Jerome M. Feldman | Scholars@Duke

Jerome M. Feldman
Professor Emeritus of Medicine

My work involves the natural history, diaginoses, and therapy of patients with neuroendocrene tumors such as carcinoid tumors and pheochromocytomas. I also am interested in research aspects of diabetes, adrenal cortical disease and pituitory gland disease. My approach has been to make detailed biochemical measurements on patients with the above described diseases in my research lab over my 30 years at Duke. I am now preparing manuscripts containing correlation of data with clinical illness. My data bases contain information on 793 patients with carcinoid turmors and 130 patients with pheorchromocytonics.

I have done and contiune to do post marketing clinical trials on hypoglycernic medications, octreotide, and alphainterfewn. I am recongized as a national expert on neuroendocrene tumors as well as deibetes mellitus.

Key words: Neuroendocrine Tumors, carcinoid tumors, pheochromocytonics, diabetes, hypoglycemic agents, serotonin, catecholamines.

Current Appointments & Affiliations

Professor Emeritus of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2000

Contact Information

Box 2963 Med Ctr, Durham, NC 27710
E3008 VA Med Ctr, 508 Fulton St, Durham, NC 27705
feld002@duke.edu (919) 286-0411

Background
Education, Training, & Certifications
- M.D., Northwestern University 1961
Previous Appointments & Affiliations
- Professor of Medicine with Tenure, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 1998 - 2000
- Associate Professor Medicine with Tenure, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 1972 - 1998
- Assistant Professor of Medicine, Medicine, Clinical Science Departments 1970 - 1972
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1968 - 1970
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Guller, Ulrich, Joe Turek, Steve Eubanks, Elizabeth R. Delong, Daniel Oertli, and Jerome M. Feldman. “Detecting pheochromocytoma: defining the most sensitive test.” Ann Surg 243, no. 1 (January 2006): 102–7. https://doi.org/10.1097/01.sla.0000193833.51108.24.
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  - Kypson, Alan P., Mark W. Onaitis, Jerome M. Feldman, and Douglas S. Tyler. “Carcinoid and chylous ascites: an unusual association.” J Gastrointest Surg 6, no. 5 (2002): 781–83. https://doi.org/10.1016/s1091-255x(02)00014-8.
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  - Onaitis, M. W., P. M. Kirshbom, T. Z. Hayward, F. J. Quayle, J. M. Feldman, H. F. Seigler, and D. S. Tyler. “Gastrointestinal carcinoids: characterization by site of origin and hormone production.” Ann Surg 232, no. 4 (October 2000): 549–56. https://doi.org/10.1097/00000658-200010000-00010.
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  - Kirshbom, P. M., A. R. Kherani, M. W. Onaitis, A. Hata, T. E. Kehoe, C. Feldman, J. M. Feldman, and D. S. Tyler. “Foregut carcinoids: a clinical and biochemical analysis.” Surgery 126, no. 6 (December 1999): 1105–10. https://doi.org/10.1067/msy.2099.101430.
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  - Kirshbom, P. M., A. R. Kherani, M. W. Onaitis, J. M. Feldman, and D. S. Tyler. “Carcinoids of unknown origin: comparative analysis with foregut, midgut, and hindgut carcinoids.” Surgery 124, no. 6 (December 1998): 1063–70. https://doi.org/10.1067/msy.1998.93105.
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  - Hanson, M. W., A. M. Schneider, D. S. Enterline, J. M. Feldman, and J. P. Gockerman. “Iodine-131-metaiodobenzylguanidine uptake in metastatic carcinoid tumor to the orbit.” J Nucl Med 39, no. 4 (April 1998): 647–50.
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  - Mergener, K., M. R. Gottfried, J. M. Feldman, and M. S. Branch. “Carcinoid of the ampulla of Vater presenting as acute pancreatitis.” Am J Gastroenterol 91, no. 11 (November 1996): 2426–27.
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  - Robiolio, P. A., V. H. Rigolin, J. S. Wilson, J. K. Harrison, L. L. Sanders, T. M. Bashore, and J. M. Feldman. “Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography.” Circulation 92, no. 4 (August 15, 1995): 790–95. https://doi.org/10.1161/01.cir.92.4.790.
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  - Robiolio, P. A., V. H. Rigolin, J. K. Harrison, J. E. Lowe, J. O. Moore, T. M. Bashore, and J. M. Feldman. “Predictors of outcome of tricuspid valve replacement in carcinoid heart disease.” Am J Cardiol 75, no. 7 (March 1, 1995): 485–88. https://doi.org/10.1016/s0002-9149(99)80586-4.
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  - Berry, C. R., K. N. Wright, E. B. Breitschwerdt, and J. M. Feldman. “USE OF ¹²³IODINE METAIODOBENZYLGUANIDINE SCINTIGRAPHY FOR THE DIAGNOSIS OF A PHEOCHROMOCYTOMA IN A DOG.” Veterinary Radiology &Amp; Ultrasound 34, no. 1 (January 1, 1993): 52–55. https://doi.org/10.1111/j.1740-8261.1993.tb01994.x.
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  - Harpole, D. H., J. M. Feldman, S. Buchanan, W. G. Young, and W. G. Wolfe. “Bronchial carcinoid tumors: a retrospective analysis of 126 patients.” Ann Thorac Surg 54, no. 1 (July 1992): 50–54. https://doi.org/10.1016/0003-4975(92)91139-z.
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  - Hanson, M. W., J. M. Feldman, C. A. Beam, G. S. Leight, and R. E. Coleman. “Iodine 131-labeled metaiodobenzylguanidine scintigraphy and biochemical analyses in suspected pheochromocytoma.” Arch Intern Med 151, no. 7 (July 1991): 1397–1402.
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  - Feldman, J. M. “Carcinoid tumors and the carcinoid syndrome.” Curr Probl Surg 26, no. 12 (December 1989): 835–85. https://doi.org/10.1016/0011-3840(89)90010-5.
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  - Hanson, M. W., J. M. Feldman, R. A. Blinder, J. O. Moore, and R. E. Coleman. “Carcinoid tumors: iodine-131 MIBG scintigraphy.” Radiology 172, no. 3 (September 1989): 699–703. https://doi.org/10.1148/radiology.172.3.2772175.
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  - Feldman, J. M. “Surgery in patients with unsuspected pheochromocytomas.” J Surg Oncol 41, no. 1 (May 1989): 65–69. https://doi.org/10.1002/jso.2930410117.
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  - Feldman, J. M. “Diagnosis and management of pheochromocytoma.” Hosp Pract (Off Ed) 24, no. 1 (January 15, 1989): 175–79. https://doi.org/10.1080/21548331.1989.11703650.
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  - Rose, S. C., W. C. Meyers, M. Saeed, and J. M. Feldman. “Limitations of angiography for mesenteric ischemia caused by midgut carcinoid tumors.” Cardiovasc Intervent Radiol 12, no. 3 (1989): 131–35. https://doi.org/10.1007/BF02577376.
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  - Mortensen, R. M., J. Medoff, and J. M. Feldman. “Case report: chylous ascites and carcinoid tumors: possible association of two rare disorders.” Am J Med Sci 296, no. 4 (October 1988): 272–74. https://doi.org/10.1016/s0002-9629(15)40870-5.
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  - Feldman, J. M. “Effect of the monoamine oxidase inhibitors clorgyline and pargyline on the hyperphagia of obese mice.” Behav Brain Res 29, no. 1–2 (July 1988): 147–58. https://doi.org/10.1016/0166-4328(88)90062-9.
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  - Feldman, J. M., and C. Castleberry. “Thin-layer chromatography of homovanillic acid with use of toluene instead of benzene.” Clin Chem 34, no. 6 (June 1988): 1355.
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  - Feldman, J. M., T. L. Benning, and H. Saltzman. “Biochemical and ultrastructural differences between muco-epidermoid and carcinoid tumors of the bronchus.” J Surg Oncol 37, no. 4 (April 1988): 227–31. https://doi.org/10.1002/jso.2930370403.
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  - Feldman, J. M. “Detection and treatment of carcinoid tumors.” Hosp Pract (Off Ed) 23, no. 2 (February 15, 1988): 219–36. https://doi.org/10.1080/21548331.1988.11703425.
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  - Feldman, J. M., and G. C. Gerritsen. “Tissue norepinephrine concentration in spontaneously diabetic Chinese hamsters.” Horm Res 29, no. 4 (1988): 168–75. https://doi.org/10.1159/000180996.
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  - Feldman, J. M. “Carcinoid and other metabolically active tumors in the elderly.” Clin Geriatr Med 3, no. 4 (November 1987): 743–64.
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  - Feldman, J. M. “Falsely elevated urinary excretion of catecholamines and metanephrines in patients receiving labetalol therapy.” J Clin Pharmacol 27, no. 4 (April 1987): 288–92. https://doi.org/10.1002/j.1552-4604.1987.tb03015.x.
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  - Feldman, J. M., N. Frankel, and R. E. Coleman. “Platelet uptake of the pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine.” Metabolism 33, no. 5 (May 1984): 397–99. https://doi.org/10.1016/0026-0495(84)90135-5.
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  - Feldman, J. M., and J. A. Davis. “Radioenzymatic assay of platelet serotonin, dopamine and norepinephrine in subjects with normal and increased serotonin production.” Clin Chim Acta 109, no. 3 (February 5, 1981): 275–83. https://doi.org/10.1016/0009-8981(81)90313-2.
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  - Feldman, J. M., J. A. Blalock, R. T. Zern, J. D. Shelburne, J. T. Gaede, R. E. Farrell, and S. A. Wells. “Deficiency of dopamine-beta-hydroxylase. A new mechanism for normotensive pheochromocytomas.” Am J Clin Pathol 72, no. 2 (August 1979): 175–85. https://doi.org/10.1093/ajcp/72.2.175.
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  - D’Ercole, A. J., M. A. Morris, L. E. Underwood, J. J. Van Wyk, and J. M. Feldman. “Treatment of Cushing disease in Childhood with cyproheptadine.” J Pediatr 90, no. 5 (May 1977): 834–35. https://doi.org/10.1016/s0022-3476(77)81265-1.
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- Conference Papers
  - Gallagher, Scott F., Daphne W. Denham, Michel M. Murr, and James G. Norman. “The impact of minimally invasive parathyroidectomy on the way endocrinologists treat primary hyperparathyroidism.” In Surgery, 134:910–17, 2003. https://doi.org/10.1016/s0039-6060(03)00414-8.
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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Publications

Academic Articles

Conference Papers