Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Hematology-Oncology Fellowship, Hematology Oncology, Dana Farber Cancer Institute 2001 - 2005
  • Internship and Residency, Internal Medicine, Massachusetts General Hospital 1999 - 2001
  • M.D., Stanford University School of Medicine 1999
  • Ph.D., Stanford University School of Medicine 1999
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2016 - 2017
  • Instructor Temporary in the Department of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2014 - 2016
• Recognition
• 

  In the News

  • JUL 18, 2018

    Mystery Solved: How Lymphoblastic Leukemia Enters Central Nervous System

  • MAY 26, 2016

    Scientists Block Breast Cancer Cells From Hiding in Bones

  • MAY 26, 2016

    The Telegraph

    Scientists block breast cancer cells from hiding in bones of mice, prompting hope for human trials

  • DEC 11, 2014

    WRAL

    Duke doctor helps deliver baby aboard jet over California
• Research
• 

  Selected Grants

  • Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
  • Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
  • Defining the Rules of Breast Cancer Cell Traffic Through Bone awarded by National Institutes of Health 2017 - 2021
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • Targeting sphingosine kinase 2 for the treatment of multiple myeloma awarded by National Institutes of Health 2015 - 2020
  • Role of Osteopontin in Induction of Leukemia Dormancy in the Bone Marrow awarded by American Cancer Society, Inc. 2014 - 2018
  • GMI-2 awarded by GlycoMimetics, Inc 2016 - 2017
  • Investigation of PI3Kdelta inhibitor activity in mouse xenograft models of pre-B acute lymphoblastic leukemia ALL awarded by Gilead Sciences, Inc. 2016 - 2017
  • Investigation of CX-01 in InVitro Pre-Clinical Models of Leukemia awarded by Cantex Pharmaceuticals, Inc. 2015 - 2016
  • Regulation of Leukemia Cell Dormancy by the Bone Marrow Microenvironment awarded by Gabrielle's Angel Foundation 2014 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yao, H, Price, TT, Cantelli, G, Ngo, B, Warner, MJ, Olivere, L, Ridge, SM, Jablonski, EM, Therrien, J, Tannheimer, S, McCall, CM, Chenn, A, and Sipkins, DA. "Leukaemia hijacks a neural mechanism to invade the central nervous system." Nature 560, no. 7716 (August 2018): 55-60.  Full Text
    • Price, TT, Burness, ML, Sivan, A, Warner, MJ, Cheng, R, Lee, CH, Olivere, L, Comatas, K, Magnani, J, Kim Lyerly, H, Cheng, Q, McCall, CM, and Sipkins, DA. "Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone." Science Translational Medicine 8, no. 340 (May 2016): 340ra73-null.  Full Text
    • Price, T, and Sipkins, DA. "Rewiring the niche: sympathetic neuropathy drives malignant niche transformation." Cell stem cell 15, no. 3 (September 2014): 261-262.  Full Text
    • Fox, MF, Pontier, A, Gurbuxani, S, and Sipkins, DA. "Stem cell factor expression in B cell malignancies is influenced by the niche." Leukemia & lymphoma 54, no. 10 (October 2013): 2274-2280.  Full Text
    • Boyerinas, B, Zafrir, M, Yesilkanal, AE, Price, TT, Hyjek, EM, and Sipkins, DA. "Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy." Blood 121, no. 24 (June 2013): 4821-4831.  Full Text
    • Boyerinas, B, and Sipkins, DA. "HSPCs in the balance: The vascular niche." Cell stem cell 7, no. 6 (December 2010): 645-646.  Full Text
    • Burness, ML, and Sipkins, DA. "The stem cell niche in health and malignancy." Seminars in cancer biology 20, no. 2 (April 2010): 107-115. (Review)  Full Text
    • Sipkins, DA. "Rendering the leukemia cell susceptible to attack." The New England journal of medicine 361, no. 13 (September 2009): 1307-1309.  Full Text
    • Colmone, A, Amorim, M, Pontier, AL, Wang, S, Jablonski, E, and Sipkins, DA. "Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells." Science (New York, N.Y.) 322, no. 5909 (December 2008): 1861-1865.  Full Text
    • Colmone, A, Amorim, M, Pontier, A, Wang, S, Jablonski, E, and Sipkins, DA. "MALIGNANT GROWTH IN THE BONE MARROW CREATES ABNORMAL HEMATOPOIETIC PROGENITOR CELL NICHES." ANTICANCER RESEARCH 28, no. 5C (2008): 3555-3555.  Link to Item
    • Sipkins, DA. "Chemotherapy and the bone marrow stroma." Leukemia & lymphoma 49, no. 1 (January 2008): 17-18.  Full Text
    • Wei, X, Sipkins, DA, Pitsillides, CM, Novak, J, Georgakoudi, I, and Lin, CP. "Real-time detection of circulating apoptotic cells by in vivo flow cytometry." Molecular imaging 4, no. 4 (October 2005): 415-416.
    • Sipkins, DA, Wei, X, Wu, JW, Runnels, JM, Côté, D, Means, TK, Luster, AD, Scadden, DT, and Lin, CP. "In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment." Nature 435, no. 7044 (June 2005): 969-973.  Full Text
    • Sipkins, DA, Gijbels, K, Tropper, FD, Bednarski, M, Li, KC, and Steinman, L. "ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging." Journal of neuroimmunology 104, no. 1 (April 2000): 1-9.  Full Text
    • Sipkins, DA, Cheresh, DA, Kazemi, MR, Nevin, LM, Bednarski, MD, and Li, KC. "Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging." Nature Medicine 4, no. 5 (May 1998): 623-626.  Full Text
    • SIPKINS, DA, CHEN, IY, SONG, CK, CHERESH, DA, BEDNARSKI, MD, and LI, KC. "MR-IMAGING OF TUMOR-INDUCED ANGIOGENESIS WITH ANTIBODY-CONJUGATED PARAMAGNETIC LIPOSOMES." RADIOLOGY 197 (November 1995): 129-129.  Link to Item
    • SIPKINS, DA, GIJBELS, K, TROPPER, FD, STEINMAN, L, and BEDNARSKI, MD. "ANTIBODY-CONJUGATED PARAMAGNETIC LIPOSOMES - TISSUE-SPECIFIC CONTRAST AGENTS FOR DISEASE PROCESSES." RADIOLOGY 197 (November 1995): 276-276.  Link to Item
    • Storrs, RW, Tropper, FD, Li, HY, Song, CK, Sipkins, DA, Kuniyoshi, JK, Bednarski, MD, Strauss, HW, and Li, KC. "Paramagnetic polymerized liposomes as new recirculating MR contrast agents." Journal of Magnetic Resonance Imaging : Jmri 5, no. 6 (November 1995): 719-724.  Full Text
    • Storrs, RW, Tropper, FD, Li, HY, Song, CK, Kuniyoshi, JK, Sipkins, DA, Li, KCP, and Bednarski, MD. "Paramagnetic polymerized liposomes: Synthesis, characterization, and applications for magnetic resonance imaging." Journal of the American Chemical Society 117, no. 28 (July 19, 1995).
    • Storrs, RW, Tropper, FD, Li, HY, Song, CK, Kuniyoshi, JK, Sipkins, DA, Li, KCP, and Bednarski, MD. "Paramagnetic Polymerized Liposomes: Synthesis, Characterization, and Applications for Magnetic Resonance Imaging." Journal of the American Chemical Society 117, no. 28 (July 1995): 7301-7306.  Full Text

  • Book Sections

    • Burger, JA, and Sipkins, DA. "The bone marrow microenvironment and its impact in acute and chronic B cell malignancies." In Bone Marrow Lymphoid Infiltrates: Diagnosis and Clinical Impact, 35-45. November 1, 2013.  Full Text

  • Conference Papers

    • Price, TT, Lee, CH, Cheng, Q, Lyerly, HK, Fogler, WE, Magnani, JL, and Sipkins, DA. "Abstract 3212: Metastatic breast cancer cell communication within a pro-dormancy bone marrow niche." August 1, 2015.  Full Text
    • Price, T, Burness, M, Sivan, A, Cheng, R, Magnani, JL, and Sipkins, DA. "Abstract 4831: Breast cancer cells metastasize to bone through E-selectin+ vascular gateways." October 1, 2014.  Full Text
    • Horton, B, Zafrir, M, Wales, P, Pontier, A, Tefferi, A, and Sipkins, DA. "Polycythemia Vera and Chronic Idiopathic Myelofibrosis CD34+Cells Preferentially Traffic to Splenic Niches." November 16, 2012.  Link to Item
    • Agarwal, R, Locke, FL, Kunnavakkam, R, van Besien, K, Larson, RA, Odenike, O, Godley, L, Liu, H, Le Beau, MM, Gurbuxani, S, Thirman, MJ, Sipkins, DA, White, C, Artz, A, and Stock, W. "A Phase II Prospective Feasibility Study of Clofarabine Cytoreduction Prior to Allogeneic Hematopoietic Cell Transplantation (HCT) for Patients with Relapsed or Refractory Acute Leukemias and Advanced Myelodysplastic Syndromes." November 18, 2011.  Link to Item
    • Boyerinas, B, Yesilkanal, AE, Pontier, A, and Sipkins, DA. "Hijacking the Niche: The Role of Stromal Osteopontin in the Induction of Leukemic Dormancy within the Bone Marrow Microenvironment." November 18, 2011.  Link to Item
    • Colmone, A, and Sipkins, DA. "Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche." January 2008.  Full Text
    • Colmone, A, Krishmamoorthy, V, and Sipkins, DA. "Dynamic in vivo imaging reveals that leukemia-induced changes in the bone marrow microenvironment alter mechanisms of metastasis." November 16, 2007.  Link to Item
    • Sipkins, DA, Wei, XB, Wu, JW, Means, TK, Luster, AD, Lin, CP, and Scadden, DT. "Specialized bone marrow endothelium defines microdomains for tumor and stem cell engraftment." November 16, 2004.  Link to Item

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