Enhui Pan

Journal Article eNeuro · 2022 Insight into the cellular and circuit mechanisms underlying development of temporal lobe epilepsy (TLE) will provide a foundation for improved therapies. We studied a model in which an episode of prolonged seizures is followed by recovery lasting two weeks ... Full text Link to item Cite

Intravenous kainic acid induces status epilepticus and late onset seizures in mice.

Journal Article Epilepsy Res · December 2021 We set out to establish a novel model of temporal lobe epilepsy (TLE) in a mouse. We sought to induce TLE through the injection of kainic acid (KA) into the tail vein with subsequent development of status epilepticus (SE). Using C57BL/6 mice, we implanted ... Full text Link to item Cite

LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling.

Journal Article J Neurophysiol · February 1, 2019 Hippocampal mossy fiber axons simultaneously activate CA3 pyramidal cells and stratum lucidum interneurons (SLINs), the latter providing feedforward inhibition to control CA3 pyramidal cell excitability. Filopodial extensions of giant boutons of mossy fibe ... Full text Link to item Cite

Autocrine BDNF-TrkB signalling within a single dendritic spine.

Journal Article Nature · October 6, 2016 Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are crucial for many forms of neuronal plasticity, including structural long-term potentiation (sLTP), which is a correlate of an animal's learning. However, it is unknown whether BDNF release ... Full text Link to item Cite

Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse.

Journal Article Neuron · September 22, 2011 The presence of zinc in glutamatergic synaptic vesicles of excitatory neurons of mammalian cerebral cortex suggests that zinc might regulate plasticity of synapses formed by these neurons. Long-term potentiation (LTP) is a form of synaptic plasticity that ... Full text Link to item Cite

Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.

Journal Article J Neurosci · May 5, 2010 The BDNF receptor, TrkB, is critical to limbic epileptogenesis, but the responsible downstream signaling pathways are unknown. We hypothesized that TrkB-dependent activation of phospholipase Cgamma1 (PLCgamma1) signaling is the key pathway and tested this ... Full text Link to item Cite

Plasticity of dentate granule cell mossy fiber synapses: A Putative mechanism of limbic epileptogenesis

Journal Article · December 1, 2008 The epilepsies constitute the third most common serious neurological disorder. Among the more than 40 different types of epilepsy, limbic epilepsy is the single most common and devastating form. Antiseizure drugs provide symptomatic relief, in that they su ... Full text Cite

Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse.

Journal Article Neuron · February 28, 2008 The receptor tyrosine kinase, TrkB, is critical to diverse functions of the mammalian nervous system in health and disease. Evidence of TrkB activation during epileptogenesis in vivo despite genetic deletion of its prototypic neurotrophin ligands led us to ... Full text Link to item Cite

Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation.

Journal Article Neuroscience · 2004 Brain-derived neurotrophic factor (BDNF) and its cognate receptor tyrosine kinase B (TrkB) play important roles in regulating survival, structure, and function of CNS neurons. One method of studying the functions of these molecules has utilized in vitro hi ... Full text Link to item Cite