Eric Leo Eisenstein
Associate Professor Emeritus in Medicine
Research Interests:
Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.
In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.
Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.
In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.
Current Appointments & Affiliations
- Associate Professor Emeritus in Medicine, Medicine, Cardiology, Medicine 2020
- Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 1995
Contact Information
- 2400 Pratt St, Durham, NC 27705
- Duke Box 3865, Durham, NC 27710
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eisen006@mc.duke.edu
(919) 668-8984
- Background
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Education, Training, & Certifications
- D.B.A., Cleveland State University 1995
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Previous Appointments & Affiliations
- Associate Professor in Family Medicine and Community Health, Family Medicine and Community Health, Clinical Science Departments 2013 - 2020
- Associate Professor in Medicine, Medicine, Cardiology, Medicine 2013 - 2020
- Assistant Professor in Medicine, Medicine, Cardiology, Medicine 2006 - 2013
- Assistant Professor in Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 2008 - 2013
- Assistant Research Professor in Medicine, Medicine, Cardiology, Medicine 1997 - 2006
- Research
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Selected Grants
- Mid Southern Primary Care Networks Node awarded by National Institutes of Health 2015 - 2023
- TRANSFORM-HF DCC awarded by National Institutes of Health 2017 - 2022
- Platform for Engaging Everyone Responsibility (PEER) Validation awarded by Genetic Alliance 2015 - 2021
- The Data FITS Study of EHR-to-EDC eSource Data Collection awarded by University of Arkansas for Medical Sciences 2019
- Steps to Health: Targeting Obesity in the Health Care Workplace awarded by National Institute for Occupational Safety and Health 2010 - 2016
- Pioneering Health Information Quality (K99) awarded by National Institutes of Health 2012 - 2015
- Idiopathic Pulmonary Fibrosis Clinical Research Network awarded by National Institutes of Health 2005 - 2014
- Idiopathic Pulmonary Fibrosis Clinical Research Network NCE awarded by National Institutes of Health 2005 - 2014
- Economic Analysis for the ATlantic C-PORT Trial awarded by Johns Hopkins University 2006 - 2013
- Improving Care Transitions for Complex Patients through Decision Support awarded by Agency for Healthcare Research and Quality 2008 - 2012
- DEcIDE DES TO4 W3 awarded by Agency for Healthcare Research and Quality 2009 - 2012
- DEcIDE Stents TO4 WA2 awarded by Agency for Healthcare Research and Quality 2009 - 2012
- Improving Quality through Decision Support for Evidence-Based Pharmacotherapy awarded by Agency for Healthcare Research and Quality 2007 - 2011
- Augmenting Healthcare through Patient Participation in a Rural Community-Based Telehealth Network awarded by Health Resources and Services Administration (HRSA) 2006 - 2010
- Collaborative Research on the Clinical Effectiveness and Long-term Outcomes of Stents in Coronary Interventions awarded by Agency for Healthcare Research and Quality 2008 - 2009
- Pharmacologic Prevention of Arteriovenous Graft Thrombosis awarded by National Institutes of Health 2007 - 2009
- Showing Health Information Value in a Community Network awarded by Agency for Healthcare Research and Quality 2004 - 2008
- Treatment of In-Stent Restenosis awarded by Agency for Healthcare Research and Quality 2005 - 2007
- Dialysis Facility Management awarded by National Institutes of Health 2002 - 2005
- Effect of renal insufficiency on cardiovascular outcomes awarded by National Institutes of Health 2001 - 2004
- Cfda #93.225 Risk-Adjusted Cost Management In Cardiovascul awarded by National Institutes of Health 1995 - 1997
- Risk Adjusted Cost Management For Cardiovascular Disease awarded by National Institutes of Health 1994 - 1996
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External Relationships
- The University of Texas Health Science Center
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Eisenstein, Eric L., Anita Walden, Katrina Donovan, Meredith N. Zozus, Feliciano B. Yu, Vivian L. West, W Ed Hammond, and Lawrence H. Muhlbaier. “Economic analysis of a single institutional review board data exchange standard in multisite clinical studies.” Contemp Clin Trials 122 (November 2022): 106953. https://doi.org/10.1016/j.cct.2022.106953.Full Text Link to Item
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Eisenstein, Eric L., Shelly Sapp, Tina Harding, Amanda Harrington, Eric J. Velazquez, Robert J. Mentz, Stephen J. Greene, Vandana Sachdev, Dong-Yun Kim, and Kevin J. Anstrom. “Ascertaining Death Events in a Pragmatic Clinical Trial: Insights From the TRANSFORM-HF Trial.” J Card Fail 28, no. 10 (October 2022): 1563–67. https://doi.org/10.1016/j.cardfail.2022.01.020.Full Text Link to Item
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Eisenstein, Eric L., Meredith N. Zozus, Sharon F. Terry, Linda Davidson-Ray, and Kevin J. Anstrom. “Ascertaining Nonfatal Endpoints in Clinical Trials: Central Adjudication Versus Patient Insurance Claims.” Ther Innov Regul Sci 55, no. 6 (November 2021): 1250–57. https://doi.org/10.1007/s43441-021-00321-9.Full Text Link to Item
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Greene, Stephen J., Eric J. Velazquez, Kevin J. Anstrom, Eric L. Eisenstein, and Robert J. Mentz. “Reply: Pragmatic Clinical Trials: The Big Picture.” Jacc Heart Fail 9, no. 8 (August 2021): 606–8. https://doi.org/10.1016/j.jchf.2021.05.018.Full Text Link to Item
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Garza, Maryam Y., Michael W. Rutherford, Bhargav Adagarla, Eric Eisenstein, Karan R. Kumar, Kanecia O. Zimmerman, Umit Topaloglu, and Meredith Zozus. “Evaluating Site-Level Implementations of the HL7 FHIR Standard to Support eSource Data Exchange in Clinical Research.” Stud Health Technol Inform 281 (May 27, 2021): 397–401. https://doi.org/10.3233/SHTI210188.Full Text Link to Item
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Greene, Stephen J., Eric J. Velazquez, Kevin J. Anstrom, Eric L. Eisenstein, Shelly Sapp, Shelby Morgan, Tina Harding, et al. “Pragmatic Design of Randomized Clinical Trials for Heart Failure: Rationale and Design of the TRANSFORM-HF Trial.” Jacc Heart Fail 9, no. 5 (May 2021): 325–35. https://doi.org/10.1016/j.jchf.2021.01.013.Full Text Link to Item
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Li, Chun, Sarah E. Deery, Eric L. Eisenstein, Zhi Ven Fong, Kirsten Dansey, Linda Davidson-Ray, Betsy O’Neal, and Marc L. Schermerhorn. “Index and follow-up costs of endovascular abdominal aortic aneurysm repair from the Endurant Stent Graft System Post Approval Study (ENGAGE PAS).” J Vasc Surg 72, no. 3 (September 2020): 886-895.e1. https://doi.org/10.1016/j.jvs.2019.11.028.Full Text Link to Item
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Eisenstein, Eric L., Maryam Y. Garza, Mitra Rocca, Gideon S. Gordon, and Meredith Zozus. “eSource-Enabled vs. Traditional Clinical Trial Data Collection Methods: A Site-Level Economic Analysis.” Stud Health Technol Inform 270 (June 16, 2020): 961–65. https://doi.org/10.3233/SHTI200304.Full Text Link to Item
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Scott, Philip J., Angela W. Brown, Taiwo Adedeji, Jeremy C. Wyatt, Andrew Georgiou, Eric L. Eisenstein, and Charles P. Friedman. “A review of measurement practice in studies of clinical decision support systems 1998-2017.” J Am Med Inform Assoc 26, no. 10 (October 1, 2019): 1120–28. https://doi.org/10.1093/jamia/ocz035.Full Text Link to Item
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Eisenstein, Eric L., Daniel Wojdyla, and David F. Kong. “Estimating Clinical Trial Bleeding Events Using Electronic Health Record Data.” Stud Health Technol Inform 257 (2019): 92–97.Link to Item
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Garza, Maryam, Sahiti Myneni, Amy Nordo, Eric L. Eisenstein, W Ed Hammond, Anita Walden, and Meredith Zozus. “eSource for Standardized Health Information Exchange in Clinical Research: A Systematic Review.” Stud Health Technol Inform 257 (2019): 115–24.Link to Item
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Nordo, Amy, Eric L. Eisenstein, Maryam Garza, W Ed Hammond, and Meredith Nahm Zozus. “Evaluative Outcomes in Direct Extraction and Use of EHR Data in Clinical Trials.” Stud Health Technol Inform 257 (2019): 333–40.Link to Item
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Eisenstein, Eric L., Kristi Prather, Stephen J. Greene, Tina Harding, Amanda Harrington, Davera Gabriel, Ingrid Jones, Robert J. Mentz, Eric J. Velazquez, and Kevin J. Anstrom. “Death: The Simple Clinical Trial Endpoint.” Stud Health Technol Inform 257 (2019): 86–91.Link to Item
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Simon, Christian M., Helen A. Schartz, Gary E. Rosenthal, Eric L. Eisenstein, and David W. Klein. “Perspectives on Electronic Informed Consent From Patients Underrepresented in Research in the United States: A Focus Group Study.” J Empir Res Hum Res Ethics 13, no. 4 (October 2018): 338–48. https://doi.org/10.1177/1556264618773883.Full Text Link to Item
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Levitan, Bennett, Kenneth Getz, Eric L. Eisenstein, Michelle Goldberg, Matthew Harker, Sharon Hesterlee, Bray Patrick-Lake, Jamie N. Roberts, and Joseph DiMasi. “Assessing the Financial Value of Patient Engagement: A Quantitative Approach from CTTI's Patient Groups and Clinical Trials Project.” Ther Innov Regul Sci 52, no. 2 (March 2018): 220–29. https://doi.org/10.1177/2168479017716715.Full Text Link to Item
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Nordo, Amy Harris, Eric L. Eisenstein, Jeffrey Hawley, Sai Vadakkeveedu, Melissa Pressley, Jennifer Pennock, and Iain Sanderson. “A comparative effectiveness study of eSource used for data capture for a clinical research registry.” Int J Med Inform 103 (July 2017): 89–94. https://doi.org/10.1016/j.ijmedinf.2017.04.015.Full Text Link to Item
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Eisenstein, Eric L., Amy Harris Nordo, and Meredith Nahm Zozus. “Using Medical Informatics to Improve Clinical Trial Operations.” Stud Health Technol Inform 234 (2017): 93–97.Link to Item
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Eisenstein, Eric L., Janese M. Willis, Rex Edwards, Kevin J. Anstrom, Kensaku Kawamoto, Guilherme Del Fiol, Fred S. Johnson, and David F. Lobach. “Randomized Trial of Population-Based Clinical Decision Support to Facilitate Care Transitions.” Stud Health Technol Inform 234 (2017): 98–103.Link to Item
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Bacharova, Ljuba, Samuel J. Bell, Jonathan Lipton, Eric Eisenstein, Gulmira Kudaiberdieva, Marilyn Wagner, Ioana Mozos, Aleksandra Misak, and Nina Hakacova. “The Research Practicum and International Research Interdisciplinary School (IRIS) initiatives: In memory of Professor Galen S. Wagner M.D., PhD.” J Electrocardiol 50, no. 1 (2017): 5–10. https://doi.org/10.1016/j.jelectrocard.2016.11.004.Full Text Link to Item
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Wagner, Marilyn, Laura Wagner, Chris Wagner, Samuel J. Bell, Brit W. Nicholson, David G. Strauss, Stafford Warren, et al. “In memory of Professor Galen S. Wagner M.D., Ph.D. (1939-2016): our mentor, colleague and friend.” J Electrocardiol 50, no. 1 (2017): 3–4. https://doi.org/10.1016/j.jelectrocard.2016.11.001.Full Text Link to Item
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Eisenstein, Eric L. “Commentary on Sertkaya et al. and Larson et al.” Clin Trials 13, no. 2 (April 2016): 137–39. https://doi.org/10.1177/1740774515626410.Full Text Link to Item
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Partin, Melissa R., Aasma Shaukat, David B. Nelson, Amy Gravely, Sean Nugent, Ziad F. Gellad, and James F. Burgess. “Reply.” Clin Gastroenterol Hepatol 14, no. 3 (March 2016): 486. https://doi.org/10.1016/j.cgh.2015.12.008.Full Text Link to Item
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Østbye, Truls, Marissa Stroo, Eric L. Eisenstein, and John M. Dement. “The Effects of Two Workplace Weight Management Programs and Weight Loss on Health Care Utilization and Costs.” J Occup Environ Med 58, no. 2 (February 2016): 162–69. https://doi.org/10.1097/JOM.0000000000000586.Full Text Link to Item
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Bain, Jesse C., David A. Turner, Kyle J. Rehder, Eric L. Eisenstein, R Duane Davis, Ira M. Cheifetz, and David W. Zaas. “Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation.” Respir Care 61, no. 1 (January 2016): 1–7. https://doi.org/10.4187/respcare.03729.Full Text Link to Item
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Andrade, Joao de, Marvin Schwarz, Harold R. Collard, Tedryl Gentry-Bumpass, Thomas Colby, David Lynch, Robert J. Kaner, and Robert J. IPFnet Investigators. “The Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet): diagnostic and adjudication processes.” Chest 148, no. 4 (October 2015): 1034–42. https://doi.org/10.1378/chest.14-2889.Full Text Link to Item
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Mentz, Robert J., Jonathan Buggey, Mona Fiuzat, Mads K. Ersbøll, Phillip J. Schulte, Adam D. DeVore, Eric L. Eisenstein, Kevin J. Anstrom, Christopher M. OʼConnor, and Eric J. Velazquez. “Torsemide versus furosemide in heart failure patients: insights from Duke University Hospital.” J Cardiovasc Pharmacol 65, no. 5 (May 2015): 438–43. https://doi.org/10.1097/FJC.0000000000000212.Full Text Open Access Copy Link to Item
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Buggey, Jonathan, Robert J. Mentz, Bertram Pitt, Eric L. Eisenstein, Kevin J. Anstrom, Eric J. Velazquez, and Christopher M. O’Connor. “A reappraisal of loop diuretic choice in heart failure patients.” Am Heart J 169, no. 3 (March 2015): 323–33. https://doi.org/10.1016/j.ahj.2014.12.009.Full Text Link to Item
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Povsic, Thomas J., Samuel Broderick, Kevin J. Anstrom, Linda K. Shaw, E Magnus Ohman, Eric L. Eisenstein, Peter K. Smith, and John H. Alexander. “Predictors of Long-term Clinical Endpoints in Patients With Refractory Angina.” Journal of the American Heart Association 4, no. 2 (February 2015). https://doi.org/10.1161/JAHA.114.001287.Full Text Link to Item
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Østbye, Truls, Marissa Stroo, Rebecca J. N. Brouwer, Bercedis L. Peterson, Eric L. Eisenstein, Bernard F. Fuemmeler, Julie Joyner, Libby Gulley, and John M. Dement. “Steps to Health employee weight management randomized control trial: short-term follow-up results.” J Occup Environ Med 57, no. 2 (February 2015): 188–95. https://doi.org/10.1097/JOM.0000000000000335.Full Text Open Access Copy Link to Item
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Povsic, Thomas J., Samuel Broderick, Kevin J. Anstrom, Linda K. Shaw, E Magnus Ohman, Eric L. Eisenstein, Peter K. Smith, and John H. Alexander. “Predictors of long-term clinical endpoints in patients with refractory angina.” J Am Heart Assoc 4, no. 2 (January 30, 2015). https://doi.org/10.1161/JAHA.114.001287.Full Text Link to Item
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Eisenstein, Eric L., and Keith A. Butler. “Health informatics-enabled workflow redesign and evaluation.” Stud Health Technol Inform 208 (2015): 131–36.Link to Item
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Anstrom, Kevin J., J Matthew Brennan, Eric L. Eisenstein, Jerome J. Federspiel, David Dai, Eric D. Peterson, and Pamela S. Douglas. “Examination of the treatment selection process in a multicenter observational study.” Circ Cardiovasc Qual Outcomes 7, no. 5 (September 2014): 764–69. https://doi.org/10.1161/CIRCOUTCOMES.113.000482.Full Text Link to Item
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Wharton, Gerold T., M Dianne Murphy, Debbie Avant, John V. Goldsmith, Grace Chai, William J. Rodriguez, and Eric L. Eisenstein. “Impact of pediatric exclusivity on drug labeling and demonstrations of efficacy.” Pediatrics 134, no. 2 (August 2014): e512–18. https://doi.org/10.1542/peds.2013-2987.Full Text Link to Item
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Miller, Timothy E., Julie K. Thacker, William D. White, Christopher Mantyh, John Migaly, Juying Jin, Anthony M. Roche, et al. “Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol.” Anesth Analg 118, no. 5 (May 2014): 1052–61. https://doi.org/10.1213/ANE.0000000000000206.Full Text Open Access Copy Link to Item
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Østbye, Truls, Marissa Stroo, Eric L. Eisenstein, Bercedis Peterson, and John Dement. “Is overweight and class I obesity associated with increased health claims costs?” Obesity (Silver Spring) 22, no. 4 (April 2014): 1179–86. https://doi.org/10.1002/oby.20669.Full Text Link to Item
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Carter, Barry L., Elizabeth A. Chrischilles, Gary Rosenthal, Brian M. Gryzlak, Eric L. Eisenstein, and Mark W. Vander Weg. “Efficacy and safety of nighttime dosing of antihypertensives: review of the literature and design of a pragmatic clinical trial.” J Clin Hypertens (Greenwich) 16, no. 2 (February 2014): 115–21. https://doi.org/10.1111/jch.12238.Full Text Link to Item
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Swigris, Jeffrey J., David L. Streiner, Kevin K. Brown, Amanda Belkin, Kathy E. Green, Frederick S. Wamboldt, and Frederick S. IPFnet Investigators. “Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis.” Respir Med 108, no. 1 (January 2014): 181–88. https://doi.org/10.1016/j.rmed.2013.12.009.Full Text Link to Item
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Eisenstein, Eric L., Linda Davidson-Ray, Rex Edwards, Kevin J. Anstrom, and Kenneth Ouriel. “Economic analysis of endovascular repair versus surveillance for patients with small abdominal aortic aneurysms.” J Vasc Surg 58, no. 2 (August 2013): 302–10. https://doi.org/10.1016/j.jvs.2013.01.038.Full Text Link to Item
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Collard, Harold R., Eric Yow, Luca Richeldi, Kevin J. Anstrom, Craig Glazer, and Craig IPFnet investigators. “Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials.” Respir Res 14, no. 1 (July 13, 2013): 73. https://doi.org/10.1186/1465-9921-14-73.Full Text Link to Item
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Østbye, Truls, Marissa Stroo, Rebecca J. N. Brouwer, Bercedis L. Peterson, Eric L. Eisenstein, Bernard F. Fuemmeler, Julie Joyner, Libby Gulley, and John M. Dement. “The steps to health employee weight management randomized control trial: rationale, design and baseline characteristics.” Contemp Clin Trials 35, no. 2 (July 2013): 68–76. https://doi.org/10.1016/j.cct.2013.04.007.Full Text Link to Item
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Lobach, David F., Kensaku Kawamoto, Kevin J. Anstrom, Garry M. Silvey, Janese M. Willis, Fred S. Johnson, Rex Edwards, et al. “A randomized trial of population-based clinical decision support to manage health and resource use for Medicaid beneficiaries.” J Med Syst 37, no. 1 (February 2013): 9922. https://doi.org/10.1007/s10916-012-9922-3.Full Text Link to Item
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Eisenstein, Elizabeth L. “Off Dutch presses.” Tls the Times Literary Supplement, no. 5758 (2013): 6–6.Link to Item
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Willis, Janese M., Rex Edwards, Kevin J. Anstrom, Fred S. Johnson, Guilherme Del Fiol, Kensaku Kawamoto, Nancy M Allen Lapointe, Eric L. Eisenstein, and David F. Lobach. “Decision support for evidence-based pharmacotherapy detects adherence problems but does not impact medication use.” Stud Health Technol Inform 183 (2013): 116–25.Link to Item
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Hillegass, William B., Manesh R. Patel, Lloyd W. Klein, Hitinder S. Gurm, J Matthew Brennan, Kevin J. Anstrom, David Dai, et al. “Long-term outcomes of older diabetic patients after percutaneous coronary stenting in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.” J Am Coll Cardiol 60, no. 22 (December 4, 2012): 2280–89. https://doi.org/10.1016/j.jacc.2012.08.993.Full Text Link to Item
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Eisenstein, Eric L., Daniel Wojdyla, Kevin J. Anstrom, J Matthew Brennan, Robert M. Califf, Eric D. Peterson, and Pamela S. Douglas. “Evaluating the impact of public health notification: Duke clopidogrel experience.” Circ Cardiovasc Qual Outcomes 5, no. 6 (November 2012): 767–74. https://doi.org/10.1161/CIRCOUTCOMES.111.963330.Full Text Link to Item
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Swigris, Jeffrey J., Meilan Han, Rekha Vij, Imre Noth, Eric L. Eisenstein, Kevin J. Anstrom, Kevin K. Brown, and Diane Fairclough. “The UCSD shortness of breath questionnaire has longitudinal construct validity in idiopathic pulmonary fibrosis.” Respir Med 106, no. 10 (October 2012): 1447–55. https://doi.org/10.1016/j.rmed.2012.06.018.Full Text Link to Item
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Brennan, J Matthew, David Dai, Manesh R. Patel, Sunil V. Rao, Ehrin J. Armstrong, John C. Messenger, Jeptha P. Curtis, et al. “Characteristics and long-term outcomes of percutaneous revascularization of unprotected left main coronary artery stenosis in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.” J Am Coll Cardiol 59, no. 7 (February 14, 2012): 648–54. https://doi.org/10.1016/j.jacc.2011.10.883.Full Text Link to Item
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Eisenstein, Eric L., David F. Kong, Patricia A. Cowper, Jay P. Bae, Krishnan Ramaswamy, and Kevin J. Anstrom. “Nonfatal myocardial infarction and long-term outcomes in coronary artery disease.” Am Heart J 163, no. 1 (January 2012): 95–103. https://doi.org/10.1016/j.ahj.2011.09.024.Full Text Link to Item
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Eisenstein, Eric L., Kevin J. Anstrom, Rex Edwards, Janese M. Willis, Jessica Simo, and David F. Lobach. “Population-based clinical decision support: a clinical and economic evaluation.” Stud Health Technol Inform 180 (2012): 343–47.Link to Item
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Brennan, J Matthew, Eric D. Peterson, John C. Messenger, John S. Rumsfeld, William S. Weintraub, Kevin J. Anstrom, Eric L. Eisenstein, et al. “Linking the National Cardiovascular Data Registry CathPCI Registry with Medicare claims data: validation of a longitudinal cohort of elderly patients undergoing cardiac catheterization.” Circ Cardiovasc Qual Outcomes 5, no. 1 (January 2012): 134–40. https://doi.org/10.1161/CIRCOUTCOMES.111.963280.Full Text Link to Item
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Eisenstein, Eric L., Lawrence W. Diener, Meredith Nahm, and Kevin P. Weinfurt. “Impact of the Patient-Reported Outcomes Management Information System (PROMIS) upon the design and operation of multi-center clinical trials: a qualitative research study.” J Med Syst 35, no. 6 (December 2011): 1521–30. https://doi.org/10.1007/s10916-010-9429-8.Full Text Link to Item
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Tsai, Thomas T., John C. Messenger, J Matthew Brennan, Uptal D. Patel, David Dai, Robert N. Piana, Kevin J. Anstrom, et al. “Safety and efficacy of drug-eluting stents in older patients with chronic kidney disease: a report from the linked CathPCI Registry-CMS claims database.” J Am Coll Cardiol 58, no. 18 (October 25, 2011): 1859–69. https://doi.org/10.1016/j.jacc.2011.06.056.Full Text Link to Item
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Anstrom, Kevin J., and Eric L. Eisenstein. “From batting average to wins above replacement to composite end points-refining clinical research using baseball statistical methods.” Am Heart J 161, no. 5 (May 2011): 805–6. https://doi.org/10.1016/j.ahj.2011.01.023.Full Text Link to Item
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Eisenstein, Eric L., Don Juzwishin, Andre W. Kushniruk, and Meredith Nahm. “Defining a framework for health information technology evaluation.” Stud Health Technol Inform 164 (2011): 94–99.Link to Item
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Eisenstein, Eric L., Kensaku Kawamoto, Kevin J. Anstrom, Janese M. Willis, Garry M. Silvey, Fred S. Johnson, Rex Edwards, Jean Mise, Susan D. Yaggy, and David F. Lobach. “Clinical and economic results from a randomized trial of clinical decision support in a rural health network.” Stud Health Technol Inform 164 (2011): 77–81.Link to Item
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Walden, Anita, Meredith Nahm, M Edwina Barnett, Jose G. Conde, Andrew Dent, Ahmed Fadiel, Theresa Perry, Chris Tolk, James E. Tcheng, and Eric L. Eisenstein. “Economic analysis of centralized vs. decentralized electronic data capture in multi-center clinical studies.” Stud Health Technol Inform 164 (2011): 82–88.Link to Item
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Frendl, Daniel M., Joshua T. Chang, Galen S. Wagner, and Eric L. Eisenstein. “Wireless Transmission of a Prehospital Electrocardiogram Can be Cost Effective for Patients with ST-Elevation Myocardial Infarction.” Circulation 122, no. 21 (November 23, 2010).Link to Item
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Tsai, Thomas T., John C. Messenger, J Matthew Brennan, Uptal D. Patel, David Dai, Robert Piana, Kevin J. Anstrom, et al. “Contemporary Risk of Follow-up Adverse Events in Older Patients with Chronic Kidney Disease and Dialysis Undergoing Percutaneous Coronary Interventions: A Report from the Merged NCDR CMS Registry.” Circulation 122, no. 21 (November 23, 2010).Link to Item
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Del Fiol, Guilherme, Kensaku Kawamoto, Nancy M Allen Lapointe, Eric L. Eisenstein, Kevin J. Anstrom, Laura L. Wood, and David F. Lobach. “Improving Medication Adherence in a Regional Healthcare Information Exchange using a Scalable, Claims-Driven, and Service-Oriented Approach.” Amia Annu Symp Proc 2010 (November 13, 2010): 137–41.Link to Item
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Idiopathic Pulmonary Fibrosis Clinical Research Network, Gary W., David A. Zisman, Marvin Schwarz, Kevin J. Anstrom, Harold R. Collard, Kevin R. Flaherty, and Gary W. Hunninghake. “A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis.” N Engl J Med 363, no. 7 (August 12, 2010): 620–28. https://doi.org/10.1056/NEJMoa1002110.Full Text Link to Item
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Eisenstein, Eric L., Emily F. Honeycutt, Kevin J. Anstrom, Richard C. Becker, Christopher B. Granger, Sunil V. Rao, Marc E. Jolicoeur, E Magnus Ohman, and E Magnus CATCH Investigators. “Economic assessment of thrombocytopenia: CATCH Registry.” J Med Syst 34, no. 3 (June 2010): 379–86. https://doi.org/10.1007/s10916-008-9250-9.Full Text Link to Item
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Petersen, John L., John J. Barron, Bradley G. Hammill, Mark J. Cziraky, Kevin J. Anstrom, Peter M. Wahl, Eric L. Eisenstein, et al. “Clopidogrel use and clinical events after drug-eluting stent implantation: findings from the HealthCore Integrated Research Database.” Am Heart J 159, no. 3 (March 2010): 462-470.e1. https://doi.org/10.1016/j.ahj.2009.11.031.Full Text Link to Item
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Rajgor, Dimple, Jatin Shah, Sun Kuie Tay, Truls Ostbye, Eric L. Eisenstein, Ranga Krishnan, and Ricardo Pietrobon. “Certificate course in outcomes research.” Med Teach 32, no. 1 (January 2010): 92.Link to Item
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Allen, Larry A., Kevin J. Anstrom, John R. Horton, Linda K. Shaw, Eric L. Eisenstein, and G Michael Felker. “Relationship between anemia and health care costs in heart failure.” J Card Fail 15, no. 10 (December 2009): 843–49. https://doi.org/10.1016/j.cardfail.2009.06.435.Full Text Link to Item
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Eisenstein, Eric L., William Wijns, Jean Fajadet, Laura Mauri, Rex Edwards, Patricia A. Cowper, David F. Kong, and Kevin J. Anstrom. “Long-term clinical and economic analysis of the Endeavor drug-eluting stent versus the Driver bare-metal stent: 4-year results from the ENDEAVOR II trial (Randomized Controlled Trial to Evaluate the Safety and Efficacy of the Medtronic AVE ABT-578 Eluting Driver Coronary Stent in De Novo Native Coronary Artery Lesions).” Jacc Cardiovasc Interv 2, no. 12 (December 2009): 1178–87. https://doi.org/10.1016/j.jcin.2009.10.011.Full Text Link to Item
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Leon, Martin B., David E. Kandzari, Eric L. Eisenstein, Kevin J. Anstrom, Laura Mauri, Donald E. Cutlip, Eugenia Nikolsky, et al. “Late safety, efficacy, and cost-effectiveness of a zotarolimus-eluting stent compared with a paclitaxel-eluting stent in patients with de novo coronary lesions: 2-year follow-up from the ENDEAVOR IV trial (Randomized, Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Taxus Paclitaxel-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions).” Jacc Cardiovasc Interv 2, no. 12 (December 2009): 1208–18. https://doi.org/10.1016/j.jcin.2009.10.008.Full Text Link to Item
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Eisenstein, Eric L., Martin B. Leon, David E. Kandzari, Laura Mauri, Rex Edwards, David F. Kong, Patricia A. Cowper, Kevin J. Anstrom, and Kevin J. ENDEAVOR III Investigators. “Long-term clinical and economic analysis of the Endeavor zotarolimus-eluting stent versus the cypher sirolimus-eluting stent: 3-year results from the ENDEAVOR III trial (Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions).” Jacc Cardiovasc Interv 2, no. 12 (December 2009): 1199–1207. https://doi.org/10.1016/j.jcin.2009.10.009.Full Text Link to Item
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Eisenstein, Eric L., Jie L. Sun, Kevin J. Anstrom, Elizabeth R. DeLong, Lynda A. Szczech, and Daniel B. Mark. “Assessing the economic attractiveness of coronary artery revascularization in chronic kidney disease patients.” J Med Syst 33, no. 4 (August 2009): 287–97. https://doi.org/10.1007/s10916-008-9190-4.Full Text Link to Item
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Douglas, Pamela S., J Matthew Brennan, Kevin J. Anstrom, Art Sedrakyan, Eric L. Eisenstein, Ghazala Haque, David Dai, et al. “Clinical effectiveness of coronary stents in elderly persons: results from 262,700 Medicare patients in the American College of Cardiology-National Cardiovascular Data Registry.” J Am Coll Cardiol 53, no. 18 (May 5, 2009): 1629–41. https://doi.org/10.1016/j.jacc.2009.03.005.Full Text Link to Item
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Eisenstein, E. L., M. B. Leon, D. E. Kandzari, R. Edwards, P. A. Cowper, D. F. Kong, M. D. Silverstein, D. B. Mark, and K. J. Anstrom. “ECONOMIC ANALYSIS OF ENDEAVOR VS. CYPHER STENTS: RESULTS FROM THE ENDEAVOR III TRIAL.” Value in Health 12, no. 3 (May 1, 2009): A152–A152.Link to Item
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Eisenstein, E. L., R. Edwards, P. A. Cowper, D. F. Kong, M. D. Silverstein, D. B. Mark, K. J. Anstrom, and W. Wijns. “ECONOMIC ANALYSIS OF THE ENDEAVOR DRUG-ELUTING STENT VS. THE DRIVER BARE METAL STENT: RESULTS FROM THE ENDEAVOR II TRIAL.” Value in Health 12, no. 3 (May 1, 2009): A152–A152.Link to Item
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Allen, Larry A., Kevin J. Anstrom, John Horton, Linda K. Shaw, Eric L. Eisenstein, and G Michael Felker. “Relationship Between Anemia Status and Health Care Costs in Patients With Symptomatic Heart Failure.” Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A391–A391.Link to Item
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Brennan, J Matthew, Kevin J. Anstrom, Eric L. Eisenstein, David Dai, Ghazala Haque, David F. Kong, Ralph G. Brindis, et al. “Long-Term Outcomes of Drug-Eluting Versus Bare-Metal Stents in Underrepresented Populations: Results From the Linked NCDR and CMS Database.” Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A386–A386.Link to Item
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Douglas, Pamela S., J Matthew Brennan, Kevin Anstrom, Eric L. Eisenstein, David Dai, Ghazala Haque, David F. Kong, et al. “Outcomes Following Coronary Stenting in a Linked NCDR and CMS Database: A National Study of Long-Term, Real World Outcomes of Bare Metal and Drug-Eluting Stents.” Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A401–2.Link to Item
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Eisenstein, Eric L., Jie L. Sun, Kevin J. Anstrom, Judith A. Stafford, Lynda A. Szczech, Lawrence H. Muhlbaier, and Daniel B. Mark. “Do income level and race influence survival in patients receiving hemodialysis?” Am J Med 122, no. 2 (February 2009): 170–80. https://doi.org/10.1016/j.amjmed.2008.08.025.Full Text Link to Item
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Eisenstein, Eric L., David F. Lobach, Kensaku Kawamoto, Rex Edwards, Janese M. Willis, Garry M. Silvey, and Kevin J. Anstrom. “A randomized clinical trial of clinical decision support in a rural community health network serving lower income individuals: study design and baseline characteristics.” Stud Health Technol Inform 143 (2009): 220–26.Link to Item
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Eisenstein, E. L., M. Ortiz, K. J. Anstrom, and D. F. Lobach. “Health information technology economic evaluation,” December 1, 2008, 240–58. https://doi.org/10.4018/978-1-59904-792-8.ch014.Full Text
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Eisenstein, Eric L. “DRIVE it home: making the case for prospective economic data collection in randomized clinical trials.” Kidney Int 74, no. 12 (December 2008): 1507–9. https://doi.org/10.1038/ki.2008.553.Full Text Link to Item
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Eisenstein, Eric L., Jie L. Sun, Kevin J. Anstrom, Judith A. Stafford, Lynda A. Szczech, Lawrence H. Muhlbaier, and Daniel B. Mark. “Re-evaluating the volume-outcome relationship in hemodialysis patients.” Health Policy 88, no. 2–3 (December 2008): 317–25. https://doi.org/10.1016/j.healthpol.2008.03.017.Full Text Link to Item
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Lobach, David F., Garry M. Silvey, Janese M. Willis, Kevin R. Kooy, Kensaku Kawamoto, Kevin J. Anstrom, Eric L. Eisenstein, and Fredrick Johnson. “Coupling direct collection of health risk information from patients through kiosks with decision support for proactive care management.” Amia Annu Symp Proc 2008 (November 6, 2008): 429–33.Link to Item
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Eisenstein, E. L., P. A. Cowper, J. P. Bae, D. F. Kong, K. Ramaswamy, and K. J. Anstrom. “CV1 WHAT IS THE CLINICAL BENEFIT OF PREVENTING NON-FATAL MYOCARDIAL INFARCTIONS?” Value in Health 11, no. 6 (November 2008): A341–42. https://doi.org/10.1016/s1098-3015(10)66185-2.Full Text
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Patel, Manesh R., Kevin J. Anstrom, Eric L. Eisenstein, Ralph G. Brindis, Eric D. Peterson, and Pamela S. Douglas. “Patients without obstructive coronary artery disease and stress test results: An analysis from the National Cardiovascular Data Registry.” Circulation 118, no. 18 (October 28, 2008): S1085–S1085.Link to Item
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Baker-Smith, Carissa M., Daniel K. Benjamin, Henry G. Grabowski, Elizabeth D. Reid, Barry Mangum, John V. Goldsmith, M Dianne Murphy, et al. “The economic returns of pediatric clinical trials of antihypertensive drugs.” Am Heart J 156, no. 4 (October 2008): 682–88. https://doi.org/10.1016/j.ahj.2008.05.001.Full Text Link to Item
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Shemilt, I., M. Mugford, S. Byford, M. Drummond, E. Eisenstein, M. Knapp, J. Mallender, D. McDaid, L. Vale, and D. Walker. “Incorporating Economics Evidence,” September 22, 2008, 449–79. https://doi.org/10.1002/9780470712184.ch15.Full Text
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Anstrom, Kevin J., David F. Kong, Linda K. Shaw, Robert M. Califf, Judith M. Kramer, Eric D. Peterson, Sunil V. Rao, et al. “Long-term clinical outcomes following coronary stenting.” Arch Intern Med 168, no. 15 (August 11, 2008): 1647–55. https://doi.org/10.1001/archinte.168.15.1647.Full Text Link to Item
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Kong, David F., Eric L. Eisenstein, and Robert Harrington. “Late adverse events after drug-eluting stent implantation.” Curr Cardiol Rep 10, no. 4 (July 2008): 253–62. https://doi.org/10.1007/s11886-008-0043-z.Full Text Link to Item
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Konstance, Richard P., Eric L. Eisenstein, Kevin J. Anstrom, Linda K. Shaw, Robert M. Califf, Robert A. Harrington, David B. Matchar, Kevin A. Schulman, and David F. Kong. “Outcomes of second revascularization procedures after stent implantation.” J Med Syst 32, no. 2 (April 2008): 177–86. https://doi.org/10.1007/s10916-007-9120-x.Full Text Link to Item
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Rao, Sunil V., Padma R. Kaul, Lawrence Liao, Paul W. Armstrong, E Magnus Ohman, Christopher B. Granger, Robert M. Califf, Robert A. Harrington, Eric L. Eisenstein, and Daniel B. Mark. “Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes.” Am Heart J 155, no. 2 (February 2008): 369–74. https://doi.org/10.1016/j.ahj.2007.10.014.Full Text Link to Item
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Oliveira, Gustavo B. F., Eric M. Crespo, Richard C. Becker, Emily F. Honeycutt, Charles S. Abrams, Kevin J. Anstrom, Peter B. Berger, et al. “Incidence and prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy.” Arch Intern Med 168, no. 1 (January 14, 2008): 94–102. https://doi.org/10.1001/archinternmed.2007.65.Full Text Link to Item
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Eisenstein, Eric L., Rory Collins, Beena S. Cracknell, Oscar Podesta, Elizabeth D. Reid, Peter Sandercock, Yuriy Shakhov, et al. “Sensible approaches for reducing clinical trial costs.” Clin Trials 5, no. 1 (2008): 75–84. https://doi.org/10.1177/1740774507087551.Full Text Link to Item
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Eisenstein, Eric L., David F. Lobach, Paul Montgomery, Kensaku Kawamoto, and Kevin J. Anstrom. “Implementation fidelity: a framework for evaluation in the health information technology field.” Amia Annu Symp Proc, October 11, 2007, 949.Link to Item
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Eisenstein, Eric L., David F. Lobach, Paul Montgomery, Kensaku Kawamoto, and Kevin J. Anstrom. “Evaluating implementation fidelity in health information technology interventions.” Amia Annu Symp Proc 2007 (October 11, 2007): 211–15.Link to Item
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Kawamoto, Kensaku, Nancy M. Allen LaPointe, Garry M. Silvey, Kevin J. Anstrom, Eric L. Eisenstein, and David F. Lobach. “Development and evaluation of an improved methodology for assessing adherence to evidence-based drug therapy guidelines using claims data.” Amia Annu Symp Proc 2007 (October 11, 2007): 394–98.Link to Item
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Lobach, David F., Kensaku Kawamoto, Kevin J. Anstrom, Kevin R. Kooy, Eric L. Eisenstein, Garry M. Silvey, Janese M. Willis, Frederick Johnson, and Jessica Simo. “Proactive population health management in the context of a regional health information exchange using standards-based decision support.” Amia Annu Symp Proc 2007 (October 11, 2007): 473–77.Link to Item
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Curtis, Lesley H., Bradley G. Hammill, Eric L. Eisenstein, Judith M. Kramer, and Kevin J. Anstrom. “Using inverse probability-weighted estimators in comparative effectiveness analyses with observational databases.” Med Care 45, no. 10 Supl 2 (October 2007): S103–7. https://doi.org/10.1097/MLR.0b013e31806518ac.Full Text Link to Item
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Kang, David E., Michaella M. Maloney, George E. Haleblian, W Patrick Springhart, Emily F. Honeycutt, Eric L. Eisenstein, Charles G. Marguet, and Glenn M. Preminger. “Effect of medical management on recurrent stone formation following percutaneous nephrolithotomy.” J Urol 177, no. 5 (May 2007): 1785–88. https://doi.org/10.1016/j.juro.2007.01.061.Full Text Link to Item
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Eisenstein, Eric L., David F. Kong, Kevin J. Anstrom, and Robert M. Califf. “Clopidogrel and Long-term Outcomes After Drug-Eluting Stent Implantation—Reply.” Jama 297, no. 16 (April 25, 2007): 1769–1769. https://doi.org/10.1001/jama.297.16.1770-c.Full Text
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Li, Jennifer S., Eric L. Eisenstein, Henry G. Grabowski, Elizabeth D. Reid, Barry Mangum, Kevin A. Schulman, John V. Goldsmith, M Dianne Murphy, Robert M. Califf, and Daniel K. Benjamin. “Economic return of clinical trials performed under the pediatric exclusivity program.” Jama 297, no. 5 (February 7, 2007): 480–88. https://doi.org/10.1001/jama.297.5.480.Full Text Open Access Copy Link to Item
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Eisenstein, Eric L., Kevin J. Anstrom, David F. Kong, Linda K. Shaw, Robert H. Tuttle, Daniel B. Mark, Judith M. Kramer, et al. “Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation.” Jama 297, no. 2 (January 10, 2007): 159–68. https://doi.org/10.1001/jama.297.2.joc60179.Full Text Link to Item
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Turner, H. M., C. Nye, M. Ortiz, E. Liu, and E. L. Eisenstein. “Producing systematic reviews of interventions in speech–language pathology: A framework for sustainability.” Evidence Based Communication Assessment and Intervention 1, no. 4 (January 1, 2007): 201–12. https://doi.org/10.1080/17489530701856577.Full Text
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Shemilt, Ian, Miranda Mugford, Michael Drummond, Eric Eisenstein, Jacqueline Mallender, David McDaid, Luke Vale, Damian Walker, and Damian Campbell & Cochrane Economics Methods Group (CCEMG). “Economics methods in Cochrane systematic reviews of health promotion and public health related interventions.” Bmc Med Res Methodol 6 (November 15, 2006): 55. https://doi.org/10.1186/1471-2288-6-55.Full Text Link to Item
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Eisenstein, E. L., E. F. Honeycutt, K. J. Anstrom, C. B. Granger, R. C. Becker, and E. M. Ohman. “PHM3 HEPARIN-RELATED THROMBOCYTOPENIA ASSOCIATED WITH MAJOR INCREASE IN HOSPITAL COSTS.” Value in Health 9, no. 6 (November 2006): A248–A248. https://doi.org/10.1016/s1098-3015(10)63347-5.Full Text
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Eisenstein, E. L., R. H. Tuttle, L. K. Shaw, K. J. Anstrom, and D. F. Kong. “PCV5 DRUG-ELUTING STENT USE IS ASSOCIATED WITH SIGNIFICANT IMPROVEMENTS IN LONG-TERM CLINICAL OUTCOMES.” Value in Health 9, no. 6 (November 2006): A338–A338. https://doi.org/10.1016/s1098-3015(10)63622-4.Full Text
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Eisenstein, Eric L., Salim Yusuf, Vishal Bindal, Martial G. Bourassa, Anne Horney, Joseph F. Collins, Daniel B. Mark, and Daniel B. DIG investigators. “What is the economic value of digoxin therapy in congestive heart failure patients? Results from the DIG trial.” J Card Fail 12, no. 5 (June 2006): 336–42. https://doi.org/10.1016/j.cardfail.2006.04.002.Full Text Link to Item
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Eisenstein, Eric L. “Conducting an economic analysis to assess the electrocardiogram's value.” J Electrocardiol 39, no. 2 (April 2006): 241–47. https://doi.org/10.1016/j.jelectrocard.2005.08.012.Full Text Link to Item
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Davis, Thomas H., Galen S. Wagner, Gilbert Gleim, Kathryn M. Andolsek, Hakan Arheden, Robert Austin, Anne Courtney-Eighmy, et al. “Problem-based learning of research skills.” J Electrocardiol 39, no. 1 (January 2006): 120–28. https://doi.org/10.1016/j.jelectrocard.2005.06.107.Full Text Link to Item
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Eisenstein, Eric L., Maqui Ortiz, Kevin J. Anstrom, David R. Crosslin, and David F. Lobach. “Assessing the quality of medical information technology economic evaluations: room for improvement.” Amia Annu Symp Proc 2006 (2006): 234–38.Link to Item
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Eisenstein, Eric L., Maqui Ortiz, Kevin J. Anstrom, David R. Crosslin, and David F. Lobach. “Economic evaluation in medical information technology: why the numbers don't add up.” Amia Annu Symp Proc 2006 (2006): 914.Link to Item
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Scales, Charles D., Peter J. Jones, Eric L. Eisenstein, Glenn M. Preminger, and David M. Albala. “Local cost structures and the economics of robot assisted radical prostatectomy.” J Urol 174, no. 6 (December 2005): 2323–29. https://doi.org/10.1097/01.ju.0000181830.43340.e7.Full Text Link to Item
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Eisenstein, Eric L., Darren K. McGuire, Manjushri V. Bhapkar, Arni Kristinsson, Judith S. Hochman, David F. Kong, Robert M. Califf, Frans Van de Werf, William S. Yancy, and L Kristin Newby. “Elevated body mass index and intermediate-term clinical outcomes after acute coronary syndromes.” Am J Med 118, no. 9 (September 2005): 981–90. https://doi.org/10.1016/j.amjmed.2005.02.017.Full Text Link to Item
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Kong, David F., and Eric L. Eisenstein. “Decision models for assessing the cost effectiveness of drug-eluting stents.” Expert Opin Pharmacother 6, no. 6 (June 2005): 965–74. https://doi.org/10.1517/14656566.6.6.965.Full Text Link to Item
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Al-Khatib, Sana M., Kevin J. Anstrom, Eric L. Eisenstein, Eric D. Peterson, James G. Jollis, Daniel B. Mark, Yun Li, Christopher M. O’Connor, Linda K. Shaw, and Robert M. Califf. “Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II.” Ann Intern Med 142, no. 8 (April 19, 2005): 593–600. https://doi.org/10.7326/0003-4819-142-8-200504190-00007.Full Text Link to Item
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Eisenstein, Eric L., Charles F. Bethea, Lawrence H. Muhlbaier, Marie Davidian, Eric D. Peterson, Judith A. Stafford, and Daniel B. Mark. “Surgeons' economic profiles: can we get the "right" answers?” J Med Syst 29, no. 2 (April 2005): 111–24. https://doi.org/10.1007/s10916-005-3000-z.Full Text Link to Item
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Kaul, Padma, Paul W. Armstrong, Patricia A. Cowper, Eric L. Eisenstein, Christopher B. Granger, Frans Van de Werf, and Daniel B. Mark. “Economic analysis of the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT-3) study: costs of reperfusion strategies in acute myocardial infarction.” Am Heart J 149, no. 4 (April 2005): 637–44. https://doi.org/10.1016/j.ahj.2004.02.019.Full Text Link to Item
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Eisenstein, Eric L., Philip W. Lemons, Barbara E. Tardiff, Kevin A. Schulman, M King Jolly, and Robert M. Califf. “Reducing the costs of phase III cardiovascular clinical trials.” Am Heart J 149, no. 3 (March 2005): 482–88. https://doi.org/10.1016/j.ahj.2004.04.049.Full Text Link to Item
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Eisenstein, Eric L., Kevin J. Anstrom, Jennifer M. Macri, David R. Crosslin, Frederick S. Johnson, Kensaku Kawamoto, and David F. Lobach. “Assessing the potential economic value of health information technology interventions in a community-based health network.” Amia Annu Symp Proc 2005 (2005): 221–25.Link to Item
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Eisenstein, Eric L., Kevin J. Anstrom, Jennifer M. Macri, David R. Crosslin, Frederick S. Johnson, Kensaku Kawamoto, and David F. Lobach. “Developing a framework for conducting economic evaluations of community-based health information technology interventions.” Amia Annu Symp Proc 2005 (2005): 948.Link to Item
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Kong, David F., Eric L. Eisenstein, Michael H. Sketch, James P. Zidar, Thomas J. Ryan, Robert A. Harrington, Mark F. Newman, Peter K. Smith, Daniel B. Mark, and Robert M. Califf. “Economic impact of drug-eluting stents on hospital systems: a disease-state model.” Am Heart J 147, no. 3 (March 2004): 449–56. https://doi.org/10.1016/j.ahj.2003.11.005.Full Text Link to Item
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Ostbye, Truls, Katrina M. Krause, Margaret Gradison, Eric L. Eisenstein, and Galen S. Wagner. “A problem-based approach to teaching outcomes research in family medicine residency.” Fam Med 36, no. 7 (2004): 470–72.Link to Item
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Myszka, D. G., Y. N. Abdiche, F. Arisaka, O. Byron, E. Eisenstein, P. Hensley, J. A. Thomson, et al. “The ABRF-MIRG'02 study: assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction.” Journal of Biomolecular Techniques : Jbt 14, no. 4 (December 2003): 247–69.
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Teplyakov, A., G. Obmolova, S. Y. Chu, J. Toedt, E. Eisenstein, A. J. Howard, and G. L. Gilliland. “Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid.” Journal of Bacteriology 185, no. 14 (July 2003): 4031–37.
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Parsons, J. F., K. Calabrese, E. Eisenstein, and J. E. Ladner. “Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway.” Biochemistry 42, no. 19 (May 2003): 5684–93.
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Lim, K., H. Zhang, A. Tempczyk, W. Krajewski, N. Bonander, J. Toedt, A. Howard, E. Eisenstein, and O. Herzberg. “Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): a cofactor bound at a site formed by a knot.” Proteins 51, no. 1 (April 2003): 56–67.
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Lim, K., A. Tempczyk, N. Bonander, J. Toedt, A. Howard, E. Eisenstein, and O. Herzberg. “A catalytic mechanism for D-Tyr-tRNATyr deacylase based on the crystal structure of Hemophilus influenzae HI0670.” The Journal of Biological Chemistry 278, no. 15 (April 2003): 13496–502.
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Krueger, S., S. K. Gregurick, J. Zondlo, and E. Eisenstein. “Interaction of GroEL and GroEL/GroES complexes with a nonnative subtilisin variant: a small-angle neutron scattering study.” Journal of Structural Biology 141, no. 3 (March 2003): 240–58.
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Lim, K., A. Tempczyk, J. F. Parsons, N. Bonander, J. Toedt, Z. Kelman, A. Howard, E. Eisenstein, and O. Herzberg. “Crystal structure of YbaB from Haemophilus influenzae (HI0442), a protein of unknown function coexpressed with the recombinational DNA repair protein RecR.” Proteins 50, no. 2 (February 2003): 375–79.
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Parsons, L., N. Bonander, E. Eisenstein, M. Gilson, V. Kairys, and J. Orban. “Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family.” Biochemistry 42, no. 1 (January 2003): 80–89.
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Thomas, Harold D., Charles Maynard, Galen S. Wagner, and Eric L. Eisenstein. “Results from a practice-based lipid clinic model in achieving low density lipoprotein cholesterol goals.” N C Med J 64, no. 6 (2003): 263–66.Link to Item
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Gilliland, G. L., A. Teplyakov, G. Obmolova, M. Tordova, N. Thanki, J. Ladner, O. Herzberg, et al. “Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics.” Current Drug Targets. Infectious Disorders 2, no. 4 (December 2002): 339–53.
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Lehmann, C., K. Lim, J. Toedt, W. Krajewski, A. Howard, E. Eisenstein, and O. Herzberg. “Structure of 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase from Haemophilus influenzae: activation by conformational transition.” Proteins 49, no. 1 (October 2002): 135–38.
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Teplyakov, A., G. Obmolova, M. Tordova, N. Thanki, N. Bonander, E. Eisenstein, A. J. Howard, and G. L. Gilliland. “Crystal structure of the YjeE protein from Haemophilus influenzae: a putative Atpase involved in cell wall synthesis.” Proteins 48, no. 2 (August 2002): 220–26.
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Buell, Hope E., Rodney H. Stables, Elizabeth R. DeLong, Kathy B. Shuping, Donna M. Killip, Harry M. Lever, William J. McKenna, et al. “Percutaneous transluminal septal reduction for hypertrophic obstructive cardiomyopathy: report from an international pilot study.” J Med Syst 26, no. 4 (August 2002): 293–300. https://doi.org/10.1023/a:1015812603042.Full Text Link to Item
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Eisenstein, Eric L., Charlotte L. Nelson, Teresa A. Simon, Allison L. Smitten, Pablo Lapuerta, and Daniel B. Mark. “Vasopeptidase inhibitor reduces inhospital costs for patients with congestive heart failure: results from the IMPRESS trial. Inhibition of Metallo Protease by BMS-186716 in a Randomized Exercise and Symptoms Study in Subjects With Heart Failure.” Am Heart J 143, no. 6 (June 2002): 1112–17. https://doi.org/10.1067/mhj.2002.123111.Full Text Link to Item
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Tewari, Yadu B., Pia Y. Jensen, Nand Kishore, Martin P. Mayhew, James F. Parsons, Edward Eisenstein, and Robert N. Goldberg. “Thermodynamics of reactions catalyzed by PABA synthase.” Biophys Chem 96, no. 1 (April 10, 2002): 33–51. https://doi.org/10.1016/s0301-4622(02)00034-0.Full Text Link to Item
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Parsons, J. F., K. Lim, A. Tempczyk, W. Krajewski, E. Eisenstein, and O. Herzberg. “From structure to function: YrbI from Haemophilus influenzae (HI1679) is a phosphatase.” Proteins 46, no. 4 (March 2002): 393–404.
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Eisenstein, Eric L., Linda K. Shaw, Charlotte L. Nelson, Kevin J. Anstrom, Zafar Hakim, and Daniel B. Mark. “Obesity and long-term clinical and economic outcomes in coronary artery disease patients.” Obes Res 10, no. 2 (February 2002): 83–91. https://doi.org/10.1038/oby.2002.14.Full Text Link to Item
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Parsons, J. F., P. Y. Jensen, A. S. Pachikara, A. J. Howard, E. Eisenstein, and J. E. Ladner. “Structure of Escherichia coli aminodeoxychorismate synthase: architectural conservation and diversity in chorismate-utilizing enzymes.” Biochemistry 41, no. 7 (February 2002): 2198–2208.
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Blumenthal, James A., Michael Babyak, Jiang Wei, Christopher O’Connor, Robert Waugh, Eric Eisenstein, Daniel Mark, et al. “Usefulness of psychosocial treatment of mental stress-induced myocardial ischemia in men.” Am J Cardiol 89, no. 2 (January 15, 2002): 164–68. https://doi.org/10.1016/s0002-9149(01)02194-4.Full Text Link to Item
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Andersen, O. M., F. P. Schwarz, E. Eisenstein, C. Jacobsen, S. K. Moestrup, M. Etzerodt, and H. C. Thøgersen. “Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP.” Biochemistry 40, no. 50 (December 2001): 15408–17.
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Lim, K., H. Zhang, A. Tempczyk, N. Bonander, J. Toedt, A. Howard, E. Eisenstein, and O. Herzberg. “Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine.” Proteins 45, no. 4 (December 2001): 397–407.
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Kandzari, D. E., L. C. Lam, E. L. Eisenstein, N. Clapp-Channing, J. T. Fine, R. M. Califf, D. B. Mark, and J. G. Jollis. “Advanced coronary artery disease: Appropriate end points for trials of novel therapies.” Am Heart J 142, no. 5 (November 2001): 843–51. https://doi.org/10.1067/mhj.2001.119136.Full Text Link to Item
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Obmolova, G., A. Teplyakov, N. Bonander, E. Eisenstein, A. J. Howard, and G. L. Gilliland. “Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae.” Journal of Structural Biology 136, no. 2 (November 2001): 119–25.
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Eisenstein, E. L., S. Yusuf, M. G. Bourassa, D. A. Egan, W. O. Williford, A. Horney, and D. Mark. “What is the economic value of digoxin therapy in congestive heart failure patients? Results from the DIG trial.” Circulation 104, no. 17 (October 23, 2001): 798–798.Link to Item
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Bennett, D. L., and E. Eisenstein. “Adolescent health in a globalised world: a picture of health inequalities.” Adolescent Medicine (Philadelphia, Pa.) 12, no. 3 (October 2001): 411–26.
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Parsons, L., E. Eisenstein, and J. Orban. “Solution structure of HI0257, a bacterial ribosome binding protein.” Biochemistry 40, no. 37 (September 2001): 10979–86.
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Eisenstein, E. L., L. K. Shaw, K. J. Anstrom, C. L. Nelson, Z. Hakim, V. Hasselblad, and D. B. Mark. “Assessing the clinical and economic burden of coronary artery disease: 1986-1998.” Med Care 39, no. 8 (August 2001): 824–35. https://doi.org/10.1097/00005650-200108000-00008.Full Text Link to Item
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Tangrea, M. A., P. Alexander, P. N. Bryan, E. Eisenstein, J. Toedt, and J. Orban. “Stability and global fold of the mouse prohormone convertase 1 pro-domain.” Biochemistry 40, no. 18 (May 2001): 5488–95.
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Eisenstein, E. L., L. K. Shaw, C. L. Nelson, K. J. Anstrom, Z. Hakim, and D. B. Mark. “Assessing the relationship between obesity and long-term clinical and economic outcomes in coronary artery disease patients.” Journal of the American College of Cardiology 37, no. 2 (February 1, 2001): 508A-509A.Link to Item
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Wagner, G. S., H. Engblom, T. Billgren, M. Carlsson, E. Hedstrom, M. Ugander, R. H. Selvester, et al. “A method for assembling a collaborative research team from multiple disciplines and academic centers to study the relationships between ECG estimation and MRI measurement of myocardial infarct size.” J Electrocardiol 34 Suppl (2001): 1–6. https://doi.org/10.1054/jelc.2001.28810.Full Text Link to Item
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Califf, R. M., and E. L. Eisenstein. “Critical concepts in cost-effectiveness for cardiovascular specialists.” Am Heart J 140, no. 6 Suppl (December 2000): S143–47. https://doi.org/10.1067/mhj.2000.111610.Full Text Link to Item
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Newby, L. K., E. L. Eisenstein, and R. M. Califf. “Hospitalisation for more than 3 days after thrombolysis for uncomplicated myocardial infarction was not cost effective.” Evidence Based Medicine 5, no. 6 (December 1, 2000): 190. https://doi.org/10.1136/ebm.5.6.190.Full Text
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Eisenstein, E., K. S. Coelho, S. C. Coelho, and M. A. Coelho. “[Nutrition in adolescence].” Jornal De Pediatria. 76 Suppl 3 (November 2000): S263–74.
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Zhang, H., K. Huang, Z. Li, L. Banerjei, K. E. Fisher, N. V. Grishin, E. Eisenstein, and O. Herzberg. “Crystal structure of YbaK protein from Haemophilus influenzae (HI1434) at 1.8 A resolution: functional implications.” Proteins 40, no. 1 (July 2000): 86–97.
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Newby, L. K., E. L. Eisenstein, R. M. Califf, T. D. Thompson, C. L. Nelson, E. D. Peterson, P. W. Armstrong, et al. “Cost effectiveness of early discharge after uncomplicated acute myocardial infarction.” N Engl J Med 342, no. 11 (March 16, 2000): 749–55. https://doi.org/10.1056/NEJM200003163421101.Full Text Link to Item
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Eisenstein, E. L., E. D. Peterson, J. G. Jollis, B. E. Tardiff, R. M. Califf, J. D. Knight, and D. B. Mark. “Evaluating the potential 'economic attractiveness' of new therapies in patients with non-ST elevation acute coronary syndrome.” Pharmacoeconomics 17, no. 3 (March 2000): 263–72. https://doi.org/10.2165/00019053-200017030-00004.Full Text Link to Item
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Kandzari, D. E., L. C. Lam, E. L. Eisenstein, N. Clapp-Channing, D. B. Mark, and J. G. Jollis. “Quality of life with end-stage coronary artery disease.” Journal of the American College of Cardiology 35, no. 2 (February 1, 2000): 554A-554A.Link to Item
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Eisenstein, E., G. L. Gilliland, O. Herzberg, J. Moult, J. Orban, R. J. Poljak, L. Banerjei, D. Richardson, and A. J. Howard. “Biological function made crystal clear - annotation of hypothetical proteins via structural genomics.” Current Opinion in Biotechnology 11, no. 1 (February 2000): 25–30.
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Asfour, W., S. Bell, A. M. Amkieh, E. B. Sgarbossa, R. K. Azzam, P. Clemmensen, M. Cohen, et al. “The correlation between presenting ST-segment depression and the final size of acute myocardial infarcts in patients with acute coronary syndromes.” J Electrocardiol 33 Suppl (2000): 61–63. https://doi.org/10.1054/jelc.2000.20338.Full Text Link to Item
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Hartmann, W. K., and E. Eisenstein. “Interaction of nonnative polypeptide substrates with the Escherichia coli chaperonin GroEL.” Methods in Molecular Biology (Clifton, N.J.) 140 (2000): 97–109.
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Stowers, Stephen A., Eric L. Eisenstein, Frans J Th Wackers, Daniel S. Berman, Joseph L. Blackshear, Arthur D. Jones, Theodore J. Szymanski, et al. “An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial.” Ann Emerg Med 35, no. 1 (January 2000): 17–25. https://doi.org/10.1016/S0196-0644(00)70100-4.Full Text Link to Item
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Eisenstein, E. L., and C. F. Bethea. “The use of patient mix-adjusted control charts to compare in-hospital costs of care.” Health Care Manag Sci 2, no. 4 (December 1999): 193–98. https://doi.org/10.1023/a:1019008400263.Full Text Link to Item
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Eisenstein, E. L., C. L. Nelson, L. K. Shaw, Z. Hakim, and D. B. Mark. “Assessing the relationship between obesity and life expectancy in past-acute coronary syndrome patients: A weighty matter.” Circulation 100, no. 18 (November 2, 1999): 317–317.Link to Item
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Eisenstein, E. L., L. K. Shaw, C. L. Nelson, Z. Hakim, and D. B. Mark. “Estimating long-term clinical and economic outcomes in post-acute coronary syndrome patients.” Circulation 100, no. 18 (November 2, 1999): 317–317.Link to Item
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Eisenstein, E., and D. Beckett. “Dimerization of the Escherichia coli biotin repressor: corepressor function in protein assembly.” Biochemistry 38, no. 40 (October 1999): 13077–84.
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Eisenstein, E. L., F. J. Wackers, G. S. Wagner, D. Natale, L. C. Lam, and S. A. Stowers. “The cost-effectiveness of an aggressive diagnostic strategy with SPECT myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain and nondiagnostic ECGs.” Circulation 98, no. 17 (October 27, 1998): 580–580.Link to Item
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Newby, L. K., E. L. Eisenstein, R. M. Califf, T. D. Thompson, C. L. Nelson, E. D. Peterson, and D. B. Mark. “Hospital stays past 72 hours in uncomplicated acute myocardial infarction patients are not cost effective.” Circulation 98, no. 17 (October 27, 1998): 753–753.Link to Item
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Abdulaev, N. G., G. N. Karaschuk, J. E. Ladner, D. L. Kakuev, A. V. Yakhyaev, M. Tordova, I. O. Gaidarov, et al. “Nucleoside diphosphate kinase from bovine retina: purification, subcellular localization, molecular cloning, and three-dimensional structure.” Biochemistry 37, no. 40 (October 1998): 13958–67.
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Eisenstein, E. L. “Patient risk or physician practice: what factors drive resource use in unstable angina?” Am Heart J 136, no. 3 (September 1998): 365–67. https://doi.org/10.1016/s0002-8703(98)70206-6.Full Text Link to Item
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Chinchilla, D., F. P. Schwarz, and E. Eisenstein. “Amino acid substitutions in the C-terminal regulatory domain disrupt allosteric effector binding to biosynthetic threonine deaminase from Escherichia coli.” The Journal of Biological Chemistry 273, no. 36 (September 1998): 23219–24.
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Gallagher, D. T., E. Eisenstein, K. E. Fisher, J. Zondlo, D. Chinchilla, H. D. Yu, J. Dill, et al. “Polymorphous crystallization and diffraction of threonine deaminase from Escherichia coli.” Acta Crystallographica. Section D, Biological Crystallography 54, no. Pt 3 (May 1998): 467–69.
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Gallagher, D. T., G. L. Gilliland, G. Xiao, J. Zondlo, K. E. Fisher, D. Chinchilla, and E. Eisenstein. “Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase.” Structure 6, no. 4 (April 1998): 465–75.
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Eisenstein, E., P. Reddy, and M. T. Fisher. “Overexpression, purification, and properties of GroES from Escherichia coli.” Methods in Enzymology 290 (1998): 119–35.
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Ismael, M. B., E. L. Eisenstein, and W. E. Hammond. “A comparison of neural network models for the prediction of the cost of care for acute coronary syndrome patients.” Proc Amia Symp, 1998, 533–37.Link to Item
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Simons, G. R., E. L. Eisenstein, L. J. Shaw, D. B. Mark, and E. L. Pritchett. “Cost effectiveness of inpatient initiation of antiarrhythmic therapy for supraventricular tachycardias.” Am J Cardiol 80, no. 12 (December 15, 1997): 1551–57. https://doi.org/10.1016/s0002-9149(97)00773-x.Full Text Link to Item
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Shaw, L. J., R. Hachamovitch, M. Cohen, D. S. Berman, S. Borges-Neto, J. E. Udelson, G. V. Heller, et al. “Cost implications of selective preoperative risk screening in the care of candidates for peripheral vascular operations.” Am J Manag Care 3, no. 12 (December 1997): 1817–27.Link to Item
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Eisenstein, E. L., E. D. Peterson, J. G. Jollis, B. E. Tardiff, J. D. Knight, and D. B. Mark. “Assessing the cost-effectiveness of newer therapies in non-ST elevation acute coronary syndrome patients.” Circulation 96, no. 8 (October 21, 1997): 1011–1011.Link to Item
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Kamireddi, M., E. Eisenstein, and P. Reddy. “Stable expression and rapid purification of Escherichia coli GroEL and GroES chaperonins.” Protein Expression and Purification 11, no. 1 (October 1997): 47–52.
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Ruvinov, S., L. Wang, B. Ruan, O. Almog, G. L. Gilliland, E. Eisenstein, and P. N. Bryan. “Engineering the independent folding of the subtilisin BPN' prodomain: analysis of two-state folding versus protein stability.” Biochemistry 36, no. 34 (August 1997): 10414–21.
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Eisenstein, E. “Chronic undernutrition during adolescence.” Annals of the New York Academy of Sciences 817 (May 1997): 138–61.
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Simons, G. R., E. L. Eisenstein, L. J. Shaw, D. B. Mark, and E. L. C. Pritchett. “Cost-effectiveness of inpatient initiation of antiarrhythmic therapy for supraventricular tachycardias.” Journal of the American College of Cardiology 29, no. 2 (February 1, 1997): 36103–36103.Link to Item
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Eisenstein, E. L., E. D. Peterson, J. G. Jollis, B. E. Tardiff, R. M. Califf, J. D. Knight, and D. B. Mark. “Assessing the value of newer pharmacologic agents in non-ST elevation patients: a decision support system application.” Proc Amia Annu Fall Symp, 1997, 273–77.Link to Item
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Eisenstein, E. L., E. D. Peterson, J. G. Jollis, B. E. Tardiff, R. M. Califf, J. D. Knight, and D. B. Mark. “Assessing the Value of Newer Pharmacologic Agents in Non-ST Elevation Patients: A Decision Support System Application.” Journal of the American Medical Informatics Association 4, no. SUPPL. (January 1, 1997): 273–77.
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Shaw, L. J., E. L. Eisenstein, R. Hachamovitch, G. V. Heller, and D. D. Miller. “A primer of biostatistic and economic methods for diagnostic and prognostic modeling in nuclear cardiology: Part II.” J Nucl Cardiol 4, no. 1 Pt 1 (1997): 52–60. https://doi.org/10.1016/s1071-3581(97)90049-0.Full Text Link to Item
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Bradrick, T. D., C. Shattuck, M. B. Strader, C. Wicker, E. Eisenstein, and E. E. Howell. “Redesigning the quaternary structure of R67 dihydrofolate reductase. Creation of an active monomer from a tetrameric protein by quadruplication of the gene.” The Journal of Biological Chemistry 271, no. 45 (November 1996): 28031–37.
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Eisenstein, E. L., L. K. Newby, L. Pilote, and E. D. Peterson. “Do regional differences in invasive cardiac procedure hates drive costs of care for the acute myocardial infarction patient?” Circulation 94, no. 8 (October 15, 1996): 2965–2965.Link to Item
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Miller, D., E. L. Eisenstein, and M. Travin. “Improving cost-effectiveness of coronary angioplasty in medically treated angina patients: The economic value of documenting myocardial ischemia.” Circulation 94, no. 8 (October 15, 1996): 4262–4262.Link to Item
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Peterson, E. D., J. G. Jollis, E. R. DeLong, J. A. Stafford, L. H. Muhlbaier, L. J. Shaw, E. L. Eisenstein, and D. B. Mark. “National patterns of post-MI non-invasive testing in the elderly: Results in 190,237 patients.” Circulation 94, no. 8 (October 15, 1996): 2972–2972.Link to Item
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Shaw, L. J., R. Hachamovitch, T. H. Marwick, G. V. Helfer, M. I. Travin, S. BorgesNeto, E. L. Eisenstein, and D. Miller. “Does the use of noninvasive testing reduce short- and long-term cost of care?” Circulation 94, no. 8 (October 15, 1996): 978–978.Link to Item
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Eisenstein, E. L., D. B. Mark, and R. M. Califf. “Importance of cost and quality of life in decisions about routine angiography after acute myocardial infarction. The role of cost-effectiveness models.” Circulation 94, no. 5 (September 1, 1996): 869–71. https://doi.org/10.1161/01.cir.94.5.869.Full Text Link to Item
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Dall’Acqua, W., E. R. Goldman, E. Eisenstein, and R. A. Mariuzza. “A mutational analysis of the binding of two different proteins to the same antibody.” Biochemistry 35, no. 30 (July 1996): 9667–76.
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Shaw, L. J., R. Hachamovitch, E. L. Eisenstein, M. Cohen, J. E. Udelson, R. C. Hendel, S. BorgesNeto, D. S. Berman, K. A. Eagle, and D. D. Miller. “An economic decision analysis of preoperative risk stratification in 6,489 intermediate risk patients undergoing vascular surgery.” Journal of Nuclear Medicine 37, no. 5 (May 1, 1996): 45–45.Link to Item
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Lin, Z., and E. Eisenstein. “Nucleotide binding-promoted conformational changes release a nonnative polypeptide from the Escherichia coli chaperonin GroEL.” Proceedings of the National Academy of Sciences of the United States of America 93, no. 5 (March 1996): 1977–81.
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Alemi, F., W. Rom, and E. Eisenstein. “Risk-adjusted control charts for health care assessment.” Annals of Operations Research 67 (January 1, 1996): 45–60. https://doi.org/10.1007/BF02187023.Full Text
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Eisenstein, E. L., and F. Alemi. “A comparison of three techniques for rapid model development: an application in patient risk-stratification.” Proc Amia Annu Fall Symp, 1996, 443–47.Link to Item
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Goldbaum, F. A., F. P. Schwarz, E. Eisenstein, A. Cauerhff, R. A. Mariuzza, and R. J. Poljak. “The effect of water activity on the association constant and the enthalpy of reaction between lysozyme and the specific antibodies D1.3 and D44.1.” Journal of Molecular Recognition : Jmr 9, no. 1 (1996): 6–12.
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Shaw, L. J., R. Hachamovitch, E. L. Eisenstein, K. L. Kesler, G. V. Heller, and D. D. Miller. “A primer of biostatistic and economic methods for diagnostic and prognostic modeling in nuclear cardiology: Part I.” J Nucl Cardiol 3, no. 6 Pt 1 (1996): 538–45. https://doi.org/10.1016/s1071-3581(96)90062-8.Full Text Link to Item
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Malchiodi, E. L., E. Eisenstein, B. A. Fields, D. H. Ohlendorf, P. M. Schlievert, K. Karjalainen, and R. A. Mariuzza. “Superantigen binding to a T cell receptor beta chain of known three-dimensional structure.” The Journal of Experimental Medicine 182, no. 6 (December 1995): 1833–45.
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Kanter, I., D. A. Kessler, A. Priel, and E. Eisenstein. “Analytical study of time series generation by feed-forward networks.” Phys Rev Lett 75, no. 13 (September 1995): 2614–17.
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White, Z. W., K. E. Fisher, and E. Eisenstein. “A monomeric variant of GroEL binds nucleotides but is inactive as a molecular chaperone.” The Journal of Biological Chemistry 270, no. 35 (September 1995): 20404–9.
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Zondlo, J., K. E. Fisher, Z. Lin, K. R. Ducote, and E. Eisenstein. “Monomer-heptamer equilibrium of the Escherichia coli chaperonin GroES.” Biochemistry 34, no. 33 (August 1995): 10334–39.
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Eisenstein, E., H. D. Yu, K. E. Fisher, D. A. Iacuzio, K. R. Ducote, and F. P. Schwarz. “An expanded two-state model accounts for homotropic cooperativity in biosynthetic threonine deaminase from Escherichia coli.” Biochemistry 34, no. 29 (July 1995): 9403–12.
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Braden, B. C., W. Dall’Acqua, E. Eisenstein, B. A. Fields, F. A. Goldbaum, E. L. Malchiodi, R. A. Mariuzza, F. P. Schwarz, X. Ysern, and R. J. Poljak. “Protein motion and lock and key complementarity in antigen-antibody reactions.” Pharmaceutica Acta Helvetiae 69, no. 4 (March 1995): 225–30.
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Eisenstein, E. L., and J. W. Hales. “A clinical economics workstation for risk-adjusted health care cost management.” Proc Annu Symp Comput Appl Med Care, 1995, 620–24.Link to Item
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Eisenstein, E., I. Kanter, D. A. Kessler, and W. Kinzel. “Generation and prediction of time series by a neural network.” Phys Rev Lett 74, no. 1 (January 1995): 6–9.
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Eisenstein, E. “Allosteric regulation of biosynthetic threonine deaminase from Escherichia coli: effects of isoleucine and valine on active-site ligand binding and catalysis.” Archives of Biochemistry and Biophysics 316, no. 1 (January 1995): 311–18.
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Lin, Z., F. P. Schwartz, and E. Eisenstein. “The hydrophobic nature of GroEL-substrate binding.” The Journal of Biological Chemistry 270, no. 3 (January 1995): 1011–14.
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Eisenstein, E. “Energetics of cooperative ligand binding to the active sites of biosynthetic threonine deaminase from Escherichia coli.” The Journal of Biological Chemistry 269, no. 47 (November 1994): 29416–22.
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Eisenstein, E., H. D. Yu, and F. P. Schwarz. “Cooperative binding of the feedback modifiers isoleucine and valine to biosynthetic threonine deaminase from Escherichia coli.” The Journal of Biological Chemistry 269, no. 47 (November 1994): 29423–29.
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Eisenstein, E., I. Kanter, and D. A. Kessler. “Interpolating between ferromagnets and spin glasses.” Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 50, no. 5 (November 1994): 3526–29.
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Govindaraj, S., E. Eisenstein, L. H. Jones, J. Sanders Loehr, A. Y. Chistoserdov, V. L. Davidson, and S. L. Edwards. “Aromatic amine dehydrogenase, a second tryptophan tryptophylquinone enzyme.” Journal of Bacteriology 176, no. 10 (May 1994): 2922–29.
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Zhuang, P., E. Eisenstein, and E. E. Howell. “Equilibrium folding studies of tetrameric R67 dihydrofolate reductase.” Biochemistry 33, no. 14 (April 1994): 4237–44.
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Tello, D., E. Eisenstein, F. P. Schwarz, F. A. Goldbaum, B. A. Fields, R. A. Mariuzza, and R. J. Poljak. “Structural and physicochemical analysis of the reaction between the anti-lysozyme antibody D1.3 and the anti-idiotopic antibodies E225 and E5.2.” Journal of Molecular Recognition : Jmr 7, no. 1 (March 1994): 57–62.
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Eisenstein, E. “[Anthropometry and pediatrics].” Jornal De Pediatria 70, no. 4 (1994): 193–94.
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Alemi, F., R. Stephens, T. Parran, S. Llorens, P. Bhatt, A. Ghadiri, and E. Eisenstein. “Automated monitoring of outcomes: application to treatment of drug abuse.” Med Decis Making 14, no. 2 (1994): 180–87. https://doi.org/10.1177/0272989X9401400211.Full Text Link to Item
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Eisenstein, E. L., and F. Alemi. “An evaluation of factors influencing Bayesian learning systems.” J Am Med Inform Assoc 1, no. 3 (1994): 272–84. https://doi.org/10.1136/jamia.1994.95236158.Full Text Link to Item
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Fisher, K. E., and E. Eisenstein. “An efficient approach to identify ilvA mutations reveals an amino-terminal catalytic domain in biosynthetic threonine deaminase from Escherichia coli.” Journal of Bacteriology 175, no. 20 (October 1993): 6605–13.
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Eisenstein, E., and I. Kanter. “Generalization performance of complex adaptive tasks.” Phys Rev Lett 70, no. 23 (June 1993): 3667–70.
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Sneller, M. C., W. Strober, E. Eisenstein, J. S. Jaffe, and C. Cunningham Rundles. “NIH conference. New insights into common variable immunodeficiency.” Annals of Internal Medicine 118, no. 9 (May 1993): 720–30.
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Nichols, R., C. D. Weaver, E. Eisenstein, R. L. Blakley, J. Appleman, T. H. Huang, F. Y. Huang, and E. E. Howell. “Titration of histidine 62 in R67 dihydrofolate reductase is linked to a tetramertwo-dimer equilibrium.” Biochemistry 32, no. 7 (February 1993): 1695–1706.
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Eisenstein, E. L., and F. Alemi. “An evaluation of factors influencing Bayesian learning systems.” Proc Annu Symp Comput Appl Med Care, 1993, 485–91.Link to Item
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Eisenstein, E. “Street youth: social imbalance and health risks.” Journal of Paediatrics and Child Health 29 Suppl 1 (1993): S46–49.
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Jaffe, J. S., E. Eisenstein, M. C. Sneller, and W. Strober. “T-cell abnormalities in common variable immunodeficiency.” Pediatric Research 33, no. 1 Suppl (January 1993): S24–27.
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Eisenstein, E., M. S. Han, T. S. Woo, J. M. Ritchey, I. Gibbons, Y. R. Yang, and H. K. Schachman. “Negative complementation in aspartate transcarbamylase. Analysis of hybrid enzyme molecules containing different arrangements of polypeptide chains from wild-type and inactive mutant catalytic subunits.” The Journal of Biological Chemistry 267, no. 31 (November 1992): 22148–55.
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Eisenstein, E. “Cloning, expression, purification, and characterization of biosynthetic threonine deaminase from Escherichia coli.” The Journal of Biological Chemistry 266, no. 9 (March 1991): 5801–7.
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Kanter, I., and E. Eisenstein. “Neural networks and the solution of nonlinear equations.” Phys Rev Lett 65, no. 4 (July 1990): 520–23.
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Eisenstein, E., D. W. Markby, and H. K. Schachman. “Heterotropic effectors promote a global conformational change in aspartate transcarbamoylase.” Biochemistry 29, no. 15 (April 1990): 3724–31.
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Green, S. M., E. Eisenstein, P. McPhie, and P. Hensley. “The purification and characterization of arginase from Saccharomyces cerevisiae.” The Journal of Biological Chemistry 265, no. 3 (January 1990): 1601–7.
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Eisenstein, E., D. W. Markby, and H. K. Schachman. “Changes in stability and allosteric properties of aspartate transcarbamoylase resulting from amino acid substitutions in the zinc-binding domain of the regulatory chains.” Proceedings of the National Academy of Sciences of the United States of America 86, no. 9 (May 1989): 3094–98.
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Duong, L. T., E. Eisenstein, S. M. Green, R. L. Ornberg, and P. Hensley. “The quaternary structure of ornithine transcarbamoylase and arginase from Saccharomyces cerevisiae.” The Journal of Biological Chemistry 261, no. 27 (September 1986): 12807–13.
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Eisenstein, E., L. T. Duong, R. L. Ornberg, J. C. Osborne, and P. Hensley. “Regulation of arginine metabolism in Saccharomyces cerevisiae. Association of arginase and ornithine transcarbamoylase.” The Journal of Biological Chemistry 261, no. 27 (September 1986): 12814–19.
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Eisenstein, E., and P. Hensley. “Ligand binding-promoted conformational changes in yeast ornithine transcarbamoylase.” The Journal of Biological Chemistry 261, no. 14 (May 1986): 6192–6200.
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Eisenstein, E., J. C. Osborne, I. M. Chaiken, and P. Hensley. “Purification and characterization of ornithine transcarbamoylase from Saccharomyces cerevisiae.” The Journal of Biological Chemistry 259, no. 8 (April 1984): 5139–45.
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Eisenstein, E., L. Plotnick, R. Lanes, P. A. Lee, C. J. Migeon, and A. A. Kowarski. “Evaluation of the growth hormone exercise test in normal and growth hormone-deficient children.” Pediatrics 62, no. 4 (October 1978): 526–28.
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Book Sections
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Willis JM, M. R., R. Edwards, K. J. Anstrom, F. S. Johnson, G. Del Fiol, K. Kawamoto, N. M. Allen lapointe, E. L. Eisenstein, and D. F. Lobach. “Decision Support for Evidence-Based Pharmacotherapy Detects Adherence Problems but Does Not Impact Medication Use.” In Enabling Health and Healthcare Through ICT, edited by Karen L. Courtney, Omid Shabestari, and Alexander Kuo, 183:116–25. IOS Press, 2013.
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Conference Papers
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Adagarla, Bhargav, Maryam Y. Garza, Karan R. Kumar, Umit Topaloglu, Anita Walden, Kanecia Zimmerman, Meredith N. Zozus, and Eric L. Eisenstein. “Understanding facilitators and barriers to development and adoption of EHR-to-eCRF technology in multi-site clinical research.” In Amia. AMIA, 2020.
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Garza, Maryam Y., Michael Rutherford, Sahiti Myneni, Susan Fenton, Anita Walden, Umit Topaloglu, Eric Eisenstein, et al. “Evaluating the Coverage of the HL7 ® FHIR ® Standard to Support eSource Data Exchange Implementations for use in Multi-Site Clinical Research Studies.” In Amia Annu Symp Proc, 2020:472–81, 2020.Link to Item
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Li, Chun, Sarah E. Deery, Eric L. Eisenstein, Zhi Ven Fong, Thomas F. X. O’Donnell, Nicholas J. Swerdlow, Linda Davidson-Ray, and Marc L. Schermerhorn. “IP059. Early and Late Costs of Endovascular Abdominal Aortic Aneurysm Repair From the Endurant Stent Graft System Post Approval Study (ENGAGE PAS).” In Journal of Vascular Surgery, 67:e105–e105. Elsevier BV, 2018. https://doi.org/10.1016/j.jvs.2018.03.119.Full Text
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Levitan, B., K. A. Getz, E. L. Eisenstein, M. Goldberg, M. Harker, S. E. Hesterlee, B. Patrick-Lake, J. Roberts, and J. A. DiMasi. “ASSESSING THE FINANCIAL VALUE OF PATIENT ENGAGEMENT.” In Value in Health, 20:A33–A33. ELSEVIER SCIENCE INC, 2017.Link to Item
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Ammenwerth, Elske, Nicolet De Keizer, Jytte Brender McNair, Catherine K. Craven, Eric Eisenstein, Andrew Georgiou, Saif Khairat, et al. “How to Teach Health IT Evaluation: Recommendations for Health IT Evaluation Courses.” In Stud Health Technol Inform, 243:3–7, 2017.Link to Item
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Eisenstein, E. L., B. Levitan, K. A. Getz, B. Patrick-Lake, and M. Harker. “Identifying And Valuing Patient Group Engagement Methods.” In Value in Health, 19:A103–A103. Elsevier BV, 2016. https://doi.org/10.1016/j.jval.2016.03.1672.Full Text
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Tibbs, Sheri R., Cynthia Kluchar, Sharon F. Terry, and Eric L. Eisenstein. “Platform for Engaging Everyone Responsibly (PEER) Validation Study Plan.” In Amia. AMIA, 2015.
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Mentz, Robert J., Jonathan Buggey, Phillip J. Schulte, Adam D. DeVore, Kevin J. Anstrom, Eric L. Eisenstein, Mona Fiuzat, Christopher M. O’Connor, and Eric J. Velazquez. “Torsemide vs. Furosemide in Heart Failure Patients: Insights from Duke University Hospital.” In Journal of Cardiac Failure, 20:S95–S95. Elsevier BV, 2014. https://doi.org/10.1016/j.cardfail.2014.06.267.Full Text
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Eisenstein, Eric L., Linda Davidson-Ray, Rex Edwards, Kevin J. Anstrom, Patricia A. Cowper, Daniel B. Mark, and Thomas R. Aversano. “Economic Outcomes of Percutaneous Coronary Intervention Performed at Sites With and Without On-Site Cardiac Surgery.” In Circulation, 126:2779–2779. LIPPINCOTT WILLIAMS & WILKINS, 2012.Link to Item
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Hillegass, William B., Manesh R. Patel, Kevin J. Anstrom, David Dai, Lloyd W. Klein, Hitinder S. Guram, Eric L. Eisenstein, Eric D. Peterson, John C. Messenger, and Pamela S. Douglas. “ACUTE AND LONG-TERM OUTCOMES IN OLDER DIABETIC PATIENTS RECEIVING A CORONARY STENT: CONTEMPORARY RESULTS IN 405,679 PATIENTS.” In Journal of the American College of Cardiology, 57:E1695–E1695. Elsevier BV, 2011. https://doi.org/10.1016/s0735-1097(11)61695-1.Full Text
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Riles, Eric M., Eric L. Eisenstein, Kevin J. Anstrom, Rex Edwards, Daniel B. Mark, and Judith Hochman. “Cost-effectiveness of an Early Revascularization Strategy for Cardiogenic Shock Based on Long-term Outcomes.” In Circulation, 120:S989–S989. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Eisenstein, Eric L., Patricia A. Cowper, Jay Bae, David F. Kong, and Kevin J. Anstrom. “Assessing proportions of higher-risk acute coronary syndrome-percutaneous coronary intervention patients in clinical trials and clinical practice.” In Circulation, 117:E421–22. LIPPINCOTT WILLIAMS & WILKINS, 2008.Link to Item
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Baker-Smith, Carissa M., Daniel K. Benjamin, Dianne Murphy, Eric L. Eisenstein, and Jennifer S. Li. “The economic return of performing pediatric anti-hypertensive drug clinical trials.” In Circulation, 116:822–822. LIPPINCOTT WILLIAMS & WILKINS, 2007.Link to Item
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Rao, Sunil V., Padma Kaul, Lawrence Liao, Daniel B. Mark, Eric L. Eisenstein, Paul W. Armstrong, Magnus Ohman, Christopher B. Granger, Robert M. Califf, and Robert A. Harrington. “Bleeding complications are a major driver of resource use among patients with acute coronary syndromes.” In Journal of the American College of Cardiology, 49:252A-252A. ELSEVIER SCIENCE INC, 2007.Link to Item
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Eisenstein, Eric L., Robert M. Tuttle, Linda K. Shaw, Kevin J. Anstrom, and David F. Kong. “Drug-eluting stent use is associated with significant improvements in long-term clinical outcomes.” In Circulation, 114:863–863. LIPPINCOTT WILLIAMS & WILKINS, 2006.Link to Item
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Sur, Roger L., Charles D. Scales, George E. Haleblian, Peter J. Jones, Kristy M. Borawski, Eric L. Eisenstein, Glenn M. Preminger, and David M. Albala. “220: Local Cost Structures and the Economics of Robot Assisted Radical Prostatectomy.” In Journal of Urology, 175:73–73. Ovid Technologies (Wolters Kluwer Health), 2006. https://doi.org/10.1016/s0022-5347(18)32487-x.Full Text
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Eisenstein, E. L., J. L. Sun, K. J. Anstrom, and D. B. Mark. “Assessing the economic attractiveness of coronary artery revascularization in chronic kidney disease patients.” In Journal of the American College of Cardiology, 45:340A-340A. ELSEVIER SCIENCE INC, 2005.Link to Item
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Eisenstein, E. L., J. L. Sun, E. R. Delong, D. B. Mark, D. N. Reddan, L. P. Svetkey, L. A. Szczech, A. A. Tsiatis, and W. F. Owen. “Is coronary artery revascularization associated with, increased life expectancy in chronic kidney disease patients?” In Journal of the American Society of Nephrology, 14:675A-675A. LIPPINCOTT WILLIAMS & WILKINS, 2003.Link to Item
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Eisenstein, E. L., D. K. McGuire, M. V. Bhapkar, D. F. Kong, R. M. Califf, and L. K. Newby. “Moderate obesity is associated with better intermediate-term survival in acute coronary syndromes: Results from the SYMPHONY and 2nd SYMPHONY clinical trials.” In Journal of the American College of Cardiology, 41:387A-387A. ELSEVIER SCIENCE INC, 2003.Link to Item
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Biswas, M. S., E. L. Eisenstein, and K. P. Alexander. “The right test for the right price.” In Circulation, 106:759–759. LIPPINCOTT WILLIAMS & WILKINS, 2002.Link to Item
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