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Guido Ferrari

Professor in Surgery
Surgery, Surgical Sciences
Box 2926 Med Ctr, Durham, NC 27710
915 S. LaSalle Street, SORF Building Room 208, Durham, NC 27710
Office hours Monday-Friday 08:00-18:00
Saturday and Sunday upon request  

Overview


The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Current Appointments & Affiliations


Professor in Surgery · 2021 - Present Surgery, Surgical Sciences, Surgery
Research Professor in Molecular Genetics and Microbiology · 2021 - Present Molecular Genetics and Microbiology, Basic Science Departments
Member of the Duke Human Vaccine Institute · 2009 - Present Duke Human Vaccine Institute, Institutes and Centers
Affiliate, Duke Global Health Institute · 2009 - Present Duke Global Health Institute, University Institutes and Centers

In the News


Published October 11, 2022
Federal Grant to Duke University School of Medicine Expands HIV Research
Published November 19, 2019
Global List of Highly Cited Puts Duke in Top Ten
Published November 27, 2018
Duke Faculty Plentiful On ‘Highly Cited’ List

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Recent Publications


Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques.

Journal Article Commun Med (Lond) · May 15, 2025 BACKGROUND: Sequential multivalent immunizations are used to counter diversity in rapidly mutating viruses. Here, we evaluated the effect of HIV-1 immunogen formats on the binding profile of memory B-cells elicited in two independent Rhesus macaque trials. ... Full text Link to item Cite

A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.

Journal Article Structure · May 6, 2025 Anti-HIV envelope broadly neutralizing antibodies (bnAbs) are alternatives to conventional antiretrovirals with the potential to prevent and treat infection, reduce latent reservoirs, and/or mediate a functional cure. Clinical trials with "first-generation ... Full text Link to item Cite

Distinct immune responses in people living with HIV following SARS-CoV-2 recovery.

Journal Article Commun Med (Lond) · April 23, 2025 BACKGROUND: SARS-CoV-2 infection results in greater disease severity among immunocompromised individuals compared to healthy individuals. However, there is conflicting information about the impact of chronic HIV infection on immune responses to SARS-CoV-2 ... Full text Link to item Cite
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Recent Grants


Nonhuman Primate Core-Option 6

ResearchInvestigator · Awarded by National Institutes of Health · 2025 - 2032

External Quality Assurance Program Oversight Laboratory (EQAPOL)

ResearchInvestigator · Awarded by National Institutes of Health · 2024 - 2031

HVTN Lab Center: B Cell Supplement

ResearchCo Investigator · Awarded by Fred Hutchinson Cancer Center · 2023 - 2027

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Education, Training & Certifications


University of Genoa (Italy) · 1985 M.D.