Francis Joseph Miller Jr.

Francis Joseph Miller Jr.
Adjunct Professor in the Department of Medicine

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Current Research Interests

Current Projects:

Studies identifying the mechanisms responsible for accelerated vascular disease in conditions of chronic inflammation. We are testing the hypothesis that chronic inflammation increases circulating epidermal growth factor (EGF)-like ligands, which induces vascular Nox1 expression and primes smooth muscle cells to cytokine activation.
Studies are exploring a molecular mechanism of redox homeostasis in the vasculature by testing the hypothesis that miRNA-mediated changes in Nox4 expression dynamically regulate the cellular redox state and coordinate the expression of genes implicated in the development of vascular disease.
Studies are identifying the molecular mechanisms involved in the activation of Nox1 NADPH oxidase and identifying specific motifs necessary for its phosphorylation and trafficking. We are testing a small peptide as a potential selective inhibitor of Nox1 activation.
Studies are developing vascular cell-targeted aptamers for bio-drug delivery. Experiments are testing whether RNA aptamers can selectively inhibit SMC activation and deliver RNAi modulators for the treatment of neointimal hyperplasia.
Studies are exploring novel approaches to neutralize the effects of circulating histones for the treatment of multiple organ dysfunction syndrome (MODS) and acute respiratory distress syndrome (ARDS).

Current Appointments & Affiliations

Adjunct Professor in the Department of Medicine, Medicine, Cardiology, Medicine 2020

Contact Information

203 Research Drive, 397 Msrb1, Durham, NC 27705
508 Fulton St, Bldg 15, Room 306, Durham, NC 27705
(919) 668-2688

Background
Education, Training, & Certifications
- Cardiovascular Diseases Fellowship, University of Iowa, Roy J. and Lucille A. Carver College of Medicine 1992 - 1995
- Internal Medicine Residency, University of Texas Southwestern Medical Center, Medical School 1989 - 1992
- M.D., University of Iowa, Roy J. and Lucille A. Carver College of Medicine 1989
Medical Licensure
- 2016-00305. North Carolina. 2016
Previous Appointments & Affiliations
- Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2017 - 2020
- Professor of Medicine, Medicine, Cardiology, Medicine 2017 - 2020
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2016 - 2017
Leadership & Clinical Positions at Duke
- Director of Cardiovascular Research, VA Medical Center, Durham, 2016-
  Chair, Basic & Translational Branch, Faculty Development Academy, Department of Medicine, 2017-
Recognition
Awards & Honors
- Fellow, Council on Arteriosclerosis, Thrombosis and Vascular Biology. American Heart Association. 2013
Expertise
Subject Headings
Research
Selected Grants
- Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health 1975 - 2026
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2024
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2023
- Improving the Performance and Design of Potentiometric Biosensors for the Detection of Extracellular Histones in Blood with Deep Learning awarded by North Carolina State University 2019 - 2022
- Zeiss Lightsheet Upgrade to Expand Imaging Capabilities awarded by National Institutes of Health 2021 - 2022
- Extracellular Histones and Sepsis-induced Cardiomyopathy awarded by American Heart Association 2019 - 2020
- IPA - Chaojian Wang awarded by Durham Veterans Affairs Medical Center 2018 - 2020
- IPA- Kamie Snow awarded by Durham Veterans Affairs Medical Center 2018 - 2020
- Integrated MiRNA regulation of Nox4 and cellular redox in vascular disease awarded by National Institutes of Health 2016 - 2020
- IPA - Simone Sartoretto awarded by Durham Veterans Affairs Medical Center 2019 - 2020
- IPA- Jennifer Lucitti awarded by Durham Veterans Affairs Medical Center 2019 - 2020
- Targeting Extracellular Histones with Novel RNA Biodrugs for the Treatment of Acute Lung Injury awarded by Department of Defense 2016 - 2020
- Role of Debrin in Vascular Smooth Muscle Transdifferentiation awarded by American Heart Association 2019
- PEROXIDE MEDIATED PROTHROMBOTIC EFFECTS OF AGING awarded by University of Iowa 2016 - 2018
Fellowships, Supported Research, & Other Grants
- Regulation of the Nox1 NADPH Oxidase in Vascular Smooth Muscle Cells awarded by VA Merit 2016 - 2020
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Yazdani, Saami K., Beilei Lei, Claire V. Cawthon, Kathryn Cooper, Clifton Huett, Paloma H. Giangrande, and Francis J. Miller. “Local intraluminal delivery of a smooth muscle-targeted RNA ligand inhibits neointima growth in a porcine model of peripheral vascular disease.” Mol Ther Nucleic Acids 29 (September 13, 2022): 577–83. https://doi.org/10.1016/j.omtn.2022.08.007.
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  - Wu, Jiao-Hui, Lisheng Zhang, Igor Nepliouev, Leigh Brian, Taiqin Huang, Kamie P. Snow, Brandon M. Schickling, et al. “Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.” Cardiovasc Res 118, no. 3 (February 21, 2022): 772–84. https://doi.org/10.1093/cvr/cvab156.
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  - Schickling, Brandon M., and Francis J. Miller. “Outside-in Signaling by Adventitial Fibroblasts.” Arterioscler Thromb Vasc Biol 41, no. 2 (February 2021): 711–13. https://doi.org/10.1161/ATVBAHA.120.315466.
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  - Buglak, Nicholas E., Jennifer Lucitti, Pablo Ariel, Sophie Maiocchi, Francis J. Miller, and Edward S. M. Bahnson. “Light sheet fluorescence microscopy as a new method for unbiased three-dimensional analysis of vascular injury.” Cardiovasc Res 117, no. 2 (January 21, 2021): 520–32. https://doi.org/10.1093/cvr/cvaa037.
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  - Miller, Francis J. “Hypertension and Mitochondrial Oxidative Stress Revisited: Sirtuin 3, the Improved "Antioxidant".” Circ Res 126, no. 4 (February 14, 2020): 453–55. https://doi.org/10.1161/CIRCRESAHA.120.316567.
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  - Buglak, Nicholas, Jennifer Lucitti, Pablo Ariel, Sophie Maiocchi, Francis Miller, and Edward Bahnson. “Light Sheet Fluorescence Microscopy as a New Method for Unbiased Three-Dimensional Analysis of Vascular Injury,” January 2, 2020. https://doi.org/10.1101/2020.01.02.893065.
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  - Udofot, Ofonime, Li-Hsien Lin, William H. Thiel, Megan Erwin, Emily Turner, Francis J. Miller, Paloma H. Giangrande, and Saami K. Yazdani. “Delivery of Cell-Specific Aptamers to the Arterial Wall with an Occlusion Perfusion Catheter.” Mol Ther Nucleic Acids 16 (June 7, 2019): 360–66. https://doi.org/10.1016/j.omtn.2019.03.005.
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  - Sonkar, Vijay K., Rahul Kumar, Melissa Jensen, Brett A. Wagner, Anjali A. Sharathkumar, Francis J. Miller, MaryBeth Fasano, Steven R. Lentz, Garry R. Buettner, and Sanjana Dayal. “Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice.” Blood Adv 3, no. 8 (April 23, 2019): 1272–84. https://doi.org/10.1182/bloodadvances.2018025569.
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  - Gimenez, Marcela, Sidney Veríssimo-Filho, Ilka Wittig, Brandon M. Schickling, Fabian Hahner, Christoph Schürmann, Luis E. S. Netto, et al. “Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells.” Arterioscler Thromb Vasc Biol 39, no. 2 (February 2019): 224–36. https://doi.org/10.1161/ATVBAHA.118.311038.
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  - Urak, Kevin T., Giselle N. Blanco, Shambhavi Shubham, Li-Hsien Lin, Justin P. Dassie, William H. Thiel, Yani Chen, et al. “RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome.” Nat Commun 10, no. 1 (January 10, 2019): 116. https://doi.org/10.1038/s41467-018-08030-y.
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  - Zhang, Lisheng, Jiao-Hui Wu, Tai-Qin Huang, Igor Nepliouev, Leigh Brian, Zhushan Zhang, Virginia Wertman, et al. “Drebrin regulates angiotensin II-induced aortic remodelling.” Cardiovasc Res 114, no. 13 (November 1, 2018): 1806–15. https://doi.org/10.1093/cvr/cvy151.
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  - Leisegang, Matthias S., Christian Fork, Ivana Josipovic, Florian Martin Richter, Jens Preussner, Jiong Hu, Matthew J. Miller, et al. “Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.” Circulation 136, no. 1 (July 4, 2017): 65–79. https://doi.org/10.1161/CIRCULATIONAHA.116.026991.
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  - Thiel, William H., Carla L. Esposito, David D. Dickey, Justin P. Dassie, Matthew E. Long, Joshua Adam, Jennifer Streeter, et al. “Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation.” Mol Ther 24, no. 4 (April 2016): 779–87. https://doi.org/10.1038/mt.2015.235.
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  - Gimenez, Marcela, Brandon M. Schickling, Lucia R. Lopes, and Francis J. Miller. “Nox1 in cardiovascular diseases: regulation and pathophysiology.” Clin Sci (Lond) 130, no. 3 (February 2016): 151–65. https://doi.org/10.1042/CS20150404.
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  - Miller, Francis J. “Nox4 NADPH oxidase: emerging from the veil of darkness.” Eur Heart J 36, no. 48 (December 21, 2015): 3457–59. https://doi.org/10.1093/eurheartj/ehv518.
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  - Pagano, Patrick J., Kathy K. Griendling, Francis J. Miller, Francisco R. M. Laurindo, and Rhian M. Touyz. “Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout.” Antioxid Redox Signal 23, no. 15 (November 20, 2015): 1246–47. https://doi.org/10.1089/ars.2015.6382.
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  - Leisegang, M. S., C. Fork, M. J. Miller, Y. Ponomareva, S. Uchida, F. J. Miller, and R. P. Brandes. “The long non-coding RNA Mantis is highly expressed during vascular regeneration and essential for the VEGF-A-induced angiogenic function.” Acta Physiologica 213 (March 1, 2015): 148–49.
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  - Thiel, William H., Kristina W. Thiel, Katie S. Flenker, Tom Bair, Adam J. Dupuy, James O. McNamara, Francis J. Miller, and Paloma H. Giangrande. “Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells.” Methods Mol Biol 1218 (2015): 187–99. https://doi.org/10.1007/978-1-4939-1538-5_11.
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  - Streeter, Jennifer, Brandon M. Schickling, Shuxia Jiang, Bojana Stanic, William H. Thiel, Lokesh Gakhar, Jon C. D. Houtman, and Francis J. Miller. “Phosphorylation of Nox1 regulates association with NoxA1 activation domain.” Circ Res 115, no. 11 (November 7, 2014): 911–18. https://doi.org/10.1161/CIRCRESAHA.115.304267.
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  - Martins, James B., Ashok K. Chaudhary, Shuxia Jiang, Michael Kwofie, Prescott Mackie, and Francis J. Miller. “Role of NADPH oxidase and xanthine oxidase in mediating inducible VT/VF and triggered activity in a canine model of myocardial ischemia.” Int J Mol Sci 15, no. 11 (November 4, 2014): 20079–100. https://doi.org/10.3390/ijms151120079.
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  - Vikram, Ajit, Young-Rae Kim, Santosh Kumar, Asma Naqvi, Timothy A. Hoffman, Ajay Kumar, Francis J. Miller, Cuk-Seong Kim, and Kaikobad Irani. “Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.” Arterioscler Thromb Vasc Biol 34, no. 10 (October 2014): 2301–9. https://doi.org/10.1161/ATVBAHA.114.304338.
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  - Steyers, Curtis M., and Francis J. Miller. “Endothelial dysfunction in chronic inflammatory diseases.” Int J Mol Sci 15, no. 7 (June 25, 2014): 11324–49. https://doi.org/10.3390/ijms150711324.
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  - Csányi, Gábor, and Francis J. Miller. “Oxidative stress in cardiovascular disease.” Int J Mol Sci 15, no. 4 (April 9, 2014): 6002–8. https://doi.org/10.3390/ijms15046002.
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  - Jiang, Shuxia, Jennifer Streeter, Brandon M. Schickling, Kathy Zimmerman, Robert M. Weiss, and Francis J. Miller. “Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning.” Cardiovasc Res 102, no. 1 (April 1, 2014): 79–87. https://doi.org/10.1093/cvr/cvu027.
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  - Xu, Shaoping, Ali H. Chamseddine, Samuel Carrell, and Francis J. Miller. “Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques.” Redox Biol 2 (2014): 642–50. https://doi.org/10.1016/j.redox.2014.04.004.
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  - Sobhakumari, Arya, Brandon M. Schickling, Laurie Love-Homan, Ayanna Raeburn, Elise V. M. Fletcher, Adam J. Case, Frederick E. Domann, Francis J. Miller, and Andrean L. Simons. “NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells.” Toxicol Appl Pharmacol 272, no. 3 (November 1, 2013): 736–45. https://doi.org/10.1016/j.taap.2013.07.013.
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  - Streeter, Jennifer, Brandon Schickling, and Francis J. Miller. “Nox1 Endocytosis and Activation Are Regulated by Intracellular Hydrophobic Motifs.” Free Radical Biology and Medicine 65 (November 2013): S83–S83. https://doi.org/10.1016/j.freeradbiomed.2013.10.594.
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  - Makki, Nader, Kristina W. Thiel, and Francis J. Miller. “The epidermal growth factor receptor and its ligands in cardiovascular disease.” Int J Mol Sci 14, no. 10 (October 15, 2013): 20597–613. https://doi.org/10.3390/ijms141020597.
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  - Kinkade, Kara, Jennifer Streeter, and Francis J. Miller. “Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.” Int J Mol Sci 14, no. 8 (August 19, 2013): 17017–28. https://doi.org/10.3390/ijms140817017.
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  - Sanders, Philip N., Olha M. Koval, Omar A. Jaffer, Anand M. Prasad, Thomas R. Businga, Jason A. Scott, Patrick J. Hayden, et al. “CaMKII is essential for the proasthmatic effects of oxidation.” Sci Transl Med 5, no. 195 (July 24, 2013): 195ra97. https://doi.org/10.1126/scitranslmed.3006135.
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  - Streeter, Jennifer, William Thiel, Kate Brieger, and Francis J. Miller. “Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease.” Cardiovasc Ther 31, no. 3 (June 2013): 125–37. https://doi.org/10.1111/j.1755-5922.2011.00310.x.
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  - Dayal, Sanjana, Katina M. Wilson, David G. Motto, Francis J. Miller, Anil K. Chauhan, and Steven R. Lentz. “Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis.” Circulation 127, no. 12 (March 26, 2013): 1308–16. https://doi.org/10.1161/CIRCULATIONAHA.112.000966.
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  - Scott, Jason A., Paula J. Klutho, Ramzi El Accaoui, Emily Nguyen, Ashlee N. Venema, Litao Xie, Shuxia Jiang, et al. “The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling.” Plos One 8, no. 8 (2013): e71550. https://doi.org/10.1371/journal.pone.0071550.
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  - Foresman, Erin L., and Francis J. Miller. “Extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction.” Redox Biol 1, no. 1 (2013): 292–96. https://doi.org/10.1016/j.redox.2013.04.003.
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  - Whitmore, Laura C., Brieanna M. Hilkin, Kelli L. Goss, Erin M. Wahle, Tarah T. Colaizy, Paola M. Boggiatto, Steven M. Varga, Francis J. Miller, and Jessica G. Moreland. “NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults.” J Innate Immun 5, no. 6 (2013): 565–80. https://doi.org/10.1159/000347212.
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  - Stanic, Bojana, Deepesh Pandey, David J. Fulton, and Francis J. Miller. “Increased epidermal growth factor-like ligands are associated with elevated vascular nicotinamide adenine dinucleotide phosphate oxidase in a primate model of atherosclerosis.” Arterioscler Thromb Vasc Biol 32, no. 10 (October 2012): 2452–60. https://doi.org/10.1161/ATVBAHA.112.256107.
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  - Chen, Biyi, Yue Li, Shuxia Jiang, Yu-Ping Xie, Ang Guo, William Kutschke, Kathy Zimmerman, et al. “β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction.” Faseb J 26, no. 6 (June 2012): 2531–37. https://doi.org/10.1096/fj.11-199505.
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  - Jagadeesha, Dammanahalli K., Maysam Takapoo, Botond Banfi, Ramesh C. Bhalla, and Francis J. Miller. “Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration.” Cardiovasc Res 93, no. 3 (March 1, 2012): 406–13. https://doi.org/10.1093/cvr/cvr308.
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  - Thiel, William H., Thomas Bair, Andrew S. Peek, Xiuying Liu, Justin Dassie, Katie R. Stockdale, Mark A. Behlke, Francis J. Miller, and Paloma H. Giangrande. “Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection.” Plos One 7, no. 9 (2012): e43836. https://doi.org/10.1371/journal.pone.0043836.
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  - Xu, Shaoping, Amy S. Shriver, Dammanahalli K. Jagadeesha, Ali H. Chamseddine, Katalin Szőcs, Neal L. Weintraub, Kathy K. Griendling, Ramesh C. Bhalla, and Francis J. Miller. “Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9.” J Vasc Res 49, no. 3 (2012): 242–48. https://doi.org/10.1159/000332958.
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  - Brieger, K., S. Schiavone, F. J. Miller, and K. -. H. Krause. “Reactive oxygen species: from health to disease.” Swiss Med Wkly 142 (2012): w13659. https://doi.org/10.4414/smw.2012.13659.
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  - Karrowni, Wassef, Saadeddine Dughman, Georges P. Hajj, and Francis J. Miller. “Statin therapy reduces growth of abdominal aortic aneurysms.” J Investig Med 59, no. 8 (December 2011): 1239–43. https://doi.org/10.2130/JIM.0b013e31823548e8.
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  - Zimmerman, Matthew C., Maysam Takapoo, Dammanahalli K. Jagadeesha, Bojana Stanic, Botond Banfi, Ramesh C. Bhalla, and Francis J. Miller. “Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells.” Hypertension 58, no. 3 (September 2011): 446–53. https://doi.org/10.1161/HYPERTENSIONAHA.111.177006.
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  - Orcutt, Kevin P., Arlene D. Parsons, Zita A. Sibenaller, Peter M. Scarbrough, Yueming Zhu, Arya Sobhakumari, Werner W. Wilke, et al. “Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.” Cancer Res 71, no. 11 (June 1, 2011): 3932–40. https://doi.org/10.1158/0008-5472.CAN-10-3425.
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  - Sheehan, Andrea L., Samuel Carrell, Bryon Johnson, Bojana Stanic, Botond Banfi, and Francis J. Miller. “Role for Nox1 NADPH oxidase in atherosclerosis.” Atherosclerosis 216, no. 2 (June 2011): 321–26. https://doi.org/10.1016/j.atherosclerosis.2011.02.028.
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  - Karrowni, Wassef, and Francis J. Miller. “Was the role of statins in slowing the progression of abdominal aortic aneurysms underestimated?” Am Heart J 161, no. 5 (May 2011): e29. https://doi.org/10.1016/j.ahj.2011.02.024.
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  - Streeter, Jennifer, and Francis J. Miller. “Any questions? A concise guide to navigating the Q&A session after a presentation.” Embo Rep 12, no. 3 (March 2011): 202–5. https://doi.org/10.1038/embor.2011.20.
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  - Chu, Xi, Mohammed Filali, Bojana Stanic, Maysam Takapoo, Andrea Sheehan, Ramesh Bhalla, Fred S. Lamb, and Francis J. Miller. “A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation.” Arterioscler Thromb Vasc Biol 31, no. 2 (February 2011): 345–51. https://doi.org/10.1161/ATVBAHA.110.217604.
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  - Takapoo, Maysam, Ali H. Chamseddine, Ramesh C. Bhalla, and Francis J. Miller. “Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A.” Vascul Pharmacol 55, no. 5–6 (2011): 143–48. https://doi.org/10.1016/j.vph.2011.07.002.
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  - Dayal, Sanjana, Katina M. Wilson, Francis J. Miller, and Steven R. Lentz. “Overexpression Of Glutathione Peroxidase-1 Protects Mice From Increased Susceptibility To Experimental Thrombosis With Aging.” Circulation 122, no. 21 (November 23, 2010).
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  - Stanic, Bojana, Masato Katsuyama, and Francis J. Miller. “An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation.” Arterioscler Thromb Vasc Biol 30, no. 11 (November 2010): 2234–41. https://doi.org/10.1161/ATVBAHA.110.207639.
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  - Matsuda, James J., Mohammed S. Filali, Jessica G. Moreland, Francis J. Miller, and Fred S. Lamb. “Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production.” J Biol Chem 285, no. 30 (July 23, 2010): 22864–73. https://doi.org/10.1074/jbc.M109.099838.
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  - Miller, Francis J., Xi Chu, Bojana Stanic, Xin Tian, Ram V. Sharma, Robin L. Davisson, and Fred S. Lamb. “A differential role for endocytosis in receptor-mediated activation of Nox1.” Antioxid Redox Signal 12, no. 5 (March 1, 2010): 583–93. https://doi.org/10.1089/ars.2009.2857.
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  - Miller, Francis J. “NADPH oxidase 4: walking the walk with Poldip2.” Circ Res 105, no. 3 (July 31, 2009): 209–10. https://doi.org/10.1161/CIRCRESAHA.109.202986.
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  - Lamb, Fred S., Jessica G. Moreland, and Francis J. Miller. “Electrophysiology of reactive oxygen production in signaling endosomes.” Antioxid Redox Signal 11, no. 6 (June 2009): 1335–47. https://doi.org/10.1089/ars.2008.2448.
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  - Xing, Dezhi, Ashok K. Chaudhary, Francis J. Miller, and James B. Martins. “Free radical scavenger specifically prevents ischemic focal ventricular tachycardia.” Heart Rhythm 6, no. 4 (April 2009): 530–36. https://doi.org/10.1016/j.hrthm.2008.12.032.
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  - Delfs, J., B. Stanic, and F. J. Miller. “TNF-alpha AND THROMBIN DIFFERENTIALY ACTIVATE NOX1 TRAFFICKING IN MOUSE AORTIC SMOOTH MUSCLE CELLS.” Journal of Investigative Medicine 57, no. 3 (March 1, 2009): 537–537.
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  - Ashby, A. R., G. A. Schmidt, and F. J. Miller. “Prophylactic Beta Blockade To Prevent Peri-Extubation Cardiac Ischemia and Congestive Heart Failure.” American Journal of Respiratory and Critical Care Medicine 179 (January 1, 2009).
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  - Jagadeesha, Dammanahalli K., Francis J. Miller, and Ramesh C. Bhalla. “Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury.” J Vasc Res 46, no. 2 (2009): 109–18. https://doi.org/10.1159/000151444.
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  - Xing, Dezhi, Ashok K. Chaudhary, Francis J Jr Miller, and James B. Martins. “Free radical scavenger specifically prevents ischemic focal ventricular tachycardia (vol 6, pg 530, 2009).” Heart Rhythm 6, no. 11 (2009): 1698–1698.
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  - Tannous, Paul, Hongxin Zhu, Andriy Nemchenko, Jeff M. Berry, Janet L. Johnstone, John M. Shelton, Francis J. Miller, Beverly A. Rothermel, and Joseph A. Hill. “Intracellular Protein Aggregation Is a Proximal Trigger of Cardiomyocyte Autophagy.” Circulation Research 103, no. 5 (August 29, 2008): E53–E53.
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  - Tannous, Paul, Hongxin Zhu, Andriy Nemchenko, Jeff M. Berry, Janet L. Johnstone, John M. Shelton, Francis J. Miller, Beverly A. Rothermel, and Joseph A. Hill. “Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy.” Circulation 117, no. 24 (June 17, 2008): 3070–78. https://doi.org/10.1161/CIRCULATIONAHA.107.763870.
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  - Filali, Mohammed S., James J. Matsuda, Jordan R. Gross, Sarah K. Storm, Jessica G. Moreland, Francis J. Miller, and Fred S. Lamb. “ClC-3 anion current is required for superoxide production in early endosomes and subsequent NF-B-kappa activation by TNF alpha.” Faseb Journal 22 (April 1, 2008).
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  - Roghair, Robert D., Francis J. Miller, Thomas D. Scholz, Fred S. Lamb, and Jeffrey L. Segar. “Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone.” Pediatr Res 63, no. 4 (April 2008): 370–74. https://doi.org/10.1203/PDR.0b013e3181659bfa.
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  - Roghair, Robert D., Francis J. Miller, Thomas D. Scholz, Fred S. Lamb, and Jeffrey L. Segar. “Endothelial superoxide production is altered in sheep programmed by early gestation dexamethasone exposure.” Neonatology 93, no. 1 (2008): 19–27. https://doi.org/10.1159/000105521.
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  - Chu, Xi, Andrea L. Sheehan, Fred S. Lamb, and Francis J. Miller. “The chloride transporter CIC-3 is required for TNF-alpha-induced proliferation of vascular smooth muscle cells, activation of matrix metalloproteinase-9, and neointima formation.” Circulation 116, no. 16 (October 16, 2007): 113–113.
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  - Sheehan, Andrea L., Maysam Takapoo, Botond Banfi, and Francis J. Miller. “Role for Nox1 NADPH oxidase in atherosclerosis.” Circulation 116, no. 16 (October 16, 2007): 244–244.
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  - Miller, Francis J., Mohammed Filali, Gina J. Huss, Bojana Stanic, Ali Chamseddine, Thomas J. Barna, and Fred S. Lamb. “Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3.” Circ Res 101, no. 7 (September 28, 2007): 663–71. https://doi.org/10.1161/CIRCRESAHA.107.151076.
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  - Tsimikas, Sotirios, Masanori Aikawa, Francis J. Miller, Elizabeth R. Miller, Michael Torzewski, Steven R. Lentz, Claes Bergmark, Donald D. Heistad, Peter Libby, and Joseph L. Witztum. “Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression.” Arterioscler Thromb Vasc Biol 27, no. 1 (January 2007): 175–81. https://doi.org/10.1161/01.ATV.0000251501.86410.03.
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  - Thomas, Manesh, Dan Gavrila, Michael L. McCormick, Francis J. Miller, Alan Daugherty, Lisa A. Cassis, Kevin C. Dellsperger, and Neal L. Weintraub. “Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.” Circulation 114, no. 5 (August 1, 2006): 404–13. https://doi.org/10.1161/CIRCULATIONAHA.105.607168.
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  - Jagadeesha, D. K., Timothy E. Lindley, Jason Deleon, Ram V. Sharma, Francis Miller, and Ramesh C. Bhalla. “Tempol therapy attenuates medial smooth muscle cell apoptosis and neointima formation after balloon catheter injury in carotid artery of diabetic rats.” Am J Physiol Heart Circ Physiol 289, no. 3 (September 2005): H1047–53. https://doi.org/10.1152/ajpheart.01071.2004.
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  - Gavrila, Dan, Wei Gen Li, Michael L. McCormick, Manesh Thomas, Alan Daugherty, Lisa A. Cassis, Francis J. Miller, Larry W. Oberley, Kevin C. Dellsperger, and Neal L. Weintraub. “Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice.” Arterioscler Thromb Vasc Biol 25, no. 8 (August 2005): 1671–77. https://doi.org/10.1161/01.ATV.0000172631.50972.0f.
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  - Roghair, Robert D., Fred S. Lamb, Francis J. Miller, Thomas D. Scholz, and Jeffrey L. Segar. “Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity.” Am J Physiol Regul Integr Comp Physiol 288, no. 1 (January 2005): R46–53. https://doi.org/10.1152/ajpregu.00165.2004.
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  - Stoll, Lynn L., Gerene M. Denning, Wei-Gen Li, James B. Rice, Allan L. Harrelson, Sara A. Romig, Skuli T. Gunnlaugsson, Francis J. Miller, and Neal L. Weintraub. “Regulation of endotoxin-induced proinflammatory activation in human coronary artery cells: expression of functional membrane-bound CD14 by human coronary artery smooth muscle cells.” J Immunol 173, no. 2 (July 15, 2004): 1336–43. https://doi.org/10.4049/jimmunol.173.2.1336.
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  - Clark, Craig B., Yi Zhang, Sean M. Martin, L Ray Davies, Linjing Xu, Kevin C. Kregel, Francis J. Miller, Garry R. Buettner, and Richard E. Kerber. “The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation.” Resuscitation 60, no. 3 (March 2004): 351–57. https://doi.org/10.1016/j.resuscitation.2004.02.003.
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  - Chamseddine, Ali H., and Francis J. Miller. “Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells.” Am J Physiol Heart Circ Physiol 285, no. 6 (December 2003): H2284–89. https://doi.org/10.1152/ajpheart.00459.2003.
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  - Oltman, Christine L., Neal L. Kane, Francis J. Miller, Arthur A. Spector, Neal L. Weintraub, and Kevin C. Dellsperger. “Reactive oxygen species mediate arachidonic acid-induced dilation in porcine coronary microvessels.” Am J Physiol Heart Circ Physiol 285, no. 6 (December 2003): H2309–15. https://doi.org/10.1152/ajpheart.00456.2003.
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  - Zhang, Yi, Loyd R. Davies, Sean M. Martin, William J. Coddington, Francis J. Miller, Garry R. Buettner, and Richard E. Kerber. “The nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) increases free radical generation and degrades left ventricular function after myocardial ischemia-reperfusion.” Resuscitation 59, no. 3 (December 2003): 345–52. https://doi.org/10.1016/s0300-9572(03)00240-5.
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  - Rice, James B., Lynn L. Stoll, Wei-Gen Li, Gerene M. Denning, Jamie Weydert, Elizabeth Charipar, Wayne E. Richenbacher, Francis J. Miller, and Neal L. Weintraub. “Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins.” Arterioscler Thromb Vasc Biol 23, no. 9 (September 1, 2003): 1576–82. https://doi.org/10.1161/01.ATV.0000081741.38087.F9.
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  - Clark, Craig B., Yi Zhang, Sean M. Martin, L. Ray Davies, Linjing Xu, Kevin C. Kregel, Francis J. Miller, Garry R. Buettner, and Richard E. Kerber. “The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation.” Resuscitation 57, no. 1 (April 2003): 101–8. https://doi.org/10.1016/s0300-9572(02)00413-6.
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  - Li, Wei-Gen, Lynn L. Stoll, James B. Rice, Shao-Ping Xu, Francis J. Miller, Papri Chatterjee, Ling Hu, Larry W. Oberley, Arthur A. Spector, and Neal L. Weintraub. “Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity.” Free Radic Biol Med 34, no. 7 (April 1, 2003): 937–46. https://doi.org/10.1016/s0891-5849(03)00032-7.
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  - Miller, Francis J. “Aortic aneurysms: It's all about the stress.” Arterioscler Thromb Vasc Biol 22, no. 12 (December 1, 2002): 1948–49. https://doi.org/10.1161/01.atv.0000047947.37203.82.
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  - Lentz, Steven R., Francis J. Miller, Donald J. Piegors, Rochelle A. Erger, José A. Fernández, John H. Griffin, and Donald D. Heistad. “Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys.” Circulation 106, no. 7 (August 13, 2002): 842–46. https://doi.org/10.1161/01.cir.0000024982.11646.25.
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  - Brandes, Ralf P., Francis J. Miller, Stefani Beer, Judith Haendeler, Jörg Hoffmann, Tulinh Ha, Steven M. Holland, Agnes Görlach, and Rudi Busse. “The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.” Free Radic Biol Med 32, no. 11 (June 1, 2002): 1116–22. https://doi.org/10.1016/s0891-5849(02)00789-x.
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  - Miller, Francis J., William J. Sharp, Xiang Fang, Larry W. Oberley, Terry D. Oberley, and Neal L. Weintraub. “Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling.” Arterioscler Thromb Vasc Biol 22, no. 4 (April 1, 2002): 560–65. https://doi.org/10.1161/01.atv.0000013778.72404.30.
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  - Shihabi, Ahmad, Wei-Gen Li, Francis J. Miller, and Neal L. Weintraub. “Antioxidant therapy for atherosclerotic vascular disease: the promise and the pitfalls.” Am J Physiol Heart Circ Physiol 282, no. 3 (March 2002): H797–802. https://doi.org/10.1152/ajpheart.2002.282.3.H797.
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  - Hathaway, Christopher A., Donald D. Heistad, Donald J. Piegors, and Francis J. Miller. “Regression of atherosclerosis in monkeys reduces vascular superoxide levels.” Circ Res 90, no. 3 (February 22, 2002): 277–83. https://doi.org/10.1161/hh0302.104724.
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  - Miller, Francis J., and Kathy K. Griendling. “Functional evaluation of nonphagocytic NAD(P)H oxidases.” Methods Enzymol 353 (2002): 220–33. https://doi.org/10.1016/s0076-6879(02)53050-0.
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  - Lentz, S. R., F. J. Miller, D. J. Piegors, R. A. Erger, J. A. Fernandez, J. H. Griffin, and D. D. Heistad. “Impaired anticoagulant response to thrombin improves after regression of atherosclerosis in monkeys.” Blood 98, no. 11 (November 16, 2001): 257A-257A.
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  - Li, W. G., F. J. Miller, H. J. Zhang, D. R. Spitz, L. W. Oberley, and N. L. Weintraub. “H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury.” J Biol Chem 276, no. 31 (August 3, 2001): 29251–56. https://doi.org/10.1074/jbc.M102124200.
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  - Zhang, Y., J. W. Bissing, L. Xu, A. J. Ryan, S. M. Martin, F. J. Miller, K. C. Kregel, G. R. Buettner, and R. E. Kerber. “Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model.” J Am Coll Cardiol 38, no. 2 (August 2001): 546–54. https://doi.org/10.1016/s0735-1097(01)01400-0.
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  - Bocker, J. M., F. J. Miller, C. L. Oltman, D. A. Chappell, and D. D. Gutterman. “Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta.” Jpn Heart J 42, no. 3 (May 2001): 317–26. https://doi.org/10.1536/jhj.42.317.
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  - Miller, F. J. “Adventitial fibroblasts: backstage journeymen.” Arterioscler Thromb Vasc Biol 21, no. 5 (May 2001): 722–23. https://doi.org/10.1161/01.atv.21.5.722.
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  - Hathaway, C. A., D. D. Heistad, and F. J. Miller. “Localization of NADPH oxidase in blood vessels from atherosclerotic monkeys.” Faseb Journal 15, no. 5 (March 8, 2001): A1128–A1128.
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  - Martin, S. M., Y. Zhang, K. C. Kregel, F. J. Miller, G. R. Buettner, and R. E. Kerber. “The nitric oxide synthase inhibitor NG-nitro-L-arginine decreases defibrillation induced free radical generation.” Free Radical Biology and Medicine 31 (January 1, 2001): S71–S71.
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  - Miller, F. J., W. M. Ferley, and C. A. Hathaway. “Nitric oxide and peroxynitrite inhibits NADPH oxidase in human vascular smooth muscle cells.” Free Radical Biology and Medicine 31 (January 1, 2001): S71–S71.
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  - Yao, Y., N. N. Lomis, S. M. Scott, H. C. Yoon, and F. J. Miller. “Percutaneous sclerotherapy for congenital venous malformations in the extremities.” Orthopedics 24, no. 1 (January 2001): 45–51. https://doi.org/10.3928/0147-7447-20010101-18.
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  - Brandes, R. P., F. J. Miller, S. M. Holland, R. Busse, and A. Goriach. “The NADPH oxidase subunit p47phox contributes to vascular superoxide anion generation.” Circulation 102, no. 18 (October 31, 2000): 233–233.
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  - Hathaway, C. A., D. D. Heistad, D. J. Piegors, and F. J. Miller. “Regression of atherosclerosis in monkeys reduces vascular superoxide levels.” Circulation 102, no. 18 (October 31, 2000): 176–176.
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  - He, T., N. L. Weintraub, F. J. Miller, P. Chatterjee, W. Zhao, D. R. Spitz, F. E. Domann, and L. W. Oberley. “Redox regulation of smooth muscle cell proliferation by platelet-derived growth Factor-BB: Redox factor-1 as an intermediate.” Circulation 102, no. 18 (October 31, 2000): 353–353.
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  - Li, W. G., F. J. Miller, P. Chattergee, H. J. Zhang, L. W. Oberley, and N. L. Weintraub. “H2O2 increases O-2(.-) in vascular smooth muscle cells: A novel role for NAD(P)H oxidase in promoting cell death.” Circulation 102, no. 18 (October 31, 2000): 122–122.
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  - Miller, F. J., A. E. Shriver, W. G. Li, T. He, and N. L. Weintraub. “Superoxide levels and NADPH oxidase activity are increased in neointimal as compared with medial smooth muscle cells.” Circulation 102, no. 18 (October 31, 2000): 126–126.
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  - Miller, F. J., and A. H. Chamseddine. “The gp91phox subunit is necessary for production of superoxide by NADPH oxidase in vascular fibroblasts but not smooth muscle cells.” Circulation 102, no. 18 (October 31, 2000): 233–233.
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  - Szscs, K., B. Lassegue, D. Sorescu, N. L. Weintraub, F. J. Miller, J. D. Lambeth, and K. K. Griendling. “Nox-1, a novel gp91phox homologue, is upregulated in restenosis following balloon injury.” Circulation 102, no. 18 (October 31, 2000): 303–303.
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  - Chamseddine, A. H., and F. J. Miller. “GP91PHOX is necessary for production of superoxide by NADPH oxidase in vascular fibroblasts but not smooth muscle cells.” Journal of Investigative Medicine 48, no. 5 (September 1, 2000): 247A-247A.
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  - Kinkade, K., X. Fang, and F. J. Miller. “Quinacrine inhibits development of atherosclerosis in mice.” Journal of Investigative Medicine 48, no. 5 (September 1, 2000): 247A-247A.
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  - Li, W. G., F. J. Miller, P. Chatterjee, H. J. Zhan, L. W. Oberley, and N. L. Weintraub. “H2O2 increases O-2(center dot-) in vascular smooth muscle cells: A novel role for NAD(P)H oxidase in promoting cell death.” Journal of Investigative Medicine 48, no. 5 (September 1, 2000): 247A-247A.
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  - Shriver, A. E., W. Li, N. L. Weintraub, and F. J. Miller. “Superoxide levels and NADPH oxidase activity are increased in neointimal as compared with medial smooth muscle cells.” Journal of Investigative Medicine 48, no. 5 (September 1, 2000): 248A-248A.
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  - McDonald, J. E., F. J. Miller, S. E. Hallam, L. Nelson, D. A. Marchuk, and K. J. Ward. “Clinical manifestations in a large hereditary hemorrhagic telangiectasia (HHT) type 2 kindred.” Am J Med Genet 93, no. 4 (August 14, 2000): 320–27. https://doi.org/10.1002/1096-8628(20000814)93:4<320::aid-ajmg12>3.0.co;2-r.
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  - Miller, F. J. “AIF-1 in the activated smooth muscle cell : spectator or participant?” Arterioscler Thromb Vasc Biol 20, no. 7 (July 2000): 1701–3. https://doi.org/10.1161/01.atv.20.7.1701.
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  - Li, W. G., F. J. Miller, M. R. Brown, P. Chatterjee, G. R. Aylsworth, J. Shao, A. A. Spector, L. W. Oberley, and N. L. Weintraub. “Enhanced H(2)O(2)-induced cytotoxicity in "epithelioid" smooth muscle cells: implications for neointimal regression.” Arterioscler Thromb Vasc Biol 20, no. 6 (June 2000): 1473–79. https://doi.org/10.1161/01.atv.20.6.1473.
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  - Hathaway, C. A., and F. J. Miller. “Preferential utilization of NADH by the vascular NAD(P)H oxidase: Fact or artifact?” Faseb Journal 14, no. 4 (March 15, 2000): A119–A119.
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  - Li, W. G., T. R. He, F. J. Miller, P. Q. Wang, K. C. Dellsperger, L. W. Oberley, and N. L. Weintraub. “Elevated glucose sensitizes vascular smooth muscle cells to H2O2-induced oxidative stress.” Faseb Journal 14, no. 4 (March 15, 2000): A119–A119.
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  - Miller, F. J., W. J. Sharp, X. Fang, and N. L. Weintraub. “Oxidative stress is enhanced in human abdominal aortic aneurysms.” Faseb Journal 14, no. 4 (March 15, 2000): A119–A119.
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  - Lund, D. D., F. M. Faraci, F. J. Miller, and D. D. Heistad. “Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits.” Circulation 101, no. 9 (March 7, 2000): 1027–33. https://doi.org/10.1161/01.cir.101.9.1027.
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  - Nakane, H., F. J. Miller, F. M. Faraci, K. Toyoda, and D. D. Heistad. “Gene transfer of endothelial nitric oxide synthase reduces angiotensin II-induced endothelial dysfunction.” Hypertension 35, no. 2 (February 2000): 595–601. https://doi.org/10.1161/01.hyp.35.2.595.
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  - Li, W. G., F. J. Miller, G. R. Aylsworth, M. R. Brown, A. A. Spector, and N. L. Weintraub. “Elevated glucose enhances reactive oxygen species-induced apoptosis of vascular smooth muscle cells.” Circulation 100, no. 18 (November 2, 1999): 235–235.
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  - Li, W. G., F. J. Miller, M. R. Brown, P. Chatterjee, G. R. Aylsworth, A. A. Spector, and N. L. Weintraub. “Enhanced H2O2-induced cytotoxicity in epithelioid as compared with fusiform vascular smooth muscle cells.” Circulation 100, no. 18 (November 2, 1999): 543–543.
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  - Brown, M. R., F. J. Miller, W. G. Li, A. N. Ellingson, J. D. Mozena, P. Chatterjee, J. F. Engelhardt, et al. “Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells.” Circ Res 85, no. 6 (September 17, 1999): 524–33. https://doi.org/10.1161/01.res.85.6.524.
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  - Hinchcliffe, E. H., E. A. Thompson, F. J. Miller, J. Yang, and G. Sluder. “Nucleo-cytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote.” J Cell Sci 112 ( Pt 8) (April 1999): 1139–48. https://doi.org/10.1242/jcs.112.8.1139.
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  - Li, W. G., F. J. Miller, M. R. Brown, P. Chatterjee, G. R. Aylsworth, A. A. Spector, and N. L. Weintraub. “Reactive oxygen species-mediated cytotoxicity is enhanced in "epitheloid" versus "fusiform" smooth muscle cells.” Faseb Journal 13, no. 5 (March 15, 1999): A1116–A1116.
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  - Miller, F. J., J. D. Mozena, and K. M. Neitzke. “Basal superoxide levels and NADH oxidase activity are increased in atherosclerotic human vessels.” Faseb Journal 13, no. 5 (March 15, 1999): A1116–A1116.
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  - Lund, D. D., F. M. Faraci, F. J. Miller, and D. D. Heistad. “Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits.” Faseb Journal 13, no. 4 (March 12, 1999): A91–A91.
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  - Lund, D. D., F. M. Faraci, F. J. Miller, and D. D. Heistad. “Gene transfer of endothelial nitric oxide synthase reduces endothelial dysfunction in angiotensin II-treated rabbits.” Faseb Journal 13, no. 4 (March 12, 1999): A91–A91.
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  - Sluder, G., E. A. Thompson, F. J. Miller, J. Yang, and E. H. Hinchcliffe. “Nucleo-cytoplasmic interactions in the control of nuclear envelope breakdown in the sea urchin zygote.” Molecular Biology of the Cell 9 (November 1, 1998): 3A-3A.
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  - Miller, F. J., J. E. Mozena, E. L. Foresman, B. L. Davidson, and D. D. Gutterman. “Smooth muscle cell production of superoxide is increased in atherosclerosis.” Circulation 98, no. 17 (October 27, 1998): 311–311.
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  - Miller, F. J., J. Mozena, E. L. Foresman, D. D. Gutterman, and B. L. Davidson. “Superoxide production is increased throughout the vascular wall of atherosclerotic mice aorta and mediated by a membrane bound NAD(P)H oxidase.” Circulation 98, no. 17 (October 27, 1998): 733–34.
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  - Terata, K., F. J. Miller, and D. D. Gutterman. “Effect of superoxide( 0(2)(-)) on K+-channel mediated responses in human coronary arterioles.” Circulation 98, no. 17 (October 27, 1998): 825–825.
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  - Mozena, J. D., F. J. Miller, E. L. Foresman, B. L. Davidson, and D. D. Gutterman. “Smooth muscle cell production of superoxide is increased in atherosclerosis.” Journal of Investigative Medicine 46, no. 7 (September 1, 1998): 288A-288A.
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  - Miller, F. J., D. D. Gutterman, C. D. Rios, D. D. Heistad, and B. L. Davidson. “Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis.” Circ Res 82, no. 12 (June 29, 1998): 1298–1305. https://doi.org/10.1161/01.res.82.12.1298.
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  - Miller, F. J., K. C. Dellsperger, and D. D. Gutterman. “Pharmacologic activation of the human coronary microcirculation in vitro: endothelium-dependent dilation and differential responses to acetylcholine.” Cardiovasc Res 38, no. 3 (June 1998): 744–50. https://doi.org/10.1016/s0008-6363(98)00035-2.
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  - Miller, F. J., D. D. Gutterman, and B. L. Davidson. “Gene transfer of superoxide dismutase protects against free radical mediated impairment of vasodilation.” Faseb Journal 12, no. 5 (March 20, 1998).
  - Miller, F. J., D. D. Gutterman, D. D. Heistad, and B. L. Davidson. “Gene transfer of superoxide dismutase reduces superoxide anion but does not improve endothelial dependent relaxation in atherosclerosis.” Circulation 96, no. 8 (October 21, 1997): 956–956.
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  - Miller, F. J., J. D. Mozena, D. D. Gutterman, and B. L. Davidson. “In situ visualization of reactive oxygen species in atherosclerosis.” Circulation 96, no. 8 (October 21, 1997): 2323–2323.
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  - Miller, F. J., K. C. Dellsperger, and D. D. Gutterman. “Myogenic constriction of human coronary arterioles.” Am J Physiol 273, no. 1 Pt 2 (July 1997): H257–64. https://doi.org/10.1152/ajpheart.1997.273.1.H257.
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  - Miller, F. J., K. C. Dellsperger, and D. D. Gutterman. “Myogenic constriction of human coronary arterioles.” American Journal of Physiology Heart and Circulatory Physiology 273, no. 1 (July 1, 1997): H257–64.
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  - Miller, F. J., D. D. Gutterman, and B. L. Davidson. “Adenovirus mediated gene transfer to isolated canine and human coronary conduit and resistance vessels.” Circulation 94, no. 8 (October 15, 1996): 1421–1421.
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  - Miller, F. J., K. C. Dellsperger, and D. D. Gutterman. “Protein kinase C dependent myogenic constriction of isolated human coronary arterioles.” Circulation 94, no. 8 (October 15, 1996): 2865–2865.
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  - Miura, H., F. J. Miller, D. M. McCoy, and D. D. Gutterman. “Mechanism of human coronary arteriolar relaxation to bradykinin.” Circulation 94, no. 8 (October 15, 1996): 1412–1412.
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  - MILLER, F. J., K. C. DELLSPERGER, and D. D. GUTTERMAN. “BASAL TONE OF ISOLATED HUMAN CORONARY ARTERIOLES DEPENDS ON PROTEIN-KINASE-C ACTIVATION.” Circulation 92, no. 8 (October 15, 1995): 2053–2053.
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  - MILLER, F. J., K. C. DELLSPERGER, and D. D. GUTTERMAN. “MECHANISM OF HUMAN CORONARY ARTERIOLAR RELAXATION TO ADENOSINE-DIPHOSPHATE.” Circulation 92, no. 8 (October 15, 1995): 621–621.
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  - RODRIGUEZIGLESIAS, E., F. J. MILLER, K. C. DELLSPERGER, and D. D. GUTTERMAN. “ROLE OF PROSTAGLANDINS AND NITRIC-OXIDE IN THE HUMAN ATRIAL CORONARY ARTERIOLAR RESPONSE TO ACETYLCHOLINE.” Faseb Journal 9, no. 4 (March 10, 1995): A912–A912.
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  - MILLER, F. J., K. C. DELLSPERGER, C. L. OLTMAN, and D. D. GUTTERMAN. “ALLOXAN-INDUCED DIABETES-MELLITUS IMPAIRS ENDOTHELIUM-DEPENDENT VASODILATION OF CANINE CORONARY ARTERIOLES.” Circulation 90, no. 4 (October 1, 1994): 430–430.
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  - MILLER, F. J., K. C. DELLSPERGER, R. P. EMBREY, and D. D. GUTTERMAN. “DIFFERENTIAL EFFECT OF ACETYLCHOLINE ON ATRIAL AND VENTRICULAR RESISTANCE VESSELS ISOLATED FROM HUMAN HEARTS.” Journal of the American College of Cardiology, February 1, 1994, A427–A427.
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  - MILLER, F. J., K. C. DELLSPERGER, R. P. EMBREY, and D. D. GUTTERMAN. “ACETYLCHOLINE CONSTRICTS ISOLATED HUMAN CORONARY RESISTANCE VESSELS.” Circulation 88, no. 4 (October 1, 1993): 374–374.
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  - MILLER, F. J., K. C. DELLSPERGER, R. P. EMBREY, and D. D. GUTTERMAN. “ISOLATED HUMAN CORONARY ARTERIOLES EXHIBIT MYOGENIC TONE.” Circulation 88, no. 4 (October 1, 1993): 471–471.
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  - MILLER, F. J., K. C. DELLSPERGER, and D. D. GUTTERMAN. “HYPERGLYCEMIA ALTERS ENDOTHELIUM DEPENDENT RELAXATION OF CORONARY MICROVESSELS BUT NOT CONDUIT VESSELS INVITRO.” Faseb Journal 7, no. 3 (February 19, 1993): A423–A423.
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  - Gutterman, D. D., D. A. Morgan, and F. J. Miller. “Effect of brief myocardial ischemia on sympathetic coronary vasoconstriction.” Circ Res 71, no. 4 (October 1992): 960–69. https://doi.org/10.1161/01.res.71.4.960.
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  - Miller, F. J., M. L. Marcus, M. J. Brody, and D. D. Gutterman. “Activation in the region of parabrachial nucleus elicits neurogenically mediated coronary vasoconstriction.” Am J Physiol 261, no. 5 Pt 2 (November 1991): H1585–96. https://doi.org/10.1152/ajpheart.1991.261.5.H1585.
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  - Miller, F. J., M. L. Marcus, M. J. Brody, and D. D. Gutterman. “Activation in the region of parabrachial nucleus elicits neurogenically mediated coronary vasoconstriction.” American Journal of Physiology Heart and Circulatory Physiology 261, no. 5 30-5 (January 1, 1991). https://doi.org/10.1152/ajpheart.1991.261.5.h1585.
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  - GUTTERMAN, D. D., F. J. MILLER, and D. A. MORGAN. “DOES MYOCARDIAL STUNNING ALTER NEURALLY-MEDIATED CORONARY VASOCONSTRICTION.” Clinical Research 36, no. 6 (October 1, 1988): A820–A820.
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  - GUTTERMAN, D. D., M. L. MARCUS, M. J. BRODY, and F. J. MILLER. “PARABRACHIAL NUCLEAR REGION - AN IMPORTANT NEURONAL SITE MEDIATING CORONARY VASOCONSTRICTION.” Clinical Research 36, no. 6 (October 1, 1988): A820–A820.
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  - MILLER, F. J., J. M. ARTHUR, M. L. MARCUS, M. J. BRODY, and D. D. GUTTERMAN. “PONTINE PROJECTION OF A HYPOTHALAMIC CORONARY VASOCONSTRICTOR PATHWAY.” Faseb Journal 2, no. 4 (March 15, 1988): A495–A495.
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  - MILLER, F. J., J. STUHLMULLER, P. PARDUBSKY, M. L. MARCUS, M. J. BRODY, and D. D. GUTTERMAN. “CEREBELLAR REGULATION OF CORONARY BLOOD-FLOW.” Clinical Research 35, no. 6 (October 1, 1987): A877–A877.
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  - Brown, B. J., D. K. Heaston, A. M. Poulson, H. A. Gabert, D. E. Mineau, and F. J. Miller. “Uncontrollable postpartum bleeding: a new approach to hemostasis through angiographic arterial embolization.” Obstet Gynecol 54, no. 3 (September 1979): 361–65.
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- Conference Papers
  - “Redox-regulation of NADPH Oxidase 4 in Cardiovascular Disease.” In Free Radical Biology and Medicine, 145:S109–S109. Elsevier BV, 2019. https://doi.org/10.1016/j.freeradbiomed.2019.10.291.
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  - Schickling, Brandon M., Jennifer Streeter, and Francis J. Miller. “Nadph Oxidase Nox1-dependent Endocytosis and Activation is Regulated by a Conserved Trafficking Motif in Vascular Smooth Muscle Cells.” In Circulation Research, Vol. 125. LIPPINCOTT WILLIAMS & WILKINS, 2019.
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  - Lei, Beilei, Kamie Snow, Jacob Fang, Robert M. Tighe, Paloma H. Giangrande, and Francis J. Miller. “Inhalation of an RNA Aptamer Targeting Extracellular Histones Protects from Acute Lung Injury.” In Molecular Therapy, 27:334–334. CELL PRESS, 2019.
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  - Aitchison, Alexandra H., Jennifer L. Lucitti, and Francis J. Miller. “Effect of Circulating EGF-like Ligands on NADPH Oxidase Expression in Vascular Cells.” In Faseb Journal, Vol. 33, 2019.
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  - Conti, Amanda L., Brandon M. Schickling, and Francis Miller. “Smooth Muscle Cell MicroRNA-9 is Transcriptionally Regulated by MicroRNA-25 in Vascular Disease.” In Faseb Journal, Vol. 33, 2019.
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  - Sartoretto, Simone M., Brandon M. Schickling, Laurynn Garcia, Jennifer L. Lucitti, and Francis J. Miller. “Transcriptional Activation of Nox1 NADPH Oxidase by Protein Disulfide Isomerase in Chronic Inflammation.” In Arteriosclerosis Thrombosis and Vascular Biology, Vol. 39, 2019.
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  - Scott, Danielle A., Brandon M. Schickling, and Francis J. Miller. “Expression of Nox4 NADPH Oxidase Splice Variants Generate Hydrogen Peroxide and Modify the Cell Cycle.” In Faseb Journal, Vol. 33, 2019.
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  - Schickling, Brandon, and Francis Miller. “Alternative splicing of Nox4 regulates subcellular redox-dependent pathways in vascular smooth muscle cells.” In Free Radical Biology and Medicine, 128:S39–S39. Elsevier BV, 2018. https://doi.org/10.1016/j.freeradbiomed.2018.10.056.
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  - Giangrande, Paloma H., Francis J. Miller, and William H. Thiel. “VSMC Specific Aptamer Ligands for the Next Generation of DES to Prevent Neointimal Formation.” In Molecular Therapy, 26:146–146. CELL PRESS, 2018.
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  - Udofot, Ofonime, Kevin Urak, Giselle Blanco, Li-Hsien Lin, Robert M. Weiss, Vladimir Badovinac, Francis Miller, and Paloma Giangrande. “Inhibition of Extracellular Histones in Sepsis-Induced Cardiovascular Function.” In Molecular Therapy, 26:37–37, 2018.
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  - Urak, Kevin T., Giselle Blanco, Li-Hsien Lin, Justin Dassie, Shambhavi Shubham, William Thiel Thiel, Yani Chen, et al. “Rna Inhibitors of Nuclear Proteins Implicated in Multiple Organ Dysfunction Syndrome.” In Molecular Therapy, 26:37–37, 2018.
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  - Miller, Francis. “The Regulation Of Nox In Vascular Disease.” In Free Radical Biology and Medicine, 112:2–2. Elsevier BV, 2017. https://doi.org/10.1016/j.freeradbiomed.2017.10.348.
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  - Schickling, Brandon M., Maysam Takapoo, Eric J. Devor, and Francis J. Miller. “Abstract 172: Vascular Smooth Muscle Cell Activation is Regulated by miR25 Induced miR-9 Suppression of Nox4 and Myocardin.” In Circulation Research, Vol. 121. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Urak, Kevin T., Francis J. Miller, and Paloma Giangrande. “Treatment of Sepsis by Neutralization of Extracellular Histones with Nucleic Acid Aptamers.” In Molecular Therapy, 25:35–35. CELL PRESS, 2017.
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  - Leisegang, M. S., C. Fork, I. Josipovic, F. Richler, J. Preussner, M. J. Millers, J. Epah, et al. “LncRNA MANTIS facilitates endothelial angiogenic function.” In Acta Physiologica, 219:58–58. WILEY, 2017.
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  - Schickling, Brandon M., Maysam Takapoo, Rohan Khera, and Francis J. Miller. “Circulating EGF-Like Ligands in Obesity Increase Neointimal Formation through Upregulation of NADPH Oxidase 1.” In Free Radical Biology and Medicine, 100:S151–S151. Elsevier BV, 2016. https://doi.org/10.1016/j.freeradbiomed.2016.10.397.
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  - Thiel, William H., Carla L. Esposito, David D. Dickey, Justin P. Dassie, Matthew E. Long, Joshua Adam, Jennifer Streeter, et al. “61. Vascular Smooth Muscle Cell RNA Aptamers for the Treatment of Cardiovascular Disease.” In Molecular Therapy, 23:S27–S27. Elsevier BV, 2015. https://doi.org/10.1016/s1525-0016(16)33666-8.
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  - Thiel, William H., David D. Dickey, Jennifer Streeter, Schickling Brandon, Justin P. Dassie, Maysam Takapoo, Xiuying Liu, Francis J. Miller, and Paloma H. Giangrande. “Cell-Targeted RNA-Based Therapies for Cardiovascular Disease.” In Molecular Therapy, 22:S230–S230. NATURE PUBLISHING GROUP, 2014.
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  - Makki, Nader M., Eric G. Heller, Wassef Y. Karrowni, Shuxia Jiang, Maysam Takapoo, Brandon M. Schickling, Bojana Stanic, Frances Johnson, and Francis J. Miller. “EGF-Like Ligands Contribute to Neointimal Formation via Nox1-Mediated SMC Growth.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Thiel, William H., Maysam Takapoo, Shuxia Jiang, Jennifer Streeter, Bojana Stanic, Xiuying Liu, Francis J. Miller, and Paloma H. Giangrande. “Smooth Muscle Cell Targeted RNA Aptamers for the Treatment of Vascular Disease.” In Molecular Therapy, 21:S197–98. NATURE PUBLISHING GROUP, 2013.
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  - Jiang, Shuxia, Jennifer Streeter, and Francis Miller. “Nox1 NADPH Oxidase is Necessary for Late, but not Early, Ischemic Preconditioning against Myocardial Infarction in Mice.” In Free Radical Biology and Medicine, 53:S164–S164. Elsevier BV, 2012. https://doi.org/10.1016/j.freeradbiomed.2012.10.450.
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  - Streeter, Jennifer, Brandon Schickling, William Thiel, and Francis Miller. “Nox1 Phosphorylation in Cardiovascular Disease.” In Free Radical Biology and Medicine, 53:S175–S175. Elsevier BV, 2012. https://doi.org/10.1016/j.freeradbiomed.2012.10.483.
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  - Thiel, William H., Thomas Bair, Andrew S. Peek, Bojana Stanic, Maysam Takapoo, Jennifer Streeter, Mark A. Behlke, Francis J. Miller, and Paloma H. Giangrande. “Aptamer-siRNA Chimera Inhibitors of Intimal Hyperplasia.” In Molecular Therapy, 20:S103–4. NATURE PUBLISHING GROUP, 2012.
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  - Carrell, Samuel, Bojana Stanic, and Francis Miller. “Nox4 NADPH Oxidase Modulates the Intracellular Redox State.” In Free Radical Biology and Medicine, 49:S17–S17. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.011.
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  - Simons, Andrean L., Kevin P. Orcutt, Arlene D. Parsons, Zita A. Sibenaller, Peter M. Scarbrough, Arya Sobhakumari, Yueming Zhu, et al. “Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress in Human Head and Neck Cancer Cells.” In Free Radical Biology and Medicine, 49:S102–3. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.270.
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  - Stanic, Bojana, and Francis Miller. “EGF-like Ligands Modulate NADPH Oxidase Expression and Activity in a Primate Model of Atherosclerosis.” In Free Radical Biology and Medicine, 49:S30–S30. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.052.
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  - Streeter, Jennifer, and Francis Miller. “The Majority of Nox1 Resides at Internal Membranes and Traffics Differentially with Stimulation.” In Free Radical Biology and Medicine, 49:S135–36. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.375.
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  - Streeter, Jennifer, and Francis Miller. “Potential Role of Protein Kinase C-beta I as a Novel Regulator of Nox1 Activation.” In Free Radical Biology and Medicine, 47:S23–S23, 2009.
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  - Miller, Francis Jr. “PATHOLOGICAL ROLE OF Nox PROTEINS.” In Free Radical Biology and Medicine, 45:S9–S9, 2008.
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  - Miller, Francis, Jagadeesha Dammanahalli, Botond Banfi, Maysam Takapoo, and Ramesh Bhalla. “Nox1-mediated EGFR transactivation increases N-cadherin shedding and smooth muscle migration.” In Faseb Journal, Vol. 22, 2008.
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  - Stanic, Bojana, and Francis Miller. “Oxidized extracellular redox state increases Nox1 expression in vascular smooth muscle cells.” In Faseb Journal, Vol. 22, 2008.
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  - Zimmerman, Matthew, Maysam Takapoo, Jagadeesha Damahalli, Bojana Stanic, Botond Banfi, Francis Miller, and Ramesh Bhalla. “Nox1-derived reactive oxygen species (ROS) mediate thrombin-induced influx of calcium in vascular smooth muscle cells (SMC).” In Faseb Journal, Vol. 22, 2008.
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  - Dammanahalli, Jagadeesha K., Francis J. Miller, and Ramesh C. Bhalla. “Effect of oxidative stress on apoptosis and regulation of Bax and Bel-xL in development of intimal thickening of balloon-injured rat carotid artery.” In Faseb Journal, 21:A1343–A1343. FEDERATION AMER SOC EXP BIOL, 2007.
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  - Dammanahalli, Jagadeesha K., Botond Banfi, Ramesh C. Bhalla, and Francis J. Miller. “Nox1 is required for smooth muscle cell activation of matrix-metalloproteinase-9 and cell migration in response to thrombin.” In Circulation, 114:30–30. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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  - Takapoo, Maysam, Ali Chamseddine, Ramesh C. Bhalla, and Francis J. Miller. “Secretion of cyclophilin A by glutathione peroxidase-1 deficient smooth muscle cells has a paracrine effect on normal smooth muscle cells to activate NF-kB and increase cell growth.” In Circulation, 114:2–2. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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  - Tsimikas, Sotirios, Masanori Aikawa, Francis J. Miller, Elizabeth R. Miller, Michael Torzewski, Steven R. Lentz, Donald D. Heistad, Peter Libby, and Joseph L. Witztum. “Increased Plasma oxidized Phospholipid : Apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions following dietary lipid lowering: A potential biomarker of early atherosclerosis regression.” In Circulation, 114:111–111. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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  - Dammanahalli, J. K., J. DeLeon, F. J. Miller, and R. C. Bhalla. “Superoxide mediates the medial smooth muscle cell apoptosis associated with vascular injury.” In Faseb Journal, 20:A1453–A1453. FEDERATION AMER SOC EXP BIOL, 2006.
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  - Filali, M., G. J. Huss, T. J. Barna, F. J. Miller, and F. S. Lamb. “CIC-3 is required for normal NF-kappa B activation by inflammatory mediators in vascular smooth muscle (VSM).” In Faseb Journal, 20:A1163–A1163. FEDERATION AMER SOC EXP BIOL, 2006.
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  - Roghair, R. D., F. S. Lamb, F. J. Miller, and J. L. Segar. “Early gestation dexamethasone-exposure programs tissue-specific alterations in reactive oxygen species production.” In Pediatric Research, 58:1012–13. INT PEDIATRIC RESEARCH FOUNDATION, INC, 2005.
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  - Thomas, M., M. L. McCormick, D. Gavrila, F. J. Miller, A. Daugherty, K. C. Dellsperger, and N. L. Weintraub. “Role of p47(phox) in angiotensin II-induced abdominal aortic aneurysm formation in ApoE knock-out mice.” In Circulation, 112:U104–U104. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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  - Roghair, R. D., F. S. Lamb, F. J. Miller, T. D. Scholz, and J. L. Segar. “Altered prostaglandin production in the fetal programming of ovine coronary artery vascular reactivity.” In Faseb Journal, 19:A740–A740. FEDERATION AMER SOC EXP BIOL, 2005.
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  - Xu, S. P., and F. J. Miller. “Role of the NADPH oxidase subunit Nox4 in generation of reactive oxygen species and growth arrest of vascular smooth muscle cells in atherosclerosis.” In Journal of Investigative Medicine, 53:S363–S363. B C DECKER INC, 2005.
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  - Jeney, V., S. Ito, Z. Y. On, T. Tojo, F. J. Miller, M. Ushio-Fukai, and T. Fukai. “Dual role of antioxidant-1 in modulating the activity and expression of extracellular superoxide dismutase.” In Circulation, 110:284–284. LIPPINCOTT WILLIAMS & WILKINS, 2004.
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  - Xu, S. P., and F. J. Miller. “Nox4-derived reactive oxygen species and growth arrest of vascular smooth muscle cells in atherosclerosis.” In Circulation, 110:282–282. LIPPINCOTT WILLIAMS & WILKINS, 2004.
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  - Roghair, R. D., M. C. Bailey, F. S. Lamb, F. J. Miller, T. D. Scholz, and J. L. Segar. “Early Gestation Dexamethasone Exposure Alters Coronary Artery Reactivity in Newborn Lambs.” In Pediatric Research, 56:669–669. Springer Science and Business Media LLC, 2004. https://doi.org/10.1203/00006450-200410000-00038.
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  - Roghair, R. D., F. S. Lamb, F. J. Miller, T. D. Scholz, and J. L. Segar. “Coronary Artery NAD(P)H oxidase expression and superoxide anion production is enhanced by early gestation glucocorticoid exposure.” In Pediatric Research, 55:178A-178A. INT PEDIATRIC RESEARCH FOUNDATION, INC, 2004.
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  - Roghair, R. D., F. S. Lamb, F. J. Miller, T. D. Scholz, and J. L. Segar. “Early gestation glucocorticoid exposure enhances postnatal coronary artery vasoconstriction.” In Pediatric Research, 55:96A-96A. NATURE PUBLISHING GROUP, 2004.
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  - Lamb, F. S., M. Bailey, E. Lazartigues, D. W. Nuno, A. H. Chamseddine, L. W. Dickerson, K. G. Lamping, R. L. Davisson, and F. J. Miller. “Hypertension, vasomotor dysfunction and oxidative stress in ClC-3 deficient mice.” In Faseb Journal, 18:A1033–A1033. FEDERATION AMER SOC EXP BIOL, 2004.
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  - Hahn, D. M., A. H. Chamseddine, and F. J. Miller. “The differential role of superoxide and hydrogen peroxide in atherosclerosis.” In Faseb Journal, 18:A280–A280. FEDERATION AMER SOC EXP BIOL, 2004.
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  - Miller, F. J., A. H. Chamseddine, T. J. Barna, and F. S. Lamb. “Role of ClC3 chloride channels in intracellular superoxide levels and cell growth.” In Faseb Journal, 18:A311–12. FEDERATION AMER SOC EXP BIOL, 2004.
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  - Segar, J. L., R. D. Roghair, F. J. Miller, T. D. Scholz, and F. S. Lamb. “Early gestation dexamethasone exposure programs coronary artery dysfunction.” In Faseb Journal, 18:A684–A684. FEDERATION AMER SOC EXP BIOL, 2004.
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  - Boseman, J. P., and F. J. Miller. “C-REACTIVE PROTEIN INCREASES VIABILITY AND DECREASES MIGRATION OF SMOOTH MUSCLE CELLS.” In Journal of Investigative Medicine, 52:S346–S346. SAGE Publications, 2004. https://doi.org/10.1097/00042871-200403002-00004.
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  - Chamseddine, A. H., M. McCormick, J. McGregor, and F. J. Miller. “CHRONIC ELEVATION OF ENDOGENOUS HYDROGEN PEROXIDE DECREASES GROWTH AND MIGRATION OF VASCULAR SMOOTH MUSCLE CELLS.” In Journal of Investigative Medicine, 52:S346–S346. SAGE Publications, 2004. https://doi.org/10.1097/00042871-200403002-00005.
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  - Gavrila, D., W. G. Li, A. Daugherty, L. A. Cassis, F. J. Miller, L. W. Oberley, K. C. Dellsperger, and N. L. Weintraub. “VITAMIN E INHIBITS ABDOMINAL AORTIC ANEURYSM FORMATION IN ANGIOTENSIN II-INFUSED, APOLIPOPROTEIN E-DEFICIENT MICE.” In Journal of Investigative Medicine, 52:S357–58. SAGE Publications, 2004. https://doi.org/10.1097/00042871-200403002-00071.
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  - Hahn, D. M., A. H. Chamseddine, and F. J. Miller. “THE EFFECT OF SUPEROXIDE AND HYDROGEN PEROXIDE IN ATHEROSCLEROSIS.” In Journal of Investigative Medicine, 52:S350–S350. SAGE Publications, 2004. https://doi.org/10.1097/00042871-200403002-00025.
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  - Xu, S. P., and F. J. Miller. “ROLE OF THE GP91PHOX HOMOLOGUES NOX1 AND NOX4 IN ATHEROSCLEROSIS.” In Journal of Investigative Medicine, 52:S357–S357. SAGE Publications, 2004. https://doi.org/10.1097/00042871-200403002-00069.
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  - McCormick, M. L., D. Gavrila, A. Daugherty, L. A. Cassis, F. J. Miller, L. W. Oberley, K. C. Dellsperger, and N. L. Weintraub. “Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused, apolipoprotein E-deficient mice.” In Free Radical Biology and Medicine, 37:S137–S137. PERGAMON-ELSEVIER SCIENCE LTD, 2004.
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  - Roghair, R. D., F. S. Lamb, F. J. Miller, T. D. Scholz, and J. L. Segar. “Programming of coronary artery dysfunction by early gestation dexamethasone exposure.” In Pediatric Research, 54:773–773. INT PEDIATRIC RESEARCH FOUNDATION, INC, 2003.
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  - Gavrila, D., W. G. Li, A. Daugherty, L. A. Cassis, F. J. Miller, K. C. Dellsperger, and N. L. Weintraub. “Vitamin E inhibits angiotensin II-induced abdominal aortic aneurysm formation in ApoE knock-out mice.” In Circulation, 108:200–200. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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  - Jeney, V., S. A. Mertens, O. Gradek, F. J. Miller, A. Nguyen, and T. Fukai. “Antioxidant-1 (Atox1), copper delivery system, and extracellular superoxide dismutase.” In Circulation, 108:235–36. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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  - Chamseddine, A. H., and F. J. Miller. “Deficiency of gp91phox is associated with decreased superoxide levels and increased proliferation in vascular fibroblasts.” In Faseb Journal, 17:A523–A523. FEDERATION AMER SOC EXP BIOL, 2003.
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  - Miller, F. J., and K. Kinkade. “Apocynin inhibits atherosclerosis in mice.” In Faseb Journal, 17:A523–A523. FEDERATION AMER SOC EXP BIOL, 2003.
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  - Oltman, C. L., N. L. Kane, F. J. Miller, N. L. Weintraub, and K. C. Dellsperger. “Reactive oxygen species mediate arachidonic acid-induced dilation in porcine coronary microvessels.” In Faseb Journal, 17:A509–A509. FEDERATION AMER SOC EXP BIOL, 2003.
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  - Xu, S. P., A. H. Chamseddine, and F. J. Miller. “Expression of p22phox in smooth muscle cells from atherosclerotic lesions is associated with abnormal cell growth.” In Faseb Journal, 17:A501–2. FEDERATION AMER SOC EXP BIOL, 2003.
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  - Xu, S., A. H. Chamseddine, and F. J. Miller. “Expression of p22phox in smooth muscle cells from atherosclerotic lesions is associated with abnormal cell growth.” In Journal of Investigative Medicine, 51:S447–S447. B C DECKER INC, 2003.
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  - Jeney, V., S. Mertens, Q. Gradek, F. J. Miller, A. Nguyen, and T. Fukai. “The role of antioxidant-1 in extracellular superoxide dismutase function.” In Free Radical Biology and Medicine, 35:S35–S35. PERGAMON-ELSEVIER SCIENCE LTD, 2003.
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  - Xu, S. P., A. Chamseddine, and F. J. Miller. “Increased expression of Nox4 is associated with increased superoxide levels and altered growth of smooth muscle cells in atherosclerosis.” In Circulation, 106:261–261. LIPPINCOTT WILLIAMS & WILKINS, 2002.
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  - Lentz, S. R., D. J. Piegors, J. A. Fernandez, R. A. Erger, M. R. Malinow, J. H. Griffin, W. G. Haynes, and D. D. Heistad. “Effect of hyperhomocysteinemia on protein C activation and activity in vivo.” In Blood, 98:257A-258A. AMER SOC HEMATOLOGY, 2001.
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- Preprints
  - Boos, Frederike, James A. Oo, Timothy Warwick, Stefan Günther, Judit Izquierdo Ponce, Giulia Buchmann, Tianfu Li, et al. “The endothelial-specific LINC00607 mediates endothelial angiogenic function.” Cold Spring Harbor Laboratory, May 10, 2022. https://doi.org/10.1101/2022.05.09.491127.
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Teaching & Mentoring
Recent Courses
Advising & Mentoring
- Department of Medicine Residency Coaching Program, 2016-
  Faculty Development Academy, Department of Medicine, 2016-
Scholarly, Clinical, & Service Activities
Service to the Profession
- Chair. AHA Peer Review. 2012 - 2016 2012 - 2016
- Member, Board of Directors. Federation of American Societies for Experimental Biology. 2011 - 2014 2011 - 2014
- Associate Editor. Cardiovascular Therapeutics. 2010 - 2015 2010 - 2015
- President. American Federation for Medical Research. 2010 - 2011 2010 - 2011

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Education, Training, & Certifications

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Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Awards & Honors

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Selected Publications

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Conference Papers

Preprints

Recent Courses

Advising & Mentoring

Service to the Profession