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Dorlan J Kimbrough

Dorlan J Kimbrough

Assistant Professor of Neurology
Neurology, MS & Neuroimmunology
DUMC Box 3849, Durham, NC 27710
40 Duke Medicine Circle, Clinic 1L, Durham, NC 27710

Selected Publications

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.

Journal Article Science · September 27, 2019 We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), ... Full text Link to item Cite

Early complement genes are associated with visual system degeneration in multiple sclerosis.

Journal Article Brain · September 1, 2019 Multiple sclerosis is a heterogeneous disease with an unpredictable course and a wide range of severity; some individuals rapidly progress to a disabled state whereas others experience only mild symptoms. Though genetic studies have identified variants tha ... Full text Link to item Cite

Brain and retinal atrophy in African-Americans versus Caucasian-Americans with multiple sclerosis: a longitudinal study.

Journal Article Brain · November 1, 2018 On average, African Americans with multiple sclerosis demonstrate higher inflammatory disease activity, faster disability accumulation, greater visual dysfunction, more pronounced brain tissue damage and higher lesion volume loads compared to Caucasian Ame ... Full text Link to item Cite

Retinal damage and vision loss in African American multiple sclerosis patients.

Journal Article Ann Neurol · February 2015 OBJECTIVE: To determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian American (CA) MS patients. METHODS: A total of 687 MS patients (81 AAs) and 110 healthy control ( ... Full text Link to item Cite

Predictors of recurrence following an initial episode of transverse myelitis.

Journal Article Neurol Neuroimmunol Neuroinflamm · June 2014 OBJECTIVE: This study sought to identify factors that increased the risk of recurrence after an initial transverse myelitis (TM) presentation. METHODS: Retrospective cohort study of 192 patients initially presenting with TM of unknown etiology. Patients di ... Full text Link to item Cite

Treatment of Neuromyelitis Optica: Review and Recommendations.

Journal Article Mult Scler Relat Disord · October 2012 Neuromyelitis optica (NMO) is an autoimmune demyelinating disease preferentially targeting the optic nerves and spinal cord. Once regarded as a variant of multiple sclerosis (MS), NMO is now recognized to be a different disease with unique pathology and im ... Full text Link to item Cite