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Douglas Alan Marchuk

James B. Duke Distinguished Professor of Molecular Genetics and Microbiology
Molecular Genetics and Microbiology
Duke Box 3175, Durham, NC 27710
213 Research Dr, 265 Clinical and Research Labs, Durham, NC 27710

Selected Grants


Eastern North Carolina and southern Virginia regIonal Stroke trIal cONsortium (ENVISION)

ResearchCollaborator · Awarded by National Institutes of Health · 2023 - 2028

Preclinical Development of Gene Replacement Therapy Using Novel AV Vectors in Familial Cerebral Cavernous Malformations

ResearchPrincipal Investigator · Awarded by Department of Defense · 2023 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Genetic and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Signaling Aberrations and Cerebral Cavernous Malformation Pathogenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2025

Eastern North Carolina and southern Virginia regIonal Stroke trIal cONsortium (ENVISION)

ResearchCollaborator · Awarded by National Institutes of Health · 2023 - 2028

Preclinical Development of Gene Replacement Therapy Using Novel AV Vectors in Familial Cerebral Cavernous Malformations

ResearchPrincipal Investigator · Awarded by Department of Defense · 2023 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Genetic and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Signaling Aberrations and Cerebral Cavernous Malformation Pathogenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2025

A consortium effort to translate therapies for neurological diseases via an immune-competent organotypic platform

ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2021 - 2025

A novel platform to determine RABEP2 function as a therapeutic target in human ischemic stroke

ResearchMentor · Awarded by American Heart Association · 2022 - 2025

Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

Brain Vasular Malformation Consortium: Predictors of clinical course

ResearchPrincipal Investigator · Awarded by The Regents of the University of California · 2014 - 2024

Novel Targets for Stroke Intervention - Gene Discovery for Modulators of Infarction

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2023

Multidisciplinary Heart and Vascular Diseases

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2023

Identification of the precise developmental window and tissue bed for the somatic mutation causing Sturge Weber Syndrome

ResearchPrincipal Investigator · Awarded by Department of Defense · 2021 - 2023

Pathogenesis of vascular malformations in hereditary hemorrhagic telangiectasia: from disease mechanism to new therapies

ResearchPrincipal Investigator · Awarded by Barrow Neurological Institute · 2017 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

Investigating the Role of Somatic Mutations in Arteriovenous Malformations

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2022

Gene Replacement Therapy for a mouse model of Cerebral Cavernous Malformations

ResearchPrincipal Investigator · Awarded by StrideBio LLC · 2021 - 2022

Endothelial Cell Lineage Studies in Cerebral Cavernous Malformations

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021

Characterizing lesion development in a mouse model of Sturge-Weber Syndrome

ResearchPrincipal Investigator · Awarded by Sturge-Weber Foundation · 2020 - 2020

Genetics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

to test whether propranolol will reduce lesion burden and/ or hemorrhage in a mouse model of Cerebral Cavernous malformations

ResearchPrincipal Investigator · Awarded by Barrow Neurological Institute · 2018 - 2019

Development of BA-1049 for treatment of cerebral cavernous malformations

ResearchPrincipal Investigator · Awarded by BioAxone Biosciences, Inc. · 2016 - 2018

Functional Characterization of the GNAQ somatic mutation causing Sturge Weber syndrome

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2018

Rock Inhibition as Therapy for Cerebral Cavernous Malformation

ResearchPrincipal Investigator · Awarded by University of Chicago · 2016 - 2017

Institutional Training Grant in Pediatric Cardiology

Inst. Training Prgm or CMEFaculty Member · Awarded by National Institutes of Health · 2009 - 2015

Project 2: Innovative approaches to gauge progression of Sturge-Weber syndrome

ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2009 - 2014

Natural genetic variation regulating infarct volume

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2014

Peripheral endothelial and muscle cell pathology in cardiovascular disease

ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2013

Studying Early-Stage Lesions in Mouse Models of Cerebral Cavernous Malformations

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2013

Genesis and Progression of Cerebral Cavernous Malformations

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2013

Genetic modifiers of dilated cardiomyopathy in adult Drosophila

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2007 - 2012

Identification of genetics modifiers of heart disease

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2011

Genes That Regulate Progression of Kidney Disease and Its Cardiovascular Effects

ResearchConsultant · Awarded by National Institutes of Health · 2007 - 2009

Investigation of the two-hit hypothesis for Cerebral Cavernous Malformations

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2009

Duke PREP: Minority Recruitment into Biomedical Sciences

Inst. Training Prgm or CMEAdvisor · Awarded by National Institutes of Health · 2003 - 2008

Identification of Modifier Genes in Heart Disease

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2008

Gene Discovery for Cerebral Cavernous Malformations

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2008

Identifying the CCM3 Gene: Understanding Familial Stroke

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2007

Modifier Genes in Heart Failure

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2001 - 2007

Mitochondrial DNA Stability and Mutagenesis

ResearchPrincipal Investigator · Awarded by Army Research Office · 2004 - 2007

Genes that Regulate Target Organ Damage in Hypertension

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2001 - 2006

Genetics of Hereditary Hemorrhagic Telangiectasia

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 2006

Investigating the function of the Mcgl Family

ResearchPrincipal Investigator · Awarded by Army Research Office · 2001 - 2005

A Mouse Model of Cerebral Cavernous Malformations

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2003

The Genetics Of Hereditary Hemorrhagic Telangiectasia

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 1999

Diversity Of Tgf Beta Receptor Mutations In Hht Syndrome

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Cloning The Hereditary Hemorrhagic Telangiectasia Gene

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1996

Cloning Of Hereditary Hemorrhagic Telangiectasia Gene

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 1996

External Relationships


  • Japan Neurological Society Annual Meeting Speaker

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.