Dorothy Anna Sipkins
Associate Professor of Medicine
Current Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2020
- Associate Research Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2017
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- DUMC 103867, Durham, NC 27710
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dorothy.sipkins@duke.edu
- Background
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Education, Training, & Certifications
- Hematology-Oncology Fellowship, Hematology Oncology, Dana-Farber Cancer Institute 2001 - 2005
- Internship and Residency, Internal Medicine, Massachusetts General Hospital 1999 - 2001
- M.D., Stanford University, School of Medicine 1999
- Ph.D., Stanford University, School of Medicine 1999
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Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2017 - 2020
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2016 - 2017
- Instructor Temporary in the Department of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2014 - 2016
- Recognition
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In the News
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JUL 18, 2018 -
MAY 26, 2016 -
MAY 26, 2016 The Telegraph -
DEC 11, 2014 WRAL
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- Research
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Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health 1975 - 2026
- e Window trial to evaluate molecular response of PI3K inhibition with copanlisib in relapsed or refractory adult B-cell acute lymphoblastic leukemia awarded by Bayer HealthCare, LLC 2021 - 2026
- R01 Defining and targeting a novel pathway for central nervous system leptomeningeal metastasis awarded by National Institutes of Health 2022 - 2024
- A DUAL ROLE OF INTEGRIN ALPHA-3 IN BREAST CANCER CNS METASTASIS & CHEMORESISTANCE (F31) awarded by National Institutes of Health 2021 - 2024
- R21 Novel use of PI3K inhibition to prevent recurrence of B-cell acute lymphoblastic leukemia awarded by National Institutes of Health 2021 - 2023
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2023
- Defining the Rules of Breast Cancer Cell Traffic Through Bone awarded by National Institutes of Health 2017 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Targeting Dormant Breast Cancer Micrometastases to Prevent Disease Relapse awarded by American Cancer Society, Inc. 2019 - 2022
- Studying the Effects of Combined E-selectin and CXCR4 Inhibition on Breast Cancer Cell Immune Recognition awarded by GlycoMimetics, Inc 2020 - 2021
- Targeting sphingosine kinase 2 for the treatment of multiple myeloma awarded by National Institutes of Health 2015 - 2021
- Role of Osteopontin in Induction of Leukemia Dormancy in the Bone Marrow awarded by American Cancer Society, Inc. 2014 - 2018
- Studying the Effects of Combined E-Selectin/CXCR4 Inhibition on Breast Cancer Cell Metastasis, Growth and Immune Regulation awarded by GlycoMimetics, Inc 2016 - 2017
- Investigation of PI3Kdelta inhibitor activity in mouse xenograft models of pre-B acute lymphoblastic leukemia ALL awarded by Gilead Sciences, Inc. 2016 - 2017
- Investigation of CX-01 in InVitro Pre-Clinical Models of Leukemia awarded by Cantex Pharmaceuticals, Inc. 2015 - 2016
- Regulation of Leukemia Cell Dormancy by the Bone Marrow Microenvironment awarded by Gabrielle's Angel Foundation 2014 - 2015
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External Relationships
- Zentalis Pharmaceuticals (formerly Zeno Pharma)
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Whiteley, Andrew E., Trevor T. Price, Gaia Cantelli, and Dorothy A. Sipkins. “Leukaemia: a model metastatic disease.” Nat Rev Cancer 21, no. 7 (July 2021): 461–75. https://doi.org/10.1038/s41568-021-00355-z.Full Text Open Access Copy Link to Item
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Yao, Hisayuki, Trevor T. Price, Gaia Cantelli, Brandon Ngo, Matthew J. Warner, Lindsey Olivere, Sarah M. Ridge, et al. “Leukaemia hijacks a neural mechanism to invade the central nervous system.” Nature 560, no. 7716 (August 2018): 55–60. https://doi.org/10.1038/s41586-018-0342-5.Full Text Link to Item
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Price, Trevor T., Monika L. Burness, Ayelet Sivan, Matthew J. Warner, Renee Cheng, Clara H. Lee, Lindsey Olivere, et al. “Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone.” Sci Transl Med 8, no. 340 (May 25, 2016): 340ra73. https://doi.org/10.1126/scitranslmed.aad4059.Full Text Link to Item
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Price, Trevor, and Dorothy A. Sipkins. “Rewiring the niche: sympathetic neuropathy drives malignant niche transformation.” Cell Stem Cell 15, no. 3 (September 4, 2014): 261–62. https://doi.org/10.1016/j.stem.2014.08.012.Full Text Link to Item
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Fox, Matthew F., Andrea Pontier, Sandeep Gurbuxani, and Dorothy A. Sipkins. “Stem cell factor expression in B cell malignancies is influenced by the niche.” Leuk Lymphoma 54, no. 10 (October 2013): 2274–80. https://doi.org/10.3109/10428194.2013.777067.Full Text Link to Item
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Boyerinas, Benjamin, Maya Zafrir, Ali E. Yesilkanal, Trevor T. Price, Elizabeth M. Hyjek, and Dorothy A. Sipkins. “Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy.” Blood 121, no. 24 (June 13, 2013): 4821–31. https://doi.org/10.1182/blood-2012-12-475483.Full Text Link to Item
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Boyerinas, Benjamin, and Dorothy A. Sipkins. “HSPCs in the balance: The vascular niche.” Cell Stem Cell 7, no. 6 (December 3, 2010): 645–46. https://doi.org/10.1016/j.stem.2010.11.021.Full Text Link to Item
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Burness, Monika L., and Dorothy A. Sipkins. “The stem cell niche in health and malignancy.” Semin Cancer Biol 20, no. 2 (April 2010): 107–15. https://doi.org/10.1016/j.semcancer.2010.05.006.Full Text Link to Item
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Sipkins, Dorothy A. “Rendering the leukemia cell susceptible to attack.” N Engl J Med 361, no. 13 (September 24, 2009): 1307–9. https://doi.org/10.1056/NEJMcibr0904291.Full Text Link to Item
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Colmone, Angela, Maria Amorim, Andrea L. Pontier, Sheng Wang, Elizabeth Jablonski, and Dorothy A. Sipkins. “Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells.” Science 322, no. 5909 (December 19, 2008): 1861–65. https://doi.org/10.1126/science.1164390.Full Text Link to Item
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Colmone, Angela, Maria Amorim, Andrea Pontier, Sheng Wang, Elizabeth Jablonski, and Dorothy A. Sipkins. “MALIGNANT GROWTH IN THE BONE MARROW CREATES ABNORMAL HEMATOPOIETIC PROGENITOR CELL NICHES.” Anticancer Research 28, no. 5C (September 1, 2008): 3555–3555.Link to Item
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Sipkins, Dorothy A. “Chemotherapy and the bone marrow stroma.” Leuk Lymphoma 49, no. 1 (January 2008): 17–18. https://doi.org/10.1080/10428190701784748.Full Text Link to Item
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Wei, Xunbin, Dorothy A. Sipkins, Costas M. Pitsillides, John Novak, Irene Georgakoudi, and Charles P. Lin. “Real-time detection of circulating apoptotic cells by in vivo flow cytometry.” Mol Imaging 4, no. 4 (October 2005): 415–16.Link to Item
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Sipkins, Dorothy A., Xunbin Wei, Juwell W. Wu, Judith M. Runnels, Daniel Côté, Terry K. Means, Andrew D. Luster, David T. Scadden, and Charles P. Lin. “In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.” Nature 435, no. 7044 (June 16, 2005): 969–73. https://doi.org/10.1038/nature03703.Full Text Link to Item
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Sipkins, D. A., K. Gijbels, F. D. Tropper, M. Bednarski, K. C. Li, and L. Steinman. “ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging.” J Neuroimmunol 104, no. 1 (April 3, 2000): 1–9. https://doi.org/10.1016/s0165-5728(99)00248-9.Full Text Link to Item
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Sipkins, D. A., D. A. Cheresh, M. R. Kazemi, L. M. Nevin, M. D. Bednarski, and K. C. Li. “Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging.” Nat Med 4, no. 5 (May 1998): 623–26. https://doi.org/10.1038/nm0598-623.Full Text Link to Item
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SIPKINS, D. A., I. Y. CHEN, C. K. SONG, D. A. CHERESH, M. D. BEDNARSKI, and K. C. LI. “MR-IMAGING OF TUMOR-INDUCED ANGIOGENESIS WITH ANTIBODY-CONJUGATED PARAMAGNETIC LIPOSOMES.” Radiology 197 (November 1, 1995): 129–129.Link to Item
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SIPKINS, D. A., K. GIJBELS, F. D. TROPPER, L. STEINMAN, and M. D. BEDNARSKI. “ANTIBODY-CONJUGATED PARAMAGNETIC LIPOSOMES - TISSUE-SPECIFIC CONTRAST AGENTS FOR DISEASE PROCESSES.” Radiology 197 (November 1, 1995): 276–276.Link to Item
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Storrs, R. W., F. D. Tropper, H. Y. Li, C. K. Song, D. A. Sipkins, J. K. Kuniyoshi, M. D. Bednarski, H. W. Strauss, and K. C. Li. “Paramagnetic polymerized liposomes as new recirculating MR contrast agents.” J Magn Reson Imaging 5, no. 6 (November 1995): 719–24. https://doi.org/10.1002/jmri.1880050617.Full Text Link to Item
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Storrs, R. W., F. D. Tropper, H. Y. Li, C. K. Song, J. K. Kuniyoshi, D. A. Sipkins, K. C. P. Li, and M. D. Bednarski. “Paramagnetic Polymerized Liposomes: Synthesis, Characterization, and Applications for Magnetic Resonance Imaging.” Journal of the American Chemical Society 117, no. 28 (January 1, 1995): 7301–6. https://doi.org/10.1021/ja00133a001.Full Text
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Book Sections
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Burger, J. A., and D. A. Sipkins. “The bone marrow microenvironment and its impact in acute and chronic B cell malignancies.” In Bone Marrow Lymphoid Infiltrates: Diagnosis and Clinical Impact, 35–45, 2013. https://doi.org/10.1007/978-1-4471-4174-7_3.Full Text
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Conference Papers
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Price, Trevor T., Clara H. Lee, Qing Cheng, H Kim Lyerly, William E. Fogler, John L. Magnani, and Dorothy A. Sipkins. “Abstract 3212: Metastatic breast cancer cell communication within a pro-dormancy bone marrow niche.” In Tumor Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-3212.Full Text
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Price, Trevor, Monika Burness, Ayelet Sivan, Renee Cheng, John L. Magnani, and Dorothy A. Sipkins. “Abstract 4831: Breast cancer cells metastasize to bone through E-selectin+ vascular gateways.” In Tumor Biology. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-4831.Full Text
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Horton, Brendan, Maya Zafrir, Pauline Wales, Andrea Pontier, Ayalew Tefferi, and Dorothy A. Sipkins. “Polycythemia Vera and Chronic Idiopathic Myelofibrosis CD34+ Cells Preferentially Traffic to Splenic Niches.” In Blood, 120:1750–1750. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.1750.1750.Full Text
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Agarwal, Rajiv, Frederick L. Locke, Rangesh Kunnavakkam, Koen van Besien, Richard A. Larson, Olatoyosi Odenike, Lucy Godley, et al. “A Phase II Prospective Feasibility Study of Clofarabine Cytoreduction Prior to Allogeneic Hematopoietic Cell Transplantation (HCT) for Patients with Relapsed or Refractory Acute Leukemias and Advanced Myelodysplastic Syndromes.” In Blood, 118:231–32. AMER SOC HEMATOLOGY, 2011.Link to Item
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Boyerinas, Benjamin, Ali Ekrem Yesilkanal, Andrea Pontier, and Dorothy A. Sipkins. “Hijacking the Niche: The Role of Stromal Osteopontin in the Induction of Leukemic Dormancy within the Bone Marrow Microenvironment.” In Blood, 118:342–43. AMER SOC HEMATOLOGY, 2011.Link to Item
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Colmone, Angela, and Dorothy A. Sipkins. “Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche.” In Transl Res, 151:1–9, 2008. https://doi.org/10.1016/j.trsl.2007.09.003.Full Text Link to Item
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Colmone, Angela, Veena Krishnamoorthy, and Dorothy A. Sipkins. “Dynamic In Vivo Imaging Reveals That Leukemia-Induced Changes in the Bone Marrow Microenvironment Alter Mechanisms of Metastasis.” In Blood, 110:2805–2805. American Society of Hematology, 2007. https://doi.org/10.1182/blood.v110.11.2805.2805.Full Text
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Sipkins, Dorothy A., Xunbin Wei, Juwell W. Wu, Terry K. Means, Andrew D. Luster, Charles P. Lin, and David T. Scadden. “Specialized Bone Marrow Endothelium Defines Microdomains for Tumor and Stem Cell Engraftment.” In Blood, 104:663–663. American Society of Hematology, 2004. https://doi.org/10.1182/blood.v104.11.663.663.Full Text
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- Teaching & Mentoring
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Recent Courses
- PHARM 394: Research Independent Study 2022
- PHARM 494: Research Independent Study 2022
- PHARM 495: Research Independent Study 2022
- PHARM 394: Research Independent Study 2021
- PHARM 494: Research Independent Study 2021
- PHARM 495: Research Independent Study 2021
- PHARM 394: Research Independent Study 2020
- PHARM 494: Research Independent Study 2020
- PHARM 495: Research Independent Study 2020
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