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Anna Mae Diehl

Florence McAlister Distinguished Professor of Medicine
Medicine, Gastroenterology
Duke Box 3256, 905 S. LaSalle Street, GSRB 1, Durham, NC 27710
Ste 1073, GSRB 1, 595 LaSalle Street, Durham, NC 27710

Selected Grants


Targeting Hepatocyte Senescence to Improve NAFLD

ResearchMentor · Awarded by National Institutes of Health · 2024 - 2029

The Duke Preparing Research scholars In bioMEdical sciences (PRIME): Cancer Research Program

ResearchPreceptor · Awarded by National Institutes of Health · 2023 - 2028

Genomic Imprinting in the Development of NAFLD

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2024 - 2028

Therapeutic modulation of a proteomic HCC risk signature with statins in patients with liver cirrhosis

ResearchPrincipal Investigator · Awarded by University of Texas - Southwestern · 2023 - 2027

Duke Training Grant in Digestive Diseases and Nutrition

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1988 - 2027

Targeting Hepatocyte Senescence to Improve NAFLD

ResearchMentor · Awarded by National Institutes of Health · 2024 - 2029

The Duke Preparing Research scholars In bioMEdical sciences (PRIME): Cancer Research Program

ResearchPreceptor · Awarded by National Institutes of Health · 2023 - 2028

Genomic Imprinting in the Development of NAFLD

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2024 - 2028

Therapeutic modulation of a proteomic HCC risk signature with statins in patients with liver cirrhosis

ResearchPrincipal Investigator · Awarded by University of Texas - Southwestern · 2023 - 2027

Duke Training Grant in Digestive Diseases and Nutrition

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1988 - 2027

Building Interdisciplinary Research Careers in Women's Health - BIRCWH

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2027

Prediction and Prevention of Hepatic Decompensation in Patients with Cirrhosis

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026

Inventiva NATiV3

Clinical TrialPrincipal Investigator · Awarded by Inventiva · 2022 - 2025

The Imprinted Gene Network in the programming of non-alcoholic fatty liver disease by early life cadmium exposure

ResearchPrincipal Investigator · Awarded by North Carolina State University · 2020 - 2025

Hepta Bio - Biorepository

ResearchPrincipal Investigator · Awarded by Hepta Bio, Inc. · 2023 - 2024

Hepatic Lipotoxicity, Metabolic Homeostasis and NAFLD Pathogenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2024

Hippo-Yap Pathway, Ferroptosis of Hepatic Stellate Cells and Liver Fibrosis

ResearchPrincipal Investigator · Awarded by American Association for the Study of Liver Diseases · 2021 - 2024

TNF Alpha and Recovery from Alcoholic Liver Injury

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2024

Vitamin E Dosing Study (VEDS): A dose finding clinical trial of vitamin E for the treatment of adult NAFLD

Clinical TrialPrincipal Investigator · Awarded by Johns Hopkins University · 2022 - 2024

Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2024

Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

Postdoctoral Training in Genomic Medicine Research

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2017 - 2023

Is Heart Failure with Preserved Edection Fraction the Symptomatic Manifestation of Liver Disease

ResearchCollaborator · Awarded by American Heart Association · 2021 - 2022

Hedgehog Signaling and Adult Liver Regeneration

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2022

Transmission electron microscope (TEM)

EquipmentMajor User · Awarded by National Institutes of Health · 2019 - 2021

Pathophysiological Role of Glutaminolysis in Human NAFLD Progression

ResearchPrincipal Investigator · Awarded by American Association for the Study of Liver Diseases · 2018 - 2020

TAIWANJ JKB 121-001

Clinical TrialPrincipal Investigator · Awarded by TaiwanJ Pharmaceuticals Co. Ltd · 2015 - 2020

Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease

ResearchMentor · Awarded by American Association for the Study of Liver Diseases · 2018 - 2020

Epigenetics and the Development of Nonalcoholic Fatty Liver Disease

ResearchMentor · Awarded by American College of Gastroenterology · 2015 - 2019

Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma

ResearchPrincipal Investigator · Awarded by Fibrolamellar Cancer Foundation · 2016 - 2019

Submucosal esophageal structures as a progenitor niche for esophageal repair

ResearchMentor · Awarded by National Institutes of Health · 2013 - 2018

Serial Block Face Scanning Electron Microscope

EquipmentMajor User · Awarded by National Institutes of Health · 2016 - 2018

Impact of IMM-124E on Innate Immune and Fibrogenic Responses in Preclinical Mouse Model of NASH

ResearchPrincipal Investigator · Awarded by Immuron, Ltd · 2016 - 2018

Impact of Fructose on Metabolism, Energy Homeostasis and MR biomarkers in NAFLD

ResearchCollaborator · Awarded by National Institutes of Health · 2012 - 2016

Pathogenesis of NASH Cirrhosis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2016

Cancer Biology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 1993 - 2016

Liver Disease in Obesity

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1999 - 2015

TNF Alpha and Recovery from Alchoholic Liver Injury

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 2014

Rac1 Promotes Hepatic Stellate Accumulation/Activation in Liver Injury

ResearchMentor · Awarded by National Institutes of Health · 2009 - 2014

Characterizing Alcohol's Effects on Repair of Liver Injury

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2012

Hyperinsulimia and Insulin Resistance in Nonalcoholic Fatty Liver Disease

Clinical TrialMentor · Awarded by National Institutes of Health · 2006 - 2010

Cholesterol, Hedgehog Signaling & Fetal Alcohol Syndrome

ResearchCo Investigator · Awarded by National Institutes of Health · 2007 - 2010

Drug Abuse: Discovering Ligands for Pertinent GPCRs

ResearchCollaborator · Awarded by National Institutes of Health · 2006 - 2010

Innovative Assays for Oncogenic Hedgehog Signaling

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2010

Liver Derived Microparticles In Cirrhosis Pathogenesis

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2009

Metabolic Profiling to Identify Alcohol Biomarker Signature

ResearchCo Investigator · Awarded by National Institutes of Health · 2006 - 2009

Bioenergetics and Alcoholic Liver Disease Pathogenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2006

External Relationships


  • American Association for Study of Liver Diseases and American Gastroenterological Association
  • American Association for the Study of Liver Disease (AASLD)
  • Boehringer Ingleheim
  • International Society for Cells of Hepatic Sinusoid
  • Keystone Symposia
  • American Association for Study of Liver Diseases and American Gastroenterological Association
  • American Association for the Study of Liver Disease (AASLD)
  • Boehringer Ingleheim
  • International Society for Cells of Hepatic Sinusoid
  • Keystone Symposia
  • LA CATS (Lousiana CTSA)
  • NCI
  • NIAAA
  • Northern Ohio Alcohol Research Center
  • University of Louisville
  • University of Massachusetts Worster
  • University of Pittsburgh

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.