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Eugene John Vaios

Assistant Professor of Radiation Oncology
Radiation Oncology
30 Duke Medicne Cir, Box 3085, Durham, NC 27710

Research Interests


My NIH-funded research aims to develop non-invasive ways to diagnose and monitor brain tumors after treatment, without the need for a surgical procedure, by leveraging omics platforms. I am also interested in how radiation therapy can be safely combined with novel systemic therapies, such as immunotherapy, to improve the effectiveness of our treatment while minimizing potential long-term side effects. I am an active participant in clinical trials through the Department of Radiation Oncology, the Duke Center for Brain and Spine Metastasis, and the Preston Robert Tisch Brain Tumor Center at Duke. Our hope is that these studies yield discoveries that improve the effectiveness of our treatments and the quality of life of our patients.

Global Scholarship:

I serve on The Lancet Commission on Neurorehabilitation as a Commissioner in the working group on Neurorehabilitation in Neuro-Oncology. This initiative, led by the World Health Organization (WHO), aims to develop evidence-based pragmatic solutions to improve neurorehabilitation services worldwide, with a focus on overcoming barriers in existing services and fostering available, accessible, affordable, and effective interventions along the care continuum in diverse settings across the globe. (Location: Geneva, Switzerland)

Selected Grants


Elucidating Brain Tumor Biology and Response to Radiotherapy Using Cell-Free-DNA Methylation Signatures

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2026

Fellowships, Gifts, and Supported Research


A Pilot Study of ctDNA as a Biomarker for Tumor Biology, Treatment Response, and Clinical Outcomes in Patients with Glioblastoma Receiving Radiotherapy · February 1, 2025 - June 30, 2025 Awarded by: Caris Life Sciences Co-PI: Vaios, Floyd
Leveraging Explainable AI to Develop a Non-invasive Radionecrosis Diagnostic Program for Patients with Brain Metastases · January 1, 2025 - December 31, 2025 Awarded by: Duke Cancer Institute Pilot Award (P30 Cancer Center Support Grant, NIH CA014236) PI: Vaios
Cell-Free DNA Methylation Patterns as a Biomarker for Tumor Biology and Clinical Outcomes for Glioblastoma Patients · August 1, 2024 - July 31, 2026 Awarded by: NIH/NCI K38 Stimulating Access to Research in Residency Transition Scholar (StARRTS) Award (K38CA292995) PI: Vaios
An Ensemble Diagnostic and Surveillance Platform: Integrating Deep Learning Radiomics Techniques with Liquid Biopsies to Elucidate Tumor Biology and Response to Radiotherapy in Glioblastoma · July 1, 2024 - June 30, 2025 Awarded by: Duke Office of Physician Scientist Development (OPSD) R38 Technician Support Award PI: Vaios
cfDNA Methylation Patterns as Biomarkers for Tumor Biology and Clinical Outcomes in Glioblastoma Patients · July 1, 2022 - June 30, 2023 Awarded by: NIH Stimulating Access to Research in Residency (StARR) R38 Award (5R38-CA245204) PI: Vaios
Circulating Biomarkers for Clinical Outcomes in Glioblastoma Patients · June 1, 2015 - August 1, 2015 Awarded by: National Neurosurgery Research and Education Foundation Research Fellowship PI: Vaios

External Relationships


  • American Society for Radiation Oncology
  • Glasshouse Health
  • Servier Pharmaceuticals
  • Vaios Healthcare Consulting, LLC

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.