Scholars@Duke
Eric James Benner

Eric James Benner

Assistant Professor of Pediatrics
Pediatrics, Neonatology
eric.benner@duke.edu
Box 2739 Med Ctr, Durham, NC 27710
2424 Erwin Road - Suite 504, Durham, NC 27710

Selected Publications

Electrophysiological Mechanisms and Validation of Ferritin-Based Magnetogenetics for Remote Control of Neurons.

Journal Article J Neurosci · July 24, 2024 Magnetogenetics was developed to remotely control genetically targeted neurons. A variant of magnetogenetics uses magnetic fields to activate transient receptor potential vanilloid (TRPV) channels when coupled with ferritin. Stimulation with static or RF m ... Full text Link to item Cite

Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment.

Journal Article Cell Stem Cell · April 4, 2024 Brain injury is highly associated with preterm birth. Complications of prematurity, including spontaneous or necrotizing enterocolitis (NEC)-associated intestinal perforations, are linked to lifelong neurologic impairment, yet the mechanisms are poorly und ... Full text Link to item Cite

20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis.

Journal Article Cell Stem Cell · August 3, 2023 White matter injuries (WMIs) are the leading cause of neurologic impairment in infants born premature. There are no treatment options available. The most common forms of WMIs in infants occur prior to the onset of normal myelination, making its pathophysio ... Full text Link to item Cite

Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age.

Journal Article Br J Ophthalmol · February 2023 BACKGROUND/AIMS: Neonatal insults from systemic diseases have been implicated in the pathway of impaired neurodevelopment in preterm infants. We aimed to investigate the associations between systemic health factors and retinal nerve fibre layer (RNFL) thic ... Full text Link to item Cite

Proceedings of the 13th International Newborn Brain Conference: Neuro-imaging studies.

Journal Article Journal of neonatal-perinatal medicine · January 2022 Full text Cite

Imaging microstructure with diffusion and susceptibility MR: neuronal density correlation in Disrupted-in-Schizophrenia-1 mutant mice.

Journal Article NMR Biomed · October 2020 PURPOSE: To probe cerebral microstructural abnormalities and assess changes of neuronal density in Disrupted-in-Schizophrenia-1 (DISC1) mice using non-Gaussian diffusion and quantitative susceptibility mapping (QSM). MATERIALS AND METHODS: Brain specimens ... Full text Link to item Cite

Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects.

Journal Article Sci Signal · October 10, 2017 Birth defects of the heart and face are common, and most have no known genetic cause, suggesting a role for environmental factors. Maternal fever during the first trimester is an environmental risk factor linked to these defects. Neural crest cells are pre ... Full text Open Access Link to item Cite

Intermittent hypoxia during recovery from neonatal hyperoxic lung injury causes long-term impairment of alveolar development: A new rat model of BPD.

Journal Article Am J Physiol Lung Cell Mol Physiol · February 1, 2017 Bronchopulmonary dysplasia (BPD) is a chronic lung injury characterized by impaired alveologenesis that may persist into adulthood. Rat models of BPD using varying degrees of hyperoxia to produce injury either cause early mortality or spontaneously recover ... Full text Link to item Cite

An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.

Journal Article Nat Neurosci · December 2016 Inflammation induced by innate immunity influences the development of T cell-mediated autoimmunity in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). We found that strong activation of innate immunity induced Nod-l ... Full text Link to item Cite

Laryngeal Cleft.

Journal Article Anesthesiology · August 30, 2016 Full text Link to item Cite

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice.

Journal Article Proc Natl Acad Sci U S A · March 29, 2016 Disrupted brain iron homeostasis is a common feature of neurodegenerative disease. To begin to understand how neuronal iron handling might be involved, we focused on dopaminergic neurons and asked how inactivation of transport proteins affected iron homeos ... Full text Link to item Cite

Control of neuroinflammation for therapeutic gain

Chapter · January 1, 2016 Immunology, neuroscience and pharmacology are each independent broad multidisciplinary fields that are well developed for the biomedical sciences. The evolution of each at the molecular, biochemical and cellular levels have been, by any measure, enormous i ... Full text Cite

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.

Journal Article Nature · May 16, 2013 Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also called subependymal zone) generate doublecortin (Dcx)(+) neuroblasts that migrate and integrate into olfactory bulb circuitry. Continuous production of neuroblasts is ... Full text Open Access Link to item Cite

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4

Journal Article Nature · 2013 Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also called subependymal zone) generate doublecortin (Dcx) + neuroblasts that migrate and integrate into olfactory bulb circuitry. Continuous production of neuroblasts is ... Full text Open Access Cite

Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease.

Journal Article J Immunol · March 1, 2010 Nitrated alpha-synuclein (N-alpha-syn) immunization elicits adaptive immune responses to novel antigenic epitopes that exacerbate neuroinflammation and nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson ... Full text Link to item Cite

Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury.

Journal Article Am J Kidney Dis · May 2009 Cryoglobulinemia is rarely reported in children, and kidney failure secondary to cryoglobulinemia is even more uncommon. We report the case of a 7-year-old boy with cryoglobulins and a systemic illness, including persistent fever, arthralgias, rash, hypoco ... Full text Link to item Cite

Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.

Journal Article PLoS One · January 2, 2008 BACKGROUND: The neuropathology of Parkinson's disease (PD) includes loss of dopaminergic neurons in the substantia nigra, nitrated alpha-synuclein (N-alpha-Syn) enriched intraneuronal inclusions or Lewy bodies and neuroinflammation. While the contribution ... Full text Link to item Cite

Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson's disease

Journal Article Clinical Neuroscience Research · December 1, 2006 Neuroinflammatory processes play a significant role in the pathogenesis of Parkinson's disease (PD). Epidemiologic, animal, human, and therapeutic studies all support the presence of a neuroinflammatory cascade in disease. This is highlighted by the neurot ... Full text Cite

Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease.

Journal Article J Neurosci · February 16, 2005 Nigrostriatal degeneration, the pathological hallmark of Parkinson's disease (PD), is mirrored by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. MPTP-treated animals show the common behavioral, motor, and pathological features of human d ... Full text Link to item Cite

Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.

Journal Article Proc Natl Acad Sci U S A · June 22, 2004 Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune c ... Full text Link to item Cite

Neuroimaging and proteomic tracking of neurodegeneration in MPTP-treated mice

Journal Article Annals of the New York Academy of Sciences · January 1, 2003 Full text Cite

Oligonucleotide enhanced cytotoxicity of Idarubicin for lymphoma cells.

Journal Article Leuk Lymphoma · July 2001 Oligonucleotides offer the potential to manipulate gene expression in targeted cells which might be exploitable for therapeutic benefit. The effects of combining a phosphorothioate oligonucleotide OL(1) p53, which transiently down-regulates p53 levels, wit ... Full text Link to item Cite

Cadmium- and chromium-induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripheral blood mononuclear cells.

Journal Article J Biochem Mol Toxicol · 2000 Sodium dichromate [Cr(VI)] and cadmium chloride [Cd(II)] are both cytotoxic and mutagenic. This study examined the toxic and apoptotic potentials of these two cations on three cell types in vitro, namely, human chronic myelogenous leukemic (CML) K562 cells ... Full text Link to item Cite

Amelioration of the cytotoxic effects of chemotherapeutic agents by grape seed proanthocyanidin extract.

Journal Article Antioxid Redox Signal · 1999 Anticancer chemotherapeutic agents are effective in inhibiting growth of cancer cells in vitro and in vivo, however, toxicity to normal cells is a major problem. In this study, we assessed the effect of a novel IH636 grape seed proanthocyanidin extract (GS ... Full text Link to item Cite

Amelioration of cytotoxic effects of idarubicin and 4HC on Chang liver cells by a novel grape seed proanthocyanidin extract

Journal Article FASEB Journal · March 20, 1998 Despite anticancer chemotherapeutic agents are very effective in inhibiting growth of cancer cells in vitro and in vivo, toxicity to normal cells is a major problem. In an attempt to ameliorate the toxic effects in this study we have used a novel grape see ... Cite

Cadmium and chromium induced oxidative stress and apoptopic cell death in cultured human chronic myelogenous leukemic k562 cells

Journal Article FASEB Journal · December 1, 1997 Both sodium dichromate [Cr VI] and cadmium chloride [Cd II] are cytotoxic and mutagenic. This in vitro study focuses on the toxic and apoptopic potentials of these two cations on human K562 chronic myelogenous and HL-60 promyelocytic leukemic cells. The ce ... Cite

Isolation and dna sequence of the gene encoding thermus aquaticus yt-1 aspartate aminotransferase

Journal Article FASEB Journal · December 1, 1997 The Aspartate Aminotransferase (AspAT) (E.C. 2.6.1.1) was purified to homogeneity from the gram negative, extremely thermophilic, bacteria Thermus aquaticus YT-1 and Thermus ruber Murrieta (isolated from Murrieta Hot Spring in California USA). The purified ... Cite

Combination of antisense oligonucleotide and low-dose chemotherapy in hematological malignancies.

Journal Article J Pharmacol Toxicol Methods · June 1997 Current conventional chemotherapy for the treatment of hematological malignancies, although quite effective, has associated toxicities to normal tissue and organs, which is still a major dose limiting factor. In addition, high dose chemotherapy followed by ... Full text Link to item Cite

Increased growth inhibition of human chronic myelogenous leukemic cells by a combination of c-myb antisense oligonucleotide and 4-hydroxyperoxycyclophosphamide in vitro

Journal Article International Journal of Oncology · January 1, 1997 Human chronic myelogenous leukemia (CML) is a unique malignancy in its cellular and molecular phenotypes. High dose therapy followed by stem cell transplantation seems to be one of the most effective treatment modalities for CML. However, allogeneic stem c ... Full text Cite