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Eduardo Chaparro

Research Scholar
MSRB1 283, Durham, NC 27701
203 Research Dr., MSRB1 - 285, Durham, NC 27701

Selected Publications

Endovascular middle cerebral artery embolic stroke model: a novel approach.

Journal Article J Neurointerv Surg · April 2022 A video (video 1) describing a novel murine endovascular embolic stroke model is presented. Traditional middle cerebral artery (MCA) occlusion models include a blind insertion of a monofilament string1 2 into the common or external carotid artery with the ... Full text Open Access Link to item Cite

Time-varying caloric vestibular stimulation for the treatment of neurodegenerative disease.

Journal Article Frontiers in aging neuroscience · January 2022 Time-varying caloric vestibular stimulation (tvCVS) is a new form of non-invasive neuromodulation similar to, but different from, diagnostic caloric vestibular stimulation (CVS). Using a non-invasive, solid-state delivery device, tvCVS has been successfull ... Full text Open Access Cite

Thromboembolic Events with Enterprise Versus Pipeline: Porcine In Vivo Experiment.

Journal Article World Neurosurg · February 2019 BACKGROUND: Thromboembolic complications are serious adverse events associated with stenting of intracranial aneurysms. For the development of novel devices, currently no practical model exists to evaluate distal embolic events. The purpose of the current ... Full text Link to item Cite

Video training and certification program improves reliability of postischemic neurologic deficit measurement in the rat.

Journal Article J Cereb Blood Flow Metab · December 2016 Scoring systems are used to measure behavioral deficits in stroke research. Video-assisted training is used to standardize stroke-related neurologic deficit scoring in humans. We hypothesized that a video-assisted training and certification program can imp ... Full text Open Access Link to item Cite

Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice.

Journal Article J Cereb Blood Flow Metab · June 2015 Hepatocyte growth factor (HGF), efficacious in preclinical models of acute central nervous system injury, is burdened by administration of full-length proteins. A multiinstitutional consortium investigated the efficacy of BB3, a small molecule with HGF-lik ... Full text Open Access Link to item Cite

Isoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats.

Journal Article Journal of enzyme inhibition and medicinal chemistry · December 2014 ContextHypotension causes histologic changes in the hippocampal CA1 area, while behavior remains unchanged. We believe that an even stronger insult may also cause behavioral changes.ObjectiveWe used a rat hemorrhagic shock model plus temp ... Full text Cite

Effects of repetitive exposure to anesthetics and analgesics in the Tg2576 mouse Alzheimer's model.

Journal Article Neurotoxicity research · November 2014 The use of anesthetics and sedatives has been suggested to be a contributor to Alzheimer's disease neuropathogenesis. We wanted to address the in vivo relevance of those substances in the Tg2576 Alzheimer's mouse model. Tg7526 mice were anesthesia-sedated ... Full text Cite

Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders.

Journal Article Antioxid Redox Signal · May 20, 2014 SIGNIFICANCE: Metalloporphyrins, characterized by a redox-active transitional metal (Mn or Fe) coordinated to a cyclic porphyrin core ligand, mitigate oxidative/nitrosative stress in biological systems. Side-chain substitutions tune redox properties of met ... Full text Open Access Link to item Cite

Repetitive intraperitoneal caspase-3 inhibitor and anesthesia reduces neuronal damage.

Journal Article Journal of enzyme inhibition and medicinal chemistry · December 2013 Caspase inhibitors are usually administered intracranially. There's very limited evidence showing that they can be used intraperitoneally, and still have a beneficial effect. We tested the hypothesis that, during focal cerebral ischemia, caspase inhibitors ... Full text Cite

Hippocampal cellular loss after brief hypotension.

Journal Article SpringerPlus · December 2013 Brief episodes of hypotension have been shown to cause acute brain damage in animal models. We used a rat hemorrhagic shock model to assess functional outcome and to measure the relative neuronal damage at 1, 4 and 14 days post-injury (3 min of hypotension ... Full text Open Access Cite

Quantitative assessment of new cell proliferation in the dentate gyrus and learning after isoflurane or propofol anesthesia in young and aged rats.

Journal Article Brain research · March 2012 There is a growing body of evidence showing that a statistically significant number of people experience long-term changes in cognition after anesthesia. We hypothesize that this cognitive impairment may result from an anesthetic-induced alteration of post ... Full text Cite

Effect of continuous infusion of asialoerythropoietin on short-term changes in infarct volume, penumbra apoptosis and behaviour following middle cerebral artery occlusion in rats.

Journal Article Clinical and experimental pharmacology & physiology · February 2010 1. Asialoerythropoietin (aEPO), a derivative of cytokine erythropoietin, has been shown to have neuroprotective effects without haematological complications when administered in single or repeated doses. The present study examines our hypothesis that aEPO ... Full text Cite