Scholars@Duke
Emily Franklin Ozdowski

Emily Franklin Ozdowski

Lecturer of Biology
Biology
emily.ozdowski@duke.edu
130 Science Dr., Box 90338 Biosci, Durham, NC 27710
130 Science Drive, Box 90338, Biosci 072A, Durham, NC 27708-0338

Selected Publications

Suppression of spastin Mutant Phenotypes by Pak3 Loss Implicates a Role for Reactive Glia in AD-HSP.

Journal Article Frontiers in neuroscience · January 2020 Featured Publication Neurodegenerative mechanisms due to mutations in spastin currently center on neuronal defects, primarily in microtubule and endomembrane regulation. Spastin loss in Drosophila larvae compromises neuronal microtubule distribution, alters synap ... Full text Cite

Quantitative expression of MMPs 2, 9, 14, and collagen IV in LCIS and paired normal breast tissue

Journal Article Scientific Reports · September 17, 2019 AbstractCertain matrix metalloproteinases (MMPs) have the ability to degrade collagen IV, a main component of the breast lobular basement membrane. In this cross-sectional study, we evaluated expression of MMPs 2, 9, and 14 ... Full text Cite

Drosophila Models of Hereditary Spastic Paraplegia

Chapter · January 1, 2015 Hereditary spastic paraplegia (HSP) is a debilitating movement disorder with no prevention, no cure, and few options for symptom management. Rapid and relevant information is required, and the model organism Drosophila melanogaster can contribute significa ... Full text Cite

Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations.

Journal Article Genetics · September 2011 Microtubules are dynamic structures that must elongate, disassemble, and be cleaved into smaller pieces for proper neuronal development and function. The AAA ATPase Spastin severs microtubules along their lengths and is thought to regulate the balance betw ... Full text Cite

Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia.

Journal Article Hum Mol Genet · May 15, 2010 Mutations in spastin are the most frequent cause of the neurodegenerative disease autosomal dominant-hereditary spastic paraplegia (AD-HSP). Drosophila melanogaster lacking spastin exhibit striking behavioral similarities to human patients suffering from A ... Full text Link to item Cite

Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation.

Journal Article Genetics · November 2009 Ovarian follicle formation in Drosophila melanogaster requires stall (stl) gene function, both within and outside the ovary, for follicle individualization, stalk cell intercalation, and oocyte localization. We have identified the stl transcript as CG3622 ... Full text Link to item Cite