Overview
The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.
Current Appointments & Affiliations
Adjunct Professor in the Department of Medicine
·
2020 - Present
Medicine, Cardiology,
Medicine
Recent Publications
Local intraluminal delivery of a smooth muscle-targeted RNA ligand inhibits neointima growth in a porcine model of peripheral vascular disease.
Journal Article Mol Ther Nucleic Acids · September 13, 2022 Anti-proliferative agents have been the primary therapeutic drug of choice to inhibit restenosis after endovascular treatment. However, recent safety and efficacy concerns for patients who underwent peripheral artery disease revascularization have demonstr ... Full text Link to item CiteThe endothelial-specific LINC00607 mediates endothelial angiogenic function
Preprint · May 10, 2022 Full text CiteDrebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.
Journal Article Cardiovasc Res · February 21, 2022 AIMS: The F-actin-binding protein Drebrin inhibits smooth muscle cell (SMC) migration, proliferation, and pro-inflammatory signalling. Therefore, we tested the hypothesis that Drebrin constrains atherosclerosis. METHODS AND RESULTS: SM22-Cre+/Dbnflox/flox/ ... Full text Open Access Link to item CiteRecent Grants
Hematology & Transfusion Medicine (T32)
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1975 - 2026Duke CTSA (TL1) Year 5
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024Multidisciplinary Heart and Vascular Diseases
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2023View All Grants
Education, Training & Certifications
University of Iowa, Roy J. and Lucille A. Carver College of Medicine ·
1989
M.D.