Overview
Epilepsy affects more than !% US population. Temporal lobe epilepsy is one of the most common form and most complicated epilepsy. Over 35 years epilepsy research, I have been working on the synaptic mechanism of temporal lobe epileptogenesid. Now, my research is focused on the critical period plasticity which could reoccur following brain insults. To discover when, where and which hippocampal region critical period reopened after brain insults could be a fundamental achievement for understanding the mechanism of temporal lobe epilepsy. The finding is also for other pathological disorders, such as PTSD, Schizophrenia and Alzheimer Disease as well as normal learning and memory.
Current Appointments & Affiliations
Assistant Professor in Neurology
·
2021 - Present
Neurology, Epilepsy and Sleep,
Neurology
Recent Publications
Long-Term Potentiation of Mossy Fiber Feedforward Inhibition of CA3 Pyramidal Cells Maintains E/I Balance in Epilepsy Model.
Journal Article eNeuro · 2022 Insight into the cellular and circuit mechanisms underlying development of temporal lobe epilepsy (TLE) will provide a foundation for improved therapies. We studied a model in which an episode of prolonged seizures is followed by recovery lasting two weeks ... Full text Link to item CiteIntravenous kainic acid induces status epilepticus and late onset seizures in mice.
Journal Article Epilepsy Res · December 2021 We set out to establish a novel model of temporal lobe epilepsy (TLE) in a mouse. We sought to induce TLE through the injection of kainic acid (KA) into the tail vein with subsequent development of status epilepticus (SE). Using C57BL/6 mice, we implanted ... Full text Link to item CiteLTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling.
Journal Article J Neurophysiol · February 1, 2019 Hippocampal mossy fiber axons simultaneously activate CA3 pyramidal cells and stratum lucidum interneurons (SLINs), the latter providing feedforward inhibition to control CA3 pyramidal cell excitability. Filopodial extensions of giant boutons of mossy fibe ... Full text Link to item CiteRecent Grants
Neurotrophins and Epileptogenesis
ResearchScientist · Awarded by National Institutes of Health · 2006 - 2024Cellular and Circuit Mechanisms of Temporal Lobe Epilepsy
ResearchAssistant Research Professor · Awarded by National Institutes of Health · 2017 - 2023Seizures Epileptogenesis and TrkB Transactivation
ResearchAssistant Research Professor · Awarded by National Institutes of Health · 2010 - 2015View All Grants
Education, Training & Certifications
Tianjin Medical University (China) ·
1982
M.D.