Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Hematology-Oncology Fellowship, Hematology Oncology, Dana Farber Cancer Institute 2001 - 2005
  • Internship and Residency, Internal Medicine, Massachusetts General Hospital 1999 - 2001
  • M.D., Stanford University School of Medicine 1999
  • Ph.D., Stanford University School of Medicine 1999
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2016 - 2017
  • Instructor Temporary in the Department of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2014 - 2016
• Recognition
• 

  In the News

  • JUL 18, 2018

    Mystery Solved: How Lymphoblastic Leukemia Enters Central Nervous System

  • MAY 26, 2016

    Scientists Block Breast Cancer Cells From Hiding in Bones

  • MAY 26, 2016

    The Telegraph

    Scientists block breast cancer cells from hiding in bones of mice, prompting hope for human trials

  • DEC 11, 2014

    WRAL

    Duke doctor helps deliver baby aboard jet over California
• Research
• 

  Selected Grants

  • Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
  • Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
  • Defining the Rules of Breast Cancer Cell Traffic Through Bone awarded by National Institutes of Health 2017 - 2021
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • Targeting Dormant Breast Cancer Micrometastases to Prevent Disease Relapse 2019 - 2020
  • Targeting sphingosine kinase 2 for the treatment of multiple myeloma awarded by National Institutes of Health 2015 - 2020
  • Targeting sphingosine kinase 2 for the treatment of multiple myeloma awarded by National Institutes of Health 2015 - 2020
  • Role of Osteopontin in Induction of Leukemia Dormancy in the Bone Marrow 2014 - 2018
  • GMI-2 2016 - 2017
  • Investigation of PI3Kdelta inhibitor activity in mouse xenograft models of pre-B acute lymphoblastic leukemia ALL 2016 - 2017
  • Investigation of CX-01 in InVitro Pre-Clinical Models of Leukemia 2015 - 2016
  • Regulation of Leukemia Cell Dormancy by the Bone Marrow Microenvironment 2014 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yao, Hisayuki, Trevor T. Price, Gaia Cantelli, Brandon Ngo, Matthew J. Warner, Lindsey Olivere, Sarah M. Ridge, et al. “Leukaemia hijacks a neural mechanism to invade the central nervous system..” Nature 560, no. 7716 (August 2018): 55–60. https://doi.org/10.1038/s41586-018-0342-5.
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    • Price, Trevor T., Monika L. Burness, Ayelet Sivan, Matthew J. Warner, Renee Cheng, Clara H. Lee, Lindsey Olivere, et al. “Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone..” Sci Transl Med 8, no. 340 (May 25, 2016). https://doi.org/10.1126/scitranslmed.aad4059.
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    • Price, Trevor, and Dorothy A. Sipkins. “Rewiring the niche: sympathetic neuropathy drives malignant niche transformation..” Cell Stem Cell 15, no. 3 (September 4, 2014): 261–62. https://doi.org/10.1016/j.stem.2014.08.012.
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    • Fox, Matthew F., Andrea Pontier, Sandeep Gurbuxani, and Dorothy A. Sipkins. “Stem cell factor expression in B cell malignancies is influenced by the niche..” Leuk Lymphoma 54, no. 10 (October 2013): 2274–80. https://doi.org/10.3109/10428194.2013.777067.
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    • Boyerinas, Benjamin, Maya Zafrir, Ali E. Yesilkanal, Trevor T. Price, Elizabeth M. Hyjek, and Dorothy A. Sipkins. “Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy..” Blood 121, no. 24 (June 13, 2013): 4821–31. https://doi.org/10.1182/blood-2012-12-475483.
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    • Boyerinas, Benjamin, and Dorothy A. Sipkins. “HSPCs in the balance: The vascular niche..” Cell Stem Cell 7, no. 6 (December 3, 2010): 645–46. https://doi.org/10.1016/j.stem.2010.11.021.
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    • Burness, Monika L., and Dorothy A. Sipkins. “The stem cell niche in health and malignancy..” Semin Cancer Biol 20, no. 2 (April 2010): 107–15. https://doi.org/10.1016/j.semcancer.2010.05.006.
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    • Sipkins, Dorothy A. “Rendering the leukemia cell susceptible to attack..” N Engl J Med 361, no. 13 (September 24, 2009): 1307–9. https://doi.org/10.1056/NEJMcibr0904291.
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    • Colmone, Angela, Maria Amorim, Andrea L. Pontier, Sheng Wang, Elizabeth Jablonski, and Dorothy A. Sipkins. “Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells..” Science 322, no. 5909 (December 19, 2008): 1861–65. https://doi.org/10.1126/science.1164390.
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    • Colmone, Angela, Maria Amorim, Andrea Pontier, Sheng Wang, Elizabeth Jablonski, and Dorothy A. Sipkins. “MALIGNANT GROWTH IN THE BONE MARROW CREATES ABNORMAL HEMATOPOIETIC PROGENITOR CELL NICHES.” Anticancer Research 28, no. 5C (September 1, 2008): 3555–3555.
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    • Sipkins, Dorothy A. “Chemotherapy and the bone marrow stroma..” Leuk Lymphoma 49, no. 1 (January 2008): 17–18. https://doi.org/10.1080/10428190701784748.
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    • Wei, Xunbin, Dorothy A. Sipkins, Costas M. Pitsillides, John Novak, Irene Georgakoudi, and Charles P. Lin. “Real-time detection of circulating apoptotic cells by in vivo flow cytometry..” Mol Imaging 4, no. 4 (October 2005): 415–16.
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    • Sipkins, Dorothy A., Xunbin Wei, Juwell W. Wu, Judith M. Runnels, Daniel Côté, Terry K. Means, Andrew D. Luster, David T. Scadden, and Charles P. Lin. “In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment..” Nature 435, no. 7044 (June 16, 2005): 969–73. https://doi.org/10.1038/nature03703.
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    • Sipkins, D. A., K. Gijbels, F. D. Tropper, M. Bednarski, K. C. Li, and L. Steinman. “ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging..” J Neuroimmunol 104, no. 1 (April 3, 2000): 1–9. https://doi.org/10.1016/s0165-5728(99)00248-9.
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    • Sipkins, D. A., D. A. Cheresh, M. R. Kazemi, L. M. Nevin, M. D. Bednarski, and K. C. Li. “Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging..” Nat Med 4, no. 5 (May 1998): 623–26.
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    • SIPKINS, D. A., I. Y. CHEN, C. K. SONG, D. A. CHERESH, M. D. BEDNARSKI, and K. C. LI. “MR-IMAGING OF TUMOR-INDUCED ANGIOGENESIS WITH ANTIBODY-CONJUGATED PARAMAGNETIC LIPOSOMES.” Radiology 197 (November 1, 1995): 129–129.
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    • SIPKINS, D. A., K. GIJBELS, F. D. TROPPER, L. STEINMAN, and M. D. BEDNARSKI. “ANTIBODY-CONJUGATED PARAMAGNETIC LIPOSOMES - TISSUE-SPECIFIC CONTRAST AGENTS FOR DISEASE PROCESSES.” Radiology 197 (November 1, 1995): 276–276.
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    • Storrs, R. W., F. D. Tropper, H. Y. Li, C. K. Song, D. A. Sipkins, J. K. Kuniyoshi, M. D. Bednarski, H. W. Strauss, and K. C. Li. “Paramagnetic polymerized liposomes as new recirculating MR contrast agents..” J Magn Reson Imaging 5, no. 6 (November 1995): 719–24.
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    • Storrs, R. W., F. D. Tropper, H. Y. Li, C. K. Song, J. K. Kuniyoshi, D. A. Sipkins, K. C. P. Li, and M. D. Bednarski. “Paramagnetic polymerized liposomes: Synthesis, characterization, and applications for magnetic resonance imaging.” Journal of the American Chemical Society 117, no. 28 (July 19, 1995).
    • Storrs, R. W., F. D. Tropper, H. Y. Li, C. K. Song, J. K. Kuniyoshi, D. A. Sipkins, K. C. P. Li, and M. D. Bednarski. “Paramagnetic Polymerized Liposomes: Synthesis, Characterization, and Applications for Magnetic Resonance Imaging.” Journal of the American Chemical Society 117, no. 28 (January 1, 1995): 7301–6. https://doi.org/10.1021/ja00133a001.
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  • Book Sections

    • Burger, J. A., and D. A. Sipkins. “The bone marrow microenvironment and its impact in acute and chronic B cell malignancies.” In Bone Marrow Lymphoid Infiltrates: Diagnosis and Clinical Impact, 35–45, 2013. https://doi.org/10.1007/978-1-4471-4174-7_3.
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  • Conference Papers

    • Price, Trevor T., Clara H. Lee, Qing Cheng, H Kim Lyerly, William E. Fogler, John L. Magnani, and Dorothy A. Sipkins. “Abstract 3212: Metastatic breast cancer cell communication within a pro-dormancy bone marrow niche.” In Tumor Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-3212.
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    • Price, Trevor, Monika Burness, Ayelet Sivan, Renee Cheng, John L. Magnani, and Dorothy A. Sipkins. “Abstract 4831: Breast cancer cells metastasize to bone through E-selectin+ vascular gateways.” In Tumor Biology. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-4831.
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    • Horton, Brendan, Maya Zafrir, Pauline Wales, Andrea Pontier, Ayalew Tefferi, and Dorothy A. Sipkins. “Polycythemia Vera and Chronic Idiopathic Myelofibrosis CD34+Cells Preferentially Traffic to Splenic Niches.” In Blood, Vol. 120. AMER SOC HEMATOLOGY, 2012.
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    • Agarwal, Rajiv, Frederick L. Locke, Rangesh Kunnavakkam, Koen van Besien, Richard A. Larson, Olatoyosi Odenike, Lucy Godley, et al. “A Phase II Prospective Feasibility Study of Clofarabine Cytoreduction Prior to Allogeneic Hematopoietic Cell Transplantation (HCT) for Patients with Relapsed or Refractory Acute Leukemias and Advanced Myelodysplastic Syndromes.” In Blood, 118:231–32. AMER SOC HEMATOLOGY, 2011.
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    • Boyerinas, Benjamin, Ali Ekrem Yesilkanal, Andrea Pontier, and Dorothy A. Sipkins. “Hijacking the Niche: The Role of Stromal Osteopontin in the Induction of Leukemic Dormancy within the Bone Marrow Microenvironment.” In Blood, 118:342–43. AMER SOC HEMATOLOGY, 2011.
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    • Colmone, Angela, and Dorothy A. Sipkins. “Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche..” In Transl Res, 151:1–9, 2008. https://doi.org/10.1016/j.trsl.2007.09.003.
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    • Colmone, Angela, Veena Krishmamoorthy, and Dorothy A. Sipkins. “Dynamic in vivo imaging reveals that leukemia-induced changes in the bone marrow microenvironment alter mechanisms of metastasis.” In Blood, 110:825A-825A. AMER SOC HEMATOLOGY, 2007.
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    • Sipkins, D. A., X. B. Wei, J. W. Wu, T. K. Means, A. D. Luster, C. P. Lin, and D. T. Scadden. “Specialized bone marrow endothelium defines microdomains for tumor and stem cell engraftment..” In Blood, 104:191A-191A. AMER SOC HEMATOLOGY, 2004.
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• Teaching & Mentoring
• 

  Recent Courses

  • PHARM 494: Research Independent Study 2019
  • PHARM 495: Research Independent Study 2019

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