Ying Wang, et al. “Succinate-GPR-91 receptor signalling is responsible for nonalcoholic steatohepatitis-associated fibrosis: Effects of DHA supplementation.” Liver Int 40, no. 4 (April 2020): 830–43. https://doi.org/10.1111/liv.14370.Full Text Link to Item
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Du, Kuo, Satish K. Chitneni, Ayako Suzuki, Ying Wang, Ricardo Henao, Jeongeun Hyun, Richard T. Premont, et al. “Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression.” Cell Mol Gastroenterol Hepatol 10, no. 1 (2020): 1–21. https://doi.org/10.1016/j.jcmgh.2019.12.006.Full Text Open Access Copy Link to Item
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Jewell, Mark L., Jason R. Gibson, Cynthia D. Guy, Jeongeun Hyun, Kuo Du, Seh-Hoon Oh, Richard T. Premont, et al. “Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma.” Am J Pathol 190, no. 1 (January 2020): 93–107. https://doi.org/10.1016/j.ajpath.2019.09.018.Full Text Link to Item
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Maung, Ko, Sendhilnathan Ramalingam, Mohammad Chaudhry, Yi Ren, Sin-Ho Jung, Kristi Romero, Kelly Corbet, et al. “Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality.” Plos One 15, no. 9 (2020): e0238824. https://doi.org/10.1371/journal.pone.0238824.Full Text Link to Item
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Win, Sanda, Robert Wm Min, Christopher Q. Chen, Jun Zhang, Yibu Chen, Meng Li, Ayako Suzuki, et al. “Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.” J Clin Invest 129, no. 12 (December 2, 2019): 5278–93. https://doi.org/10.1172/JCI128289.Full Text Link to Item
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Gawrieh, Samer, Xiuqing Guo, Jingyi Tan, Marie Lauzon, Kent D. Taylor, Rohit Loomba, Oscar W. Cummings, et al. “A Pilot Genome-Wide Analysis Study Identifies Loci Associated With Response to Obeticholic Acid in Patients With NASH.” Hepatol Commun 3, no. 12 (December 2019): 1571–84. https://doi.org/10.1002/hep4.1439.Full Text Link to Item
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Sanyal, Arun J., Stephen A. Harrison, Vlad Ratziu, Manal F. Abdelmalek, Anna Mae Diehl, Stephen Caldwell, Mitchell L. Shiffman, et al. “The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials.” Hepatology 70, no. 6 (December 2019): 1913–27. https://doi.org/10.1002/hep.30664.Full Text Link to Item
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Diehl, Anna Mae, Nathalie J. Farpour-Lambert, Liping Zhao, and Herbert Tilg. “Why we need to curb the emerging worldwide epidemic of nonalcoholic fatty liver disease.” Nat Metab 1, no. 11 (November 2019): 1027–29. https://doi.org/10.1038/s42255-019-0140-x.Full Text Link to Item
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Kleiner, David E., Elizabeth M. Brunt, Laura A. Wilson, Cynthia Behling, Cynthia Guy, Melissa Contos, Oscar Cummings, et al. “Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease.” Jama Netw Open 2, no. 10 (October 2, 2019): e1912565. https://doi.org/10.1001/jamanetworkopen.2019.12565.Full Text Link to Item
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Albadrani, Muayad, Ratanesh K. Seth, Sutapa Sarkar, Diana Kimono, Ayan Mondal, Dipro Bose, Dwayne E. Porter, et al. “Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.” Am J Physiol Gastrointest Liver Physiol 317, no. 4 (October 1, 2019): G408–28. https://doi.org/10.1152/ajpgi.00061.2019.Full Text Link to Item
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Loomba, Rohit, Anjali Jain, Anna Mae Diehl, Cynthia D. Guy, Dana Portenier, Ranjan Sudan, Seema Singh, et al. “Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis.” Clin Gastroenterol Hepatol 17, no. 9 (August 2019): 1867-1876.e3. https://doi.org/10.1016/j.cgh.2018.11.004.Full Text Link to Item
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Siddiqui, Mohammad Shadab, Goro Yamada, Raj Vuppalanchi, Mark Van Natta, Rohit Loomba, Cynthia Guy, Danielle Brandman, et al. “Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage.” Clin Gastroenterol Hepatol 17, no. 9 (August 2019): 1877-1885.e5. https://doi.org/10.1016/j.cgh.2018.12.031.Full Text Link to Item
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Sundaram, Shikha S., Marzena Swiderska-Syn, Ronald J. Sokol, Ann C. Halbower, Kelley E. Capocelli, Zhaoxing Pan, Kristen Robbins, Brian Graham, and Anna Mae Diehl. “Nocturnal Hypoxia Activation of the Hedgehog Signaling Pathway Affects Pediatric Nonalcoholic Fatty Liver Disease Severity.” Hepatol Commun 3, no. 7 (July 2019): 883–93. https://doi.org/10.1002/hep4.1354.Full Text Link to Item
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Hyun, Jeongeun, Seh-Hoon Oh, Richard T. Premont, Cynthia D. Guy, Carl L. Berg, and Anna Mae Diehl. “Dysregulated activation of fetal liver programme in acute liver failure.” Gut 68, no. 6 (June 2019): 1076–87. https://doi.org/10.1136/gutjnl-2018-317603.Full Text Link to Item
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Corey, Kathleen E., Laura A. Wilson, Akif Altinbas, Katherine P. Yates, David E. Kleiner, Raymond T. Chung, Ronald M. Krauss, Naga Chalasani, and Naga NASH Clinical Research Network. “Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial.” Aliment Pharmacol Ther 49, no. 9 (May 2019): 1205–13. https://doi.org/10.1111/apt.15216.Full Text Link to Item
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Dinh, Timothy A., Mark L. Jewell, Matt Kanke, Adam Francisco, Ramja Sritharan, Rigney E. Turnham, Seona Lee, et al. “MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.” Cell Mol Gastroenterol Hepatol 7, no. 4 (2019): 803–17. https://doi.org/10.1016/j.jcmgh.2019.01.008.Full Text Link to Item
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Dattaroy, Diptadip, Ratanesh Kumar Seth, Sutapa Sarkar, Diana Kimono, Muayad Albadrani, Varun Chandrashekaran, Firas Al Hasson, et al. “Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.” Eur J Pharmacol 841 (December 15, 2018): 33–48. https://doi.org/10.1016/j.ejphar.2018.08.040.Full Text Link to Item
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Reese, Aspen T., Fátima C. Pereira, Arno Schintlmeister, David Berry, Michael Wagner, Laura P. Hale, Anchi Wu, et al. “Microbial nitrogen limitation in the mammalian large intestine.” Nat Microbiol 3, no. 12 (December 2018): 1441–50. https://doi.org/10.1038/s41564-018-0267-7.Full Text Link to Item
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Younossi, Zobair, Maria Stepanova, Arun J. Sanyal, Stephen A. Harrison, Vlad Ratziu, Manal F. Abdelmalek, Anna Mae Diehl, et al. “The conundrum of cryptogenic cirrhosis: Adverse outcomes without treatment options.” J Hepatol 69, no. 6 (December 2018): 1365–70. https://doi.org/10.1016/j.jhep.2018.08.013.Full Text Link to Item
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Zhu, Changyu, KyeongJin Kim, Xiaobo Wang, Alberto Bartolome, Marcela Salomao, Paola Dongiovanni, Marica Meroni, et al. “Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.” Sci Transl Med 10, no. 468 (November 21, 2018). https://doi.org/10.1126/scitranslmed.aat0344.Full Text Link to Item
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Harrison, Stephen A., Manal F. Abdelmalek, Stephen Caldwell, Mitchell L. Shiffman, Anna Mae Diehl, Reem Ghalib, Eric J. Lawitz, et al. “Simtuzumab Is Ineffective for Patients With Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis.” Gastroenterology 155, no. 4 (October 2018): 1140–53. https://doi.org/10.1053/j.gastro.2018.07.006.Full Text Link to Item
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Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Anna Mae Diehl, and Ayako Suzuki. “Reply.” Clin Gastroenterol Hepatol 16, no. 10 (October 2018): 1684. https://doi.org/10.1016/j.cgh.2017.05.003.Full Text Open Access Copy Link to Item
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Castro, Rui E., and Anna Mae Diehl. “Towards a definite mouse model of NAFLD.” J Hepatol 69, no. 2 (August 2018): 272–74. https://doi.org/10.1016/j.jhep.2018.05.002.Full Text Link to Item
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Oh, Seh-Hoon, Marzena Swiderska-Syn, Mark L. Jewell, Richard T. Premont, and Anna Mae Diehl. “Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.” J Hepatol 69, no. 2 (August 2018): 359–67. https://doi.org/10.1016/j.jhep.2018.05.008.Full Text Open Access Copy Link to Item
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Alhasson, Firas, Ratanesh Kumar Seth, Sutapa Sarkar, Diana A. Kimono, Muayad S. Albadrani, Diptadip Dattaroy, Varun Chandrashekaran, et al. “High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease.” Redox Biol 17 (July 2018): 1–15. https://doi.org/10.1016/j.redox.2018.04.002.Full Text Link to Item
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Naggie, Susanna, Marzena Swiderska-Syn, Steve Choi, Sam Lusk, Audrey Lan, Guido Ferrari, Wing-Kin Syn, Cynthia D. Guy, and Anna Mae Diehl. “Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.” Open Forum Infect Dis 5, no. 7 (July 2018): ofy138. https://doi.org/10.1093/ofid/ofy138.Full Text Open Access Copy Link to Item
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Chen, Kai-Yuan, Xiling Shen, and Anna Mae Diehl. “Prometheus revisited.” J Clin Invest 128, no. 6 (June 1, 2018): 2192–93. https://doi.org/10.1172/JCI120933.Full Text Link to Item
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Verdelho Machado, Mariana, and Anna Mae Diehl. “The hedgehog pathway in nonalcoholic fatty liver disease.” Crit Rev Biochem Mol Biol 53, no. 3 (June 2018): 264–78. https://doi.org/10.1080/10409238.2018.1448752.Full Text Link to Item
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Jensen, Thomas, Manal F. Abdelmalek, Shelby Sullivan, Kristen J. Nadeau, Melanie Green, Carlos Roncal, Takahiko Nakagawa, et al. “Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.” J Hepatol 68, no. 5 (May 2018): 1063–75. https://doi.org/10.1016/j.jhep.2018.01.019.Full Text Link to Item
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Wegermann, Kara, Anna Mae Diehl, and Cynthia A. Moylan. “Disease pathways and molecular mechanisms of nonalcoholic steatohepatitis.” Clin Liver Dis (Hoboken) 11, no. 4 (April 2018): 87–91. https://doi.org/10.1002/cld.709.Full Text Link to Item
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Machado, Mariana Verdelho, and Anna Mae Diehl. “Hedgehog signalling in liver pathophysiology.” J Hepatol 68, no. 3 (March 2018): 550–62. https://doi.org/10.1016/j.jhep.2017.10.017.Full Text Link to Item
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Mendrick, Donna L., Anna Mae Diehl, Lisa S. Topor, Rodney R. Dietert, Yvonne Will, Michele A. La Merrill, Sebastien Bouret, et al. “Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic.” Toxicol Sci 162, no. 1 (March 1, 2018): 36–42. https://doi.org/10.1093/toxsci/kfx233.Full Text Link to Item
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Loomba, Rohit, Eric Lawitz, Parvez S. Mantry, Saumya Jayakumar, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl, et al. “The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial.” Hepatology 67, no. 2 (February 2018): 549–59. https://doi.org/10.1002/hep.29514.Full Text Link to Item
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Loomba, Rohit, Yevgeniy Gindin, Zhaoshi Jiang, Eric Lawitz, Stephen Caldwell, C Stephen Djedjos, Ren Xu, et al. “DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis.” Jci Insight 3, no. 2 (January 25, 2018). https://doi.org/10.1172/jci.insight.96685.Full Text Link to Item
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Diehl, Anna Mae. “Developmental Morphogens & Recovery from Alcoholic Liver Disease.” Adv Exp Med Biol 1032 (2018): 145–51. https://doi.org/10.1007/978-3-319-98788-0_11.Full Text Link to Item
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Wang, Sihyung, Youngmi Jung, Jeongeun Hyun, Matthew Friedersdorf, Seh-Hoon Oh, Jieun Kim, Richard T. Premont, Jack D. Keene, and Anna Mae Diehl. “RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts.” Cell Physiol Biochem 48, no. 3 (2018): 1215–29. https://doi.org/10.1159/000491987.Full Text Link to Item
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Wegermann, Kara, Ricardo Henao, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, and Cynthia A. Moylan. “Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study.” Plos One 13, no. 9 (2018): e0204308. https://doi.org/10.1371/journal.pone.0204308.Full Text Link to Item
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Diehl, Anna M., and Christopher Day. “Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis.” N Engl J Med 377, no. 21 (November 23, 2017): 2063–72. https://doi.org/10.1056/NEJMra1503519.Full Text Link to Item
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Chandrashekaran, Varun, Ratanesh K. Seth, Diptadip Dattaroy, Firas Alhasson, Jacek Ziolenka, James Carson, Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, and Saurabh Chatterjee. “HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease.” Redox Biol 13 (October 2017): 8–19. https://doi.org/10.1016/j.redox.2017.05.005.Full Text Link to Item
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Chen, Jiamei, Long Chen, Mark A. Zern, Neil D. Theise, Ann Mae Diehl, Ping Liu, and Yuyou Duan. “The diversity and plasticity of adult hepatic progenitor cells and their niche.” Liver Int 37, no. 9 (September 2017): 1260–71. https://doi.org/10.1111/liv.13377.Full Text Open Access Copy Link to Item
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Perito, Emily R., Veeral Ajmera, Nathan M. Bass, Philip Rosenthal, Joel E. Lavine, Jeffrey B. Schwimmer, Katherine P. Yates, et al. “Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease.” Hepatol Commun 1, no. 7 (September 2017): 609–22. https://doi.org/10.1002/hep4.1068.Full Text Link to Item
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Newton, Kimberly P., Haruna S. Feldman, Christina D. Chambers, Laura Wilson, Cynthia Behling, Jeanne M. Clark, Jean P. Molleston, et al. “Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children.” J Pediatr 187 (August 2017): 141-146.e1. https://doi.org/10.1016/j.jpeds.2017.03.007.Full Text Link to Item
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Kim, Jieun, Jeongeun Hyun, Sihyung Wang, Chanbin Lee, Jae-Wook Lee, Eun-Yi Moon, Heejae Cha, Anna Mae Diehl, and Youngmi Jung. “Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.” Sci Rep 7, no. 1 (June 19, 2017): 3815. https://doi.org/10.1038/s41598-017-03782-x.Full Text Link to Item
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Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Reply to Kim et al.” Am J Gastroenterol 112, no. 5 (May 2017): 807–8. https://doi.org/10.1038/ajg.2017.45.Full Text Link to Item
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Xie, Guanhua, Marzena Swiderska-Syn, Mark L. Jewell, Mariana Verdelho Machado, Gregory A. Michelotti, Richard T. Premont, and Anna Mae Diehl. “Loss of pericyte smoothened activity in mice with genetic deficiency of leptin.” Bmc Cell Biol 18, no. 1 (April 20, 2017): 20. https://doi.org/10.1186/s12860-017-0135-y.Full Text Open Access Copy Link to Item
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Li, Jia, Sumedha Roy, Young-Mi Kim, Shibo Li, Baojun Zhang, Cassandra Love, Anupama Reddy, et al. “Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors.” J Immunol 198, no. 8 (April 15, 2017): 3136–48. https://doi.org/10.4049/jimmunol.1601935.Full Text Link to Item
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Schadde, Erik, Christopher Tsatsaris, Marzena Swiderska-Syn, Stefan Breitenstein, Martin Urner, Roman Schimmer, Christa Booy, et al. “Hypoxia of the growing liver accelerates regeneration.” Surgery 161, no. 3 (March 2017): 666–79. https://doi.org/10.1016/j.surg.2016.05.018.Full Text Link to Item
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Suzuki, Ayako, and Anna Mae Diehl. “Nonalcoholic Steatohepatitis.” Annu Rev Med 68 (January 14, 2017): 85–98. https://doi.org/10.1146/annurev-med-051215-031109.Full Text Link to Item
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Diehl, Anna Mae. “Timing Is Everything.” Cell Metab 25, no. 1 (January 10, 2017): 2–4. https://doi.org/10.1016/j.cmet.2016.12.015.Full Text Link to Item
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Ajmera, Veeral, Emily R. Perito, Nathan M. Bass, Norah A. Terrault, Katherine P. Yates, Ryan Gill, Rohit Loomba, Anna Mae Diehl, Bradley E. Aouizerat, and Bradley E. NASH Clinical Research Network. “Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease.” Hepatology 65, no. 1 (January 2017): 65–77. https://doi.org/10.1002/hep.28776.Full Text Link to Item
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Seth, Ratanesh K., Suvarthi Das, Diptadip Dattaroy, Varun Chandrashekaran, Firas Alhasson, Gregory Michelotti, Mitzi Nagarkatti, et al. “TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity.” Free Radic Biol Med 102 (January 2017): 260–73. https://doi.org/10.1016/j.freeradbiomed.2016.11.047.Full Text Link to Item
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Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Joel E. Lavine, Katherine Yates, Jagpal Klair, et al. “Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis.” Clin Gastroenterol Hepatol 15, no. 1 (January 2017): 127-131.e2. https://doi.org/10.1016/j.cgh.2016.07.034.Full Text Link to Item
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Nelson, J. E., P. Handa, B. Aouizerat, L. Wilson, L. A. Vemulakonda, M. M. Yeh, K. V. Kowdley, and K. V. NASH Clinical Research Network. “Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms.” Aliment Pharmacol Ther 44, no. 11–12 (December 2016): 1253–64. https://doi.org/10.1111/apt.13824.Full Text Link to Item
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Pereira, Thiago Almeida, Wing-Kin Syn, Fausto E. L. Pereira, José Roberto Lambertucci, William Evan Secor, and Anna Mae Diehl. “Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.” Int J Parasitol 46, no. 13–14 (December 2016): 829–32. https://doi.org/10.1016/j.ijpara.2016.08.004.Full Text Link to Item
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Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis.” Am J Gastroenterol 111, no. 11 (November 2016): 1591–98. https://doi.org/10.1038/ajg.2016.406.Full Text Link to Item
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Pereira, Thiago Almeida, Wing-Kin Syn, Frederico Figueiredo Amâncio, Pedro Henrique Diniz Cunha, Julia Fonseca Morais Caporali, Guilherme Vaz de Melo Trindade, Elisângela Trindade Santos, et al. “Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni.” Plos Negl Trop Dis 10, no. 10 (October 2016): e0005057. https://doi.org/10.1371/journal.pntd.0005057.Full Text Link to Item
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Boursier, Jérôme, Matthieu Barret, and Anna Mae Diehl. “Reply.” Hepatology 64, no. 3 (September 2016): 994–95. https://doi.org/10.1002/hep.28562.Full Text Link to Item
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Klair, Jagpal Singh, Ju Dong Yang, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Katherine Yates, Aynur Unalp-Arida, et al. “A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease.” Hepatology 64, no. 1 (July 2016): 85–91. https://doi.org/10.1002/hep.28514.Full Text Link to Item
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Machado, Mariana Verdelho, and Anna Mae Diehl. “Pathogenesis of Nonalcoholic Steatohepatitis.” Gastroenterology 150, no. 8 (June 2016): 1769–77. https://doi.org/10.1053/j.gastro.2016.02.066.Full Text Link to Item
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Verdelho Machado, Mariana, and Anna Mae Diehl. “Role of Hedgehog Signaling Pathway in NASH.” Int J Mol Sci 17, no. 6 (June 1, 2016). https://doi.org/10.3390/ijms17060857.Full Text Link to Item
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Boursier, Jerome, and Anna Mae Diehl. “Nonalcoholic Fatty Liver Disease and the Gut Microbiome.” Clin Liver Dis 20, no. 2 (May 2016): 263–75. https://doi.org/10.1016/j.cld.2015.10.012.Full Text Link to Item
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Markowitz, Geoffrey J., Pengyuan Yang, Jing Fu, Gregory A. Michelotti, Rui Chen, Jianhua Sui, Bin Yang, et al. “Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes.” Cancer Res 76, no. 8 (April 15, 2016): 2394–2405. https://doi.org/10.1158/0008-5472.CAN-15-1548.Full Text Link to Item
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Dattaroy, Diptadip, Ratanesh Kumar Seth, Suvarthi Das, Firas Alhasson, Varun Chandrashekaran, Gregory Michelotti, Daping Fan, et al. “Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation.” Am J Physiol Gastrointest Liver Physiol 310, no. 7 (April 1, 2016): G510–25. https://doi.org/10.1152/ajpgi.00259.2015.Full Text Link to Item
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Michelotti, Gregory A., Anikia Tucker, Marzena Swiderska-Syn, Mariana Verdelho Machado, Steve S. Choi, Leandi Kruger, Erik Soderblom, et al. “Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.” Gut 65, no. 4 (April 2016): 683–92. https://doi.org/10.1136/gutjnl-2014-308176.Full Text Open Access Copy Link to Item
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Boursier, Jérôme, Olaf Mueller, Matthieu Barret, Mariana Machado, Lionel Fizanne, Felix Araujo-Perez, Cynthia D. Guy, et al. “The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota.” Hepatology 63, no. 3 (March 2016): 764–75. https://doi.org/10.1002/hep.28356.Full Text Link to Item
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Guy, Cynthia D., and Anna Mae Diehl. “Reply.” Hepatology 63, no. 3 (March 2016): 1057–58. https://doi.org/10.1002/hep.28011.Full Text Link to Item
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Zhu, Ruixin, Susan S. Baker, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, Fausto Zamboni, Dingfeng Wu, et al. “Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers.” J Pathol 238, no. 4 (March 2016): 531–42. https://doi.org/10.1002/path.4650.Full Text Link to Item
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Machado, M. V., G. A. Michelotti, M. L. Jewell, T. A. Pereira, G. Xie, R. T. Premont, and A. M. Diehl. “Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.” Cell Death Dis 7, no. 2 (February 18, 2016): e2096. https://doi.org/10.1038/cddis.2016.19.Full Text Link to Item
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Chandrashekaran, Varun, Suvarthi Das, Ratanesh Kumar Seth, Diptadip Dattaroy, Firas Alhasson, Gregory Michelotti, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, and Saurabh Chatterjee. “Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis.” Biochim Biophys Acta 1862, no. 1 (January 2016): 32–45. https://doi.org/10.1016/j.bbadis.2015.10.009.Full Text Link to Item
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Coombes, Jason D., Steve S. Choi, Marzena Swiderska-Syn, Paul Manka, Danielle T. Reid, Elena Palma, Marco A. Briones-Orta, et al. “Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.” Biochim Biophys Acta 1862, no. 1 (January 2016): 135–44. https://doi.org/10.1016/j.bbadis.2015.10.028.Full Text Link to Item
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Machado, Mariana Verdelho, Leandi Kruger, Mark L. Jewell, Gregory Alexander Michelotti, Thiago de Almeida Pereira, Guanhua Xie, Cynthia A. Moylan, and Anna Mae Diehl. “Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.” Dig Dis Sci 61, no. 1 (January 2016): 137–48. https://doi.org/10.1007/s10620-015-3871-x.Full Text Link to Item
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Michelotti, Gregory A., Anikia Tucker, Marzena Swiderska-Syn, Mariana Verdelho Machado, Steve S. Choi, Leandi Kruger, Erik Soderblom, et al. “Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.” Gut 65, no. 4 (2016): 683–92. https://doi.org/10.1136/gutjnl-2014-308176.Full Text Link to Item
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Zhou, Qing, Dipali Patel, Timothy Kwa, Amranul Haque, Zimple Matharu, Gulnaz Stybayeva, Yandong Gao, Anna Mae Diehl, and Alexander Revzin. “Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury.” Lab Chip 15, no. 23 (December 7, 2015): 4467–78. https://doi.org/10.1039/c5lc00874c.Full Text Link to Item
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Garman, Katherine S., Leandi Kruger, Samantha Thomas, Marzena Swiderska-Syn, Barry K. Moser, Anna Mae Diehl, and Shannon J. McCall. “Ductal metaplasia in oesophageal submucosal glands is associated with inflammation and oesophageal adenocarcinoma.” Histopathology 67, no. 6 (December 2015): 771–82. https://doi.org/10.1111/his.12707.Full Text Link to Item
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Block, Keith I., Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, ARM Ruhul Amin, Amr Amin, Katia Aquilano, et al. “Designing a broad-spectrum integrative approach for cancer prevention and treatment.” Semin Cancer Biol 35 Suppl, no. Suppl (December 2015): S276–304. https://doi.org/10.1016/j.semcancer.2015.09.007.Full Text Link to Item
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Hirschey, Matthew D., Ralph J. DeBerardinis, Anna Mae E. Diehl, Janice E. Drew, Christian Frezza, Michelle F. Green, Lee W. Jones, et al. “Dysregulated metabolism contributes to oncogenesis.” Semin Cancer Biol 35 Suppl (December 2015): S129–50. https://doi.org/10.1016/j.semcancer.2015.10.002.Full Text Link to Item
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Pereira, Thiago A., Wing-Kin Syn, Mariana V. Machado, Paula V. Vidigal, Vivian Resende, Izabela Voieta, Guanhua Xie, et al. “Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.” Clin Sci (Lond) 129, no. 10 (November 2015): 875–83. https://doi.org/10.1042/CS20150117.Full Text Open Access Copy Link to Item
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Michelotti, Gregory, Xiaoyin Jiang, Julie Ann Sosa, Anna Mae Diehl, and Brittany Bohinc Henderson. “LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.” Oncotarget 6, no. 33 (October 27, 2015): 34549–60. https://doi.org/10.18632/oncotarget.5330.Full Text Link to Item
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Machado, Mariana Verdelho, Gregory Alexander Michelotti, Thiago Almeida Pereira, Guanhua Xie, Richard Premont, Helena Cortez-Pinto, and Anna Mae Diehl. “Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease.” J Hepatol 63, no. 4 (October 2015): 962–70. https://doi.org/10.1016/j.jhep.2015.05.031.Full Text Link to Item
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Uschner, Frank E., Ganesh Ranabhat, Steve S. Choi, Michaela Granzow, Sabine Klein, Robert Schierwagen, Esther Raskopf, et al. “Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension.” Sci Rep 5 (September 28, 2015): 14573. https://doi.org/10.1038/srep14573.Full Text Link to Item
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Coombes, J. D., M. Swiderska-Syn, L. Dollé, D. Reid, B. Eksteen, L. Claridge, M. A. Briones-Orta, et al. “Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice.” Gut 64, no. 7 (July 2015): 1120–31. https://doi.org/10.1136/gutjnl-2013-306484.Full Text Link to Item
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Das, Suvarthi, Firas Alhasson, Diptadip Dattaroy, Sahar Pourhoseini, Ratanesh Kumar Seth, Mitzi Nagarkatti, Prakash S. Nagarkatti, et al. “NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment.” Am J Pathol 185, no. 7 (July 2015): 1944–57. https://doi.org/10.1016/j.ajpath.2015.03.024.Full Text Link to Item
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Machado, M. V., G. A. Michelotti, T de Almeida Pereira, J. Boursier, L. Kruger, M. Swiderska-Syn, G. Karaca, et al. “Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.” Gut 64, no. 7 (July 2015): 1148–57. https://doi.org/10.1136/gutjnl-2014-307362.Full Text Link to Item
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Angulo, Paul, Mariana Verdelho Machado, and Anna Mae Diehl. “Fibrosis in nonalcoholic Fatty liver disease: mechanisms and clinical implications.” Semin Liver Dis 35, no. 2 (May 2015): 132–45. https://doi.org/10.1055/s-0035-1550065.Full Text Link to Item
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Guy, Cynthia, Ayako Suzuki, Manal Abdelmalek, James Burchette, and Anna Mae Diehl. “Reply: To PMID 24849310.” Hepatology 61, no. 5 (May 2015): 1770–71. https://doi.org/10.1002/hep.27430.Full Text Link to Item
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Diehl, Anna Mae. “Prometheus and progenitors.” Hepatology 61, no. 4 (April 2015): 1427–29. https://doi.org/10.1002/hep.27676.Full Text Link to Item
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Markowitz, Geoffrey J., Gregory A. Michelotti, Anna Mae Diehl, and Xiao-Fan Wang. “Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma.” Sci Bull (Beijing) 60, no. 8 (April 1, 2015): 762–72. https://doi.org/10.1007/s11434-015-0772-5.Full Text Link to Item
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Neuschwander-Tetri, Brent A., Rohit Loomba, Arun J. Sanyal, Joel E. Lavine, Mark L. Van Natta, Manal F. Abdelmalek, Naga Chalasani, et al. “Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial.” Lancet 385, no. 9972 (March 14, 2015): 956–65. https://doi.org/10.1016/S0140-6736(14)61933-4.Full Text Link to Item
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Dattaroy, Diptadip, Sahar Pourhoseini, Suvarthi Das, Firas Alhasson, Ratanesh Kumar Seth, Mitzi Nagarkatti, Gregory A. Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. “Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis.” Am J Physiol Gastrointest Liver Physiol 308, no. 4 (February 15, 2015): G298–312. https://doi.org/10.1152/ajpgi.00346.2014.Full Text Link to Item
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Karaca, Gamze, Guanhua Xie, Cynthia Moylan, Marzena Swiderska-Syn, Cynthia D. Guy, Leandi Krüger, Mariana Verdelho Machado, et al. “Role of Fn14 in acute alcoholic steatohepatitis in mice.” Am J Physiol Gastrointest Liver Physiol 308, no. 4 (February 15, 2015): G325–34. https://doi.org/10.1152/ajpgi.00429.2013.Full Text Link to Item
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Asai, Akihiro, Samyukta Malladi, Jonathan Misch, Xiaomin Pan, Padmini Malladi, Anna Mae Diehl, and Peter F. Whitington. “Elaboration of tubules with active hedgehog drives parenchymal fibrogenesis in gestational alloimmune liver disease.” Hum Pathol 46, no. 1 (January 2015): 84–93. https://doi.org/10.1016/j.humpath.2014.09.010.Full Text Link to Item
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Boursier, Jerome, and Anna Mae Diehl. “Implication of gut microbiota in nonalcoholic fatty liver disease.” Plos Pathog 11, no. 1 (January 2015): e1004559. https://doi.org/10.1371/journal.ppat.1004559.Full Text Link to Item
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Machado, Mariana Verdelho, Gregory Alexander Michelotti, Guanhua Xie, Thiago Almeida Pereira, Jerome Boursier, Brittany Bohnic, Cynthia D. Guy, and Anna Mae Diehl. “Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.” Plos One 10, no. 5 (2015): e0127991. https://doi.org/10.1371/journal.pone.0127991.Full Text Link to Item
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Pourhoseini, Sahar, Ratanesh Kumar Seth, Suvarthi Das, Diptadip Dattaroy, Maria B. Kadiiska, Guanhua Xie, Gregory A. Michelotti, Mitzi Nagarkatti, Anna Mae Diehl, and Saurabh Chatterjee. “Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.” Plos One 10, no. 2 (2015): e0116780. https://doi.org/10.1371/journal.pone.0116780.Full Text Link to Item
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Boursier, Jérôme, and Anna Mae Diehl. “Patatin-like phospholipase domain-containing protein 3 and liver disease: opportunities to unravel mechanisms underlying statistical associations.” Hepatology 61, no. 1 (January 2015): 18–20. https://doi.org/10.1002/hep.27445.Full Text Link to Item
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Guy, Cynthia D., Ayako Suzuki, Manal F. Abdelmalek, James L. Burchette, Anna Mae Diehl, and Anna Mae NASH CRN. “Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity.” Hepatology 61, no. 1 (January 2015): 98–107. https://doi.org/10.1002/hep.27235.Full Text Link to Item
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Machado, Mariana Verdelho, Gregory Alexander Michelotti, Guanhua Xie, Thiago Pereira de Almeida, Jerome Boursier, Brittany Bohnic, Cynthia D. Guy, and Anna Mae Diehl. “Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease.” Plos One 10, no. 6 (2015): e0132315. https://doi.org/10.1371/journal.pone.0132315.Full Text Link to Item
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Seth, Ratanesh Kumar, Suvarthi Das, Sahar Pourhoseini, Diptadip Dattaroy, Stephen Igwe, Julie Basu Ray, Daping Fan, Gregory A. Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. “M1 polarization bias and subsequent nonalcoholic steatohepatitis progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1-induced oxidative stress in obese mice.” J Pharmacol Exp Ther 352, no. 1 (January 2015): 77–89. https://doi.org/10.1124/jpet.114.218131.Full Text Link to Item
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Das, Suvarthi, Ratanesh K. Seth, Sahar Pourhoseini, Diptadip Dattaroy, Firas Alhasson, Mitzi Nagarkatti, Gregory A. Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. “NADPH oxidase-induced TLR4 recruitment to hepatic lipid rafts mediates NASH progression.” Hepatology 60, no. 6 (December 1, 2014): 1289A-1289A.Link to Item
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Bohinc, Brittany N., Gregory Michelotti, Guanhua Xie, Herbert Pang, Ayako Suzuki, Cynthia D. Guy, Dawn Piercy, et al. “Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.” Endocrinology 155, no. 11 (November 2014): 4591–4601. https://doi.org/10.1210/en.2014-1302.Full Text Link to Item
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Kelley, Carly E., Ann J. Brown, Anna Mae Diehl, and Tracy L. Setji. “Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome.” World J Gastroenterol 20, no. 39 (October 21, 2014): 14172–84. https://doi.org/10.3748/wjg.v20.i39.14172.Full Text Link to Item
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Moylan, Cynthia A., Herbert Pang, Gregory Michelotti, and Anna Mae Diehl. “Reply: To PMID 23913408.” Hepatology 60, no. 4 (October 2014): 1445–46. https://doi.org/10.1002/hep.27038.Full Text Link to Item
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Soeda, Junpei, Angelina Mouralidarane, Shuvra Ray, Marco Novelli, Steven Thomas, Tania Roskams, Anna Mae Diehl, and Jude A. Oben. “The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice.” Hepatology 60, no. 3 (September 2014): 1023–34. https://doi.org/10.1002/hep.27266.Full Text Link to Item
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Swiderska-Syn, M., W. K. Syn, G. Xie, L. Krüger, M. V. Machado, G. Karaca, G. A. Michelotti, S. S. Choi, R. T. Premont, and A. M. Diehl. “Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy.” Gut 63, no. 8 (August 2014): 1333–44. https://doi.org/10.1136/gutjnl-2013-305962.Full Text Link to Item
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Siddique, Asma, James E. Nelson, Bradley Aouizerat, Matthew M. Yeh, Kris V. Kowdley, and Kris V. NASH Clinical Research Network. “Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin.” Clin Gastroenterol Hepatol 12, no. 7 (July 2014): 1170–78. https://doi.org/10.1016/j.cgh.2013.11.017.Full Text Link to Item
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Choi, Steve S., Lee C. Claridge, Ravi Jhaveri, Marzena Swiderska-Syn, Paul Clark, Ayako Suzuki, Thiago A. Pereira, et al. “Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication.” Clin Sci (Lond) 126, no. 12 (June 2014): 845–55. https://doi.org/10.1042/CS20130473.Full Text Link to Item
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Chan, Isaac S., Cynthia D. Guy, Mariana V. Machado, Abigail Wank, Vishnu Kadiyala, Gregory Michelotti, Steve Choi, et al. “Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis.” Alcohol Clin Exp Res 38, no. 3 (March 2014): 787–800. https://doi.org/10.1111/acer.12279.Full Text Link to Item
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Gellad, Ziad F., and Javad Taheri. “Reply: To PMID 23978500.” Clin Gastroenterol Hepatol 12, no. 3 (March 2014): 527. https://doi.org/10.1016/j.cgh.2013.12.003.Full Text Link to Item
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Hyun, Jeongeun, Steve S. Choi, Anna Mae Diehl, and Youngmi Jung. “Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse.” J Mol Histol 45, no. 1 (February 2014): 103–12. https://doi.org/10.1007/s10735-013-9532-5.Full Text Link to Item
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Moylan, Cynthia A., Herbert Pang, Andrew Dellinger, Ayako Suzuki, Melanie E. Garrett, Cynthia D. Guy, Susan K. Murphy, et al. “Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.” Hepatology 59, no. 2 (February 2014): 471–82. https://doi.org/10.1002/hep.26661.Full Text Link to Item
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Karaca, Gamze, Marzena Swiderska-Syn, Guanhua Xie, Wing-Kin Syn, Leandi Krüger, Mariana Verdelho Machado, Katherine Garman, et al. “TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice.” Plos One 9, no. 1 (2014): e83987. https://doi.org/10.1371/journal.pone.0083987.Full Text Open Access Copy Link to Item
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Machado, Mariana Verdelho, and Anna Mae Diehl. “Liver renewal: detecting misrepair and optimizing regeneration.” Mayo Clin Proc 89, no. 1 (January 2014): 120–30. https://doi.org/10.1016/j.mayocp.2013.10.009.Full Text Link to Item
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Seth, Ratanesh Kumar, Suvarthi Das, Ashutosh Kumar, Anindya Chanda, Maria B. Kadiiska, Gregory Michelotti, Jose Manautou, Anna Mae Diehl, and Saurabh Chatterjee. “CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis.” Toxicol Appl Pharmacol 274, no. 1 (January 1, 2014): 42–54. https://doi.org/10.1016/j.taap.2013.10.029.Full Text Link to Item
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Xie, Guanhua, and Anna Mae Diehl. “Evidence for and against epithelial-to-mesenchymal transition in the liver.” Am J Physiol Gastrointest Liver Physiol 305, no. 12 (December 2013): G881–90. https://doi.org/10.1152/ajpgi.00289.2013.Full Text Link to Item
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Das, Suvarthi, Ratanesh Kumar Seth, Ashutosh Kumar, Maria B. Kadiiska, Gregory Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. “Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis.” Am J Physiol Gastrointest Liver Physiol 305, no. 12 (December 2013): G950–63. https://doi.org/10.1152/ajpgi.00235.2013.Full Text Link to Item
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Garman, Katherine S., Kouros Owzar, Elizabeth R. Hauser, Kristen Westfall, Blair R. Anderson, Rhonda F. Souza, Anna Mae Diehl, Dawn Provenzale, and Nicholas J. Shaheen. “MicroRNA expression differentiates squamous epithelium from Barrett's esophagus and esophageal cancer.” Dig Dis Sci 58, no. 11 (November 2013): 3178–88. https://doi.org/10.1007/s10620-013-2806-7.Full Text Link to Item
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Michelotti, Gregory A., Mariana V. Machado, and Anna Mae Diehl. “NAFLD, NASH and liver cancer.” Nat Rev Gastroenterol Hepatol 10, no. 11 (November 2013): 656–65. https://doi.org/10.1038/nrgastro.2013.183.Full Text Link to Item
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Murphy, Susan K., Hyuna Yang, Cynthia A. Moylan, Herbert Pang, Andrew Dellinger, Manal F. Abdelmalek, Melanie E. Garrett, et al. “Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.” Gastroenterology 145, no. 5 (November 2013): 1076–87. https://doi.org/10.1053/j.gastro.2013.07.047.Full Text Link to Item
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Xie, Guanhua, Gamze Karaca, Marzena Swiderska-Syn, Gregory A. Michelotti, Leandi Krüger, Yuping Chen, Richard T. Premont, Steve S. Choi, and Anna Mae Diehl. “Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice.” Hepatology 58, no. 5 (November 2013): 1801–13. https://doi.org/10.1002/hep.26511.Full Text Link to Item
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Deng, Yan-Ru, Hong-Di Ma, Koichi Tsuneyama, Wei Yang, Yin-Hu Wang, Fang-Ting Lu, Cheng-Hai Liu, et al. “STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib.” J Autoimmun 46 (October 2013): 25–34. https://doi.org/10.1016/j.jaut.2013.07.008.Full Text Link to Item
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Bohinc, Brittany, Gregory Michelotti, and Anna Mae Diehl. “Hedgehog signaling in human medullary thyroid carcinoma: a novel signaling pathway.” Thyroid 23, no. 9 (September 2013): 1119–26. https://doi.org/10.1089/thy.2012.0474.Full Text Link to Item
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Seth, Ratanesh Kumar, Ashutosh Kumar, Suvarthi Das, Maria B. Kadiiska, Gregory Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. “Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice.” Toxicol Sci 134, no. 2 (August 2013): 291–303. https://doi.org/10.1093/toxsci/kft104.Full Text Link to Item
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Youssef, Nagy A., Manal F. Abdelmalek, Martin Binks, Cynthia D. Guy, Alessia Omenetti, Alastair D. Smith, Anna Mae E. Diehl, and Ayako Suzuki. “Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease.” Liver Int 33, no. 7 (August 2013): 1062–70. https://doi.org/10.1111/liv.12165.Full Text Link to Item
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Boursier, Jerome, John F. Rawls, and Anna Mae Diehl. “Obese humans with nonalcoholic fatty liver disease display alterations in fecal microbiota and volatile organic compounds.” Clin Gastroenterol Hepatol 11, no. 7 (July 2013): 876–78. https://doi.org/10.1016/j.cgh.2013.04.016.Full Text Link to Item
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Michelotti, Gregory A., Guanhua Xie, Marzena Swiderska, Steve S. Choi, Gamze Karaca, Leandi Krüger, Richard Premont, et al. “Smoothened is a master regulator of adult liver repair.” J Clin Invest 123, no. 6 (June 2013): 2380–94. https://doi.org/10.1172/JCI66904.Full Text Link to Item
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Diehl, Anna Mae, and John Chute. “Underlying potential: cellular and molecular determinants of adult liver repair.” J Clin Invest 123, no. 5 (May 2013): 1858–60. https://doi.org/10.1172/JCI69966.Full Text Link to Item
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Swiderska-Syn, Marzena, Ayako Suzuki, Cynthia D. Guy, Jeffrey B. Schwimmer, Manal F. Abdelmalek, Joel E. Lavine, and Anna Mae Diehl. “Hedgehog pathway and pediatric nonalcoholic fatty liver disease.” Hepatology 57, no. 5 (May 2013): 1814–25. https://doi.org/10.1002/hep.26230.Full Text Link to Item
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Chatterjee, Saurabh, Douglas Ganini, Erik J. Tokar, Ashutosh Kumar, Suvarthi Das, Jean Corbett, Maria B. Kadiiska, Michael P. Waalkes, Anna Mae Diehl, and Ronald P. Mason. “Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis.” J Hepatol 58, no. 4 (April 2013): 778–84. https://doi.org/10.1016/j.jhep.2012.11.035.Full Text Link to Item
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Corbin, Karen D., Manal F. Abdelmalek, Melanie D. Spencer, Kerry-Ann da Costa, Joseph A. Galanko, Wei Sha, Ayako Suzuki, et al. “Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.” Faseb J 27, no. 4 (April 2013): 1674–89. https://doi.org/10.1096/fj.12-219097.Full Text Link to Item
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Garrett, Melanie E., Manal F. Abdelmalek, Allison Ashley-Koch, Michael A. Hauser, Cynthia A. Moylan, Herbert Pang, Anna Mae Diehl, and Hans L. Tillmann. “IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients.” J Hepatol 58, no. 2 (February 2013): 402–3. https://doi.org/10.1016/j.jhep.2012.09.035.Full Text Link to Item
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Xie, Guanhua, Steve S. Choi, Wing-Kin Syn, Gregory A. Michelotti, Marzena Swiderska, Gamze Karaca, Isaac S. Chan, Yuping Chen, and Anna Mae Diehl. “Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation.” Gut 62, no. 2 (February 2013): 299–309. https://doi.org/10.1136/gutjnl-2011-301494.Full Text Link to Item
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Machado, Mariana Verdelho, Yiping Yang, and Anna Mae Diehl. “The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis.” J Clin Invest 123, no. 1 (January 2013): 115–17. https://doi.org/10.1172/JCI67238.Full Text Link to Item
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Pereira, Thiago A., Guanhua Xie, Steve S. Choi, Wing-Kin Syn, Izabela Voieta, Jiuyi Lu, Isaac S. Chan, et al. “Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni.” Liver Int 33, no. 1 (January 2013): 149–61. https://doi.org/10.1111/liv.12016.Full Text Link to Item
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Chan, Isaac S., Cynthia D. Guy, Yuping Chen, Jiuyi Lu, Marzena Swiderska-Syn, Gregory A. Michelotti, Gamze Karaca, et al. “Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.” Cancer Res 72, no. 24 (December 15, 2012): 6344–50. https://doi.org/10.1158/0008-5472.CAN-12-1068.Full Text Link to Item
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Jou, J. H., and A. M. Diehl. “Alcoholic liver disease,” December 1, 2012, 95–105. https://doi.org/10.1016/B978-1-4377-1725-9.10006-1.Full Text
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Arzumanyan, Alla, Vaishnavi Sambandam, Marcia M. Clayton, Steve S. Choi, Guanhua Xie, Anna Mae Diehl, Dae-Yeul Yu, and Mark A. Feitelson. “Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein.” Cancer Res 72, no. 22 (November 15, 2012): 5912–20. https://doi.org/10.1158/0008-5472.CAN-12-2329.Full Text Link to Item
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Chen, Yuping, Steve S. Choi, Gregory A. Michelotti, Isaac S. Chan, Marzena Swiderska-Syn, Gamze F. Karaca, Guanhua Xie, et al. “Hedgehog controls hepatic stellate cell fate by regulating metabolism.” Gastroenterology 143, no. 5 (November 2012): 1319-1329.e11. https://doi.org/10.1053/j.gastro.2012.07.115.Full Text Link to Item
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Nelson, James E., Elizabeth M. Brunt, Kris V. Kowdley, and Kris V. Nonalcoholic Steatohepatitis Clinical Research Network. “Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.” Hepatology 56, no. 5 (November 2012): 1730–40. https://doi.org/10.1002/hep.25856.Full Text Link to Item
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Chalasani, N., Z. Younossi, J. E. Lavine, A. M. Diehl, E. M. Brunt, K. Cusi, M. Charlton, and A. J. Sanyal. “Erratum: The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the american association for the study of liver diseases, American College of Gastroenterology, and the American Gastroenterological Association (American Journal of Gastroenterology (2012) 107 (811-826) DOI: 10.1038/ajg.2012.128).” American Journal of Gastroenterology 107, no. 10 (October 1, 2012): 1598. https://doi.org/10.1038/ajg.2012.217.Full Text
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Bell, Lauren N., Jiangxia Wang, Sriya Muralidharan, Sadhana Chalasani, Allison M. Fullenkamp, Laura A. Wilson, Arun J. Sanyal, et al. “Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic steatohepatitis: a pioglitazone versus vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis trial follow-up study.” Hepatology 56, no. 4 (October 2012): 1311–18. https://doi.org/10.1002/hep.25805.Full Text Link to Item
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Bohinc, Brittany, Ayako Suzuki, Cynthia Guy, Herbert Pang, Dawn Piercy, Mark Feinglos, Paul Yen, Anna Mae Diehl, and Manal Abdelmalek. “The Association of Serum Thyroid Hormone Levels and Hepatic Gene Expression of Potential Regulators of Intracellular Thyroid Hormone Concentration with Severity of Nonalcoholic Fatty Liver Disease.” American Journal of Gastroenterology 107 (October 2012): S193–S193. https://doi.org/10.14309/00000434-201210001-00464.Full Text
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Rangwala, Fatima, Kevin P. Williams, Ginger R. Smith, Zainab Thomas, Jennifer L. Allensworth, H Kim Lyerly, Anna Mae Diehl, Michael A. Morse, and Gayathri R. Devi. “Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines.” Bmc Cancer 12 (September 10, 2012): 402. https://doi.org/10.1186/1471-2407-12-402.Full Text Link to Item
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Syn, Wing-Kin, Kolade M. Agboola, Marzena Swiderska, Gregory A. Michelotti, Evaggelia Liaskou, Herbert Pang, Guanhua Xie, et al. “NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.” Gut 61, no. 9 (September 2012): 1323–29. https://doi.org/10.1136/gutjnl-2011-301857.Full Text Link to Item
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Abdelmalek, Manal F., Mariana Lazo, Alena Horska, Susanne Bonekamp, Edward W. Lipkin, Ashok Balasubramanyam, John P. Bantle, et al. “Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes.” Hepatology 56, no. 3 (September 2012): 952–60. https://doi.org/10.1002/hep.25741.Full Text Link to Item
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Bohinc, Brittany N., and Anna Mae Diehl. “Mechanisms of disease progression in NASH: new paradigms.” Clin Liver Dis 16, no. 3 (August 2012): 549–65. https://doi.org/10.1016/j.cld.2012.05.002.Full Text Link to Item
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Suzuki, Ayako, Manal F. Abdelmalek, Jeffrey B. Schwimmer, Joel E. Lavine, Ann O. Scheimann, Aynur Unalp-Arida, Katherine P. Yates, et al. “Association between puberty and features of nonalcoholic fatty liver disease.” Clin Gastroenterol Hepatol 10, no. 7 (July 2012): 786–94. https://doi.org/10.1016/j.cgh.2012.01.020.Full Text Link to Item
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Liaskou, E., L. C. Claridge, R. Younis, H. Shah, J. Shaw, Y. H. Oo, Z. Mi, et al. “PMO-121 Osteopontin promotes natural killer T (NKT) cell accumulation in nonalcoholic steatohepatitis (NASH).” Gut 61, no. Suppl 2 (July 2012): A122.1-A122. https://doi.org/10.1136/gutjnl-2012-302514b.121.Full Text
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Chalasani, Naga, Zobair Younossi, Joel E. Lavine, Anna Mae Diehl, Elizabeth M. Brunt, Kenneth Cusi, Michael Charlton, et al. “The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association.” Am J Gastroenterol 107, no. 6 (June 2012): 811–26. https://doi.org/10.1038/ajg.2012.128.Full Text Link to Item
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Chalasani, Naga, Zobair Younossi, Joel E. Lavine, Anna Mae Diehl, Elizabeth M. Brunt, Kenneth Cusi, Michael Charlton, and Arun J. Sanyal. “The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association.” Hepatology 55, no. 6 (June 2012): 2005–23. https://doi.org/10.1002/hep.25762.Full Text Link to Item
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Chalasani, Naga, Zobair Younossi, Joel E. Lavine, Anna Mae Diehl, Elizabeth M. Brunt, Kenneth Cusi, Michael Charlton, et al. “The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology.” Gastroenterology 142, no. 7 (June 2012): 1592–1609. https://doi.org/10.1053/j.gastro.2012.04.001.Full Text Link to Item
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Guy, Cynthia D., Ayako Suzuki, James L. Burchette, Elizabeth M. Brunt, Manal F. Abdelmalek, Diana Cardona, Shannon J. McCall, et al. “Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease.” Hum Pathol 43, no. 6 (June 2012): 790–800. https://doi.org/10.1016/j.humpath.2011.07.007.Full Text Link to Item
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Guy, Cynthia D., Ayako Suzuki, Marzena Zdanowicz, Manal F. Abdelmalek, James Burchette, Aynur Unalp, Anna Mae Diehl, and Anna Mae NASH CRN. “Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease.” Hepatology 55, no. 6 (June 2012): 1711–21. https://doi.org/10.1002/hep.25559.Full Text Link to Item
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Jones, L., and A. M. Diehl. “Diabetes and the Liver,” April 19, 2012, 67–82. https://doi.org/10.1002/9781118405550.ch3.Full Text
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Diehl, Anna Mae. “Neighborhood watch orchestrates liver regeneration.” Nat Med 18, no. 4 (April 5, 2012): 497–99. https://doi.org/10.1038/nm.2719.Full Text Link to Item
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Guerrerio, Anthony L., Ryan M. Colvin, Amy K. Schwartz, Jean P. Molleston, Karen F. Murray, AnnaMae Diehl, Parvathi Mohan, et al. “Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.” Am J Clin Nutr 95, no. 4 (April 2012): 892–900. https://doi.org/10.3945/ajcn.111.020156.Full Text Link to Item
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Choi, Steve, and Anna Mae Diehl. “After goodbye? Dead hepatocytes as a biomarker for fibrosis and steatohepatitis.” Hepatology 55, no. 2 (February 2012): 333–35. https://doi.org/10.1002/hep.25540.Full Text Link to Item
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Vos, Miriam B., Ryan Colvin, Patricia Belt, Jean P. Molleston, Karen F. Murray, Philip Rosenthal, Jeffrey B. Schwimmer, et al. “Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD.” J Pediatr Gastroenterol Nutr 54, no. 1 (January 2012): 90–96. https://doi.org/10.1097/MPG.0b013e318229da1a.Full Text Link to Item
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Choi, Steve S., Shelton Bradrick, Guan Qiang, Anahita Mostafavi, Gaurav Chaturvedi, Steven A. Weinman, Anna Mae Diehl, and Ravi Jhaveri. “Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication.” Hepatology 54, no. 5 (November 2011): 1580–90. https://doi.org/10.1002/hep.24576.Full Text Link to Item
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Garman, Katherine S., Chaitanya R. Acharya, Elena Edelman, Marian Grade, Jochen Gaedcke, Shivani Sud, William Barry, et al. “Retraction for Garman et al: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.” Proc Natl Acad Sci U S A 108, no. 42 (October 18, 2011): 17569. https://doi.org/10.1073/pnas.1115170108.Full Text Link to Item
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Liaskou, E., L. C. Claridge, H. Shah, Y. Oo, J. Shaw, Z. Mi, P. C. Kuo, et al. “P89 Osteopontin promotes lymphocyte recruitment in steatohepatitis.” Gut 60, no. Suppl 2 (September 1, 2011): A41–A41. https://doi.org/10.1136/gutjnl-2011-300857a.89.Full Text
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Palmeri, Mark L., Michael H. Wang, Ned C. Rouze, Manal F. Abdelmalek, Cynthia D. Guy, Barry Moser, Anna Mae Diehl, and Kathryn R. Nightingale. “Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease.” J Hepatol 55, no. 3 (September 2011): 666–72. https://doi.org/10.1016/j.jhep.2010.12.019.Full Text Link to Item
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Seth, Devanshi, Paul S. Haber, Wing-Kin Syn, Anna Mae Diehl, and Christopher P. Day. “Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances.” J Gastroenterol Hepatol 26, no. 7 (July 2011): 1089–1105. https://doi.org/10.1111/j.1440-1746.2011.06756.x.Full Text Link to Item
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Rangwala, Fatima, Cynthia D. Guy, Jiuyi Lu, Ayako Suzuki, James L. Burchette, Manal F. Abdelmalek, Wei Chen, and Anna Mae Diehl. “Increased production of sonic hedgehog by ballooned hepatocytes.” J Pathol 224, no. 3 (July 2011): 401–10. https://doi.org/10.1002/path.2888.Full Text Link to Item
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Tilg, Herbert, and Anna Mae Diehl. “NAFLD and extrahepatic cancers: have a look at the colon.” Gut 60, no. 6 (June 2011): 745–46. https://doi.org/10.1136/gut.2011.239392.Full Text Link to Item
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Omenetti, Alessia, and Anna Mae Diehl. “Hedgehog signaling in cholangiocytes.” Curr Opin Gastroenterol 27, no. 3 (May 2011): 268–75. https://doi.org/10.1097/MOG.0b013e32834550b4.Full Text Link to Item
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Omenetti, Alessia, Lee M. Bass, Robert A. Anders, Maria G. Clemente, Heather Francis, Cynthia D. Guy, Shannon McCall, et al. “Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia.” Hepatology 53, no. 4 (April 2011): 1246–58. https://doi.org/10.1002/hep.24156.Full Text Link to Item
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Kistler, Kristin D., Elizabeth M. Brunt, Jeanne M. Clark, Anna Mae Diehl, James F. Sallis, Jeffrey B. Schwimmer, and Jeffrey B. NASH CRN Research Group. “Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease.” Am J Gastroenterol 106, no. 3 (March 2011): 460–68. https://doi.org/10.1038/ajg.2010.488.Full Text Link to Item
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Speliotes, Elizabeth K., Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Cameron D. Palmer, Vilmundur Gudnason, et al. “Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.” Plos Genet 7, no. 3 (March 2011): e1001324. https://doi.org/10.1371/journal.pgen.1001324.Full Text Link to Item
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Omenetti, Alessia, Liu Yang, Raul R. Gainetdinov, Cynthia D. Guy, Steve S. Choi, Wei Chen, Marc G. Caron, and Anna Mae Diehl. “Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults.” Am J Physiol Gastrointest Liver Physiol 300, no. 2 (February 2011): G303–15. https://doi.org/10.1152/ajpgi.00368.2010.Full Text Link to Item
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Choi, Steve S., Alessia Omenetti, Wing-Kin Syn, and Anna Mae Diehl. “The role of Hedgehog signaling in fibrogenic liver repair.” Int J Biochem Cell Biol 43, no. 2 (February 2011): 238–44. https://doi.org/10.1016/j.biocel.2010.10.015.Full Text Link to Item
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Omenetti, Alessia, Steve Choi, Gregory Michelotti, and Anna Mae Diehl. “Hedgehog signaling in the liver.” J Hepatol 54, no. 2 (February 2011): 366–73. https://doi.org/10.1016/j.jhep.2010.10.003.Full Text Link to Item
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Rangwala, Fatima, Alessia Omenetti, and Anna Mae Diehl. “Cancer stem cells: repair gone awry?” J Oncol 2011 (2011): 465343. https://doi.org/10.1155/2011/465343.Full Text Link to Item
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Philips, George M., Isaac S. Chan, Marzena Swiderska, Vanessa T. Schroder, Cynthia Guy, Gamze F. Karaca, Cynthia Moylan, et al. “Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.” Plos One 6, no. 9 (2011): e23943. https://doi.org/10.1371/journal.pone.0023943.Full Text Open Access Copy Link to Item
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Rojkind, Marcos, George Philips, and Anna Mae Diehl. “Microarchitecture of the liver: a jigsaw puzzle.” J Hepatol 54, no. 1 (January 2011): 187–88. https://doi.org/10.1016/j.jhep.2010.09.004.Full Text Link to Item
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Syn, Wing-Kin, Steve S. Choi, Evaggelia Liaskou, Gamze F. Karaca, Kolade M. Agboola, Ye Htun Oo, Zhiyong Mi, et al. “Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.” Hepatology 53, no. 1 (January 2011): 106–15. https://doi.org/10.1002/hep.23998.Full Text Link to Item
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Omenetti, A., and A. M. Diehl. “Sonic hedgehog pathway,” December 1, 2010, 393–401. https://doi.org/10.1007/978-3-642-00150-5_26.Full Text
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Pereira, Thiago de Almeida, Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Shelton Bradrick, Gamze F. Karaca, Kolade M. Agboola, et al. “Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma.” Lab Invest 90, no. 12 (December 2010): 1690–1703. https://doi.org/10.1038/labinvest.2010.147.Full Text Open Access Copy Link to Item
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Suzuki, Ayako, Manal F. Abdelmalek, Aynur Unalp-Arida, Katherine Yates, Arun Sanyal, Cynthia Guy, and Anna Mae Diehl. “Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease.” Clin Gastroenterol Hepatol 8, no. 12 (December 2010): 1062–69. https://doi.org/10.1016/j.cgh.2010.08.005.Full Text Link to Item
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Choi, Steve S., Wing-Kin Syn, Gamze F. Karaca, Alessia Omenetti, Cynthia A. Moylan, Rafal P. Witek, Kolade M. Agboola, Youngmi Jung, Gregory A. Michelotti, and Anna Mae Diehl. “Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.” J Biol Chem 285, no. 47 (November 19, 2010): 36551–60. https://doi.org/10.1074/jbc.M110.168542.Full Text Link to Item
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Lazo, Mariana, Steven F. Solga, Alena Horska, Susanne Bonekamp, Anna Mae Diehl, Frederick L. Brancati, Lynne E. Wagenknecht, et al. “Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes.” Diabetes Care 33, no. 10 (October 2010): 2156–63. https://doi.org/10.2337/dc10-0856.Full Text Link to Item
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Neuschwander-Tetri, Brent A., Jeanne M. Clark, Nathan M. Bass, Mark L. Van Natta, Aynur Unalp-Arida, James Tonascia, Claudia O. Zein, et al. “Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease.” Hepatology 52, no. 3 (September 2010): 913–24. https://doi.org/10.1002/hep.23784.Full Text Link to Item
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Choi, Steve S., Rafal P. Witek, Liu Yang, Alessia Omenetti, Wing-Kin Syn, Cynthia A. Moylan, Youngmi Jung, et al. “Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells.” Hepatology 52, no. 1 (July 2010): 278–90. https://doi.org/10.1002/hep.23649.Full Text Link to Item
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Abdelmalek, Manal F., Ayako Suzuki, Cynthia Guy, Aynur Unalp-Arida, Ryan Colvin, Richard J. Johnson, Anna Mae Diehl, and Anna Mae Nonalcoholic Steatohepatitis Clinical Research Network. “Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease.” Hepatology 51, no. 6 (June 2010): 1961–71. https://doi.org/10.1002/hep.23535.Full Text Link to Item
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Syn, Wing-Kin, Ye Htun Oo, Thiago A. Pereira, Gamze F. Karaca, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, et al. “Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.” Hepatology 51, no. 6 (June 2010): 1998–2007. https://doi.org/10.1002/hep.23599.Full Text Link to Item
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Sanyal, Arun J., Naga Chalasani, Kris V. Kowdley, Arthur McCullough, Anna Mae Diehl, Nathan M. Bass, Brent A. Neuschwander-Tetri, et al. “Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.” N Engl J Med 362, no. 18 (May 6, 2010): 1675–85. https://doi.org/10.1056/NEJMoa0907929.Full Text Link to Item
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Jung, Youngmi, Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Alessia Omenetti, Richard Premont, Cynthia D. Guy, and Anna Mae Diehl. “Signals from dying hepatocytes trigger growth of liver progenitors.” Gut 59, no. 5 (May 2010): 655–65. https://doi.org/10.1136/gut.2009.204354.Full Text Link to Item
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Ochoa, Begoña, Wing-Kin Syn, Igotz Delgado, Gamze F. Karaca, Youngmi Jung, Jiangbo Wang, Ana M. Zubiaga, et al. “Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice.” Hepatology 51, no. 5 (May 2010): 1712–23. https://doi.org/10.1002/hep.23525.Full Text Link to Item
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Jou, Janice, and Anna Mae Diehl. “Epithelial-mesenchymal transitions and hepatocarcinogenesis.” J Clin Invest 120, no. 4 (April 2010): 1031–34. https://doi.org/10.1172/JCI42615.Full Text Open Access Copy Link to Item
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Diehl, Anna Mae. “Genetic susceptibility to hepatic steatosis.” N Engl J Med 362, no. 12 (March 25, 2010): 1142–43. https://doi.org/10.1056/NEJMe1000206.Full Text Link to Item
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Diehl, Anna Mae. “Hepatic complications of obesity.” Gastroenterol Clin North Am 39, no. 1 (March 2010): 57–68. https://doi.org/10.1016/j.gtc.2009.12.001.Full Text Link to Item
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Suzuki, Ayako, Martin Binks, Ronald Sha, Amy Wachholtz, Howard Eisenson, and Anna Mae Diehl. “Serum aminotransferase changes with significant weight loss: sex and age effects.” Metabolism 59, no. 2 (February 2010): 177–85. https://doi.org/10.1016/j.metabol.2009.06.030.Full Text Link to Item
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Jung, Youngmi, and Anna Mae Diehl. “Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression.” Dig Dis 28, no. 1 (2010): 225–28. https://doi.org/10.1159/000282092.Full Text Link to Item
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Lavine, Joel E., Jeffrey B. Schwimmer, Jean P. Molleston, Ann O. Scheimann, Karen F. Murray, Stephanie H. Abrams, Philip Rosenthal, et al. “Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.” Contemp Clin Trials 31, no. 1 (January 2010): 62–70. https://doi.org/10.1016/j.cct.2009.09.001.Full Text Link to Item
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Jhaveri, Ravi, Guan Qiang, and Anna Mae Diehl. “Domain 3 of hepatitis C virus core protein is sufficient for intracellular lipid accumulation.” J Infect Dis 200, no. 11 (December 1, 2009): 1781–88. https://doi.org/10.1086/648094.Full Text Link to Item
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Choi, Steve S., Alessia Omenetti, Rafal P. Witek, Cynthia A. Moylan, Wing-Kin Syn, Youngmi Jung, Liu Yang, et al. “Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.” Am J Physiol Gastrointest Liver Physiol 297, no. 6 (December 2009): G1093–1106. https://doi.org/10.1152/ajpgi.00292.2009.Full Text Link to Item
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Choi, Steve S., and Anna Mae Diehl. “Epithelial-to-mesenchymal transitions in the liver.” Hepatology 50, no. 6 (December 2009): 2007–13. https://doi.org/10.1002/hep.23196.Full Text Link to Item
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Syn, Wing-Kin, Steve S. Choi, and Anna Mae Diehl. “Apoptosis and cytokines in non-alcoholic steatohepatitis.” Clin Liver Dis 13, no. 4 (November 2009): 565–80. https://doi.org/10.1016/j.cld.2009.07.003.Full Text Link to Item
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Witek, Rafal P., W Carl Stone, F Gamze Karaca, Wing-Kin Syn, Thiago A. Pereira, Kolade M. Agboola, Alessia Omenetti, et al. “Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis.” Hepatology 50, no. 5 (November 2009): 1421–30. https://doi.org/10.1002/hep.23167.Full Text Link to Item
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Wang, Michael H., Mark L. Palmeri, Cynthia D. Guy, Liu Yang, Laurence W. Hedlund, Anna Mae Diehl, and Kathryn R. Nightingale. “In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force.” Ultrasound Med Biol 35, no. 10 (October 2009): 1709–21. https://doi.org/10.1016/j.ultrasmedbio.2009.04.019.Full Text Link to Item
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Shah, Amy G., Alison Lydecker, Karen Murray, Brent N. Tetri, Melissa J. Contos, Arun J. Sanyal, and Arun J. Nash Clinical Research Network. “Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease.” Clin Gastroenterol Hepatol 7, no. 10 (October 2009): 1104–12. https://doi.org/10.1016/j.cgh.2009.05.033.Full Text Link to Item
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Syn, Wing-Kin, Youngmi Jung, Alessia Omenetti, Manal Abdelmalek, Cynthia D. Guy, Liu Yang, Jiangbo Wang, et al. “Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.” Gastroenterology 137, no. 4 (October 2009): 1478-1488.e8. https://doi.org/10.1053/j.gastro.2009.06.051.Full Text Link to Item
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Syn, Wing-Kin, Liu Yang, Dian Jung Chiang, Yue Qian, Youngmi Jung, Gamze Karaca, Steve S. Choi, et al. “Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice.” Liver Int 29, no. 8 (September 2009): 1262–72. https://doi.org/10.1111/j.1478-3231.2009.02036.x.Full Text Link to Item
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Sun, Baodong, Songtao Li, Liu Yang, Tirupapuliyur Damodaran, Dev Desai, Anna Mae Diehl, Oscar Alzate, and Dwight D. Koeberl. “Activation of glycolysis and apoptosis in glycogen storage disease type Ia.” Mol Genet Metab 97, no. 4 (August 2009): 267–71. https://doi.org/10.1016/j.ymgme.2009.04.003.Full Text Link to Item
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Suzuki, Ayako, Nancy Yuen, John Walsh, Julie Papay, Christine M. Hunt, and Anna Mae Diehl. “Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury.” Clin Gastroenterol Hepatol 7, no. 8 (August 2009): 882–88. https://doi.org/10.1016/j.cgh.2009.03.034.Full Text Link to Item
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Omenetti, Alessia, Wing-Kin Syn, Youngmi Jung, Heather Francis, Alessandro Porrello, Rafal P. Witek, Steve S. Choi, et al. “Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production.” Hepatology 50, no. 2 (August 2009): 518–27. https://doi.org/10.1002/hep.23019.Full Text Link to Item
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Syn, Wing-Kin, Rafal P. Witek, Stuart M. Curbishley, Youngmi Jung, Steve S. Choi, Barbara Enrich, Alessia Omenetti, et al. “Role for hedgehog pathway in regulating growth and function of invariant NKT cells.” Eur J Immunol 39, no. 7 (July 2009): 1879–92. https://doi.org/10.1002/eji.200838890.Full Text Link to Item
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Jung, Y., A. Omenetti, W. -. K. Syn, R. Witek, S. Choi, and A. M. Diehl. “REGULATION OF PROGENITOR RESPONSE TO ALCOHOL-INDUCED LIVER INJURY.” Alcoholism Clinical and Experimental Research 33, no. 6 (June 1, 2009): 270A-270A.Link to Item
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David, Kristin, Kris V. Kowdley, Aynur Unalp, Fasiha Kanwal, Elizabeth M. Brunt, Jeffrey B. Schwimmer, and Jeffrey B. NASH CRN Research Group. “Quality of life in adults with nonalcoholic fatty liver disease: baseline data from the nonalcoholic steatohepatitis clinical research network.” Hepatology 49, no. 6 (June 2009): 1904–12. https://doi.org/10.1002/hep.22868.Full Text Link to Item
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Syn, Wing-Kin, Vanessa Teaberry, Steve S. Choi, and Anna Mae Diehl. “Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis.” Semin Liver Dis 29, no. 2 (May 2009): 200–210. https://doi.org/10.1055/s-0029-1214375.Full Text Link to Item
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Garman, K. S., C. R. Acharya, E. Edelman, M. Grade, J. Gaedcke, S. Sud, W. Barry, et al. “Erratum: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities (Proceedings of the National Academy of Sciences of the United States of America (2008) 105:49 (19432-19437) Doi: 10.1073/pnas.0806674105).” Proceedings of the National Academy of Sciences of the United States of America 106, no. 16 (April 21, 2009): 6878. https://doi.org/10.1073/pnas.0902004106.Full Text
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Omenetti, A., W. -. K. Syn, Y. Jung, R. P. Witek, S. S. Choi, and A. M. Diehl. “75 MYOFIBROBLASTS PROVIDE HEDGEHOG PARACRINE SIGNALS THAT DRIVE CHOLANGIOCYTES TO RECRUIT NKT CELLS TO PORTAL TRACTS.” Journal of Hepatology 50 (April 2009): S31–32. https://doi.org/10.1016/s0168-8278(09)60077-5.Full Text
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Mao, Hua, Anna Mae Diehl, and Yin-Xiong Li. “Sonic hedgehog ligand partners with caveolin-1 for intracellular transport.” Lab Invest 89, no. 3 (March 2009): 290–300. https://doi.org/10.1038/labinvest.2008.163.Full Text Link to Item
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Brunt, Elizabeth M., David E. Kleiner, Laura A. Wilson, Aynur Unalp, Cynthia E. Behling, Joel E. Lavine, Brent A. Neuschwander-Tetri, and Brent A. NASH Clinical Research NetworkA list of members of the Nonalcoholic Steatohepatitis Clinical Research Network can be found in the Appendix. “Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network.” Hepatology 49, no. 3 (March 2009): 809–20. https://doi.org/10.1002/hep.22724.Full Text Link to Item
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Sicklick, J. K., J. Wang, D. N. Watkins, J. Huang, W. Chen, and A. M. Diehl. “Novel Mutant Smoothened in Hepatomas Can Activate Hedgehog Signaling.” Annals of Surgical Oncology 16 (February 1, 2009): 15–15.Link to Item
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Sun, Zhaoli, Xiuying Zhang, Jayme E. Locke, Qizhi Zheng, Shingo Tachibana, Anna Mae Diehl, and George Melville Williams. “Recruitment of host progenitor cells in rat liver transplants.” Hepatology 49, no. 2 (February 2009): 587–97. https://doi.org/10.1002/hep.22653.Full Text Link to Item
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Sicklick, J. K., J. Huang, S. J. McCall, M. S. Torbenson, and A. M. Diehl. “Analysis of Hepatic Progenitor Populations in Methyl Deficient Liver Injury.” Annals of Surgical Oncology 16 (2009): 33–33.Link to Item
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Witek, Rafal P., Liu Yang, Renshui Liu, Youngmi Jung, Alessia Omenetti, Wing-Kin Syn, Steve S. Choi, et al. “Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells.” Gastroenterology 136, no. 1 (January 2009): 320-330.e2. https://doi.org/10.1053/j.gastro.2008.09.066.Full Text Link to Item
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Garman, Katherine S., Chaitanya R. Acharya, Elena Edelman, Marian Grade, Jochen Gaedcke, Shivani Sud, William Barry, et al. “A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.” Proc Natl Acad Sci U S A 105, no. 49 (December 9, 2008): 19432–37. https://doi.org/10.1073/pnas.0806674105.Full Text Link to Item
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Patton, Heather M., Joel E. Lavine, Mark L. Van Natta, Jeffrey B. Schwimmer, David Kleiner, Jean Molleston, and Jean Nonalcoholic Steatohepatitis Clinical Research Network. “Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis.” Gastroenterology 135, no. 6 (December 2008): 1961-1971.e2. https://doi.org/10.1053/j.gastro.2008.08.050.Full Text Link to Item
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Jou, Janice, Steve S. Choi, and Anna Mae Diehl. “Mechanisms of disease progression in nonalcoholic fatty liver disease.” Semin Liver Dis 28, no. 4 (November 2008): 370–79. https://doi.org/10.1055/s-0028-1091981.Full Text Link to Item
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Omenetti, Alessia, Alessandro Porrello, Youngmi Jung, Liu Yang, Yury Popov, Steve S. Choi, Rafal P. Witek, et al. “Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.” J Clin Invest 118, no. 10 (October 2008): 3331–42. https://doi.org/10.1172/JCI35875.Full Text Link to Item
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Omenetti, A., Y. Popov, Y. Jung, S. S. Choi, R. P. Witek, L. Yang, K. D. Brown, D. Schuppan, and A. M. Diehl. “The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.” Gut 57, no. 9 (September 2008): 1275–82. https://doi.org/10.1136/gut.2008.148619.Full Text Link to Item
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Yang, Liu, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, Steve Choi, Hendrika M. Vandongen, Jiawen Huang, Gianfranco D. Alpini, and Anna Mae Diehl. “Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers.” Stem Cells 26, no. 8 (August 2008): 2104–13. https://doi.org/10.1634/stemcells.2008-0115.Full Text Link to Item
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Ouyang, Xiaosen, Pietro Cirillo, Yuri Sautin, Shannon McCall, James L. Bruchette, Anna Mae Diehl, Richard J. Johnson, and Manal F. Abdelmalek. “Fructose consumption as a risk factor for non-alcoholic fatty liver disease.” J Hepatol 48, no. 6 (June 2008): 993–99. https://doi.org/10.1016/j.jhep.2008.02.011.Full Text Link to Item
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Choi, Steve S., and Anna Mae Diehl. “Hepatic triglyceride synthesis and nonalcoholic fatty liver disease.” Curr Opin Lipidol 19, no. 3 (June 2008): 295–300. https://doi.org/10.1097/MOL.0b013e3282ff5e55.Full Text Link to Item
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Jung, Youngmi, Kevin D. Brown, Rafal P. Witek, Alessia Omenetti, Liu Yang, Margon Vandongen, Richard J. Milton, et al. “Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans.” Gastroenterology 134, no. 5 (May 2008): 1532–43. https://doi.org/10.1053/j.gastro.2008.02.022.Full Text Link to Item
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Solga, Steven F., Alena Horska, Susanne Hemker, Stephen Crawford, Charalett Diggs, Anna Mae Diehl, Frederick L. Brancati, and Jeanne M. Clark. “Hepatic fat and adenosine triphosphate measurement in overweight and obese adults using 1H and 31P magnetic resonance spectroscopy.” Liver Int 28, no. 5 (May 2008): 675–81. https://doi.org/10.1111/j.1478-3231.2008.01705.x.Full Text Link to Item
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Malek, N. P., K. L. Rudolph, and A. M. Diehl. “Regulation of the Liver Cell Mass,” April 15, 2008, 274–89. https://doi.org/10.1002/9780470691861.ch2e.Full Text
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Omenetti, Alessia, and Anna Mae Diehl. “The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer.” Am J Physiol Gastrointest Liver Physiol 294, no. 3 (March 2008): G595–98. https://doi.org/10.1152/ajpgi.00543.2007.Full Text Link to Item
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Yamaguchi, Kanji, Liu Yang, Shannon McCall, Jiawen Huang, Xing Xian Yu, Sanjay K. Pandey, Sanjay Bhanot, Brett P. Monia, Yin-Xiong Li, and Anna Mae Diehl. “Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis.” Hepatology 47, no. 2 (February 2008): 625–35. https://doi.org/10.1002/hep.21988.Full Text Link to Item
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Jhaveri, Ravi, John McHutchison, Keyur Patel, Guan Qiang, and Anna Mae Diehl. “Specific polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation.” J Infect Dis 197, no. 2 (January 15, 2008): 283–91. https://doi.org/10.1086/524846.Full Text Link to Item
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Bonekamp, S., P. Ghosh, S. Crawford, S. F. Solga, A. Horska, F. L. Brancati, A. M. Diehl, S. Smith, and J. M. Clark. “Quantitative comparison and evaluation of software packages for assessment of abdominal adipose tissue distribution by magnetic resonance imaging.” Int J Obes (Lond) 32, no. 1 (January 2008): 100–111. https://doi.org/10.1038/sj.ijo.0803696.Full Text Link to Item
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Solga, Steven F., Gillian Buckley, Jeanne M. Clark, Alena Horska, and Anna Mae Diehl. “The effect of a probiotic on hepatic steatosis.” J Clin Gastroenterol 42, no. 10 (2008): 1117–19. https://doi.org/10.1097/MCG.0b013e31816d920c.Full Text Link to Item
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Yang, Liu, Ying Wang, Hua Mao, Susanne Fleig, Alessia Omenetti, Kevin D. Brown, Jason K. Sicklick, Yin-Xiong Li, and Anna Mae Diehl. “Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells.” J Hepatol 48, no. 1 (January 2008): 98–106. https://doi.org/10.1016/j.jhep.2007.07.032.Full Text Link to Item
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Fleig, Susanne V., Steve S. Choi, Liu Yang, Youngmi Jung, Alessia Omenetti, Hendrika M. VanDongen, Jiawen Huang, Jason K. Sicklick, and Anna Mae Diehl. “Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice.” Lab Invest 87, no. 12 (December 2007): 1227–39. https://doi.org/10.1038/labinvest.3700689.Full Text Link to Item
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Palmeri, M. L., M. H. Wang, K. D. Frinkley, K. R. Nightingale, M. F. Abdelmalek, and A. M. Diehl. “Dependence of in vivo, radiation force derived hepatic shear modulus estimates on imaging approach: Intercostal vs. subcostal.” Proceedings Ieee Ultrasonics Symposium, December 1, 2007, 566–69. https://doi.org/10.1109/ULTSYM.2007.147.Full Text
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Wang, M. H., L. W. Hedlund, M. L. Palmeri, C. D. Guy, L. Yang, A. M. Diehl, and K. R. Nightingale. “In-vivo staging of liver fibrosis in a rat model using acoustic radiation force.” Proceedings Ieee Ultrasonics Symposium, December 1, 2007, 562–65. https://doi.org/10.1109/ULTSYM.2007.146.Full Text
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Yang, L., and A. M. Diehl. “Role of immune response in nonalcoholic fatty liver disease: Evidence in human and animal studies,” December 1, 2007, 337–45. https://doi.org/10.1007/978-1-59745-518-3_27.Full Text
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Abdelmalek, Manal F., and Anna Mae Diehl. “Nonalcoholic fatty liver disease as a complication of insulin resistance.” Med Clin North Am 91, no. 6 (November 2007): 1125–ix. https://doi.org/10.1016/j.mcna.2007.06.001.Full Text Link to Item
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Yang, Liu, Ravi Jhaveri, Jiawen Huang, Yi Qi, and Anna Mae Diehl. “Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers.” Lab Invest 87, no. 9 (September 2007): 927–37. https://doi.org/10.1038/labinvest.3700603.Full Text Link to Item
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Abdelmalek, Manal F., and Anna Mae Diehl. “De novo nonalcoholic fatty liver disease after liver transplantation.” Liver Transpl 13, no. 6 (June 2007): 788–90. https://doi.org/10.1002/lt.21103.Full Text Link to Item
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Yamaguchi, Kanji, Liu Yang, Shannon McCall, Jiawen Huang, Xing Xian Yu, Sanjay K. Pandey, Sanjay Bhanot, Brett P. Monia, Yin-Xiong Li, and Anna Mae Diehl. “Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.” Hepatology 45, no. 6 (June 2007): 1366–74. https://doi.org/10.1002/hep.21655.Full Text Link to Item
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Omenetti, Alessia, Liu Yang, Yin-Xiong Li, Shannon J. McCall, Youngmi Jung, Jason K. Sicklick, Jiawen Huang, Steve Choi, Ayako Suzuki, and Anna Mae Diehl. “Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation.” Lab Invest 87, no. 5 (May 2007): 499–514. https://doi.org/10.1038/labinvest.3700537.Full Text Link to Item
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Jung, Youngmi, Shannon J. McCall, Yin-Xiong Li, and Anna Mae Diehl. “Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis.” Hepatology 45, no. 5 (May 2007): 1091–96. https://doi.org/10.1002/hep.21660.Full Text Link to Item
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Li, Yin-Xiong, Hai-Tao Yang, Marzena Zdanowicz, Jason K. Sicklick, Yi Qi, Terese J. Camp, and Anna Mae Diehl. “Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling.” Lab Invest 87, no. 3 (March 2007): 231–40. https://doi.org/10.1038/labinvest.3700516.Full Text Link to Item
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Abdelmalek, M. F., and A. M. Diehl. “Mechanisms underlying nonalcoholic steatohepatitis.” Drug Discovery Today: Disease Mechanisms 3, no. 4 (December 1, 2006): 479–88. https://doi.org/10.1016/j.ddmec.2006.11.001.Full Text
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Zhao, Caiyan, Wei Chen, Liu Yang, Lihong Chen, Stephen A. Stimpson, and Anna Mae Diehl. “PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.” Biochem Biophys Res Commun 350, no. 2 (November 17, 2006): 385–91. https://doi.org/10.1016/j.bbrc.2006.09.069.Full Text Link to Item
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Choi, Steve S., Jason K. Sicklick, Qi Ma, Liu Yang, Jiawen Huang, Yi Qi, Wei Chen, Yin-Xiong Li, Pascal J. Goldschmidt-Clermont, and Anna Mae Diehl. “Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice.” Hepatology 44, no. 5 (November 2006): 1267–77. https://doi.org/10.1002/hep.21375.Full Text Link to Item
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Sicklick, Jason K., Steve S. Choi, Marcia Bustamante, Shannon J. McCall, Elizabeth Hernández Pérez, Jiawen Huang, Yin-Xiong Li, Marcos Rojkind, and Anna Mae Diehl. “Evidence for epithelial-mesenchymal transitions in adult liver cells.” Am J Physiol Gastrointest Liver Physiol 291, no. 4 (October 2006): G575–83. https://doi.org/10.1152/ajpgi.00102.2006.Full Text Link to Item
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Suzuki, Ayako, Shannon McCall, Steve S. Choi, Jason K. Sicklick, Jiawen Huang, Yi Qi, Marzena Zdanowicz, Terese Camp, Yin-Xiong Li, and Anna Mae Diehl. “Interleukin-15 increases hepatic regenerative activity.” J Hepatol 45, no. 3 (September 2006): 410–18. https://doi.org/10.1016/j.jhep.2006.04.008.Full Text Link to Item
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Sicklick, Jason K., Yin-Xiong Li, Alaa Melhem, Eva Schmelzer, Marzena Zdanowicz, Jiawen Huang, Montserrat Caballero, et al. “Hedgehog signaling maintains resident hepatic progenitors throughout life.” Am J Physiol Gastrointest Liver Physiol 290, no. 5 (May 2006): G859–70. https://doi.org/10.1152/ajpgi.00456.2005.Full Text Link to Item
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Setji, Tracy L., Nicole D. Holland, Linda L. Sanders, Kathy C. Pereira, Anna Mae Diehl, and Ann J. Brown. “Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome.” J Clin Endocrinol Metab 91, no. 5 (May 2006): 1741–47. https://doi.org/10.1210/jc.2005-2774.Full Text Link to Item
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Sicklick, Jason K., Yin-Xiong Li, Aruna Jayaraman, Rajesh Kannangai, Yi Qi, Perumal Vivekanandan, John W. Ludlow, et al. “Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis.” Carcinogenesis 27, no. 4 (April 2006): 748–57. https://doi.org/10.1093/carcin/bgi292.Full Text Link to Item
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Tuttle-Newhall, Janet E., and Anna Mae Diehl. “What impact does a specialized center for transplantation and heptobiliary disease have on post-graduate resident training of gastroenterologists and surgeons?” J Hepatol 44, no. 4 (April 2006): 659–62. https://doi.org/10.1016/j.jhep.2006.01.021.Full Text Link to Item
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Cope, K. A., S. F. Solga, L. K. Hummers, F. M. Wigley, A. M. Diehl, and T. H. Risby. “Abnormal exhaled ethane concentrations in scleroderma.” Biomarkers 11, no. 1 (2006): 70–84. https://doi.org/10.1080/13547500500515046.Full Text Link to Item
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Solga, S. F., A. Alkhuraishe, K. Cope, A. Tabesh, J. M. Clark, M. Torbenson, P. Schwartz, T. Magnuson, A. M. Diehl, and T. H. Risby. “Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations.” Biomarkers 11, no. 2 (2006): 174–83. https://doi.org/10.1080/13547500500421070.Full Text Link to Item
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Choi, Steve, and Anna Mae Diehl. “Role of inflammation in nonalcoholic steatohepatitis.” Curr Opin Gastroenterol 21, no. 6 (November 2005): 702–7. https://doi.org/10.1097/01.mog.0000182863.96421.47.Full Text Link to Item
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Sicklick, Jason K., Yin-Xiong Li, Steve S. Choi, Yi Qi, Wei Chen, Marcia Bustamante, Jiawen Huang, et al. “Role for hedgehog signaling in hepatic stellate cell activation and viability.” Lab Invest 85, no. 11 (November 2005): 1368–80. https://doi.org/10.1038/labinvest.3700349.Full Text Link to Item
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Diehl, Anna Mae. “Lessons from animal models of NASH.” Hepatol Res 33, no. 2 (October 2005): 138–44. https://doi.org/10.1016/j.hepres.2005.09.022.Full Text Link to Item
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Li, Zhiping, Mark J. Soloski, and Anna Mae Diehl. “Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease.” Hepatology 42, no. 4 (October 2005): 880–85. https://doi.org/10.1002/hep.20826.Full Text Link to Item
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Clark, Jeanne M., Amir R. A. Alkhuraishi, Steven F. Solga, Patricia Alli, Anna Mae Diehl, and Thomas H. Magnuson. “Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease.” Obes Res 13, no. 7 (July 2005): 1180–86. https://doi.org/10.1038/oby.2005.140.Full Text Link to Item
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Zekry, A., J. G. McHutchison, and A. M. Diehl. “Insulin resistance and steatosis in hepatitis C virus infection.” Gut 54, no. 7 (July 2005): 903–6. https://doi.org/10.1136/gut.2004.059873.Full Text Link to Item
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Solga, Steven F., Alena Horska, Jeanne M. Clark, and Anna Mae Diehl. “Hepatic 31P magnetic resonance spectroscopy: a hepatologist's user guide.” Liver Int 25, no. 3 (June 2005): 490–500. https://doi.org/10.1111/j.1478-3231.2005.01131.x.Full Text Link to Item
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Suzuki, Ayako, and Anna Mae Diehl. “Should nonalcoholic fatty liver disease be treated differently in elderly patients?” Nat Clin Pract Gastroenterol Hepatol 2, no. 5 (May 2005): 208–9. https://doi.org/10.1038/ncpgasthep0172.Full Text Link to Item
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Kannangai, Rajesh, Anna Mae Diehl, Jason Sicklick, Marcus Rojkind, David Thomas, and Michael Torbenson. “Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile.” Hum Pathol 36, no. 4 (April 2005): 341–47. https://doi.org/10.1016/j.humpath.2005.01.002.Full Text Link to Item
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Diehl, Anna Mae. “Hepatic complications of obesity.” Gastroenterol Clin North Am 34, no. 1 (March 2005): 45–61. https://doi.org/10.1016/j.gtc.2004.12.012.Full Text Link to Item
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Diehl, A. M., Z. P. Li, H. Z. Lin, and S. Q. Yang. “Cytokines and the pathogenesis of non-alcoholic steatohepatitis.” Gut 54, no. 2 (February 2005): 303–6. https://doi.org/10.1136/gut.2003.024935.Full Text Link to Item
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Diehl, Anna Mae. “Recent events in alcoholic liver disease V. effects of ethanol on liver regeneration.” Am J Physiol Gastrointest Liver Physiol 288, no. 1 (January 2005): G1–6. https://doi.org/10.1152/ajpgi.00376.2004.Full Text Link to Item
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Goldschmidt-Clermont, Pascal J., and Anna Mae Diehl. “Arterial homeostasis, inflammation, and erythropoietic growth factors.” Rev Cardiovasc Med 6 Suppl 3 (2005): S22–26.Link to Item
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Solga, Steven F., Jeanne M. Clark, Amir R. Alkhuraishi, Michael Torbenson, Alireza Tabesh, Michael Schweitzer, Anna Mae Diehl, and Thomas H. Magnuson. “Race and comorbid factors predict nonalcoholic fatty liver disease histopathology in severely obese patients.” Surg Obes Relat Dis 1, no. 1 (2005): 6–11. https://doi.org/10.1016/j.soard.2004.12.006.Full Text Link to Item
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Gao, Daqing, Chiming Wei, Lei Chen, Jiawen Huang, Shiqi Yang, and Anna Mae Diehl. “Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease.” Am J Physiol Gastrointest Liver Physiol 287, no. 5 (November 2004): G1070–77. https://doi.org/10.1152/ajpgi.00228.2004.Full Text Link to Item
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Solga, Steven, Amir R. Alkhuraishe, Jeanne M. Clark, Mike Torbenson, Ashli Greenwald, Anna Mae Diehl, and Thomas Magnuson. “Dietary composition and nonalcoholic fatty liver disease.” Dig Dis Sci 49, no. 10 (October 2004): 1578–83. https://doi.org/10.1023/b:ddas.0000043367.69470.b7.Full Text Link to Item
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Oben, Jude A., and Anna Mae Diehl. “Sympathetic nervous system regulation of liver repair.” Anat Rec a Discov Mol Cell Evol Biol 280, no. 1 (September 2004): 874–83. https://doi.org/10.1002/ar.a.20081.Full Text Link to Item
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Diehl, Anna Mae. “Obesity and alcoholic liver disease.” Alcohol 34, no. 1 (August 2004): 81–87. https://doi.org/10.1016/j.alcohol.2004.07.010.Full Text Link to Item
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Diehl, Anna Mae. “Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease.” Clin Liver Dis 8, no. 3 (August 2004): 619–x. https://doi.org/10.1016/j.cld.2004.04.012.Full Text Link to Item
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Persad, R., C. Liu, T. T. Wu, P. S. Houlihan, S. R Hamilton, A. M. Diehl, and A. Rashid. “Erratum: Overexpression of caspase-3 in hepatocellular carcinomas (Modern Pathology (2004) 17 (861-867) doi:10.1038/modpathol.3800146.” Modern Pathology 17, no. 8 (August 1, 2004): 1026. https://doi.org/10.1038/modpathol.3800215.Full Text
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Li, Zhiping, Jude A. Oben, Shiqi Yang, Huizhi Lin, Elizabeth A. Stafford, Mark J. Soloski, Steven A. Thomas, and Anna Mae Diehl. “Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis.” Hepatology 40, no. 2 (August 2004): 434–41. https://doi.org/10.1002/hep.20320.Full Text Link to Item
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Diehl, A. M. “Fatty liver, hypertension, and the metabolic syndrome.” Gut 53, no. 7 (July 2004): 923–24. https://doi.org/10.1136/gut.2003.037309.Full Text Link to Item
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Nair, S., A. M. Diehl, M. Wiseman, G. H. Farr, and R. P. Perrillo. “Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial.” Aliment Pharmacol Ther 20, no. 1 (July 1, 2004): 23–28. https://doi.org/10.1111/j.1365-2036.2004.02025.x.Full Text Link to Item
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Persad, Rajendra, Chen Liu, Tsung-Teh Wu, Patrick S. Houlihan, Stanley R. Hamilton, Anna M. Diehl, and Asif Rashid. “Overexpression of caspase-3 in hepatocellular carcinomas.” Mod Pathol 17, no. 7 (July 2004): 861–67. https://doi.org/10.1038/modpathol.3800146.Full Text Link to Item
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Jang, Yoon-Young, Michael I. Collector, Stephen B. Baylin, Anna Mae Diehl, and Saul J. Sharkis. “Hematopoietic stem cells convert into liver cells within days without fusion.” Nat Cell Biol 6, no. 6 (June 2004): 532–39. https://doi.org/10.1038/ncb1132.Full Text Link to Item
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Solga, Steven F., and Anna Mae Diehl. “Gut flora-based therapy in liver disease? The liver cares about the gut.” Hepatology 39, no. 5 (May 2004): 1197–1200. https://doi.org/10.1002/hep.20220.Full Text Link to Item
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Koteish, A., and A. M. Diehl. “Alcoholic liver disease,” April 23, 2004, 85–94. https://doi.org/10.1016/B978-0-443-06633-7.50011-9.Full Text
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Oben, J. A., T. Roskams, S. Yang, H. Lin, N. Sinelli, M. Torbenson, U. Smedh, et al. “Hepatic fibrogenesis requires sympathetic neurotransmitters.” Gut 53, no. 3 (March 2004): 438–45. https://doi.org/10.1136/gut.2003.026658.Full Text Link to Item
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Yang, Shiqi, Ayman Koteish, Huizhi Lin, Jiawen Huang, Tania Roskams, Valina Dawson, and Anna Mae Diehl. “Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.” Hepatology 39, no. 2 (February 2004): 403–11. https://doi.org/10.1002/hep.20082.Full Text Link to Item
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Li, Zhiping, and Anna Mae Diehl. “Innate immunity in the liver.” Curr Opin Gastroenterol 19, no. 6 (November 2003): 565–71. https://doi.org/10.1097/00001574-200311000-00009.Full Text Link to Item
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Roskams, Tania, Shi Qi Yang, Aymen Koteish, Anne Durnez, Rita DeVos, Xiawen Huang, Ruth Achten, Chris Verslype, and Anna Mae Diehl. “Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease.” Am J Pathol 163, no. 4 (October 2003): 1301–11. https://doi.org/10.1016/S0002-9440(10)63489-X.Full Text Link to Item
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Mascitelli, Luca, and Francesca Pezzetta. “Diagnosis of nonalcoholic fatty liver disease.” Jama 290, no. 12 (September 24, 2003): 1577. https://doi.org/10.1001/jama.290.12.1577-c.Full Text Link to Item
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Oben, Jude A., Tania Roskams, Shiqi Yang, Huizhi Lin, Nicoletta Sinelli, Zhiping Li, Michael Torbenson, et al. “Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury.” Hepatology 38, no. 3 (September 2003): 664–73. https://doi.org/10.1053/jhep.2003.50371.Full Text Link to Item
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Oben, Jude A., Tania Roskams, Shiqi Yang, Huizhi Lin, Nicoletta Sinelli, Zhiping Li, Michael Torbenson, Steven A. Thomas, and Anna Mae Diehl. “Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice.” Biochem Biophys Res Commun 308, no. 2 (August 22, 2003): 284–92. https://doi.org/10.1016/s0006-291x(03)01360-3.Full Text Link to Item
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Perrella, Alessandro, Giovanni Tarantino, Guglielmo Borgia, Paolo Conca, Paolo Sorrentino, Paola Ragucci, Raffaella Vecchione, and Oreste Perrella. “Cytokine network during NASH and possible treatment selection.” Hepatology 38, no. 2 (August 2003): 530. https://doi.org/10.1053/jhep.2003.50272.Full Text Link to Item
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Sun, Zhaoli, Andrew S. Klein, Svetlana Radaeva, Feng Hong, Osama El-Assal, Hong-Na Pan, Barbara Jaruga, et al. “In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats.” Gastroenterology 125, no. 1 (July 2003): 202–15. https://doi.org/10.1016/s0016-5085(03)00696-6.Full Text Link to Item
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Clark, Jeanne M., and Anna Mae Diehl. “Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis.” Jama 289, no. 22 (June 11, 2003): 3000–3004. https://doi.org/10.1001/jama.289.22.3000.Full Text Link to Item
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Hughes, Douglas E., Donna Beer Stolz, Songtao Yu, Yongjun Tan, Janardan K. Reddy, Simon C. Watkins, Anna Mae Diehl, and Robert H. Costa. “Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage.” Hepatology 37, no. 6 (June 2003): 1414–24. https://doi.org/10.1053/jhep.2003.50253.Full Text Link to Item
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Ogedegbe, Anthony Emmanuel O., David L. Thomas, and Anna Mae Diehl. “Hyperlactataemia syndromes associated with HIV therapy.” Lancet Infect Dis 3, no. 6 (June 2003): 329–37. https://doi.org/10.1016/s1473-3099(03)00654-6.Full Text Link to Item
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Solga, Steven F., and A. M. Diehl. “Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics.” J Hepatol 38, no. 5 (May 2003): 681–87. https://doi.org/10.1016/s0168-8278(03)00097-7.Full Text Link to Item
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Sun, Zhaoli, Tatehiko Wada, Kosei Maemura, Keiichiro Uchikura, Sumito Hoshino, Anna Mae Diehl, and Andrew S. Klein. “Hepatic allograft-derived Kupffer cells regulate T cell response in rats.” Liver Transpl 9, no. 5 (May 2003): 489–97. https://doi.org/10.1053/jlts.2003.50091.Full Text Link to Item
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Clark, Jeanne M., Frederick L. Brancati, and Anna Mae Diehl. “The prevalence and etiology of elevated aminotransferase levels in the United States.” Am J Gastroenterol 98, no. 5 (May 2003): 960–67. https://doi.org/10.1111/j.1572-0241.2003.07486.x.Full Text Link to Item
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Oben, Jude A., Shiqi Yang, Huizhi Lin, Mafasumi Ono, and Anna Mae Diehl. “Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells.” Biochem Biophys Res Commun 302, no. 4 (March 21, 2003): 685–90. https://doi.org/10.1016/s0006-291x(03)00232-8.Full Text Link to Item
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Li, Zhiping, Shiqi Yang, Huizhi Lin, Jiawen Huang, Paul A. Watkins, Ann B. Moser, Claudio Desimone, Xiao-yu Song, and Anna Mae Diehl. “Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease.” Hepatology 37, no. 2 (February 2003): 343–50. https://doi.org/10.1053/jhep.2003.50048.Full Text Link to Item
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Nair, Satheesh, Vadappuram P Chacko, Cheryl Arnold, and Anna Mae Diehl. “Hepatic ATP reserve and efficiency of replenishing: comparison between obese and nonobese normal individuals.” Am J Gastroenterol 98, no. 2 (February 2003): 466–70. https://doi.org/10.1111/j.1572-0241.2003.07221.x.Full Text Link to Item
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Oben, Jude A., Shiqi Yang, Huizhi Lin, Mafasumi Ono, and Anna Mae Diehl. “Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells.” Biochem Biophys Res Commun 300, no. 1 (January 3, 2003): 172–77. https://doi.org/10.1016/s0006-291x(02)02773-0.Full Text Link to Item
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Clark, Jeanne M., and Anna Mae Diehl. “Defining nonalcoholic fatty liver disease: implications for epidemiologic studies.” Gastroenterology 124, no. 1 (January 2003): 248–50. https://doi.org/10.1053/gast.2003.50032.Full Text Link to Item
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Diehl, Anna Mae, Jeanne Clarke, and Frederick Brancati. “Insulin resistance syndrome and nonalcoholic fatty liver disease.” Endocr Pract 9 Suppl 2 (2003): 93–96. https://doi.org/10.4158/EP.9.S2.93.Full Text Link to Item
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Koteish, Ayman, Shiqi Yang, Huizhi Lin, Jiawen Huang, and Anna Mae Diehl. “Ethanol induces redox-sensitive cell-cycle inhibitors and inhibits liver regeneration after partial hepatectomy.” Alcohol Clin Exp Res 26, no. 11 (November 2002): 1710–18. https://doi.org/10.1097/01.ALC.0000036923.77613.59.Full Text Link to Item
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Li, Zhiping, Jeanne Clark, and Anna Mae Diehl. “The liver in obesity and type 2 diabetes mellitus.” Clin Liver Dis 6, no. 4 (November 2002): 867–77. https://doi.org/10.1016/s1089-3261(02)00060-0.Full Text Link to Item
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Koteish, Ayman, and Anna Mae Diehl. “Animal models of steatohepatitis.” Best Pract Res Clin Gastroenterol 16, no. 5 (October 2002): 679–90. https://doi.org/10.1053/bega.2002.0332.Full Text Link to Item
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Li, Zhiping, Huizhi Lin, Shiqi Yang, and Anna Mae Diehl. “Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system.” Gastroenterology 123, no. 4 (October 2002): 1304–10. https://doi.org/10.1053/gast.2002.35997.Full Text Link to Item
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Diehl, Anna Mae. “Liver regeneration.” Front Biosci 7 (July 1, 2002): e301–14. https://doi.org/10.2741/A925.Full Text Link to Item
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Torbenson, Michael, Shi Qi Yang, Hui Zhi Liu, Jiawen Huang, Wesley Gage, and Anna Mae Diehl. “STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers.” Am J Pathol 161, no. 1 (July 2002): 155–61. https://doi.org/10.1016/S0002-9440(10)64167-3.Full Text Link to Item
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Clark, Jeanne M., and Anna Mae Diehl. “Hepatic steatosis and type 2 diabetes mellitus.” Curr Diab Rep 2, no. 3 (June 2002): 210–15. https://doi.org/10.1007/s11892-002-0085-3.Full Text Link to Item
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Clark, Jeanne M., Frederick L. Brancati, and Anna Mae Diehl. “Nonalcoholic fatty liver disease.” Gastroenterology 122, no. 6 (May 2002): 1649–57. https://doi.org/10.1053/gast.2002.33573.Full Text Link to Item
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Diehl, Anna Mae. “Liver disease in alcohol abusers: clinical perspective.” Alcohol 27, no. 1 (May 2002): 7–11. https://doi.org/10.1016/s0741-8329(02)00204-5.Full Text Link to Item
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Koteish, Ayman, ShiQi Yang, HuiZhi Lin, Xiawen Huang, and Anna Mae Diehl. “Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation.” J Biol Chem 277, no. 15 (April 12, 2002): 13037–44. https://doi.org/10.1074/jbc.M101632200.Full Text Link to Item
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Younossi, Zobair M., Anna Mae Diehl, and Janus P. Ong. “Nonalcoholic fatty liver disease: an agenda for clinical research.” Hepatology 35, no. 4 (April 2002): 746–52. https://doi.org/10.1053/jhep.2002.32483.Full Text Link to Item
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Farrell, Geoffrey C., Graham R. Robertson, Isabelle Leclercq, and Yves Horsmans. “Liver regeneration in obese mice with fatty livers: does the impairment have relevance for other types of fatty liver disease?” Hepatology 35, no. 3 (March 2002): 731–32. https://doi.org/10.1053/jhep.2002.31786.Full Text Link to Item
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Diehl, Anna Mae. “Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines.” Am J Physiol Gastrointest Liver Physiol 282, no. 1 (January 2002): G1–5. https://doi.org/10.1152/ajpgi.00384.2001.Full Text Link to Item
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Harrison, Stephen A., and Anna Mae Diehl. “Fat and the liver--a molecular overview.” Semin Gastrointest Dis 13, no. 1 (January 2002): 3–16.Link to Item
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Molina, Patricia E., Craig McClain, Dominique Valla, David Guidot, Anna Mae Diehl, Charles H. Lang, and Manuela Neuman. “Molecular pathology and clinical aspects of alcohol-induced tissue injury.” Alcohol Clin Exp Res 26, no. 1 (January 2002): 120–28.Link to Item
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Yang, S. Q., H. Z. Lin, A. K. Mandal, J. Huang, and A. M. Diehl. “Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology.” Hepatology 34, no. 4 Pt 1 (October 2001): 694–706. https://doi.org/10.1053/jhep.2001.28054.Full Text Link to Item
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Yang, S., H. Lin, and A. M. Diehl. “Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation.” Am J Physiol Gastrointest Liver Physiol 281, no. 2 (August 2001): G382–92. https://doi.org/10.1152/ajpgi.2001.281.2.G382.Full Text Link to Item
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Yang, S., H. Z. Lin, J. Hwang, V. P. Chacko, and A. M. Diehl. “Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition?” Cancer Res 61, no. 13 (July 1, 2001): 5016–23.Link to Item
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Diehl, A. M. “Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis.” Alcohol Clin Exp Res 25, no. 5 Suppl ISBRA (May 2001): 8S-14S. https://doi.org/10.1097/00000374-200105051-00004.Full Text Link to Item
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Diehl, A. M. “Sugar pills for pancreatic cancer: the benefits of becoming (insulin) sensitive.” Gastroenterology 120, no. 5 (April 2001): 1291–96. https://doi.org/10.1053/gast.2001.23627.Full Text Link to Item
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Nair, S., K. Cope, T. H. Risby, and A. M. Diehl. “Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis.” Am J Gastroenterol 96, no. 4 (April 2001): 1200–1204. https://doi.org/10.1111/j.1572-0241.2001.03702.x.Full Text Link to Item
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Koteish, A., and A. M. Diehl. “Animal models of steatosis.” Semin Liver Dis 21, no. 1 (2001): 89–104. https://doi.org/10.1055/s-2001-12932.Full Text Link to Item
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Tilg, H., and A. M. Diehl. “Cytokines in alcoholic and nonalcoholic steatohepatitis.” N Engl J Med 343, no. 20 (November 16, 2000): 1467–76. https://doi.org/10.1056/NEJM200011163432007.Full Text Link to Item
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Cope, K., T. Risby, and A. M. Diehl. “Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis.” Gastroenterology 119, no. 5 (November 2000): 1340–47. https://doi.org/10.1053/gast.2000.19267.Full Text Link to Item
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Lin, H. Z., S. Q. Yang, C. Chuckaree, F. Kuhajda, G. Ronnet, and A. M. Diehl. “Metformin reverses fatty liver disease in obese, leptin-deficient mice.” Nat Med 6, no. 9 (September 2000): 998–1003. https://doi.org/10.1038/79697.Full Text Link to Item
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Yang, S., H. Zhu, Y. Li, H. Lin, K. Gabrielson, M. A. Trush, and A. M. Diehl. “Mitochondrial adaptations to obesity-related oxidant stress.” Arch Biochem Biophys 378, no. 2 (June 15, 2000): 259–68. https://doi.org/10.1006/abbi.2000.1829.Full Text Link to Item
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Diehl, A. M. “Cytokine regulation of liver injury and repair.” Immunol Rev 174 (April 2000): 160–71. https://doi.org/10.1034/j.1600-0528.2002.017411.x.Full Text Link to Item
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Guebre-Xabier, M., S. Yang, H. Z. Lin, R. Schwenk, U. Krzych, and A. M. Diehl. “Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage.” Hepatology 31, no. 3 (March 2000): 633–40. https://doi.org/10.1002/hep.510310313.Full Text Link to Item
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Meijer, C., M. J. Wiezer, A. M. Diehl, H. J. Schouten, S. Meijer, N. van Rooijen, A. A. van Lambalgen, C. D. Dijkstra, and P. A. van Leeuwen. “Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy.” Liver 20, no. 1 (February 2000): 66–77. https://doi.org/10.1034/j.1600-0676.2000.020001066.x.Full Text Link to Item
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Lin, H. Z., S. Q. Yang, G. Zeldin, and A. M. Diehl. “Chronic ethanol consumption induces the production of tumor necrosis factor-α and related cytokines in liver and adipose tissue.” Alcoholism: Clinical and Experimental Research 23, no. 5 SUPPL. (December 1, 1999).
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Cortez-Pinto, H., J. Chatham, V. P. Chacko, C. Arnold, A. Rashid, and A. M. Diehl. “Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study.” Jama 282, no. 17 (November 3, 1999): 1659–64. https://doi.org/10.1001/jama.282.17.1659.Full Text Link to Item
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Diehl, A. M. “Effect of ethanol on tumor necrosis factor signaling during liver regeneration.” Clin Biochem 32, no. 7 (October 1999): 571–78. https://doi.org/10.1016/s0009-9120(99)00057-0.Full Text Link to Item
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Diehl, A. M., and J. B. Hoek. “Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control".” J Bioenerg Biomembr 31, no. 5 (October 1999): 493–506. https://doi.org/10.1023/a:1005452624640.Full Text Link to Item
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Diehl, A. M. “Cytokines and the molecular mechanisms of alcoholic liver disease.” Alcohol Clin Exp Res 23, no. 9 (September 1999): 1419–24.Link to Item
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Cortez-Pinto, H., H. Zhi Lin, S. Qi Yang, S. Odwin Da Costa, and A. M. Diehl. “Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes.” Gastroenterology 116, no. 5 (May 1999): 1184–93. https://doi.org/10.1016/s0016-5085(99)70022-3.Full Text Link to Item
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Rashid, A., T. C. Wu, C. C. Huang, C. H. Chen, H. Z. Lin, S. Q. Yang, F. Y. Lee, and A. M. Diehl. “Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver.” Hepatology 29, no. 4 (April 1999): 1131–38. https://doi.org/10.1002/hep.510290428.Full Text Link to Item
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Lee, F. Y., Y. Li, H. Zhu, S. Yang, H. Z. Lin, M. Trush, and A. M. Diehl. “Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver.” Hepatology 29, no. 3 (March 1999): 677–87. https://doi.org/10.1002/hep.510290320.Full Text Link to Item
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Chavin, K. D., S. Yang, H. Z. Lin, J. Chatham, V. P. Chacko, J. B. Hoek, E. Walajtys-Rode, et al. “Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion.” J Biol Chem 274, no. 9 (February 26, 1999): 5692–5700. https://doi.org/10.1074/jbc.274.9.5692.Full Text Link to Item
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Lee, F. Y., Y. Li, E. K. Yang, S. Q. Yang, H. Z. Lin, M. A. Trush, A. J. Dannenberg, and A. M. Diehl. “Phenotypic abnormalities in macrophages from leptin-deficient, obese mice.” Am J Physiol 276, no. 2 (February 1999): C386–94. https://doi.org/10.1152/ajpcell.1999.276.2.C386.Full Text Link to Item
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Diehl, A. M. “Nonalcoholic steatohepatitis.” Semin Liver Dis 19, no. 2 (1999): 221–29. https://doi.org/10.1055/s-2007-1007111.Full Text Link to Item
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Diehl, A. M. “Roles of CCAAT/enhancer-binding proteins in regulation of liver regenerative growth.” J Biol Chem 273, no. 47 (November 20, 1998): 30843–46. https://doi.org/10.1074/jbc.273.47.30843.Full Text Link to Item
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Rai, R. M., F. Y. Lee, A. Rosen, S. Q. Yang, H. Z. Lin, A. Koteish, F. Y. Liew, C. Zaragoza, C. Lowenstein, and A. M. Diehl. “Impaired liver regeneration in inducible nitric oxide synthasedeficient mice.” Proc Natl Acad Sci U S A 95, no. 23 (November 10, 1998): 13829–34. https://doi.org/10.1073/pnas.95.23.13829.Full Text Link to Item
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Cortez-Pinto, H., S. Q. Yang, H. Z. Lin, S. Costa, C. S. Hwang, M. D. Lane, G. Bagby, and A. M. Diehl. “Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism.” Biochem Biophys Res Commun 251, no. 1 (October 9, 1998): 313–19. https://doi.org/10.1006/bbrc.1998.9473.Full Text Link to Item
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Yang, S. Q., H. Z. Lin, M. Yin, J. H. Albrecht, and A. M. Diehl. “Effects of chronic ethanol consumption on cytokine regulation of liver regeneration.” Am J Physiol 275, no. 4 (October 1998): G696–704. https://doi.org/10.1152/ajpgi.1998.275.4.G696.Full Text Link to Item
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Lin, H. Z., S. Q. Yang, G. Zeldin, and A. M. Diehl. “Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue.” Alcohol Clin Exp Res 22, no. 5 Suppl (August 1998): 231S-237S. https://doi.org/10.1097/00000374-199805001-00004.Full Text Link to Item
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Lawler, J. F., M. Yin, A. M. Diehl, E. Roberts, and S. Chatterjee. “Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase.” J Biol Chem 273, no. 9 (February 27, 1998): 5053–59. https://doi.org/10.1074/jbc.273.9.5053.Full Text Link to Item
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Diehl, A. M. “Alcoholic liver disease.” Clin Liver Dis 2, no. 1 (February 1998): 103–18. https://doi.org/10.1016/s1089-3261(05)70366-4.Full Text Link to Item
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Karl, P. I., A. Divald, A. M. Diehl, and S. E. Fisher. “Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol.” Biochem Pharmacol 55, no. 1 (January 1, 1998): 45–51. https://doi.org/10.1016/s0006-2952(97)00404-8.Full Text Link to Item
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Loffreda, S., S. Q. Yang, H. Z. Lin, C. L. Karp, M. L. Brengman, D. J. Wang, A. S. Klein, et al. “Leptin regulates proinflammatory immune responses.” Faseb J 12, no. 1 (January 1998): 57–65.Link to Item
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Loffreda, S., R. Rai, S. Q. Yang, H. Z. Lin, and A. M. Diehl. “Bile ducts and portal and central veins are major producers of tumor necrosis factor alpha in regenerating rat liver.” Gastroenterology 112, no. 6 (June 1997): 2089–98. https://doi.org/10.1053/gast.1997.v112.pm9178702.Full Text Link to Item
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Diehl, A. M. “Alcoholic liver disease: natural history.” Liver Transpl Surg 3, no. 3 (May 1997): 206–11.Link to Item
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Rai, R. M., S. Loffreda, C. L. Karp, S. Q. Yang, H. Z. Lin, and A. M. Diehl. “Kupffer cell depletion abolishes induction of interleukin-10 and permits sustained overexpression of tumor necrosis factor alpha messenger RNA in the regenerating rat liver.” Hepatology 25, no. 4 (April 1997): 889–95. https://doi.org/10.1002/hep.510250417.Full Text Link to Item
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Yang, S. Q., H. Z. Lin, M. D. Lane, M. Clemens, and A. M. Diehl. “Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis.” Proc Natl Acad Sci U S A 94, no. 6 (March 18, 1997): 2557–62. https://doi.org/10.1073/pnas.94.6.2557.Full Text Link to Item
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Diehl, A. M. “The role of cytokines in hepatic regeneration.” Current Opinion in Gastroenterology 13, no. 6 (January 1, 1997): 525–33. https://doi.org/10.1097/00001574-199711000-00014.Full Text
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Zeldin, G., S. Q. Yang, M. Yin, H. Z. Lin, R. Rai, and A. M. Diehl. “Alcohol and cytokine-inducible transcription factors.” Alcohol Clin Exp Res 20, no. 9 (December 1996): 1639–45. https://doi.org/10.1111/j.1530-0277.1996.tb01710.x.Full Text Link to Item
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Zibari, G. B., D. Edwin, L. Wall, A. Diehl, J. Fair, J. Burdick, and A. Klein. “Liver transplantation for alcoholic liver disease.” Clin Transplant 10, no. 6 Pt 2 (December 1996): 676–79.Link to Item
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Westwick, J. K., J. Fleckenstein, M. Yin, S. Q. Yang, C. A. Bradham, D. A. Brenner, and A. M. Diehl. “Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo.” Am J Physiol 271, no. 5 Pt 1 (November 1996): G780–90. https://doi.org/10.1152/ajpgi.1996.271.5.G780.Full Text Link to Item
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Rai, R. M., J. X. Zhang, M. G. Clemens, and A. M. Diehl. “Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and anti-inflammatory cytokines.” Shock 6, no. 4 (October 1996): 243–47. https://doi.org/10.1097/00024382-199610000-00003.Full Text Link to Item
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Yin, M., S. Q. Yang, H. Z. Lin, M. D. Lane, S. Chatterjee, and A. M. Diehl. “Tumor necrosis factor alpha promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes.” J Biol Chem 271, no. 30 (July 26, 1996): 17974–78. https://doi.org/10.1074/jbc.271.30.17974.Full Text Link to Item
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Yang, X., A. M. Diehl, and G. S. Wand. “Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellum.” J Pharmacol Exp Ther 278, no. 1 (July 1996): 338–46.Link to Item
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Rai, R. M., S. Q. Yang, C. McClain, C. L. Karp, A. S. Klein, and A. M. Diehl. “Kupffer cell depletion by gadolinium chloride enhances liver regeneration after partial hepatectomy in rats.” Am J Physiol 270, no. 6 Pt 1 (June 1996): G909–18. https://doi.org/10.1152/ajpgi.1996.270.6.G909.Full Text Link to Item
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Diehl, A. M., D. C. Johns, S. Yang, H. Lin, M. Yin, L. A. Matelis, and J. H. Lawrence. “Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes.” J Biol Chem 271, no. 13 (March 29, 1996): 7343–50. https://doi.org/10.1074/jbc.271.13.7343.Full Text Link to Item
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Diehl, A. M., and R. M. Rai. “Liver regeneration 3: Regulation of signal transduction during liver regeneration.” Faseb J 10, no. 2 (February 1996): 215–27. https://doi.org/10.1096/fasebj.10.2.8641555.Full Text Link to Item
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Diehl, A. M., and R. Rai. “REVIEW: Regulation of liver regeneration by pro-inflammatory cytokines.” Journal of Gastroenterology and Hepatology (Australia) 11, no. 5 (January 1, 1996): 466–70. https://doi.org/10.1111/j.1440-1746.1996.tb00292.x.Full Text
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Diehl, A. M. “Keratinocyte growth factor--just another mitogen or the "Holy Grail" that regulates liver regeneration?” Hepatology 22, no. 6 (December 1995): 1886–88. https://doi.org/10.1016/0270-9139(95)90220-1.Full Text Link to Item
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Liu, S. L., S. Degli Esposti, T. Yao, A. M. Diehl, and M. A. Zern. “Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding.” Hepatology 22, no. 5 (November 1995): 1474–81.Link to Item
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Diehl, A. M., S. Q. Yang, M. Yin, H. Z. Lin, S. Nelson, and G. Bagby. “Tumor necrosis factor-alpha modulates CCAAT/enhancer binding proteins-DNA binding activities and promotes hepatocyte-specific gene expression during liver regeneration.” Hepatology 22, no. 1 (July 1995): 252–61. https://doi.org/10.1016/0270-9139(95)90379-8.Full Text Link to Item
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Liu, S. L., S. D. Esposti, T. Yao, A. M. Diehl, and M. A. Zern. “Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding.” Hepatology 22, no. 5 (1995): 1474–81.
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Tamm, E. P., L. S. Rabushka, E. K. Fishman, R. H. Hruban, A. M. Diehl, and A. Klein. “Intrahepatic, extramedullary hematopoiesis mimicking hemangioma on technetium-99m red blood cell SPECT examination.” Clin Imaging 19, no. 2 (1995): 88–91. https://doi.org/10.1016/0899-7071(94)00037-d.Full Text Link to Item
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Diehl, A. M., M. Yin, J. Fleckenstein, S. Q. Yang, H. Z. Lin, D. A. Brenner, J. Westwick, G. Bagby, and S. Nelson. “Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury.” Am J Physiol 267, no. 4 Pt 1 (October 1994): G552–61. https://doi.org/10.1152/ajpgi.1994.267.4.G552.Full Text Link to Item
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Silverman, A. L., M. R. Smith, D. Sasaki, M. G. Mutchnick, and A. M. Diehl. “Altered levels of prothymosin immunoreactive peptide, a growth-related gene product, during liver regeneration after chronic ethanol feeding.” Alcohol Clin Exp Res 18, no. 3 (June 1994): 616–19. https://doi.org/10.1111/j.1530-0277.1994.tb00919.x.Full Text Link to Item
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Diehl, A. M., P. Michaelson, and S. Q. Yang. “Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development.” Gastroenterology 106, no. 6 (June 1994): 1625–37. https://doi.org/10.1016/0016-5085(94)90420-0.Full Text Link to Item
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Diehl, A. M., and S. Q. Yang. “Regenerative changes in C/EBP alpha and C/EBP beta expression modulate binding to the C/EBP site in the c-fos promoter.” Hepatology 19, no. 2 (February 1994): 447–56.Link to Item
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Lin, F. T., O. A. MacDougald, A. M. Diehl, and M. D. Lane. “A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.” Proc Natl Acad Sci U S A 90, no. 20 (October 15, 1993): 9606–10. https://doi.org/10.1073/pnas.90.20.9606.Full Text Link to Item
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Akerman, P. A., P. M. Cote, S. Q. Yang, C. McClain, S. Nelson, G. Bagby, and A. M. Diehl. “Long-term ethanol consumption alters the hepatic response to the regenerative effects of tumor necrosis factor-alpha.” Hepatology 17, no. 6 (June 1993): 1066–73.Link to Item
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McClain, C., D. Hill, J. Schmidt, and A. M. Diehl. “Cytokines and alcoholic liver disease.” Semin Liver Dis 13, no. 2 (May 1993): 170–82. https://doi.org/10.1055/s-2007-1007347.Full Text Link to Item
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Gollan, J. L., G. B. Bulkley, and A. M. Diehl. “Gallstones and Laparoscopic Cholecystectomy.” Jama: The Journal of the American Medical Association 269, no. 8 (February 24, 1993): 1018–24. https://doi.org/10.1001/jama.1993.03500080066034.Full Text
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“NIH Consensus conference. Gallstones and laparoscopic cholecystectomy.” Jama 269, no. 8 (February 24, 1993): 1018–24.Link to Item
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Wand, G. S., A. M. Diehl, M. A. Levine, D. Wolfgang, and S. Samy. “Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.” J Biol Chem 268, no. 4 (February 5, 1993): 2595–2601.Link to Item
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“National Institutes of Health Consensus Development Conference Statement: Gallstones and Laparoscopic Cholecystectomy. September 14-16, 1992.” J Laparoendosc Surg 3, no. 1 (February 1993): 77–90. https://doi.org/10.1089/lps.1993.3.77.Full Text Link to Item
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Diehl, A. M., S. Q. Yang, P. Cote, and G. S. Wand. “Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver.” Hepatology 16, no. 5 (November 1992): 1212–19.Link to Item
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Akerman, P., P. Cote, S. Q. Yang, C. McClain, S. Nelson, G. J. Bagby, and A. M. Diehl. “Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy.” Am J Physiol 263, no. 4 Pt 1 (October 1992): G579–85. https://doi.org/10.1152/ajpgi.1992.263.4.G579.Full Text Link to Item
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Diehl, A. M., S. Q. Yang, D. Wolfgang, and G. Wand. “Differential expression of guanine nucleotide-binding proteins enhances cAMP synthesis in regenerating rat liver.” J Clin Invest 89, no. 6 (June 1992): 1706–12. https://doi.org/10.1172/JCI115771.Full Text Link to Item
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Diehl, A. M. “Alcohol-related trafficking accidents.” Hepatology 15, no. 5 (May 1992): 964–66. https://doi.org/10.1002/hep.1840150533.Full Text Link to Item
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Diehl, A. M., S. Q. Yang, N. Brown, J. Smith, D. Raiford, R. Gordon, and R. Casero. “Ethanol-associated alterations in the kinetics of putrescine uptake and metabolism by the regenerating liver.” Alcohol Clin Exp Res 16, no. 1 (February 1992): 5–10. https://doi.org/10.1111/j.1530-0277.1992.tb00626.x.Full Text Link to Item
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Diehl, A. M. “Nutrition, hormones, metabolism, and liver regeneration.” Semin Liver Dis 11, no. 4 (November 1991): 315–20. https://doi.org/10.1055/s-2008-1040449.Full Text Link to Item
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Mendenhall, C. L., L. Seeff, A. M. Diehl, S. J. Ghosn, S. W. French, P. S. Gartside, S. D. Rouster, Z. Buskell-Bales, C. J. Grossman, and G. A. Roselle. “Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: their prevalence and clinical relevance. The VA Cooperative Study Group (No. 119).” Hepatology 14, no. 4 Pt 1 (October 1991): 581–89. https://doi.org/10.1016/0270-9139(91)90042-t.Full Text Link to Item
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Diehl, A. M., H. C. Bisgaard, B. T. Kren, and C. J. Steer. “Ethanol interferes with regeneration-associated changes in biotransforming enzymes: a potential mechanism underlying ethanol's carcinogenicity?” Hepatology 13, no. 4 (April 1991): 722–27.Link to Item
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Mendenhall, C. L., L. Seeff, A. M. Diehl, S. J. Ghosn, S. W. French, P. S. Gartside, S. D. Rouster, et al. “Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: Their prevalence and clinical relevance.” Hepatology 14, no. 4 (January 1, 1991): 581–89. https://doi.org/10.1002/hep.1840140402.Full Text
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Diehl, A. M., S. S. Thorgeirsson, and C. J. Steer. “Ethanol inhibits liver regeneration in rats without reducing transcripts of key protooncogenes.” Gastroenterology 99, no. 4 (October 1990): 1105–12. https://doi.org/10.1016/0016-5085(90)90631-a.Full Text Link to Item
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Diehl, A. M., S. Abdo, and N. Brown. “Supplemental putrescine reverses ethanol-associated inhibition of liver regeneration.” Hepatology 12, no. 4 Pt 1 (October 1990): 633–37. https://doi.org/10.1002/hep.1840120402.Full Text Link to Item
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Diehl, A. M., M. Wells, N. D. Brown, S. S. Thorgeirsson, and C. J. Steer. “Effect of ethanol on polyamine synthesis during liver regeneration in rats.” J Clin Invest 85, no. 2 (February 1990): 385–90. https://doi.org/10.1172/JCI114450.Full Text Link to Item
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Van Ness, M. M., and A. M. Diehl. “Liver enzymes and liver biopsy (I: Reply).” Annals of Internal Medicine 112, no. 4 (January 1, 1990): 311.
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Diehl, A. M., and L. Seeff. “Treatment of chronic hepatitis B.” Practical Gastroenterology 13, no. 8 (December 1, 1989): 53–80.
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Van Ness, M. M., and A. M. Diehl. “Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes?” Ann Intern Med 111, no. 6 (September 15, 1989): 473–78. https://doi.org/10.7326/0003-4819-111-6-473.Full Text Link to Item
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Diehl, A. M. “Alcoholic liver disease.” Med Clin North Am 73, no. 4 (July 1989): 815–30. https://doi.org/10.1016/s0025-7125(16)30640-x.Full Text Link to Item
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Carithers, R. L., H. F. Herlong, A. M. Diehl, E. W. Shaw, B. Combes, H. J. Fallon, and W. C. Maddrey. “Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial.” Ann Intern Med 110, no. 9 (May 1, 1989): 685–90. https://doi.org/10.7326/0003-4819-110-9-685.Full Text Link to Item
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Diehl, A. M., Z. Goodman, and K. G. Ishak. “Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury.” Gastroenterology 95, no. 4 (October 1988): 1056–62.Link to Item
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Mezey, E., C. J. Kolman, A. M. Diehl, M. C. Mitchell, and H. F. Herlong. “Alcohol and dietary intake in the development of chronic pancreatitis and liver disease in alcoholism.” Am J Clin Nutr 48, no. 1 (July 1988): 148–51. https://doi.org/10.1093/ajcn/48.1.148.Full Text Link to Item
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Diehl, A. M., M. Chacon, and P. Wagner. “The effect of chronic ethanol feeding on ornithine decarboxylase activity and liver regeneration.” Hepatology 8, no. 2 (1988): 237–42. https://doi.org/10.1002/hep.1840080208.Full Text Link to Item
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Van Ness, M. M., S. J. Chobanian, C. Winters, A. M. Diehl, R. L. Esposito, and E. L. Cattau. “A study of patient acceptance of double-contrast barium enema and colonoscopy. Which procedure is preferred by patients?” Arch Intern Med 147, no. 12 (December 1987): 2175–76. https://doi.org/10.1001/archinte.147.12.2175.Full Text Link to Item
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Diehl, A. M., M. A. Chacon, J. J. Potter, D. Rolfes, D. F. Cruess, and E. Mezey. “Pyridoxine deficiency and ethanol-induced liver injury.” Alcohol Clin Exp Res 11, no. 4 (August 1987): 385–91. https://doi.org/10.1111/j.1530-0277.1987.tb01329.x.Full Text Link to Item
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Johnson, D. A., A. M. Diehl, M. H. Sjogren, J. Lazar, E. L. Cattau, and R. C. Smallridge. “Serum angiotensin converting enzyme activity in evaluation of patients with liver disease.” Am J Med 83, no. 2 (August 1987): 256–60. https://doi.org/10.1016/0002-9343(87)90694-2.Full Text Link to Item
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Diehl, A. M., M. C. Mitchell, H. F. Herlong, J. J. Potter, L. Wacker, and E. Mezey. “Changes in plasma amino acids during sobriety in alcoholic patients with and without liver disease.” Am J Clin Nutr 44, no. 4 (October 1986): 453–60. https://doi.org/10.1093/ajcn/44.4.453.Full Text Link to Item
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Mezey, E., J. J. Potter, and A. M. Diehl. “Depression of alcohol dehydrogenase activity in rat hepatocyte culture by dihydrotestosterone.” Biochem Pharmacol 35, no. 2 (January 15, 1986): 335–39. https://doi.org/10.1016/0006-2952(86)90535-6.Full Text Link to Item
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Johnson, D. A., A. M. Diehl, F. D. Finkelman, and E. L. Cattau. “Crohn's disease and systemic lupus erythematosus.” Am J Gastroenterol 80, no. 11 (November 1985): 869–70.Link to Item
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Diehl, A. M., J. K. Boitnott, H. F. Herlong, J. J. Potter, M. A. Van Duyn, E. Chandler, and E. Mezey. “Effect of parenteral amino acid supplementation in alcoholic hepatitis.” Hepatology 5, no. 1 (1985): 57–63. https://doi.org/10.1002/hep.1840050114.Full Text Link to Item
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Diehl, A. M., P. Latham, J. K. Boitnott, J. Mann, and W. C. Maddrey. “Cholestatic hepatitis from erythromycin ethylsuccinate. Report of two cases.” Am J Med 76, no. 5 (May 1984): 931–34. https://doi.org/10.1016/0002-9343(84)91013-1.Full Text Link to Item
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Diehl, A. M., J. Potter, J. Boitnott, M. A. Van Duyn, H. F. Herlong, and E. Mezey. “Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis.” Gastroenterology 86, no. 4 (April 1984): 632–36.Link to Item
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Yocum, R. C., J. McArthur, B. G. Petty, A. M. Diehl, and T. R. Moench. “Septic arthritis caused by Propionibacterium acnes.” Jama 248, no. 14 (October 8, 1982): 1740–41.Link to Item
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Book Sections
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Ochoa, B., A. M. Diehl, and S. C. Stainbrook. “Tissues & organs.” In Encyclopedia of Biological Chemistry: Third Edition, 5:437–43, 2021. https://doi.org/10.1016/B978-0-12-819460-7.00268-1.Full Text
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Machado, M. V., and A. M. Diehl. “Developmental morphogens and adult liver repair.” In The Liver: Biology and Pathobiology, 539–49, 2020. https://doi.org/10.1002/9781119436812.ch43.Full Text
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Choi, S. S., and A. M. Diehl. “Alcoholic liver disease.” In Handbook of Liver Disease, 109–20, 2018. https://doi.org/10.1016/B978-0-323-47874-8.00008-0.Full Text
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Machado, M. V., and A. M. Diehl. “Hedgehog signaling in the liver.” In Signaling Pathways in Liver Diseases: Third Edition, 262–74, 2015. https://doi.org/10.1002/9781118663387.ch19.Full Text
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Machado, M. L. V. M., and A. M. Diehl. “Animal models of nonalcoholic fatty liver disease.” In Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside, 121–45, 2015. https://doi.org/10.1007/978-3-319-20538-0_6.Full Text
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Machado, M. V., and A. M. Diehl. “Role of Developmental Morphogens in Liver Regeneration.” In Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications, 137–52, 2015. https://doi.org/10.1016/B978-0-12-420128-6.00010-5.Full Text
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Ochoa, B., and A. M. Diehl. “Biochemistry of Liver Regeneration.” In Encyclopedia of Biological Chemistry: Second Edition, 190–95, 2013. https://doi.org/10.1016/B978-0-12-378630-2.00084-0.Full Text
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Li, Z., and A. M. Diehl. “Cytokines and Inflammatory Recruitment in NASH: Experimental and Human Studies.” In Fatty Liver Disease: NASH and Related Disorders, 123–31, 2007. https://doi.org/10.1002/9780470987438.ch10.Full Text
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Conference Papers
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Du, Kuo, Raquel Maeso-Díaz, Seh Hoon Oh, Ergang Wang, Tianyi Chen, Christopher Pan, Kun Xiang, et al. “Targeting YAP-mediated HSC death susceptibility and senescence for treatment of liver fibrosis.” In Hepatology, 77:1998–2015, 2023. https://doi.org/10.1097/HEP.0000000000000326.Full Text Link to Item
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Chen, Tianyi, George Dalton, Seh-Hoon Oh, Raquel Maeso-Diaz, Kuo Du, Rachel A. Meyers, Cynthia Guy, et al. “Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease.” In Cell Mol Gastroenterol Hepatol, 15:949–70, 2023. https://doi.org/10.1016/j.jcmgh.2022.12.008.Full Text Link to Item
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Maeso-Díaz, Raquel, George D. Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Tianyi Chen, Rajesh K. Dutta, Jessica H. Hartman, Joel N. Meyer, and Anna Mae Diehl. “Aging reduces liver resiliency by dysregulating Hedgehog signaling.” In Aging Cell, 21:e13530, 2022. https://doi.org/10.1111/acel.13530.Full Text Link to Item
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Du, Kuo, Jeongeun Hyun, Richard T. Premont, Steve S. Choi, Gregory A. Michelotti, Marzena Swiderska-Syn, George D. Dalton, et al. “Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.” In Gastroenterology, 154:1465-1479.e13, 2018. https://doi.org/10.1053/j.gastro.2017.12.022.Full Text Link to Item
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Loomba, Rohit, Eric Lawitz, Parvez S. Mantry, Saumya Jaya-kumar, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl, et al. “GS-4997, an Inhibitor of Apoptosis Signal-Regulating Kinase (ASK1), Alone or in Combination with Simtuzumab for the Treatment of Nonalcoholic Steatohepatitis (NASH): A Randomized, Phase 2 Trial.” In Hepatology, 64:1119A-1120A. WILEY, 2016.Link to Item
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Coombes, Jason D., Paul P. Manka, Marzena Swiderska-Syn, Danielle Reid, Antonio Riva, Lee C. Claridge, Laurent Dolle, et al. “Cholangiocyte chemokine secretion and macrophage accumulation is mediated by osteopontin in murine liver models.” In Hepatology, 64:89A-90A. WILEY, 2016.Link to Item
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Jewell, Mark, Marzena Swiderska-Syn, Guanhua Xie, Gamze Karaca, Richard T. Premont, and Anna Mae Diehl. “MMP9 is a potential mediator of TWEAK-Fn14 signaling in a rodent model of acute alcoholic steatohepatitis.” In Hepatology, 64:836A-836A. WILEY, 2016.Link to Item
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Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis.” In Hepatology, 64:577A-577A. WILEY, 2016.Link to Item
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Premont, Richard T., Marzena Swiderska-Syn, Mark Jewell, and Anna Mae Diehl. “Hepatic stellate cell Yes-associated protein 1 (Yap1) is necessary for liver regeneration.” In Hepatology, 64:837A-837A. WILEY, 2016.Link to Item
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Seth, Ratanesh K., Diptadip Dattaroy, Varun Chandrashekaran, Suvarthi Das, Firas Alhasson, Marcelo G. Bonini, Gregory A. Michelotti, et al. “TRPV4 prevents tissue injury in diseased fatty liver by blocking CYP2E1-mediated redox-toxicity via Kupffer cell-induced nitric oxide production.” In Hepatology, 64:793A-794A. WILEY, 2016.Link to Item
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Suzuki, Ayako, Horace J. Spencer, Cynthia A. Moylan, Jonathan A. Dranoff, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 64:105A-105A. WILEY, 2016.Link to Item
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Swiderska-Syn, Marzena, Guanhua Xie, and Anna Mae Diehl. “Hedgehog-responsive Myofibroblasts activate Yes-associated Protein (Yap) 1 and Promote TGFb-Signaling to Induce Epithelial-Mesenchymal Transitions in Hepatocytes during Murine Liver Regeneration.” In Hepatology, 64:835A-836A. WILEY, 2016.Link to Item
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Wegermann, Kara, Ricardo Henao, Yiping Pan, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study.” In Hepatology, 64:577A-577A. WILEY, 2016.Link to Item
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Moylan, Cynthia A., Kara J. Wegermann, Ricardo G. Henao, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study.” In American Journal of Gastroenterology, 111:S381–S381. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.14309/00000434-201610001-00871.Full Text
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Swiderska-Syn, Marzena, Guanhua Xie, Gregory A. Michelotti, Mark L. Jewell, Richard T. Premont, Wing-Kin Syn, and Anna Mae Diehl. “Hedgehog regulates yes-associated protein 1 in regenerating mouse liver.” In Hepatology, 64:232–44, 2016. https://doi.org/10.1002/hep.28542.Full Text Link to Item
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Coombes, J. D., P. P. Manka, M. Swiderska-Syn, D. Reid, A. Riva, L. C. Claridge, L. Dolle, et al. “Osteopontin Promotes Cholangiocyte Chemokine Secretion and Macrophage Accumulation in Murine Liver Fibrosis.” In Journal of Hepatology, 64:S514–15. Elsevier BV, 2016. https://doi.org/10.1016/s0168-8278(16)00898-9.Full Text
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Sanyal, A., Z. Goodman, S. Harrison, D. C. Rockey, A. M. Diehl, S. Caldwell, M. L. Shiffman, et al. “Correlation between the Hepatic Venous Pressure Gradient and Alpha-Smooth Muscle Actin (SMA) Expression in Patients with Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis.” In Journal of Hepatology, 64:S251–S251. Elsevier BV, 2016. https://doi.org/10.1016/s0168-8278(16)00267-1.Full Text
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Shea, P. R., A. Sanyal, D. C. Rockey, R. Loomba, A. M. Diehl, S. E. Kleinstein, R. P. Myers, et al. “Genome-Wide Association Study of Clinically Significant Portal Hypertension in Patients with Nonalcoholic Steatohepatitis and Advanced Fibrosis.” In Journal of Hepatology, 64:S280–S280. Elsevier BV, 2016. https://doi.org/10.1016/s0168-8278(16)00336-6.Full Text
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Shea, P. R., A. Sanyal, S. Harrison, V. Ratziu, R. Loomba, S. Caldwell, A. M. Diehl, et al. “PNPLA3 Variants Confer an Increased Risk of Advanced Fibrosis Due to Non-Alcoholic Steatohepatitis.” In Journal of Hepatology, 64:S493–S493. Elsevier BV, 2016. https://doi.org/10.1016/s0168-8278(16)00846-1.Full Text
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Boursier, Jerome, Olaf Mueller, Matthieu Barret, Mariana V. Machado, Lionel Fizanne, Cynthia D. Guy, John F. Rawls, et al. “Increasing severity of NAFLD is associated with gut dysbiosis and modification of the metabolic function of the gut microbiota.” In Hepatology, 62:1274A-1274A. WILEY-BLACKWELL, 2015.Link to Item
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Coombes, Jason D., Paul P. Manka, Marzena Swiderska-Syn, Antonio Riva, Danielle Reid, Lee C. Claridge, Laurent Dolle, et al. “Osteopontin promotes cholangiocyte chemokine secretion and macrophage accumulation in mice.” In Hepatology, 62:1251A-1251A. WILEY-BLACKWELL, 2015.Link to Item
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Harrison, Stephen A., Zachary D. Goodman, Vlad Ratziu, Rohit Loomba, Anna Mae Diehl, Eric Lawitz, Holger Hinrichsen, et al. “Serum lysyl oxidase-like-2 (sLOXL2) levels correlate with fibrosis stage in patients with nonalcoholic steatohepatitis (NASH).” In Hepatology, 62:910A-910A. WILEY-BLACKWELL, 2015.Link to Item
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Hasanaliyeva, Nigar, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Robert Streilein, Russell Hall, Anna Mae Diehl, and Manal F. Abdelmalek. “IL-8 and MCP1 are Independently Associated with Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:1265A-1265A. WILEY-BLACKWELL, 2015.Link to Item
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Henao, Ricardo, Nigar Hasanaliyeva, Lauren N. Bell, Jacob Wulff, Regis Perichon, Cynthia A. Moylan, James T. Lu, Cynthia D. Guy, Anna Mae Diehl, and Manal F. Abdelmalek. “Plasma Metabolomic Profiles Predict Advanced Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:290A-291A. WILEY-BLACKWELL, 2015.Link to Item
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Machado, Mariana V., Gregory A. Michelotti, Guanhua Xie, Thiago A. Pereira, Mark Jewell, Richard T. Premont, and Anna Mae Diehl. “Ancestral starvation-activated caspase-2 promotes obesity, the metabolic syndrome and Nonalcoholic fatty liver disease.” In Hepatology, 62:670A-670A. WILEY-BLACKWELL, 2015.Link to Item
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Moylan, Cynthia A., Susan K. Murphy, Carole Grenier, Manal F. Abdelmalek, and Anna Mae Diehl. “DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:648A-649A. WILEY-BLACKWELL, 2015.Link to Item
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Sanyal, Arun J., Zachary D. Goodman, Manal F. Abdelmalek, Stephen A. Harrison, Don C. Rockey, Anna Mae Diehl, Stephen H. Caldwell, et al. “Clinical and histologic correlates of the hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to nonalcoholic steatohepatitis (NASH).” In Hepatology, 62:577A-577A. WILEY-BLACKWELL, 2015.Link to Item
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Seth, Ratanesh K., Suvarthi Das, Diptadip Dattaroy, Firas Alhasson, Phillip D. Bell, Gregory A. Michelotti, Mitzi Nagarkatti, et al. “TRPV4 regulates inflammation and Kupffer cell activation in nonalcoholic steatohepatitis by attenuation of CYP2E1-mediated oxidative stress.” In Hepatology, 62:1248A-1248A. WILEY-BLACKWELL, 2015.Link to Item
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Sundaram, Shikha, Marzena Swiderska-Syn, Ronald J. Sokol, Zhaoxing Pan, Ann C. Halbower, Kelley E. Capocelli, Kristen N. Robbins, and Anna Mae Diehl. “Nocturnal Hypoxia is associated with Hedgehog Signaling and Severity of Pediatric Non-Alcoholic Fatty Liver Disease (NAFLD).” In Hepatology, 62:1044A-1045A. WILEY-BLACKWELL, 2015.Link to Item
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Uschner, Frank E., Ganesh Ranabhat, Michaela Granzow, Steve S. Choi, Sabine Klein, Robert Schierwagen, Esther Raskopf, et al. “Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension.” In Hepatology, 62:249A-249A. WILEY-BLACKWELL, 2015.Link to Item
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Xie, Guanhua, Marzena Swiderska-Syn, Mariana V. Machado, Mark Jewell, Richard T. Premont, Gregory A. Michelotti, Raffaele Teperino, and Anna Mae Diehl. “Characterization of obesity-related modifications in hepatic stellate cells.” In Hepatology, 62:889A-889A. WILEY-BLACKWELL, 2015.Link to Item
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De Almeida Pereira, T., L. Borthwick, G. Xie, P. Vidigal, M. Machado, I. Voieta, V. Resende, et al. “CROSS-TALK BETWEEN IL13 AND HEDGEHOG PATHWAYS CONTRIBUTES TO SCHISTOSOMIASIS MANSONI FIBROSIS.” In Journal of Hepatology, 62:S204–S204. ELSEVIER SCIENCE BV, 2015.Link to Item
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Zhu, Ruixin, Susan S. Baker, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, Fausto Zamboni, Dingfeng Wu, et al. “Systematic Analysis of NAFLD Transcriptome Revealed Elevated Expression of Alcohol Metabolizing Genes in Mild and Severe NAFLD Livers.” In Gastroenterology, 148:S1054–S1054. W B SAUNDERS CO-ELSEVIER INC, 2015.Link to Item
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Machado, M. V., G. A. Michelotti, G. Xie, J. Boursier, T. Pereira de Almeida, L. Kruger, G. Karaca, C. Guy, and A. M. Diehl. “P0935 : Non-alcoholic steatohepatitis (NASH): 2 complementary dietary mouse models.” In Journal of Hepatology, 62:S695–S695. Elsevier BV, 2015. https://doi.org/10.1016/s0168-8278(15)31136-3.Full Text
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Swiderska-Syn, M., S. Choi, A. Lan, G. Ferrari, A. M. Diehl, and S. Naggie. “P0469 : Markers of tissue repair and cellular aging are increased in liver tissue of patients with dual chronic HIV/HCV infections.” In Journal of Hepatology, 62:S489–S489. Elsevier BV, 2015. https://doi.org/10.1016/s0168-8278(15)30677-2.Full Text
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Naqvi, Ibtehaj A., Rebekah R. White, Cynthia A. Moylan, Anna Mae Diehl, and Steve S. Choi. “Abstract 4117: Utilizing RNA aptamers for biomarker discovery in a novel cell culture system for hepatocellular carcinoma.” In Cancer Research, 74:4117–4117. American Association for Cancer Research (AACR), 2014. https://doi.org/10.1158/1538-7445.am2014-4117.Full Text
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Kochhar, Sweta, Manal F. Abdelmalek, Cynthia D. Guy, Dawn Piercy, Yiping Pan, Anna Mae Diehl, and Ayako Suzuki. “Associations of Sleep Duration and Sleep Quality With Clinical and Histologic Features of Nonalcoholic Fatty Liver Disease (NAFLD).” In Gastroenterology, 146:S931–S931. W B SAUNDERS CO-ELSEVIER INC, 2014.Link to Item
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Moylan, Cynthia A., Kouros Owzar, Andrew J. Muir, Francois Cauchy, Jacques Belghiti, Anna Mae Diehl, and Valerie Paradis. “Gene Expression and Pathway Analyses Reveal Distinctions Between Hepatocellular Carcinoma Arising in Fibrotic and Non-Fibrotic Nonalcoholic Fatty Liver Disease.” In Gastroenterology, 146:S998–99. W B SAUNDERS CO-ELSEVIER INC, 2014.Link to Item
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Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Katherine P. Yates, Aynur Unalp, Joel E. Lavine, Anna Mae Diehl, and Ayako Suzuki. “Associations of Sex and Menopause With Histologic Severity of Necroinflammation and Portal Inflammation Among Patients With Nonalcoholic Fatty Liver Disease (NAFLD).” In Gastroenterology, 146:S945–S945. W B SAUNDERS CO-ELSEVIER INC, 2014.Link to Item
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Coombes, J. D., M. Swiderska-Syn, L. Dollé, D. T. Reid, B. Eksteen, L. C. Claridge, M. A. Briones-Orta, et al. “P612 OSTEOPONTIN NEUTRALIZATION ABROGATES THE LIVER PROGENITOR CELL RESPONSE AND FIBROGENIC OUTCOMES IN MICE.” In Journal of Hepatology, 60:S273–S273. Elsevier BV, 2014. https://doi.org/10.1016/s0168-8278(14)60774-1.Full Text
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Yang, Ju Dong, Manal F. Abdelmalek, Herbert Pang, Cynthia D. Guy, Alastair D. Smith, Anna Mae Diehl, and Ayako Suzuki. “Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis.” In Hepatology, 59:1406–14, 2014. https://doi.org/10.1002/hep.26761.Full Text Link to Item
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Bohinc, Brittany, Gregory A. Michelotti, Guanhua Xie, Herbert Pang, Ayako Suzuki, Cynthia D. Guy, Dawn L. Piercy, et al. “Repair-related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism.” In Hepatology, 60:411A-412A. WILEY-BLACKWELL, 2014.Link to Item
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Coombes, Jason D., Steve S. Choi, Paul P. Manka, Marco A. Briones-Orta, Marzena Swiderska-Syn, Naoto Kitamura, Rasha Younis, et al. “Osteopontin mediates fibrogenic effects of leptin and enhances NASH progression.” In Hepatology, 60:748A-749A. WILEY-BLACKWELL, 2014.Link to Item
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Dattaroy, Diptadip, Ratanesh K. Seth, Suvarthi Das, Sahar Pourhoseini, Mitzi Nagarkatti, Gregory A. Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. “Micro RNA 21 inhibition of SMAD 7 enhances fibrogenesis via leptin mediated NADPH oxidase in experimental nonalcoholic steatohepatitis.” In Hepatology, 60:249A-249A. WILEY-BLACKWELL, 2014.Link to Item
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Klair, Jagpal S., Ju Dong Yang, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Katherine P. Yates, Aynur Unalp-Arida, et al. “Risk of severe fibrosis is associated with age at menopause in nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 60:621A-621A. WILEY-BLACKWELL, 2014.Link to Item
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Seth, Ratanesh K., Suvarthi Das, Sahar Pourhoseini, Diptadip Dattaroy, Stephen Igwe, Julie Basu Ray, Gregory A. Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. “M1 Polarization bias and subsequent NASH progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1 induced oxidative stress.” In Hepatology, 60:762A-762A. WILEY-BLACKWELL, 2014.Link to Item
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Swiderska-Syn, Marzena, Guanhua Xie, Jason D. Coombes, Gregory A. Michelotti, and Anna Mae Diehl. “Hepatic Stellate Cells Express the Hepatocyte-enriched Transcription Factor, Hepatocyte Nuclear Factor 4 alpha.” In Hepatology, 60:578A-578A. WILEY-BLACKWELL, 2014.Link to Item
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Urban, Thomas J., Cynthia A. Moylan, Matthew Rein, Manal F. Abdelmalek, David B. Goldstein, and Anna Mae Diehl. “Whole Exome Sequencing of Extreme Phenotypes of NAFLD Identifies Potential Genetic Risk Factors for Advanced Hepatic Fibrosis.” In Hepatology, 60:744A-744A. WILEY-BLACKWELL, 2014.Link to Item
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Uschner, Frank E., Ganesh Ranabhat, Michaela Granzow, Steve S. Choi, Sabine Klein, Robert Schierwagen, Esther Raskopf, et al. “Hedgehog-signaling and angiogenesis in cirrhotic and non-cirrhotic portal hypertension.” In Hepatology, 60:1178A-1178A. WILEY-BLACKWELL, 2014.Link to Item
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Asai, Akihiro, Samyukta Malladi, Jonathan Misch, Padmini Malladi, Anna Mae Diehl, and Peter F. Whitington. “Hedgehog Signaling by Hepatic Epithelial Progenitor Cells Forming Neotubules Drives Parenchymal Fibrogenesis in Gestational Alloimmune Liver Disease.” In Hepatology, 58:592A-592A. WILEY-BLACKWELL, 2013.Link to Item
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Chen, Yuping, Gregory A. Michelotti, Guanhua Xie, Cynthia A. Moylan, and Anna Mae Diehl. “Hedgehog-Induced Serine Biogenesis is Required for Activation of Hepatic Stellate Cells.” In Hepatology, 58:572A-572A. WILEY-BLACKWELL, 2013.Link to Item
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Coombes, Jason, Lee C. Claridge, Marzena Swiderska-Syn, Marco A. Briones-Orta, Rasha Younis, Husnain Shah, Salvatore Papa, et al. “Osteopontin enhances liver progenitor cell responses in progressive Nonalcoholic Steatohepatitis.” In Hepatology, 58:535A-535A. WILEY-BLACKWELL, 2013.Link to Item
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Das, Suvarthi, Ratanesh K. Seth, Ashutosh Kumar, Maria B. Kadiiska, Gregory A. Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. “Purinergic Receptor X7 is a Key Modulator of Metabolic Oxidative Stress - Mediated Autophagy and Inflammation in Experimental Nonalcoholic Steatohepatitis.” In Hepatology, 58:538A-538A. WILEY-BLACKWELL, 2013.Link to Item
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Guy, Cynthia D., Ayako Suzuki, Manal F. Abdelmalek, James Burchette, and Anna Mae Diehl. “Hedgehog Pathway Targeted by Vitamin E Therapy in NASH.” In Hepatology, 58:249A-249A. WILEY-BLACKWELL, 2013.Link to Item
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Karaca, Gamze, Guanhua Xie, Marzena Swiderska-Syn, Gregory A. Michelotti, Steve S. Choi, Linda C. Burkly, and Anna Mae Diehl. “Absence of FN14 Ameliorates Acute Ethanol-Induced Steatohepatitis.” In Hepatology, 58:831A-831A. WILEY-BLACKWELL, 2013.Link to Item
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Pereira, Thiago A., Wing-Kin Syn, Steve S. Choi, Izabela Voieta, Vivian Resende, Marcia M. Souza, William E. Secor, et al. “Cholangiocyte proliferation and Osteopontin secretion is induced by Schistosoma mansoni egg antigens and correlates with fibrosis and portal hypertension in human and murine schistosomiasis.” In Hepatology, 58:847A-847A. WILEY-BLACKWELL, 2013.Link to Item
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Seth, Ratanesh K., Suvarthi Das, Ashutosh Kumar, Anindya Chanda, Maria B. Kadiiska, Gregory A. Michelotti, Anna Mae Diehl, and Saurabh Chatterjee. “CYP2E1-dependent and Leptin-induced CD57-positive cytotoxic T cells are crucial for progression of nonalcoholic steatohepatitis.” In Hepatology, 58:538A-538A. WILEY-BLACKWELL, 2013.Link to Item
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Tucker, Anikia, Gregory A. Michelotti, Steve S. Choi, Guanhua Xie, Gamze Karaca, Marzena Swiderska-Syn, Leandi Kruger, Mariana V. Machado, Katherine S. Garman, and Anna Mae Diehl. “The Role of Pleiotrophin Signaling in the Hepatic Stem Cell Niche.” In Hepatology, 58:1007A-1007A. WILEY-BLACKWELL, 2013.Link to Item
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Soeda, J., A. Mouralidarane, S. Ray, A. M. Diehl, and J. A. Oben. “312 PRAZOSIN AN ALPHA1 ADRENOCEPTOR ANTAGONIST PROTECTS LIVER FROM ACETAMINOPHEN INDUCED ACUTE LIVER INJURY AND EXPANDS THE PROGENITOR CELL POPULATION.” In Journal of Hepatology, 58:S131–S131. Elsevier BV, 2013. https://doi.org/10.1016/s0168-8278(13)60314-1.Full Text
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Garrett, Melanie E., Cynthia A. Moylan, Jason Gibson, Hyuna Yang, Herbert Pang, Andrew Dellinger, Ayako Suzuki, et al. “Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease.” In Hepatology, 56:267A-268A. WILEY-BLACKWELL, 2012.Link to Item
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Pereira, Thiago A., Clarissa A. Gurgel, Caroline B. Schlaepfer-Sales, Izabela Voieta, Carlos M. Antunes, Zilton A. Andrade, Fausto E. Pereira, Anna Mae Diehl, and Jose R. Lambertucci. “Activation Of Hedgehog Pathway In Schistosomiasis Mansoni And Its Relationship With Liver Fibrosis.” In Hepatology, 56:813A-814A. WILEY-BLACKWELL, 2012.Link to Item
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Suzuki, Ayako, Cynthia D. Guy, Herbert Pang, Alastair D. Smith, Anna Mae Diehl, and Manal F. Abdelmalek. “Impact of Gender and Menopause on Histologic Severity of Inflammation and Injury in patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 56:901A-901A. WILEY-BLACKWELL, 2012.Link to Item
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Klein, S., M. Granzow, R. Schierwagen, P. Van der Ven, E. Raskopf, U. Pieper-Fürst, D. Fürst, et al. “376 STATINS INDUCE SENESCENCE OF ACTIVATED HSC BY INHIBITION OF THE HEDGEHOG PATHWAY.” In Journal of Hepatology, 56:S152–S152. Elsevier BV, 2012. https://doi.org/10.1016/s0168-8278(12)60389-4.Full Text
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Corbin, Karen D., Melanie D. Spencer, Kerry-Ann da Costa, Wei Sha, Manal F. Abdelmalek, Yiping Pan, Ayako Suzuki, et al. “Genotype-based hierarchical clustering reveals a panel of polymorphisms in one carbon metabolism that are associated with obesity.” In Faseb Journal, Vol. 26, 2012.Link to Item
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Chatterjee, Saurabh, Erik J. Tokar, Maria Kadiiska, Michael Waalkes, Anna Mae Diehl, and Ronald P. Mason. “Leptin is Key To Macrophage-Dependent Free Radical Formation in Ccl4-Induced Exacerbation of Steatohepatitis of Obesity.” In Free Radical Biology and Medicine, 51:S26–27. Elsevier BV, 2011. https://doi.org/10.1016/j.freeradbiomed.2011.10.061.Full Text
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Chan, Isaac S., George M. Philips, Marzena Zdanowicz, Vanessa Teaberry, Gamze Karaca, Fatima Rangwala, Cynthia D. Guy, et al. “HEDGEHOG PATHWAY INHIBITION BY GDC-0449 CAUSES REGRESSION OF HEPATOCELLULAR CARCINOMAS AND IMPROVES LIVER FIBROSIS IN MDR2-DEFICIENT MICE.” In Hepatology, 54:1278A-1278A. WILEY-BLACKWELL, 2011.Link to Item
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Chen, Yuping, Steve S. Choi, Gregory A. Michelotti, Cynthia A. Moylan, Gamze Karaca, Marzena Zdanowicz, Guanhua Xie, Leandi Kruger, and Anna Mae Diehl. “TRANSITION OF QUIESCENT STELLATE CELLS INTO MYOFIBROBLASTS REQUIRES HEDGEHOG-MEDIATED INDUCTION OF GLYCOLYSIS.” In Hepatology, 54:422A-422A. WILEY-BLACKWELL, 2011.Link to Item
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Michelotti, Gregory A., Steve S. Choi, Marzena Zdanowicz, Gamze Karaca, Richard T. Premont, and Anna Mae Diehl. “ABROGATION OF CANONICAL HEDGEHOG ACTIVITY DECREASES HEPATIC FIBROSIS.” In Hepatology, 54:434A-435A. WILEY-BLACKWELL, 2011.Link to Item
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Philips, George M., Isaac S. Chan, Steve S. Choi, Guanhua Xie, Gregory A. Michelotti, Marzena Zdanowicz, Vanessa Teaberry, et al. “HEDGEHOG PATHWAY INHIBITION INDUCES HCC TUMOR NECROSIS BY REPRESSING EXPRESSION OF ANGIOPOIETIN-2 AND ITS COGNATE RECEPTOR, TIE-2.” In Hepatology, 54:1280A-1280A. WILEY-BLACKWELL, 2011.Link to Item
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Philips, George M., Marzena Zdanowicz, Gregory A. Michelotti, Steve S. Choi, Gamze Karaca, Isaac S. Chan, and Anna Mae Diehl. “HEDGEHOG PATHWAY ACTIVATION OCCURS IN PULMONARY MICROVASCULATURE DURING EXPERIMENTAL HEPATOPULMONARY SYNDROME (HPS).” In Hepatology, 54:1235A-1235A. WILEY-BLACKWELL, 2011.Link to Item
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Shah, Ketan K., Ayako Suzuki, Jeffrey B. Schwimmer, Aynur Unalp, Cynthia D. Guy, Jean P. Molleston, Peter F. Whitington, Richard Johnson, Anna Mae Diehl, and Manal F. Abdelmalek. “DOSE DEPENDENT ASSOCIATION OF FRUCTOSE CONSUMPTION WITH HYPERURICEMIA AND INSULIN RESISTANCE IN CHILDREN WITH NAFLD.” In Hepatology, 54:1116A-1116A. WILEY-BLACKWELL, 2011.Link to Item
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Xie, Guanhua, Steve S. Choi, Wing-Kin Syn, Gregory A. Michelotti, Marzena Zdanowicz, Gamze Karaca, Yuping Chen, and Anna Mae Diehl. “AUTOCRINE ACTIVATION OF THE HEDGEHOG PATHWAY DURING LIVER SINUSOIDAL ENDOTHELIAL CELL CAPILLARIZATION.” In Hepatology, 54:757A-757A. WILEY-BLACKWELL, 2011.Link to Item
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Corbin, Karen D., Kerry-Ann da Costa, Wei Sha, Manal F. Abdelmalek, Anna Mae Diehl, and Steven H. Zeisel. “Single nucleotide polymorphisms affecting phosphatidylcholine transport are associated with obesity.” In Faseb Journal, Vol. 25. FEDERATION AMER SOC EXP BIOL, 2011.Link to Item
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Guy, C. D., A. Suzuki, J. L. Burchette, E. M. Brunt, M. F. Abelmalek, D. Cardona, S. J. McCall, et al. “A Novel Immunohiostochemical Staining Pattern for Keratin 8/18 Plus Ubiquitin in Nonalcoholic Fatty Liver Disease Is Associated with Increased Disease Severity and Advanced Fibrosis.” In Laboratory Investigation, 91:361A-361A. NATURE PUBLISHING GROUP, 2011.Link to Item
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Guy, C. D., A. Suzuki, J. L. Burchette, E. M. Brunt, M. F. Abelmalek, D. Cardona, S. J. McCall, et al. “A Novel Immunohiostochemical Staining Pattern for Keratin 8/18 Plus Ubiquitin in Nonalcoholic Fatty Liver Disease Is Associated with Increased Disease Severity and Advanced Fibrosis.” In Modern Pathology, 24:361A-361A. NATURE PUBLISHING GROUP, 2011.Link to Item
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Abdelmalek, Manal F., Ayako Suzuki, Silke Schmidt, Jacqueline Rimmler, Aynur Unalp, Cynthia D. Guy, Richard Johnson, Michael A. Hauser, and Anna Mae Diehl. “FRUCTOKINASE POLYMORPHISMS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE ARE ASSOCIATED WITH DECREASED URIC ACID AND THE PRESENCE OF HEPATIC FIBROSIS.” In Hepatology, 52:644A-645A. WILEY-BLACKWELL, 2010.Link to Item
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Choi, Steve S., Thiago A. Pereira, Wing-Kin Syn, Kolade M. Agboola, Cynthia A. Moylan, Alessia Omenetti, Gamze F. Karaca, Fatima Rangwala, Ravi Jhaveri, and Anna Mae Diehl. “CO-CULTURE OF LIVER EPITHELIAL CELLS STABLY TRANSFECTED WITH HEPATITIS B VIRUS X PROTEIN PROMOTES MYOFIBROBLASTIC ACTIVATION AND ACCUMULATION VIA A HEDGEHOG-MEDIATED PROCESS IN RAT HEPATIC STELLATE CELLS.” In Hepatology, 52:977A-978A. WILEY-BLACKWELL, 2010.Link to Item
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Choi, Steve S., Wing-Kin Syn, Michael P. Smith, Anna Mae Diehl, and Gregory A. Michelotti. “NR4A NUCLEAR ORPHAN RECEPTORS ARE NOVEL REGULATORS OF HEPATIC FIBROSIS.” In Hepatology, 52:606A-607A. WILEY-BLACKWELL, 2010.Link to Item
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Karaca, Gamze F., Yuping Chen, Wing-Kin Syn, Begona Ochoa, Steve S. Choi, Aniela Jakubowski, and Anna Mae Diehl. “DEFECTIVE LIVER REGENERATION AFTER PARTIAL HEPATECTOMY IN MICE LACKING FIBROBLAST GROWTH FACTOR INDUCIBLE 14.” In Hepatology, 52:969A-970A. WILEY-BLACKWELL, 2010.Link to Item
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Moylan, Cynthia A., Manal F. Abdelmalek, Herbert Pang, Andrew Dellinger, Steve S. Choi, Alessia Omenetti, Yuping Chen, et al. “SIGNALS FROM THE FIBROTIC LIVER IN PATIENTS WITH NAFLD MAY PROMOTE DIABETES AND OBESITY.” In Hepatology, 52:1049A-1050A. WILEY-BLACKWELL, 2010.Link to Item
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Moylan, Cynthia A., Steve S. Choi, Andrew Dellinger, Herbert Pang, Manal F. Abdelmalek, Daniel Hampton, Yuping Chen, et al. “CONSERVED GENE EXPRESSION PATTERNS IN MYOFIBROBLASTIC MURINE AND HUMAN HEPATIC STELLATE CELLS AND NAFLD PATIENTS WITH LIVER FIBROSIS COMPATIBLE WITH EPITHELIAL-TO-MESENCHYMAL LIKE TRANSITION.” In Hepatology, 52:1286A-1287A. WILEY-BLACKWELL, 2010.Link to Item
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Neuschwander-Tetri, Brent A., Arun J. Sanyal, Naga P. Chalasani, Kris V. Kowdley, Arthur J. McCullough, Anna Mae Diehl, Nathan M. Bass, et al. “CHANGES IN ALT AND VITAMIN E LEVELS AND HISTOLOGICAL RESPONSE IN PATIENTS WITH NASH TREATED WITH VITAMIN E IN THE PIVENS TRIAL.” In Hepatology, 52:620A-621A. WILEY-BLACKWELL, 2010.Link to Item
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Omenetti, Alessia, Lee M. Bass, Robert A. Anders, Maria Grazia Clemente, Heather Francis, Cynthia D. Guy, Steve S. Choi, et al. “HEDGEHOG PATHWAY DRIVES THE ACQUISITION OF MESENCHYMAL MARKERS IN DUCTULAR CELLS OF PATIENTS WITH BILIARY ATRESIA.” In Hepatology, 52:1022A-1023A. WILEY-BLACKWELL, 2010.Link to Item
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Omenetti, Alessia, Liu Yang, Raul R. Gainetdinov, Cynthia D. Guy, Steve S. Choi, Wei Chen, Marc G. Caron, and Anna Mae Diehl. “MYOFIBROBLAST-DERIVED TGF beta PROMOTES BILIARY TREE GROWTH DURING CHOLESTATIC LIVER INJURY BY SUPPRESSING ANGIOPOIETIN 1/TIE2/TRYPTOPHAN HYDROXYLASE 2 AXIS AND SEROTONIN SECRETION IN NEIGHBORING CHOLANGIOCYTES.” In Hepatology, 52:407A-408A. WILEY-BLACKWELL, 2010.Link to Item
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Pereira, Thiago A., Wing-Kin Syn, Izabela Voieta, Lu Jiuyi, Steve S. Choi, Rafal P. Witek, Kolade M. Agboola, et al. “MACROPHAGE-DERIVED HEDGEHOG LIGANDS PROMOTES FIBROGENIC RESPONSES IN SCHISTOSOMIASIS MANSONI.” In Hepatology, 52:611A-612A. WILEY-BLACKWELL, 2010.Link to Item
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Piercy, Dawn L., Ayako Suzuki, Jing Feng, Yiping Pan, Cynthia D. Guy, Anna Mae Diehl, Ambrose A. Chiang, and Manal F. Abdelmalek. “OBSTRUCTIVE SLEEP APNEA WORSENS HEPATIC INFLAMMATION AND FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 52:631A-631A. WILEY-BLACKWELL, 2010.Link to Item
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Rangwala, Fatima, Cynthia D. Guy, Jiuyi Lu, Wei Chen, and Anna Mae Diehl. “INCREASED PRODUCTION OF SONIC HEDGEHOG BY BALLOONED HEPATOCYTES: IMPLICATIONS FOR FIBROSIS PROGRESSION IN NASH.” In Hepatology, 52:352A-352A. WILEY-BLACKWELL, 2010.Link to Item
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Schroder, Vanessa T., Fatima Rangwala, Wing-Kin Syn, Cynthia D. Guy, Gamze F. Karaca, and Anna Mae Diehl. “HEDGEHOG PATHWAY INHIBITOR IS A SAFE AND EFFECTIVE TREATMENT FOR HEPATOCELLULAR CARCINOMA IN MDR2-/- MICE WITH CHRONIC LIVER DISEASE.” In Hepatology, 52:1146A-1146A. WILEY-BLACKWELL, 2010.Link to Item
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Suzuki, Ayako, Martin Binks, Alessia Omenetti, Cynthia D. Guy, Aurora D. Pryor, Yiping Pan, Melissa M. Smith, Anna Mae Diehl, and Manal F. Abdelmalek. “DEPRESSION AND ANXIETY SCORES ARE INDEPENDENTLY ASSOCIATED WITH HISTOLOGIC SEVERITY IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 52:626A-626A. WILEY-BLACKWELL, 2010.Link to Item
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Syn, Wing-Kin, Steve S. Choi, Evaggelia Liaskou, Gamze F. Karaca, Ye H. Oo, Thiago A. Pereira, Syamal D. Bhattacharya, et al. “OSTEOPONTIN PROMOTES NONALCOHOLIC FATTY LIVER DISEASE PROGRESSION.” In Hepatology, 52:350A-351A. WILEY-BLACKWELL, 2010.Link to Item
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Abdelmalek, Manal, Ayako Suzuki, Cynthia Guy, Alastair Smith, Babatunde Adeyefa, YiPing Pan, Melissa Smith, and Anna Mae Diehl. “Statin Therapy Decreases Risk of Hepatic Steatosis and Lobular Inflammation in Patients with Nonalcoholic Fatty Liver Disease.” In American Journal of Gastroenterology, 105:S116–S116. Ovid Technologies (Wolters Kluwer Health), 2010. https://doi.org/10.14309/00000434-201010001-00313.Full Text
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Diehl, A. M. “HEDGEHOG PATHWAY ACTIVATION AND PATHOGENESIS OF CIRRHOSIS IN ALCOHOLIC AND NONALCOHOLIC FATTY LIVER DISEASE.” In Alcoholism Clinical and Experimental Research, 34:59A-59A. WILEY-BLACKWELL PUBLISHING, INC, 2010.Link to Item
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Sicklick, J. K., J. Wang, J. Huang, W. Chen, and A. M. Diehl. “Paradoxical Effects of Smo Proto-Oncogene Overexpression in Hepatocytes.” In Annals of Surgical Oncology, 17:S23–24. SPRINGER, 2010.Link to Item
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Abdelmalek, Manal F., Mariana Lazo, Susanne Bonekamp, Anna Mae Diehl, and Jeanne M. Clark. “INCREASED DIETARY FRUCTOSE IMPAIRS HEPATIC ATP HOMEOSTASIS IN NAFLD.” In Hepatology, 50:777A-777A. JOHN WILEY & SONS INC, 2009.Link to Item
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Choi, Steve S., Rafal P. Witek, Wing-Kin Syn, Alessia Omenetti, Gamze F. Karaca, Youngmi Jung, Vanessa S. Teaberry, and Anna Mae Diehl. “INTERACTION BETWEEN HEDGEHOG PATHWAY SIGNALING AND LEPTIN IN RAT HEPATIC STELLATE CELLS.” In Hepatology, 50:828A-828A. JOHN WILEY & SONS INC, 2009.Link to Item
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Kistler, Kristin, Elizabeth M. Brunt, Jeanne M. Clark, Anna Mae Diehl, and Jeffrey B. Schwimmer. “PHYSICAL ACTIVITY RECOMMENDATIONS, EXERCISE INTENSITY, AND HISTOLOGICAL SEVERITY OF NONALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 50:388A-388A. JOHN WILEY & SONS INC, 2009.Link to Item
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Pereira, Thiago A., Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Youngmi Jung, Gamze F. Karaca, Alessia Omenetti, Fausto E. Pereira, and Anna Mae Diehl. “HEDGEHOG SIGNALING, STELLATE CELL/ENDOTHELIAL CELL CROSS-TALK AND PROGRESSION OF VIRAL HEPATITIS.” In Hepatology, 50:935A-935A. JOHN WILEY & SONS INC, 2009.Link to Item
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Soeda, Junpei, Maelle Morgan, Chad Mckee, Barbara Sigalo, Clare Selden, Humphrey Julian F. Hodgson, Tania Roskams, Anna Mae Diehl, and Jude A. Oben. “NICOTINE INDUCES STEREOTYPIC FIBROGENIC CHANGES IN HUMAN PRIMARY HEPATIC STELLATE CELLS, VIA PI-3 AND P38 MAP KINASES, TRANSIDUCED THROUGH NICOTINIC ACETYLCHOLINE RECEPTORS, UPREGULATED IN HUMAN FIBROTIC NON-ALCOHOLIC STEATOHEPATITIS.” In Hepatology, 50:825A-825A. JOHN WILEY & SONS INC, 2009.Link to Item
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Suzuki, Ayako, Cynthia D. Guy, Alastair D. Smith, Eric J. DeMaria, Yiping Pan, Melissa M. Smith, Anna Mae Diehl, and Manal F. Abdelmalek. “GENDER AND HORMONAL STATUS ARE ASSOCIATED WITH SEVERITY OF HISTOLOGIC FEATURES AMONG PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 50:772A-773A. JOHN WILEY & SONS INC, 2009.Link to Item
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Syn, Wing-Kin, Ye Htun Oo, Rafal P. Witek, Thiago A. Pereira, Youngmi Jung, Gamze F. Karaca, Alessia Omenetti, et al. “HEDGEHOG-RELATED ACCUMULATION OF NKT CELLS PROMOTES FIBROGENESIS IN PROGRESSIVE NON ALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 50:351A-351A. JOHN WILEY & SONS INC, 2009.Link to Item
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Teaberry, Vanessa S., Gamze F. Karaca, Rafal P. Witek, Wing-Kin Syn, Alessia Omenetti, Youngmi Jung, Steve S. Choi, and Anna Mae Diehl. “NOVEL ROLE FOR HEDGEHOG PATHWAY ACTIVATION IN THE PATHOGENESIS OF PRIMARY SCLEROSING CHOLANGITIS.” In Hepatology, 50:995A-995A. JOHN WILEY & SONS INC, 2009.Link to Item
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Wang, Michael, Mark Palmeri, Ned Rouze, Veronica Rotemberg, Barry Moser, Cynthia D. Guy, Anna Mae Diehl, Manal F. Abdelmalek, and Kathryn Nightingale. “NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS WITH QUANTITATIVE ACOUSTIC RADIATION FORCE METHODS.” In Hepatology, 50:743A-744A. JOHN WILEY & SONS INC, 2009.Link to Item
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Witek, Rafal P., Thiago A. Pereira, Wing-Kin Syn, Youngmi Jung, Kolade M. Agboolo, Steve S. Choi, and Anna Mae Diehl. “TRANSIENT HEDGEHOG PATHWAY ACTIVATION AND ACCUMULATION OF HEDGEHOG-RESPONSIVE MYOFIBROBLASTS PRECEDE EXPANSION OF LIVER EPITHELIAL PROGENITORS AFTER ACUTE CARBON TETRACHLORIDE INJURY.” In Hepatology, 50:822A-822A. JOHN WILEY & SONS INC, 2009.Link to Item
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Omenetti, Alessia, Liu Yang, Raul R. Gainetdinov, Steve S. Choi, Rafal P. Witek, Youngmi Jung, Wing-Kin Syn, Wei Chen, Marc G. Caron, and Anna Mae Diehl. “Myofibroblasts Promote the Growth of Biliary Tree During Cholestatic Liver Injury By Suppressing Tryptophan Hydroxylase 2 (TPH2) Expression and Serotonin Secretion in Neighboring Cholangiocytese.” In Gastroenterology, 136:A800–A800. W B SAUNDERS CO-ELSEVIER INC, 2009.Link to Item
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Suzuki, Ayako, Manal F. Abdelmalek, Cynthia D. Guy, Jeffrey Schwimmer, Joel E. Lavine, A. O. Scheimann, and Anna Mae Diehl. “Sexual Development and Its Influence On Regional Anthropometric Measures and Histologic Features Among Pediatric Patients with NAFLD.” In Gastroenterology, 136:A845–A845. W B SAUNDERS CO-ELSEVIER INC, 2009.Link to Item
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Choi, Steve S., Rafal P. Witek, Alessia Omenetti, Liu Yang, Wing-Kin Syn, Youngmi Jung, Jason K. Sicklick, and Anna Mae Diehl. “Sustained Activation of RAC1 Enhances Hedgehog-Mediated Epithelial-Mesenchymal Transition in Mice with Chronic Liver Injury.” In Gastroenterology, 136:A792–A792, 2009.Link to Item
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Jung, Youngmi, Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Alessia Omenetti, and Anna Mae Diehl. “Specific Inhibition of Ikk beta in Hepatocytes Induces Proliferation of Liver Progenitors in Injured Livers.” In Gastroenterology, 136:A789–A789, 2009.Link to Item
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Choi, Steve S., Alessia Omenetti, Rafal P. Witek, Xiu-Rong Ren, Liu Yang, Wing-Kin Syn, Jason K. Sicklick, Youngmi Jung, Wei Chen, and Anna Mae Diehl. “SUSTAINED ACTIVATION OF RAC1 ENHANCES HEDGEHOG-MEDIATED EPITHELIAL-MESENCHYMAL TRANSITION IN CULTURED RAT HEPATIC STELLATE CELLS.” In Hepatology, 48:380A-381A. JOHN WILEY & SONS INC, 2008.Link to Item
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Jung, Youngmi, Cynthia D. Guy, Liu Yang, Manal F. Abdelmalek, and Anna Mae Diehl. “PROGRESSIVE HEDGEHOG PATHWAY ACTIVATION ACCOMPANIES THE DUCTULAR REACTION DURING NAFLD PROGRESSION IN MICE AND HUMANS.” In Hepatology, 48:829A-829A. JOHN WILEY & SONS INC, 2008.Link to Item
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Lazo, Mariana, Steven F. Solga, Alena Horska, Susanne Bonekamp, Anna Mae Diehl, Frederick L. Brancati, and Jeanne Clark. “THE EFFECT OF ONE YEAR OF INTENSIVE LIFESTYLE INTERVENTION ON HEPATIC STEATOSIS.” In Hepatology, 48:812A-812A. JOHN WILEY & SONS INC, 2008.Link to Item
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Moylan, Cynthia A., Steve S. Choi, Chaitanya R. Acharya, Kelly Salter, Andrew J. Muir, Anil Potti, and Anna Mae Diehl. “GENE EXPRESSION PROFILES COUPLED WITH SIGNATURES OF ONCOGENIC PATHWAY DYSREGULATION PROVIDE A RATIONAL APPROACH TO DISSECTING THE MOLECULAR HETEROGENEITY OF HEPATOCELLULAR CARCINOMA.” In Hepatology, 48:1120A-1120A. JOHN WILEY & SONS INC, 2008.Link to Item
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Oben, Jude A., Chad Mckee, Zhiping Li, Tonic Roskams, and Anna Moe Diehl. “PROPRANOLOL PROMOTES OVAL CELL ACCUMULATION BY ENHANCING HEPATOCYTE DEATH IN NON ALCOHOLIC STEATOHEPATITIS.” In Hepatology, 48:831A-831A. JOHN WILEY & SONS INC, 2008.Link to Item
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Omenetti, Alessia, Wing-Kin Syn, Youngmi Jung, Rafal P. Witek, Steve S. Choi, M Eric Gershwin, and Anna Mae Diehl. “PARACRINE HEDGEHOG SIGNALING BETWEEN CHOLANGIOCYTES AND MYOFIBROBLASTS PROMOTES NKT CELL MIGRATION TOWARDS BILIARY EPITHELIAL CELLS: A NOVEL MECHANISM FOR NKT CELL ACCUMULATION IN PRIMARY BILIARY CIRRHOSIS.” In Hepatology, 48:595A-596A. JOHN WILEY & SONS INC, 2008.Link to Item
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Suzuki, Ayako, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “GENDER-SPECIFIC ASSOCIATIONS BETWEEN REGIONAL ANTHROPOMETRIC MEASURES AND HEPATIC FIBROSIS IN PATIENTS WITH NAFLD.” In Hepatology, 48:804A-804A. JOHN WILEY & SONS INC, 2008.Link to Item
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Suzuki, Ayako, Nancy A. Yuen, John S. Walsh, Kim K. Adkison, Julie I. Papay, Katarino Ilic, Anna Mae Diehl, and Christine M. Hunt. “POSSIBLE MODULATION OF ACETAMINOPHEN-ASSOCIATED LIVER INJURY BY DIVERSE CO-MEDICATIONS IN THE AERS DATABASE - A QUANTITATIVE SIGNAL DETECTION ANALYSIS.” In Hepatology, 48:471A-472A. JOHN WILEY & SONS INC, 2008.Link to Item
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Syn, Wing-Kin, Liu Yang, Youngmi Jung, Rafal P. Witek, Steve S. Choi, Alessia Omenetti, and Anna Mae Diehl. “HEDGEHOG PATHWAY ACTIVATION PROMOTES HEPATIC FIBROSIS IN MICE WITH DIET-INDUCED NON-ALCOHOLIC STEATOHEPATITIS.” In Hepatology, 48:828A-829A. JOHN WILEY & SONS INC, 2008.Link to Item
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Syn, Wing-Kin, Rafal P. Witek, Youngmi Jung, Steve S. Choi, Alessia Omenetti, and Anna Mae Diehl. “HEDGEHOG ACTIVATES AND MODULATES HEPATIC INVARIANT NKT (INKT) RESPONSES.” In Hepatology, 48:1001A-1001A. JOHN WILEY & SONS INC, 2008.Link to Item
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Witek, Rafal P., Renshui Liu, Wing-Kin Syn, Youngmi Jung, Alessia Omenetti, Liu Yang, Steve S. Choi, Wei Chen, and Anna Mae Diehl. “EXOSOMES RELEASED BY HEPATIC STELLATE CELLS AND IMMATURE BILIARY EPITHELIAL CELLS CONTAIN BIOLOGICALLY-ACTIVE HEDGEHOG LIGANDS.” In Hepatology, 48:407A-407A. JOHN WILEY & SONS INC, 2008.Link to Item
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Brown, Kevin D., Jude A. Oben, Barbara Sigala, Liu Yang, Alessia Omenetti, Jason K. Sicklick, Hendrika Vandongen, and Anna Mae Diehl. “Hedgehog signaling pathway in primary human hepatic stellate cells.” In Gastroenterology, 134:A798–A798, 2008.Link to Item
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Choi, Steve S., Alessia Omenetti, Liu Yang, Rafal P. Witek, Kevin D. Brown, Mercedes Vazquez-Chantada, Jiawen Huang, et al. “Culture activation of murine hepatic stellate cells involves hedgehog pathway activation and epithelial-to-mesenchymal transitions.” In Gastroenterology, 134:A797–A797, 2008.Link to Item
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Jung, Youngmi, Kevin D. Brown, Rafal P. Witek, Alessiar Omenetti, Liu Yang, Hendrika Vandongen, Richard J. Milton, et al. “Increased short-term risk for liver-related mortality parallels accumulation of hedgehog-responsive progenitors in patients with alcoholic steatohepatitis.” In Gastroenterology, 134:A785–A785, 2008.Link to Item
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Morgan, M., B. Sigala, C. Selden, A. M. Diehl, and J. A. Oben. “482 ACETYLCHOLINE INDUCES FIBROGENIC EFFECTS IN HUMAN PRIMARY HEPATIC STELLATE CELLS.” In Journal of Hepatology, 48:S183–S183. Elsevier BV, 2008. https://doi.org/10.1016/s0168-8278(08)60484-5.Full Text
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Omenetti, Alessia, Alessandro Porrello, Wing-Kin Syn, Steve S. Choi, Youngmi Jung, Liu Yang, Kevin D. Brown, Rafal P. Witek, Hendrika Vandongen, and Anna Mae Diehl. “Myofibroblast-derived soluble factors upregulate chemokine gene expression in neighboring cholangiocytes.” In Gastroenterology, 134:A776–A776, 2008.Link to Item
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Witek, Rafal P., Renshui Liu, Liu Yang, Youngmi Jung, Kevin Brown, Alessia Omenetti, Mercedes Vazquez-Chantada, et al. “Liver-derived microparticles carry biologically-active Hedgehog morphogens, in blood and bile.” In Gastroenterology, 134:A570–A570, 2008.Link to Item
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Yang, Liu, Youngmi Jung, Jiawen Huang, Alessia Omenetti, Rafal P. Witek, Steve S. Choi, Gianfranco Alpini, and Anna Mae Diehl. “Glial fibrillary acidic protein(+) progenitors regenerate adult livers.” In Gastroenterology, 134:A768–69, 2008.Link to Item
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Abdelmalek, Monal F., Ayako Suzuki, Cynthia Guy, Richard J. Johnson, and Anna Mae Diehl. “Fructose induced hyperuricemia as a causal mechanism for nonalcoholic fatty liver disease.” In Hepatology, 46:293A-293A. JOHN WILEY & SONS INC, 2007.Link to Item
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Clark, Jeanne M., Mark Van Natta, David Kleiner, Naga P. Chalasani, Arthur J. McCullogh, Brent A. Neuschwander-Tetri, Aynur Uenalp, Jay H. Hoofnagle, and Anna Mae Diehl. “Association of AST and ALT with liver histology in adults with NAFLD.” In Hepatology, 46:738A-738A. JOHN WILEY & SONS INC, 2007.Link to Item
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Omenetti, Alessia, Alessandro Porrello, Yury Popov, Liu Yang, Youngmi Jung, Hendrika M. Vandongen, Detlef Schuppan, and Anna Mae Diehl. “Hedgehog signaling and epithelial mesenchymal transitions during biliary fibrosis.” In Hepatology, 46:336A-336A. JOHN WILEY & SONS INC, 2007.Link to Item
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Suzuki, Ayako, Ronald Sha, Amy Wachholtz, Martin Binks, and Anna Mae Diehl. “Influence of impaired glucose tolerance, glucose control status, light to moderate alcohol consumption, and reduced carbohydrate diets on serum ALT change during rapid weight loss in the residential weight loss program.” In Hepatology, 46:740A-740A. JOHN WILEY & SONS INC, 2007.Link to Item
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Yang, Liu, Ying Wang, Huo Mao, Susanne Fleig, Alessia Omenetti, Kevin Brown, Jason K. Sicklick, Yin-Xiong Li, and Anna Mae Diehl. “Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells.” In Hepatology, 46:866A-867A. JOHN WILEY & SONS INC, 2007.Link to Item
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Wang, Jiangbo, Renshui Liu, Michael Bond, Minyong Chen, Simandra Singh, Francis Ali-Osman, Robert J. Lefkowitz, et al. “Targeting hedgehog signaling in medulloblastoma.” In Neuro Oncology, 9:560–61. DUKE UNIV PRESS, 2007.Link to Item
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Jhaveri, Ravi, John G. McHutchison, Keyur Patel, and Anna Mae Diehl. “The role of hepatitis C genotype 3 core protein domain 3 in intrahepatic steatosis.” In Hepatology, 44:300A-300A. JOHN WILEY & SONS INC, 2006.Link to Item
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Omenetti, Alessia, Yin-Xiong Li, Liu Yang, Jason K. Sicklick, Steve Choi, Ayako Suzuki, and Anna Mae Diehl. “Mesenchymal-epithelial signalling by the Hedgehog pathway promotes proliferation of bile ductular cells.” In Hepatology, 44:389A-389A. WILEY-BLACKWELL, 2006.Link to Item
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Omenetti, Alessia, Yin-Xiong Li, Wei Chen, Raul R. Gainetdinov, Liu Yang, and Anna Mae Diehl. “Cross-talk between hepatic stellate cells and cholangiocytes regulates biliary growth through serotonin.” In Hepatology, 44:392A-393A. WILEY, 2006.Link to Item
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Suzuki, Ayako, Martin Binks, Ronald Sha, Howard Eisenson, and Anna Mae Diehl. “Influence of lifestyle factors and comorbidities on liver function in patients undergoing weight loss treatment.” In Hepatology, 44:646A-646A. JOHN WILEY & SONS INC, 2006.Link to Item
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Yamaguchi, Kanji, Liu Yang, Shannon McCall, Jiawen Huang, Xing Xian Yu, Sanjay K. Pandey, Sanjay Bhanot, Brett P. Monia, Yin-Xiong Li, and Anna Mae Diehl. “DGAT1 ASO treatment reduces hepatic fibrosis without improving hepatic steatosis in DB/DB mice fed methionine choline deficient diets.” In Hepatology, 44:663A-663A. JOHN WILEY & SONS INC, 2006.Link to Item
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Yamaguchi, Kanji, Liu Yang, Shannon McCall, Jiawen Huang, Xing Xian Yu, Sanjay K. Pandey, Sanjay Hanot, Brett P. Monia, Yin-Xiong Li, and Anna Mae Diehl. “DGAT2 aso treatment improves hepatic steatosis, but not fibrosis in DB/DB mice fed methionine choline deficient diets.” In Hepatology, 44:665A-665A. JOHN WILEY & SONS INC, 2006.Link to Item
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Zhao, Caiyan, Wei Chen, Liu Yang, Lihong Chen, Stephen A. Stimpson, and Anna Mae Diehl. “Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced plasminogen activator inhibitor-1 expression in human stellate cells by interfering with Smad3 phosphorylation.” In Hepatology, 44:690A-690A. JOHN WILEY & SONS INC, 2006.Link to Item
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Yamaguchi, Kanji, Bonny B. Yuen, Terese Camp, Marzdena Zdanowicz, Jason Sicklick, David Hinton, Anna Mae Diehl, and Yin-Xiong Li. “A novel model for harvesting adult liver progenitor cells.” In Hepatology, 44:473A-473A. JOHN WILEY & SONS INC, 2006.Link to Item
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Diehl, A. M. “Role of insulin resistance and extrahepatic signalling in fatty liver disease.” In Disease Progression and Disease Prevention in Hepatology and Gastroenterology, edited by P. R. Galle, W. E. Schmidt, G. Gerken, and B. Wiedenmann, 150:167–72. SPRINGER, 2006.Link to Item
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Sicklick, J. K., M. Rojkind, Y. Qi, W. Chen, M. Bustamante, S. S. Choi, J. W. Huang, et al. “Hedgehog signaling in hepatic stellate cells from adult mice and rats.” In Hepatology, 42:733A-733A. JOHN WILEY & SONS INC, 2005.Link to Item
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Sicklick, J. K., Y. X. Li, A. Melhem, E. Schmelzer, M. Zdanowicz, J. W. Huang, M. Caballero, et al. “Conserved hedgehog pathway regulation of murine and human hepatic progenitors throughout life.” In Hepatology, 42:740A-740A. JOHN WILEY & SONS INC, 2005.Link to Item
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Choi, S. S., J. W. Huang, J. K. Sicklick, Q. Ma, J. T. Camp, P. J. Goldschmidt-Clermont, and A. M. Diehl. “Rac over-expression in activated hepatic stellate cells increases susceptibility to liver injury.” In Hepatology, 42:267A-267A. JOHN WILEY & SONS INC, 2005.Link to Item
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Sicklick, J. K., A. Jayaraman, R. Kannangai, M. S. Torbenson, M. A. Choti, and A. M. Diehl. “Hedgehog signaling correlates with hepatocellular carcinoma progression.” In Journal of Clinical Oncology, 23:863S-863S. AMER SOC CLINICAL ONCOLOGY, 2005.Link to Item
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Sun, Z. L., Q. Z. Zheng, Y. Nagakawa, G. M. Williams, R. A. Montgomery, A. M. Diehl, and A. S. Klein. “Repopulation of liver allografts by recipient-derived progenitor cells via mixed cell fusion and transdifferentiation: A new insight of tolerance and regeneration.” In American Journal of Transplantation, 5:513–513. BLACKWELL PUBLISHING, 2005.Link to Item
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Zdanowicz, M., J. K. Sicklick, A. M. Diehl, and Y. X. Li. “A zebrafish model of Fetal Alcohol Syndrome parallels Hedgehog signaling defects.” In Alcoholism Clinical and Experimental Research, 29:86A-86A. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Hernandez-Perez, E., M. Bustamante, G. Desierto, J. Sicklick, A. M. Diehl, and M. Rojkind. “Hepatic Stellate cell heterogeneity may reflect cells at different stages of differentiation.” In Faseb Journal, 19:A479–A479. FEDERATION AMER SOC EXP BIOL, 2005.Link to Item
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Torbenson, A., R. Kannangai, M. Rojkind, J. Sicklick, and A. M. Diehl. “Hepatic angiomyolipomas share a similar gene expression profile with hepatic stellate cells.” In Laboratory Investigation, 85:288A-288A. NATURE PUBLISHING GROUP, 2005.Link to Item
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Torbenson, M., R. Kannangai, M. Rojkind, J. Sicklick, and A. M. Diehl. “Hepatic Angiomyolipomas share a similar gene expression profile with hepatic stellate cells.” In Modern Pathology, 18:288A-288A, 2005.Link to Item
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Li, Z. P., R. A. Anders, Y. X. Fu, and A. M. Diehl. “Natural killer T cells regulate liver regeneration.” In Hepatology, 40:182A-182A. JOHN WILEY & SONS INC, 2004.Link to Item
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Li, Z. P., and A. M. Diehl. “Dietary factors influence hepatic innate immune system and inflammation.” In Hepatology, 40:285A-285A. JOHN WILEY & SONS INC, 2004.Link to Item
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Sicklick, J., J. W. Huang, H. Z. Lin, S. Karhadkar, P. Beachy, and A. M. Diehl. “Activation of embryonic developmental programs in non-alcoholic fatty liver disease.” In Hepatology, 40:196A-196A. JOHN WILEY & SONS INC, 2004.Link to Item
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Diehl, A. M., and M. F. Abdelmalik. “Nash: Bench to bedside - lessons from animal Models,” 3–15. Springer Netherlands, n.d. https://doi.org/10.1007/978-1-4020-6523-1_1.Full Text
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