Scholars@Duke

• Background
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  Education, Training, & Certifications

  • M.D., Tianjin Medical University (China) 1982
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  Previous Appointments & Affiliations

  • Assistant Professor of Neurology, Neurology, Epilepsy and Sleep, Neurology 2013 - 2020
  • Assistant Professor of Medicine, Neurology, Clinical Science Departments 2006 - 2013
  • Assistant Research Professor of Medicine, Neurology, Clinical Science Departments 2001 - 2006
• Research
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  Selected Grants

  • Neurotrophins and Epileptogenesis awarded by National Institutes of Health 2006 - 2024
  • Cellular and Circuit Mechanisms of Temporal Lobe Epilepsy awarded by National Institutes of Health 2017 - 2023
  • Seizures Epileptogenesis and TrkB Transactivation awarded by National Institutes of Health 2010 - 2015
  • Mechanisms of Limbic Epileptogenesis awarded by National Institutes of Health 2009 - 2011
  • Epilepsy, Complement and Rasmussen's Syndrome awarded by National Institutes of Health 1998 - 2006
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Pan, Enhui, Ram S. Puranam, and James O. McNamara. “Long-Term Potentiation of Mossy Fiber Feedforward Inhibition of CA3 Pyramidal Cells Maintains E/I Balance in Epilepsy Model.” Eneuro 9, no. 1 (2022). https://doi.org/10.1523/ENEURO.0375-21.2021.
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    • Drysdale, Nicolas D., Elizabeth Matthews, Elizabeth Schuetz, Enhui Pan, and James O. McNamara. “Intravenous kainic acid induces status epilepticus and late onset seizures in mice.” Epilepsy Res 178 (December 2021): 106816. https://doi.org/10.1016/j.eplepsyres.2021.106816.
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    • Pan, Enhui, Zirun Zhao, and James O. McNamara. “LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling.” J Neurophysiol 121, no. 2 (February 1, 2019): 609–19. https://doi.org/10.1152/jn.00669.2018.
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    • Harward, Stephen C., Nathan G. Hedrick, Charles E. Hall, Paula Parra-Bueno, Teresa A. Milner, Enhui Pan, Tal Laviv, Barbara L. Hempstead, Ryohei Yasuda, and James O. McNamara. “Autocrine BDNF-TrkB signalling within a single dendritic spine.” Nature 538, no. 7623 (October 6, 2016): 99–103. https://doi.org/10.1038/nature19766.
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    • Pan, Enhui, Xiao-an Zhang, Zhen Huang, Artur Krezel, Min Zhao, Christine E. Tinberg, Stephen J. Lippard, and James O. McNamara. “Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse.” Neuron 71, no. 6 (September 22, 2011): 1116–26. https://doi.org/10.1016/j.neuron.2011.07.019.
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    • He, Xiao Ping, Enhui Pan, Carla Sciarretta, Liliana Minichiello, and James O. McNamara. “Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.” J Neurosci 30, no. 18 (May 5, 2010): 6188–96. https://doi.org/10.1523/JNEUROSCI.5821-09.2010.
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    • McNamara, J. O., Y. Z. Huang, and E. Pan. “Plasticity of dentate granule cell mossy fiber synapses: A Putative mechanism of limbic epileptogenesis,” December 1, 2008, 715–29. https://doi.org/10.1007/978-0-387-77232-5_24.
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    • Huang, Yang Z., Enhui Pan, Zhi-Qi Xiong, and James O. McNamara. “Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse.” Neuron 57, no. 4 (February 28, 2008): 546–58. https://doi.org/10.1016/j.neuron.2007.11.026.
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    • Danzer, S. C., E. Pan, S. Nef, L. F. Parada, and J. O. McNamara. “Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation.” Neuroscience 126, no. 4 (2004): 859–69. https://doi.org/10.1016/j.neuroscience.2004.03.025.
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