Selected Grants
Eastern North Carolina and southern Virginia regIonal Stroke trIal cONsortium (ENVISION)
ResearchCollaborator · Awarded by National Institutes of Health · 2023 - 2028Preclinical Development of Gene Replacement Therapy Using Novel AV Vectors in Familial Cerebral Cavernous Malformations
ResearchPrincipal Investigator · Awarded by Department of Defense · 2023 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026Genetic and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025Brain Vasular Malformation Consortium: Predictors of clinical course
ResearchPrincipal Investigator · Awarded by The Regents of the University of California · 2014 - 2025Signaling Aberrations and Cerebral Cavernous Malformation Pathogenesis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2025A consortium effort to translate therapies for neurological diseases via an immune-competent organotypic platform
ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2021 - 2025A novel platform to determine RABEP2 function as a therapeutic target in human ischemic stroke
ResearchMentor · Awarded by American Heart Association · 2022 - 2025Duke CTSA (TL1) Year 5
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024ATTRACT: Arterial flow as attractor for endothelial cell migration - a new concept in vascular malformation and stroke regeneration
ResearchPrincipal Investigator · Awarded by Fondation Leducq · 2018 - 2023Novel Targets for Stroke Intervention - Gene Discovery for Modulators of Infarction
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2023Multidisciplinary Heart and Vascular Diseases
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2023Identification of the precise developmental window and tissue bed for the somatic mutation causing Sturge Weber Syndrome
ResearchPrincipal Investigator · Awarded by Department of Defense · 2021 - 2023Pathogenesis of vascular malformations in hereditary hemorrhagic telangiectasia: from disease mechanism to new therapies
ResearchPrincipal Investigator · Awarded by Barrow Neurological Institute · 2017 - 2022Medical Scientist Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022Investigating the Role of Somatic Mutations in Arteriovenous Malformations
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2022Gene Replacement Therapy for a mouse model of Cerebral Cavernous Malformations
ResearchPrincipal Investigator · Awarded by StrideBio LLC · 2021 - 2022Effect of Low Dose Oral Propranolol on Hemorrhage and Disease Progression in a Chronic Ccm3 Model of Cerebral Cavernous Malformations
ResearchPrincipal Investigator · Awarded by Be Brave for Life · 2020 - 2021Endothelial Cell Lineage Studies in Cerebral Cavernous Malformations
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021Characterizing lesion development in a mouse model of Sturge-Weber Syndrome
ResearchPrincipal Investigator · Awarded by Sturge-Weber Foundation · 2020 - 2020Genetics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020Organization and Function of Cellular Structure
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020to test whether propranolol will reduce lesion burden and/ or hemorrhage in a mouse model of Cerebral Cavernous malformations
ResearchPrincipal Investigator · Awarded by Barrow Neurological Institute · 2018 - 2019Vascular malformation genesis vs. maintenance and progression: identifying the molecular pathways necessary for cerebral cavernous malformation (CCM) maintenance and progression through therapeutic studies with a novel CCM mouse phenotype
FellowshipPrincipal Investigator · Awarded by American Heart Association · 2018 - 2018Development of BA-1049 for treatment of cerebral cavernous malformations
ResearchPrincipal Investigator · Awarded by BioAxone Biosciences, Inc. · 2016 - 2018Functional Characterization of the GNAQ somatic mutation causing Sturge Weber syndrome
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2018Rock Inhibition as Therapy for Cerebral Cavernous Malformation
ResearchPrincipal Investigator · Awarded by University of Chicago · 2016 - 2017Institutional Training Grant in Pediatric Cardiology
Inst. Training Prgm or CMEFaculty Member · Awarded by National Institutes of Health · 2009 - 2015Project 2: Innovative approaches to gauge progression of Sturge-Weber syndrome
ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2009 - 2014Natural genetic variation regulating infarct volume
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2014Peripheral endothelial and muscle cell pathology in cardiovascular disease
ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2013Studying Early-Stage Lesions in Mouse Models of Cerebral Cavernous Malformations
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2013Genesis and Progression of Cerebral Cavernous Malformations
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2013Genetic modifiers of dilated cardiomyopathy in adult Drosophila
ResearchSignificant Contributor · Awarded by National Institutes of Health · 2007 - 2012Identification of genetics modifiers of heart disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2011Genes That Regulate Progression of Kidney Disease and Its Cardiovascular Effects
ResearchConsultant · Awarded by National Institutes of Health · 2007 - 2009Investigation of the two-hit hypothesis for Cerebral Cavernous Malformations
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2009Duke PREP: Minority Recruitment into Biomedical Sciences
Inst. Training Prgm or CMEAdvisor · Awarded by National Institutes of Health · 2003 - 2008Identification of Modifier Genes in Heart Disease
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2008Gene Discovery for Cerebral Cavernous Malformations
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2008Identifying the CCM3 Gene: Understanding Familial Stroke
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2007Modifier Genes in Heart Failure
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2001 - 2007Mitochondrial DNA Stability and Mutagenesis
ResearchPrincipal Investigator · Awarded by Army Research Office · 2004 - 2007Genes that Regulate Target Organ Damage in Hypertension
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2001 - 2006Genetics of Hereditary Hemorrhagic Telangiectasia
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 2006Investigating the function of the Mcgl Family
ResearchPrincipal Investigator · Awarded by Army Research Office · 2001 - 2005Characterization of the role of Din7 in mitochondrial DNA replication and genome integrity in the yeast Saccharomyces cerevisiae
ResearchPrincipal Investigator · Awarded by Army Research Office · 2002 - 2004A Mouse Model of Cerebral Cavernous Malformations
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2003The Genetics Of Hereditary Hemorrhagic Telangiectasia
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 1999Diversity Of Tgf Beta Receptor Mutations In Hht Syndrome
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1998Cloning The Hereditary Hemorrhagic Telangiectasia Gene
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1996Cloning Of Hereditary Hemorrhagic Telangiectasia Gene
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 1996External Relationships
- Japan Neurological Society Annual Meeting Speaker
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.