Scholars@Duke
Jerome M. Feldman

Jerome M. Feldman

Professor Emeritus of Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
feld002@duke.edu
Box 2963 Med Ctr, Durham, NC 27710
E3008 VA Med Ctr, 508 Fulton St, Durham, NC 27705

Selected Publications

Detecting pheochromocytoma: defining the most sensitive test.

Journal Article Ann Surg · January 2006 OBJECTIVE: To define the most sensitive biochemical test to establish the diagnosis of pheochromocytoma and also to assess the potential role of iodine 131-labeled metaiodobenzylguanidine scintigraphy (I-MIBG) in the diagnosis of this tumor. SUMMARY BACKGR ... Full text Link to item Cite

The impact of minimally invasive parathyroidectomy on the way endocrinologists treat primary hyperparathyroidism.

Conference Surgery · December 2003 BACKGROUND: Minimally-invasive parathyroidectomy (MIP) appears to be changing preoperative treatment and referral patterns for sporadic, nonfamilial, non-multiple endocrine neoplasia, primary hyperparathyroidism (PHPT). METHODS: The American Association of ... Full text Link to item Cite

Carcinoid and chylous ascites: an unusual association.

Journal Article J Gastrointest Surg · 2002 Chylous ascites caused by carcinoid tumors is extremely rare. While carcinoid tumors usually have an indolent course, their association with chylous ascites is a harbinger of a poor outcome. ... Full text Link to item Cite

Gastrointestinal carcinoids: characterization by site of origin and hormone production.

Journal Article Ann Surg · October 2000 OBJECTIVE: To describe a large series of patients with carcinoid tumors in terms of presenting symptoms, hormonal data, stage at diagnosis, pathologic features, and survival. SUMMARY BACKGROUND DATA: Published series have described significant prognostic f ... Full text Link to item Cite

Foregut carcinoids: a clinical and biochemical analysis.

Journal Article Surgery · December 1999 BACKGROUND: Gastrointestinal foregut carcinoids make up a small percentage (3% to 6%) of all reported carcinoids. Because these tumors are so uncommon, comparisons between the subtypes have been difficult. The goal of this study was to compare the hormonal ... Full text Link to item Cite

Carcinoids of unknown origin: comparative analysis with foregut, midgut, and hindgut carcinoids.

Journal Article Surgery · December 1998 BACKGROUND: Carcinoids are rare neuroendocrine tumors typically arising in the gastrointestinal tract. A significant percentage of these tumors present as metastatic disease of unknown primary site. The aim of this study was to better define the functional ... Full text Link to item Cite

Iodine-131-metaiodobenzylguanidine uptake in metastatic carcinoid tumor to the orbit.

Journal Article J Nucl Med · April 1998 Metastatic tumor is one of several etiologies of space-occupying masses in the orbit that accounts for 1%-13% of all orbital masses (1). In the adult patient population, breast cancer is the most common tumor to metastasize to the orbit followed by metasta ... Link to item Cite

Carcinoid of the ampulla of Vater presenting as acute pancreatitis.

Journal Article Am J Gastroenterol · November 1996 A 30-yr-old female with a carcinoid tumor of the ampulla of Vater is discussed. This rare tumor presented in an unusual fashion with isolated pancreatitis in the absence of cholestasis. The correct diagnosis was made preoperatively by endoscopic retrograde ... Link to item Cite

Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography.

Journal Article Circulation · August 15, 1995 BACKGROUND: Although serotonin has been postulated as an etiologic agent in the development of carcinoid heart disease, no direct evidence for different ambient serotonin levels in cardiac and noncardiac patients has been reported to date. METHODS AND RESU ... Full text Link to item Cite

Predictors of outcome of tricuspid valve replacement in carcinoid heart disease.

Journal Article Am J Cardiol · March 1, 1995 The cardiac valvular surgical experience of patients in the Duke Carcinoid Database was reviewed to assess operative outcome. Of the 604 patients in the database, 19 patients with carcinoid heart disease were identified by cardiac catheterization or echoca ... Full text Link to item Cite

USE OF 123IODINE METAIODOBENZYLGUANIDINE SCINTIGRAPHY FOR THE DIAGNOSIS OF A PHEOCHROMOCYTOMA IN A DOG

Journal Article Veterinary Radiology & Ultrasound · January 1, 1993 A 13‐year‐old neutered female Yorkshire terrier presented with a history of progressive episodic weakness and disorientation of 4 months duration. Physical and neurologic examinations were normal at presentation. Abdominal ultrasound revealed a mass involv ... Full text Cite

Bronchial carcinoid tumors: a retrospective analysis of 126 patients.

Journal Article Ann Thorac Surg · July 1992 From 1970 until 1990, 8,958 cases of primary carcinoma of the lung were diagnosed at the Duke University Medical Center. During the same period, 126 patients (mean age, 53 +/- 13 years) were diagnosed with bronchial carcinoid. The overall survival was 78% ... Full text Link to item Cite

Iodine 131-labeled metaiodobenzylguanidine scintigraphy and biochemical analyses in suspected pheochromocytoma.

Journal Article Arch Intern Med · July 1991 Detection of abnormal catecholamine levels and localization of tumor mass are important factors in the diagnosis and treatment of pheochromocytoma. Iodine 131-labeled metaiodobenzylguanidine scintigraphy was performed in 64 patients with suspected pheochro ... Link to item Cite

Carcinoid tumors and the carcinoid syndrome.

Journal Article Curr Probl Surg · December 1989 Full text Link to item Cite

Carcinoid tumors: iodine-131 MIBG scintigraphy.

Journal Article Radiology · September 1989 Eighty-two patients with pathologically proved carcinoid tumors were examined with iodine-131 metaio-dobenzylguanidine (MIBG) scintigraphy. Localization scores of I-131 MIBG accumulation in the primary tumor or metastatic site ranged from 0 to 3+ on the ba ... Full text Link to item Cite

Surgery in patients with unsuspected pheochromocytomas.

Journal Article J Surg Oncol · May 1989 In four of the 37 patients operated on for a pheochromocytoma in the last 12 years at Duke Medical Center, the tumor was unsuspected. The first of the four patients had stable blood pressure and pulse during the operative and postoperative period. Although ... Full text Link to item Cite

Diagnosis and management of pheochromocytoma.

Journal Article Hosp Pract (Off Ed) · January 15, 1989 Full text Link to item Cite

Limitations of angiography for mesenteric ischemia caused by midgut carcinoid tumors.

Journal Article Cardiovasc Intervent Radiol · 1989 Mesenteric ischemia associated with carcinoid tumors often presents with nonspecific abdominal pain and is usually due to mesenteric branch artery occlusion caused by elastic vascular sclerosis. Mesenteric ischemia was defined by the operative findings of ... Full text Link to item Cite

Case report: chylous ascites and carcinoid tumors: possible association of two rare disorders.

Journal Article Am J Med Sci · October 1988 Three cases of chylous ascites are reported in a series of 275 patients with carcinoid tumor. All three patients had diarrhea and elevated serotonin production. The literature is reviewed and the possible causes of the chylous ascites are discussed. It is ... Full text Link to item Cite

Effect of the monoamine oxidase inhibitors clorgyline and pargyline on the hyperphagia of obese mice.

Journal Article Behav Brain Res · July 1988 Obese-hyperglycemic mice (genotype ob/ob) have higher levels of hypothalamic norepinephrine than their normal-weight litter mates. Brain, as well as some other tissues, contains two types of monoamine oxidase (MAO). In this study we evaluated the effect of ... Full text Link to item Cite

Biochemical and ultrastructural differences between muco-epidermoid and carcinoid tumors of the bronchus.

Journal Article J Surg Oncol · April 1988 Bronchial adenomas have been classified into three types: carcinoid tumors, cylindromas (adenoid cystic carcinomas), and mucoepidermoid tumors. Studies from our laboratory have demonstrated that the quantitative measurement of monoamine oxidase (MAO) in ho ... Full text Link to item Cite

Detection and treatment of carcinoid tumors.

Journal Article Hosp Pract (Off Ed) · February 15, 1988 Full text Link to item Cite

Tissue norepinephrine concentration in spontaneously diabetic Chinese hamsters.

Journal Article Horm Res · 1988 There is some controversy concerning a possible effect of diabetes mellitus on the sympathetic nervous system in humans with spontaneous diabetes mellitus and in animals with experimental diabetes mellitus. In this study we compared the tissue norepinephri ... Full text Link to item Cite

Carcinoid and other metabolically active tumors in the elderly.

Journal Article Clin Geriatr Med · November 1987 This article reviews the clinical manifestations, diagnostic techniques, and therapy of carcinoid and other metabolically active tumors that occur in the elderly. These tumors secrete monoamine and polypeptide hormones into the vascular compartment. Becaus ... Link to item Cite

Falsely elevated urinary excretion of catecholamines and metanephrines in patients receiving labetalol therapy.

Journal Article J Clin Pharmacol · April 1987 Five patients with essential hypertension who were receiving treatment with the beta- and alpha-adrenoreceptor-blocking drug labetalol had elevated urinary excretion of catecholamines. When measured with a radioenzymatic assay, all five subjects had elevat ... Full text Link to item Cite

Platelet uptake of the pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine.

Journal Article Metabolism · May 1984 The pheochromocytoma-scanning agent 131I-meta-iodobenzylguanadine (131I-MIBG) was concentrated in the platelets of ten subjects undergoing scans for suspected pheochromocytomas. In vitro studies also demonstrated that 131I-MIBG was concentrated in platelet ... Full text Link to item Cite

Radioenzymatic assay of platelet serotonin, dopamine and norepinephrine in subjects with normal and increased serotonin production.

Journal Article Clin Chim Acta · February 5, 1981 Platelet serotonin, dopamine and norepinephrine concentrations were determined with sensitive and specific radioenzymatic methods in normal volunteers and in sick subjects with both normal and increased serotonin production. In the assays, a 3H-labeled met ... Full text Link to item Cite