Guido Ferrari | Scholars@Duke

Guido Ferrari
Professor in Surgery

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Office Hours

Monday-Friday 08:00-18:00
Saturday and Sunday upon request

Current Appointments & Affiliations

Professor in Surgery, Surgery, Surgical Sciences, Surgery 2021
Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2021
Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2009
Affiliate, Duke Global Health Institute, Duke Global Health Institute, University Institutes and Centers 2009

Contact Information

915 S. Lasalle Street, Sorf Building Room 208, Durham, NC 27710
Box 2926 Med Ctr, Durham, NC 27710
gflmp@duke.edu (919) 684-2862

Background
Education, Training, & Certifications
- M.D., University of Genoa (Italy) 1985
Previous Appointments & Affiliations
- Associate Professor of Surgery, Surgery, Surgical Sciences, Surgery 2013 - 2020
- Associate Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2014 - 2020
- Assistant Professor of Surgery, Surgery, Surgical Sciences, Surgery 2006 - 2013
- Assistant Research Professor in Surgery, Surgery, Surgical Sciences, Surgery 2001 - 2006
Academic Positions Outside Duke
- Honorary Professor, University of Cape Town. 2019 - 2024
- Adjunct Visiting Professor, University of Cape Town. 2012 - 2019
Recognition
In the News
- OCT 11, 2022 Duke Health News
  
  Federal Grant to Duke University School of Medicine Expands HIV Research
- NOV 19, 2019
  
  Global List of Highly Cited Puts Duke in Top Ten
- NOV 27, 2018
  
  Duke Faculty Plentiful On ‘Highly Cited’ List
Expertise
Subject Headings
Global Scholarship
- Research
  - South Africa (Country)
Research
Selected Grants
- SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens awarded by National Institutes of Health 2022 - 2027
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Early life B cell responses and inflammation following SARS-CoV-2 infection awarded by National Institutes of Health 2021 - 2026
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2025
- EQAPOL - Years 2017 to 2024 - BASE awarded by National Institutes of Health 2017 - 2024
- Modulation of Antigen Presenting Cell Function by HIV Vaccine induced Antibodies awarded by Triangle Community Foundation 2023 - 2024
- 17th INTERNATIONAL CONFERENCE ON HIV TREATMENT, PATHOGENESIS, AND PREVENTION RESEARCH (INTEREST) awarded by National Institutes of Health 2023 - 2024
- Synthetic DNA launched & adjuvanted Immune Focused Env immunogens for HIV awarded by Wistar Institute of Anatomy and Biology 2022 - 2023
- HVTN Supplement 2022 awarded by Fred Hutchinson Cancer Center 2022 - 2023
- HVTN LC awarded by Fred Hutchinson Cancer Center 2022 - 2023
- HVTN Laboratory Center: Phase 1 PF awarded by Fred Hutchinson Cancer Center 2022 - 2023
- CIVICS Component A - Option 3 awarded by National Institutes of Health 2019 - 2023
- Early life B cell responses and inflammation following SARS-CoV-2 infection awarded by Weill Cornell Medicine 2022 - 2023
- Targeting the HIV-1 reservoir with a combination of an IDLV-SIVGag therapeutic vaccine and Fc-engineered bnAbs (R01) awarded by National Institutes of Health 2020 - 2023
- New Analytic Approaches and Endpoints in Human HIV Vaccine Correlate Studies awarded by Dartmouth College 2022 - 2023
- Collaboratory of AIDS Researchers for Eradication (CARE) awarded by University of North Carolina - Chapel Hill 2021 - 2023
- Collaboratory of AIDS Researchers for Eradication (CARE) awarded by University of North Carolina - Chapel Hill 2021 - 2023
- 2022 International Conference on HIV Treatment, Pathogenesis, and Prevention Research (INTEREST) awarded by National Institutes of Health 2022 - 2023
- Infectious Diseases in Africa: Correlates of Protection, Lessons from Vaccines and Natural Infection Studies awarded by National Institutes of Health 2020 - 2023
- HVTN 705 Case Control Janssen awarded by Fred Hutchinson Cancer Center 2021 - 2022
- CoVPN 3001 A Phase 3, Randomized, Stratified, Observer-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1273 SARS-CoV-2 Vaccine awarded by Fred Hutchinson Cancer Center 2022
- CoVPN 3003 A Phase 3 Study to Assess the Efficacy and Safety of Ad26.COV2.S for the Prevention of SARS-CoV-2-mediated COVID-19 in Adults Aged 18 Years and Older awarded by Seattle Cancer Care Alliance 2022
- CoVPN 3005: Efficacy, Immunogenicity, and Safety of Two SARS-CoV-2 Recombinant Protein Vaccines with Adjuvant in Adults 18 Years of Age and Older awarded by Seattle Cancer Care Alliance 2022
- CoVPN 5001 A Prospective Study of Acute Immune Responses to SARS-CoV-2 Infection awarded by Fred Hutchinson Cancer Center 2022
- HVTN 405/HPTN 1901 (CoVPN) Characterizing SARS-CoV-2-specific Immunity in Convalescent Individuals awarded by Fred Hutchinson Cancer Center 2022
- In vitro characterization of antibody-dependent cellular mediated cytotoxic responses against SARS-CoV-2 awarded by St. Jude Children's Research Hospital 2021 - 2022
- Impact of Fc N-glycan structure on HIV-specific antibody functions awarded by University of Wyoming 2016 - 2022
- CARE Focus 2: Clearance of HIV Antigen-Positive Cells awarded by University of North Carolina - Chapel Hill 2016 - 2022
- HVTN Laboratory Center: Phase 1 PF awarded by Fred Hutchinson Cancer Research Center 2020 - 2022
- HVTN 405/HPTN 1901 (CoVPN) Characterizing SARS-CoV-2-specific Immunity in Convalescent Individuals awarded by Fred Hutchinson Cancer Research Center 2020 - 2022
- Combined Hepatitis B and HIV-1 Envelope Infant Vaccination to Augment T cell Help through Enhanced Linked Recognition awarded by National Institutes of Health 2017 - 2022
- Project 2: Synthetic DNA & Novel Env Vaccine for HIV awarded by Wistar Institute of Anatomy and Biology 2015 - 2022
- Seraworx - EQAPOL ELISPOT SRA awarded by Seraworx 2021
- HVTN 705 Pilot awarded by Fred Hutchinson Cancer Research Center 2020 - 2021
- MGD020 IND enabling studies awarded by MacroGenics, Inc. 2020 - 2021
- CARE Focus 1: Latency Biomarker Project awarded by University of North Carolina - Chapel Hill 2018 - 2021
- Primate Contract Expansion for Covid-19 awarded by National Institutes of Health 2020 - 2021
- 14th International Conference on HIV Treatment, Pathogenesis, and Prevention Research (INTEREST 2020) awarded by National Institutes of Health 2020 - 2021
- Protocol Development Assays awarded by Fred Hutchinson Cancer Research Center 2019 - 2020
- HVTN Laboratory Center: HVTN Phase 1 awarded by Fred Hutchinson Cancer Research Center 2015 - 2020
- HVTN Laboratory Center: HVTN 118 awarded by Fred Hutchinson Cancer Research Center 2006 - 2020
- 13th International Conference on HIV Treatment, Pathogenesis, and Prevention Research (Interest) awarded by National Institutes of Health 2019 - 2020
- Infectious Diseases in Africa: Immune Escape and HIV Vaccines awarded by National Institutes of Health 2009 - 2020
- Exploring Dual-Affinity Re-Targeting Proteins for Cure of Pediatric HIV-1 Infection awarded by National Institutes of Health 2016 - 2019
- Creation of a bnAbnectin awarded by ViiV Healthcare 2017 - 2019
- IGM Proposal awarded by IGM Biosciences, Inc. 2016 - 2019
- 2018 INTEREST Conference awarded by National Institutes of Health 2018 - 2019
- HIV Vaccine Trials Network: LC P5 PF awarded by Fred Hutchinson Cancer Research Center 2015 - 2018
- HVTN - A004 awarded by Fred Hutchinson Cancer Research Center 2015 - 2018
- Evaluation of the host immune response and viral molecular phenotype in lung transplant recipients with PTLD awarded by Mount Sinai School of Medicine 2017 - 2018
- CARE Duke-UNC Latency Biomarker Supplement Year 2 awarded by University of North Carolina - Chapel Hill 2016 - 2018
- 2017 INTEREST Conference awarded by National Institutes of Health 2017 - 2018
- Nonhuman Primate Core-Option 6 awarded by National Institutes of Health 2012 - 2018
- EQAPOL - Option 6 - 2016 to 2017 - ELISPOT awarded by National Institutes of Health 2010 - 2017
- EQAPOL Option 5 awarded by National Institutes of Health 2010 - 2017
- Focus 1: Detection of HIV Antigen-Positive Cells awarded by University of North Carolina - Chapel Hill 2016 - 2017
- Invitro Function of DART Molecules (Base) awarded by MacroGenics, Inc. 2016 - 2017
- Infant immune correlates of perinatal mother to child transmission of HIV awarded by National Institutes of Health 2015 - 2017
- Intervening with Latent HIV-1 Infection using Gnidimacrin awarded by National Institutes of Health 2014 - 2017
- 10th INTEREST Workshop on HIV awarded by National Institutes of Health 2016 - 2017
- HIV Vaccine Trials Network: LC P5 PF awarded by Fred Hutchinson Cancer Research Center 2014 - 2015
- LC: HIV Vaccine Trials Network: Phase 1 PF awarded by Fred Hutchinson Cancer Research Center 2014 - 2015
- HIV Envelope-specific functional antibody responses in HIV-exposed, HIV-vaccinated infants awarded by National Institutes of Health 2012 - 2015
- HIV-1 Gene Suppression by CD8+ T Cells awarded by National Institutes of Health 2002 - 2015
- AIDS International Training and Research Program awarded by National Institutes of Health 2003 - 2014
- Poly-functional analyses of vaccine-induced T cell responses awarded by National Institutes of Health 2001 - 2012
- Correlates of Vaccine Protection Workshop awarded by National Institutes of Health 2010 - 2011
- International Clinical Trials Unit awarded by National Institutes of Health 2004 - 2009
- Infectious Diseases in Africa: Measurement of Immune Responses awarded by National Institutes of Health 2007 - 2008
- Central Laboratory for the HIV Vaccines Trial Network awarded by National Institutes of Health 2000 - 2006
- NCRR FACSAria Cell Sorter awarded by National Center for Research Resources 2004 - 2006
- Anti-Hiv Ctl And Hiv Suppressive Cd8 Cells awarded by National Institutes of Health 1990 - 2000
- Anti-Hiv Ctl And Hiv-Suppresive Cd8+ Cells awarded by National Institutes of Health 1996 - 1999
- Anti-Hiv Ctl And Hiv Suppresive Cd8+ Cells awarded by National Institutes of Health 1995 - 1999
- Antihiv Ctl And Hiv Suppressive Cd8 Cells awarded by National Institutes of Health 1990 - 1999
External Relationships
- University of Cape Town
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Stieh, Daniel J., Dan H. Barouch, Christy Comeaux, Michal Sarnecki, Kathryn E. Stephenson, Stephen R. Walsh, Sheetal Sawant, et al. “Safety and Immunogenicity of Ad26-Vectored HIV Vaccine With Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-Uninfected Adults: A Phase 1/2a Study.” J Infect Dis 227, no. 8 (April 18, 2023): 939–50. https://doi.org/10.1093/infdis/jiac445.
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  - Wilson, Gregory J., Benigno Rodriguez, Shuying Sue Li, Mary Allen, Ian Frank, Erika Rudnicki, Meg Trahey, et al. “Cellular and humoral responses to an HIV DNA prime by electroporation boosted with recombinant vesicular stomatitis virus expressing HIV subtype C Env in a randomized controlled clinical trial.” Vaccine 41, no. 16 (April 17, 2023): 2696–2706. https://doi.org/10.1016/j.vaccine.2023.03.015.
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  - Berrong, Mark, Guido Ferrari, Cassie Porth, Devin Davis, Thomas Denny, Sylvia Janetzki, and Wes Rountree. “Validation of the performance and suitability of a new class of FBS optimized for use in single-cell functional assays.” J Immunol Methods 515 (April 2023): 113452. https://doi.org/10.1016/j.jim.2023.113452.
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  - Milligan, Emma C., Katherine Olstad, Caitlin A. Williams, Michael Mallory, Patricio Cano, Kaitlyn A. Cross, Jennifer E. Munt, et al. “Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later.” Sci Transl Med 15, no. 685 (March 2023): eadd6383. https://doi.org/10.1126/scitranslmed.add6383.
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  - Kuriakose Gift, Syna, Lindsay Wieczorek, Eric Sanders-Buell, Michelle Zemil, Sebastian Molnar, Gina Donofrio, Samantha Townsley, et al. “Evolution of Antibody Responses in HIV-1 CRF01_AE Acute Infection: Founder Envelope V1V2 Impacts the Timing and Magnitude of Autologous Neutralizing Antibodies.” J Virol 97, no. 2 (February 28, 2023): e0163522. https://doi.org/10.1128/jvi.01635-22.
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  - Cohen, Kristen W., Andrew Fiore-Gartland, Stephen R. Walsh, Karina Yusim, Nicole Frahm, Marnie L. Elizaga, Janine Maenza, et al. “Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults.” J Clin Invest 133, no. 4 (February 15, 2023). https://doi.org/10.1172/JCI163338.
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  - Bissa, Massimiliano, Sohyoung Kim, Veronica Galli, Slim Fourati, Sarkis Sarkis, Anush Arakelyan, Isabela Silva de Castro, et al. “HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC.” Nat Commun 14, no. 1 (February 2, 2023): 575. https://doi.org/10.1038/s41467-023-36109-8.
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  - Crowley, Andrew R., Simone I. Richardson, Marina Tuyishime, Madeleine Jennewein, Meredith J. Bailey, Jiwon Lee, Galit Alter, Guido Ferrari, Lynn Morris, and Margaret E. Ackerman. “Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses.” Immunogenetics 75, no. 1 (February 2023): 1–16. https://doi.org/10.1007/s00251-022-01272-7.
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  - Scarneo, Scott A., Aaron P. Smith, Jacob Favret, Robert O’Connell, Joy Pickeral, Kelly W. Yang, Guido Ferrari, et al. “Expression of membrane Hsp90 is a molecular signature of T cell activation.” Sci Rep 12, no. 1 (October 27, 2022): 18091. https://doi.org/10.1038/s41598-022-22788-8.
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  - Li, Dapeng, David R. Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L. Sutherland, Esther Lee, et al. “Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.” Nat Commun 13, no. 1 (October 23, 2022): 6309. https://doi.org/10.1038/s41467-022-33985-4.
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  - Pollara, Justin, Santosh Khanal, R Whitney Edwards, Bhavna Hora, Guido Ferrari, Barton F. Haynes, and Todd Bradley. “Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy.” Bmc Immunol 23, no. 1 (September 29, 2022): 48. https://doi.org/10.1186/s12865-022-00523-2.
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  - Nordstrom, Jeffrey L., Guido Ferrari, and David M. Margolis. “Bispecific antibody-derived molecules to target persistent HIV infection.” J Virus Erad 8, no. 3 (September 2022): 100083. https://doi.org/10.1016/j.jve.2022.100083.
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  - Garrett, Nigel, Asa Tapley, Jessica Andriesen, Ishen Seocharan, Leigh H. Fisher, Lisa Bunts, Nicole Espy, et al. “High Asymptomatic Carriage With the Omicron Variant in South Africa.” Clin Infect Dis 75, no. 1 (August 24, 2022): e289–92. https://doi.org/10.1093/cid/ciac237.
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  - Xu, Shiwei, Margaret C. Carpenter, Rachel L. Spreng, Scott D. Neidich, Sharanya Sarkar, DeAnna Tenney, Derrick Goodman, et al. “Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans.” Npj Vaccines 7, no. 1 (August 4, 2022): 90. https://doi.org/10.1038/s41541-022-00514-9.
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  - Mielke, Dieter, Sherry Stanfield-Oakley, Shalini Jha, Taylor Keyes, Adam Zalaquett, Brooke Dunn, Nicole Rodgers, et al. “Development of flow cytometry-based assays to assess the ability of antibodies to bind to SARS-CoV-2-infected and spike-transfected cells and mediate NK cell degranulation.” Cytometry A 101, no. 6 (June 2022): 483–96. https://doi.org/10.1002/cyto.a.24552.
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  - Gray, Matthew D., Junli Feng, Connor E. Weidle, Kristen W. Cohen, Lamar Ballweber-Fleming, Anna J. MacCamy, Crystal N. Huynh, et al. “Characterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain.” Sci Adv 8, no. 18 (May 6, 2022): eabm3948. https://doi.org/10.1126/sciadv.abm3948.
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  - DeGrace, Marciela M., Elodie Ghedin, Matthew B. Frieman, Florian Krammer, Alba Grifoni, Arghavan Alisoltani, Galit Alter, et al. “Defining the risk of SARS-CoV-2 variants on immune protection.” Nature 605, no. 7911 (May 2022): 640–52. https://doi.org/10.1038/s41586-022-04690-5.
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  - Li, Dapeng, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, et al. “Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.” Commun Biol 5, no. 1 (March 28, 2022): 271. https://doi.org/10.1038/s42003-022-03183-5.
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  - Gay, Cynthia L., Katherine S. James, Marina Tuyishime, Shane D. Falcinelli, Sarah B. Joseph, Matthew J. Moeser, Brigitte Allard, et al. “Stable Latent HIV Infection and Low-level Viremia Despite Treatment With the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat.” J Infect Dis 225, no. 5 (March 2, 2022): 856–61. https://doi.org/10.1093/infdis/jiab487.
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  - Curtis, Alan D., Pooja T. Saha, Maria Dennis, Stella J. Berendam, Pratamesh Ramasubramanian, Kaitlyn A. Cross, S Munir Alam, et al. “Vaccine-Induced, High-Magnitude HIV Env-Specific Antibodies with Fc-Mediated Effector Functions Are Insufficient to Protect Infant Rhesus Macaques against Oral SHIV Infection.” Msphere 7, no. 1 (February 23, 2022): e0083921. https://doi.org/10.1128/msphere.00839-21.
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  - Wang, Shixia, Nicole L. Yates, Justin Pollara, Yegor Voronin, Sherry Stanfield-Oakley, Dong Han, Guangnan Hu, et al. “Broadly binding and functional antibodies and persisting memory B cells elicited by HIV vaccine PDPHV.” Npj Vaccines 7, no. 1 (February 9, 2022): 18. https://doi.org/10.1038/s41541-022-00441-9.
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  - Mielke, Dieter, Sherry Stanfield-Oakley, Bhavesh Borate, Leigh H. Fisher, Katelyn Faircloth, Marina Tuyishime, Kelli Greene, et al. “Selection of HIV Envelope Strains for Standardized Assessments of Vaccine-Elicited Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies.” J Virol 96, no. 2 (January 26, 2022): e0164321. https://doi.org/10.1128/JVI.01643-21.
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  - Mitchell, Julie L., Justin Pollara, Kenneth Dietze, R Whitney Edwards, Junsuke Nohara, Kombo F. N’guessan, Michelle Zemil, et al. “Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection.” J Clin Invest 132, no. 1 (January 4, 2022). https://doi.org/10.1172/JCI150937.
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  - Barrows, Brittani M., Shelly J. Krebs, Ningbo Jian, Michelle Zemil, Bonnie M. Slike, Vincent Dussupt, Ursula Tran, et al. “Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission.” Front Immunol 13 (2022): 1051501. https://doi.org/10.3389/fimmu.2022.1051501.
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  - Lakhashe, Samir K., Mario Amacker, Dinesh Hariraju, Hemant K. Vyas, Kyle S. Morrison, Joshua A. Weiner, Margaret E. Ackerman, et al. “Cooperation Between Systemic and Mucosal Antibodies Induced by Virosomal Vaccines Targeting HIV-1 Env: Protection of Indian Rhesus Macaques Against Low-Dose Intravaginal SHIV Challenges.” Front Immunol 13 (2022): 788619. https://doi.org/10.3389/fimmu.2022.788619.
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  - Perdiguero, Beatriz, Benedikt Asbach, Carmen E. Gómez, Josef Köstler, Susan W. Barnett, Marguerite Koutsoukos, Deborah E. Weiss, et al. “Early and Long-Term HIV-1 Immunogenicity Induced in Macaques by the Combined Administration of DNA, NYVAC and Env Protein-Based Vaccine Candidates: The AUP512 Study.” Front Immunol 13 (2022): 939627. https://doi.org/10.3389/fimmu.2022.939627.
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  - Saunders, Kevin O., Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, et al. “Author Correction: Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.” Npj Vaccines 6, no. 1 (November 6, 2021): 136. https://doi.org/10.1038/s41541-021-00397-2.
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  - Mielke, Dieter, Gama Bandawe, Jie Zheng, Jennifer Jones, Melissa-Rose Abrahams, Valerie Bekker, Christina Ochsenbauer, et al. “ADCC-mediating non-neutralizing antibodies can exert immune pressure in early HIV-1 infection.” Plos Pathog 17, no. 11 (November 2021): e1010046. https://doi.org/10.1371/journal.ppat.1010046.
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  - Cheng, Hao D., Karen G. Dowell, Chris Bailey-Kellogg, Brittany A. Goods, J Christopher Love, Guido Ferrari, Galit Alter, et al. “Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features.” Retrovirology 18, no. 1 (October 30, 2021): 35. https://doi.org/10.1186/s12977-021-00579-9.
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  - Sherburn, Rebekah, William D. Tolbert, Suneetha Gottumukkala, Andrew P. Hederman, Guillaume Beaudoin-Bussières, Sherry Stanfield-Oakley, Marina Tuyishime, et al. “Incorporating the Cluster A and V1V2 Targets into a Minimal Structural Unit of the HIV-1 Envelope to Elicit a Cross-Clade Response with Potent Fc-Effector Functions.” Vaccines (Basel) 9, no. 9 (August 31, 2021). https://doi.org/10.3390/vaccines9090975.
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  - Pino, Maria, Talha Abid, Susan Pereira Ribeiro, Venkata Viswanadh Edara, Katharine Floyd, Justin C. Smith, Muhammad Bilal Latif, et al. “A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.” Sci Immunol 6, no. 61 (July 15, 2021). https://doi.org/10.1126/sciimmunol.abh3634.
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  - Chua, Joel V., Charles Davis, Jennifer S. Husson, Amy Nelson, Ilia Prado, Robin Flinko, Ka Wing J. Lam, et al. “Safety and immunogenicity of an HIV-1 gp120-CD4 chimeric subunit vaccine in a phase 1a randomized controlled trial.” Vaccine 39, no. 29 (June 29, 2021): 3879–91. https://doi.org/10.1016/j.vaccine.2021.05.090.
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  - Saunders, Kevin O., Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, et al. “Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.” Npj Vaccines 6, no. 1 (April 9, 2021): 50. https://doi.org/10.1038/s41541-021-00307-6.
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  - Tolbert, William D., Verna Van, Rebekah Sherburn, Marina Tuyishime, Fang Yan, Dung N. Nguyen, Sherry Stanfield-Oakley, et al. “Erratum for Tolbert et al., "Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial".” Mbio 12, no. 2 (April 6, 2021). https://doi.org/10.1128/mBio.00474-21.
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  - Andersen-Nissen, Erica, Andrew Fiore-Gartland, Lamar Ballweber Fleming, Lindsay N. Carpp, Anneta F. Naidoo, Michael S. Harper, Valentin Voillet, et al. “Innate immune signatures to a partially-efficacious HIV vaccine predict correlates of HIV-1 infection risk.” Plos Pathog 17, no. 3 (March 2021): e1009363. https://doi.org/10.1371/journal.ppat.1009363.
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  - Silva de Castro, Isabela, Giacomo Gorini, Rosemarie Mason, Jason Gorman, Massimiliano Bissa, Mohammad A. Rahman, Anush Arakelyan, et al. “Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.” Iscience 24, no. 2 (February 19, 2021): 102047. https://doi.org/10.1016/j.isci.2021.102047.
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  - Chattopadhyay, Pratip K., Andrew Filby, Evan R. Jellison, Guido Ferrari, Cherie Green, Sindhu Cherian, Jonathan Irish, Virginia Litwin, and Virginia other members of the ISAC COVID-19 Work Group. “A Cytometrist's Guide to Coordinating and Performing Effective COVID-19 Research.” Cytometry A 99, no. 1 (January 2021): 11–18. https://doi.org/10.1002/cyto.a.24210.
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  - Pollara, Justin, Matthew Zirui Tay, R Whitney Edwards, Derrick Goodman, Andrew R. Crowley, Robert J. Edwards, David Easterhoff, et al. “Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques.” Frontiers in Immunology 12 (January 2021): 678511. https://doi.org/10.3389/fimmu.2021.678511.
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  - Tolbert, William D., Dung N. Nguyen, Marina Tuyishime, Andrew R. Crowley, Yaozong Chen, Shalini Jha, Derrick Goodman, et al. “Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s.” Front Immunol 12 (2021): 787603. https://doi.org/10.3389/fimmu.2021.787603.
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  - Tuyishime, Marina, Amir Dashti, Katelyn Faircloth, Shalini Jha, Jeffrey L. Nordstrom, Barton F. Haynes, Guido Silvestri, Ann Chahroudi, David M. Margolis, and Guido Ferrari. “Elimination of SHIV Infected Cells by Combinations of Bispecific HIVxCD3 DART® Molecules.” Front Immunol 12 (2021): 710273. https://doi.org/10.3389/fimmu.2021.710273.
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  - White, Scott, John Quinn, Jennifer Enzor, Janet Staats, Sarah M. Mosier, James Almarode, Thomas N. Denny, Kent J. Weinhold, Guido Ferrari, and Cliburn Chan. “FlowKit: A Python Toolkit for Integrated Manual and Automated Cytometry Analysis Workflows.” Front Immunol 12 (2021): 768541. https://doi.org/10.3389/fimmu.2021.768541.
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  - Devasundaram, Santhi, Margherita Rosati, Antonio Valentin, Svenja Weiss, Vincenza Itri, Hung V. Trinh, Jenifer Bear, et al. “Priming with DNA Expressing Trimeric HIV V1V2 Alters the Immune Hierarchy Favoring the Development of V2-Specific Antibodies in Rhesus Macaques.” J Virol 95, no. 2 (December 22, 2020). https://doi.org/10.1128/JVI.01193-20.
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  - Gay, Cynthia L., Dayna T. Neo, Aaron S. Devanathan, Joann D. Kuruc, Kara S. McGee, John L. Schmitz, Joe Sebastian, et al. “Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection.” Aids 34, no. 13 (November 1, 2020): 1923–31. https://doi.org/10.1097/QAD.0000000000002652.
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  - Baden, Lindsey R., Daniel J. Stieh, Michal Sarnecki, Stephen R. Walsh, Georgia D. Tomaras, James G. Kublin, M Juliana McElrath, et al. “Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study.” Lancet Hiv 7, no. 10 (October 2020): e688–98. https://doi.org/10.1016/S2352-3018(20)30229-0.
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  - Tuyishime, Marina, Carolina Garrido, Shalini Jha, Matt Moeser, Dieter Mielke, Celia LaBranche, David Montefiori, et al. “Improved killing of HIV-infected cells using three neutralizing and non-neutralizing antibodies.” J Clin Invest 130, no. 10 (October 1, 2020): 5157–70. https://doi.org/10.1172/JCI135557.
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  - Stranford, S. A., J. Skurnick, D. Louria, D. Osmond, S. Y. Chang, J. Sninsky, G. Ferrari, K. Weinhold, C. Lindquist, and J. A. Levy. “Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response.” Proc Natl Acad Sci U S A 96, no. 3 (February 2, 1999): 1030–35. https://doi.org/10.1073/pnas.96.3.1030.
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  - Ferrari, G., C. Berend, J. Ottinger, R. Dodge, J. Bartlett, J. Toso, D. Moody, et al. “Replication-defective canarypox (ALVAC) vectors effectively activate anti-human immunodeficiency virus-1 cytotoxic T lymphocytes present in infected patients: implications for antigen-specific immunotherapy.” Blood 90, no. 6 (September 15, 1997): 2406–16.
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  - Ferrari, G., W. Humphrey, M. J. McElrath, J. L. Excler, A. M. Duliege, M. L. Clements, L. C. Corey, D. P. Bolognesi, and K. J. Weinhold. “Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers.” Proc Natl Acad Sci U S A 94, no. 4 (February 18, 1997): 1396–1401. https://doi.org/10.1073/pnas.94.4.1396.
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  - Toso, J. F., C. H. Chen, J. R. Mohr, L. Piglia, C. Oei, G. Ferrari, M. L. Greenberg, and K. J. Weinhold. “Oligoclonal CD8 lymphocytes from persons with asymptomatic human immunodeficiency virus (HIV) type 1 infection inhibit HIV-1 replication.” J Infect Dis 172, no. 4 (October 1995): 964–73. https://doi.org/10.1093/infdis/172.4.964.
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  - Ferrari, G., K. King, K. Rathbun, C. A. Place, M. V. Packard, J. A. Bartlett, D. P. Bolognesi, and K. J. Weinhold. “IL-7 enhancement of antigen-driven activation/expansion of HIV-1-specific cytotoxic T lymphocyte precursors (CTLp).” Clin Exp Immunol 101, no. 2 (August 1995): 239–48. https://doi.org/10.1111/j.1365-2249.1995.tb08345.x.
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  - Ferrari, G., C. A. Place, P. M. Ahearne, S. M. Nigida, L. O. Arthur, D. P. Bolognesi, and K. J. Weinhold. “Comparison of anti-HIV-1 ADCC reactivities in infected humans and chimpanzees.” J Acquir Immune Defic Syndr (1988) 7, no. 4 (April 1994): 325–31.
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  - Ferrari, G., J. Ottinger, C. Place, S. M. Nigida, L. O. Arthur, and K. J. Weinhold. “The impact of HIV-1 infection on phenotypic and functional parameters of cellular immunity in chimpanzees.” Aids Res Hum Retroviruses 9, no. 7 (July 1993): 647–56. https://doi.org/10.1089/aid.1993.9.647.
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  - Boeri, E., A. Giri, F. Lillo, G. Ferrari, O. E. Varnier, A. Ferro, S. Sabbatani, W. C. Saxinger, and G. Franchini. “In vivo genetic variability of the human immunodeficiency virus type 2 V3 region.” J Virol 66, no. 7 (July 1992): 4546–50. https://doi.org/10.1128/JVI.66.7.4546-4550.1992.
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  - CANESSA, A., F. PANTAROTTO, F. MILETICH, A. RUSSO, C. GOTTA, P. M. BOZZUFFI, G. FERRARI, A. FIORELLI, and A. TERRAGNA. “ANTIBODY PREVALENCE TO TORCH AGENTS IN PREGNANT-WOMEN AND RELATIVE RISK OF CONGENITAL INFECTIONS IN ITALY (LIGURIA).” Biological Research in Pregnancy and Perinatology 8, no. 2 (January 1, 1987): 84–88.
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  - Canessa, A., F. Pantarotto, F. Miletich, A. Russo, C. Gotta, P. M. Bozzuffi, G. Ferrari, A. Fiorelli, and A. Terragna. “Antibody prevalence to torch agents in pregnant women and relative risk of congenital infections in Italy (Liguria).” Biol Res Pregnancy Perinatol 8, no. 2 2D Half (1987): 84–88.
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- Book Sections
  - D’Souza, P., J. H. Cox, G. Ferrari, N. T. Kunwar, V. Polonis, and M. Sarzotti-Kelsoe. “Endpoint Assays in HIV-1 Vaccine Trials: Functioning in a Good Laboratory Practices Environment.” In Validation of Cell-Based Assays in the GLP Setting: A Practical Guide, 239–75, 2008. https://doi.org/10.1002/9780470987810.ch14.
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  - Cox, Josephine H., Mark deSouza, Silvia Ratto-Kim, Guido Ferrari, Kent J. Weinhold, and Deborah L. Birx. “Cellular Immune Assays for Evaluation of Vaccine Efficacy.” In MANUAL OF MOLECULAR AND CLINICAL LABORATORY IMMUNOLOGY, 7TH EDITION, 301–14, 2006.
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- Other Articles
  - Kvistborg, Pia, Cécile Gouttefangeas, Nima Aghaeepour, Angelica Cazaly, Pratip K. Chattopadhyay, Cliburn Chan, Judith Eckl, et al. “Thinking outside the gate: single-cell assessments in multiple dimensions.” Immunity, April 21, 2015. https://doi.org/10.1016/j.immuni.2015.04.006.
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  - Frahm, M. A., G. D. Tomaras, and G. Ferrari. “Response to comment on "CD4 ⁺CD8 ⁺ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection".” Journal of Immunology, June 15, 2012. https://doi.org/10.4049/jimmunol.1290029.
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  - “Approaches to the development of broadly protective HIV vaccines: challenges posed by the genetic, biological and antigenic variability of HIV-1: Report from a meeting of the WHO-UNAIDS Vaccine Advisory Committee Geneva, 21-23 February 2000.” Aids, April 13, 2001.
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  - Rodenburg, C. M., Y. Li, S. A. Trask, Y. Chen, J. Decker, D. L. Robertson, M. L. Kalish, et al. “Near full-length clones and reference sequences for subtype C isolates of HIV type 1 from three different continents.” Aids Res Hum Retroviruses, January 20, 2001. https://doi.org/10.1089/08892220150217247.
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- Conference Papers
  - Kenny, A., A. Luedtke, O. Hyrien, Y. Fong, R. Burnham, J. Heptinstall, S. Sawant, et al. “Immune correlates analysis of the Imbokodo HIV-1 vaccine efficacy trial.” In Journal of the International Aids Society, 25:214–214, 2022.
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  - Nordstrom, J. L., C. L. Gay, C. Bohac, A. R. Wahl, T. Morgan, J. L. Schmitz, H. Li, et al. “In vivo preclinical efficacy of MGD014 and MGD020 (HIV-1 envelope x CD3 DART molecules) and first-in-human phase 1 clinical safety evaluation of MGD014.” In Journal of the International Aids Society, 25:6–7, 2022.
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  - Singh, V., D. Burgess, A. Dashti, J. McBrien, H. King, R. Mason, J. Safrit, et al. “CD8 depletion and N-803 plus anti-SIV Env RhmAbs in ART-suppressed rhesus macaques.” In Journal of the International Aids Society, 25:237–237, 2022.
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  - Spreng, Rachel, Marina Tuyishime, Brady Hueber, Junsuke Nohara, Derrick Goodman, Cliburn Chan, R Whitney Edwards, et al. “Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among Rhesus macaques.” In Journal of Medical Primatology, 51:312–312, 2022.
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  - Margolis, D. M., K. S. James, M. Tuyishime, S. D. Falcinelli, S. B. Joseph, B. Allard, J. L. Kirchherr, et al. “Combination therapy with the broadly neutralizing antibody VRC07-523LS and the latency reversal agent Vorinostat fails to substantially reduce latent, resting CD4+T cell infection or reduce low-level viremia.” In Journal of the International Aids Society, 24:69–69, 2021.
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  - Tuyishime, M., C. Garrido, S. Jha, M. Moeser, D. Mielke, C. LaBranche, D. Montefiori, et al. “Improved killing of HIV-infected cells by a combination of three neutralizing and non-neutralizing antibodies.” In Journal of the International Aids Society, Vol. 24, 2021.
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  - Msafiri, Frank, Agricola Joachim, Kathrin Held, Yuka Nadai, Raquel Matavele Chissumba, Christof Geldmacher, Said Aboud, et al. “Frequent Anti-V1V2 Responses Induced by HIV-DNA Followed by HIV-MVA with or without CN54rgp140/GLA-AF in Healthy African Volunteers.” In Microorganisms, Vol. 8, 2020. https://doi.org/10.3390/microorganisms8111722.
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  - Dashti, Amir, Chevaughn Waller, Maud Mavigner, Nils Schoof, Katharine J. Bar, George M. Shaw, Thomas H. Vanderford, et al. “SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques.” In J Virol, Vol. 94, 2020. https://doi.org/10.1128/JVI.00793-20.
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  - Curtis, Alan Dale, Maria Dennis, Joshua Eudailey, Kenneth Cronin, Justin Pollara, Guido Ferrari, Michael Hudgens, Koen Van Rompay, Sallie Permar, and Kristina De Paris. “Neonatal vaccination primes persistent HIV Env-specific antibodies that are augmented by a single booster immunization in late infancy.” In Journal of Immunology, Vol. 204, 2020.
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  - Felber, B. K., Z. Lu, X. Hu, A. Valentin, M. Rosati, J. A. Weiner, X. Shen, et al. “Co-immunization of DNA and protein in the same anatomical sites induces superior protective immune responses against SHIV challenge.” In Journal of the International Aids Society, 23:7–7, 2020.
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  - Jones, Rebecca, Eric Scott, LaShanda Cheston, Morgan Gladden, Shalini Jha, Charles Beck, Justin Pollara, et al. “Vaccine-elicited memory B cells expressing ADCC-mediating antibodies lacking recognition of the V2 region did not correlate with protection of NHPs.” In Journal of Medical Primatology, 49:247–48, 2020.
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  - Zaffiri, L., J. E. Messinger, J. Yi, K. J. Weinhold, G. Ferrari, M. Luftig, and S. M. Palmer. “Evaluation of Host Immune Responses to Epstein-Barr Virus in Lung Transplant Recipients.” In American Journal of Transplantation, 20:396–396, 2020.
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  - Asbach, Benedikt, Karen V. Kibler, Josef Köstler, Beatriz Perdiguero, Nicole L. Yates, Sherry Stanfield-Oakley, Georgia D. Tomaras, et al. “Priming with a Potent HIV-1 DNA Vaccine Frames the Quality of Immune Responses prior to a Poxvirus and Protein Boost.” In J Virol, Vol. 93, 2019. https://doi.org/10.1128/JVI.01529-18.
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  - Felber, Barbara, Shakti Singh, Antonio Valentin, Margherita Rosati, Eric Ramierz, Rami Doueiri, Xintao Hu, et al. “DNA and protein co-delivery vaccines using TLR-4-based adjuvants induce potent immune responses able to delay heterologous SIV acquisition.” In Journal of Medical Primatology, 47:313–313. WILEY, 2018.
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  - Mielke, Dieter, Rutendo Ziki, Colin Anthony, Christina Ochsenbauer, Nigel Garrett, Salim S Abdool Karim, David Montefiori, et al. “Neutralizing and ADCC Activity of Anti-HIV-1 Antibodies Against Acute Subtype C Envs: Implications for Prevention and Treatment of HIV-1 Infection.” In Aids Research and Human Retroviruses, 34:53–53. MARY ANN LIEBERT, INC, 2018.
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  - Phillips, Bonnie, Genevieve Fouda, Justin Pollara, Pamela Kozlowski, Anthony Moody, Guido Ferrari, Sallie Permar, and Kristina De Parisi. “The optimization of pediatric vaccine regimens to prevent mother-to-child transmission of HIV through breast milk.” In Journal of Medical Primatology, 47:344–45. WILEY, 2018.
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  - Pollara, Justin, Dorothy I. Jones, Tori Huffman, Maria Dennis, Grace Li, Derrick Goodman, R Whitney Edwards, et al. “Bridging Vaccine-induced Antibody Responses in Rabbit and Rhesus Macaque Animal Models.” In Aids Research and Human Retroviruses, 34:129–129. MARY ANN LIEBERT, INC, 2018.
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  - Shen, Xiaoying, Zoe Moodie, Arthur McMillan, Derrick Goodman, Nicole Yates, Rachel Spreng, Nicole Grunenberg, et al. “V1V2 IgG and Antibody Fc Effector Functions in a Subtype C ALVAC-HIV and Bivalent Subtype C gp120/MF59 HIV-1 Vaccine Trial in South Africa.” In Aids Research and Human Retroviruses, 34:17–17. MARY ANN LIEBERT, INC, 2018.
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  - Tuyishime, Marina, Carolina Garrido, Shalini Jha, Anthony DeVico, Barton Haynes, David Margolis, and Guido Ferrari. “Recognition and Elimination of HIV-1-infected Cells by ADCC-mediating mAbs for Prevention and Treatment of HIV-1 Infection.” In Aids Research and Human Retroviruses, 34:126–126. MARY ANN LIEBERT, INC, 2018.
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  - Wang, Shixia, Justin Pollara, Sherry Stanfield-Oakley, Diego Farfan-Arribas, Shuying Liu, Guido Ferrari, and Shan Lu. “Cross-clade ADCC Activities in Human Volunteer Sera Elicited by a Polyvalent DNA Prime-protein Boost HIV Vaccine DP6-001.” In Aids Research and Human Retroviruses, 34:129–129. MARY ANN LIEBERT, INC, 2018.
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  - Williams, LaTonya, Matthew Zirui Tay, Xiaoying Shen, Sheetal Sawant, Lindsay Dahora, Nicole Yates, David Easterhoff, et al. “Delayed and Repetitive Boosting of RV144 Vaccinees Improves Antiviral Immunity Associated With Correlates of HIV-1 Infection Risk.” In Aids Research and Human Retroviruses, 34:88–88. MARY ANN LIEBERT, INC, 2018.
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  - Ferrari, Guido, Jeffrey Nordstrom, Scott Koenig, Julia Sung, David Margolis, and Barton Haynes. “A-102 Antibody binding to HIV-1 infected cells as mechanism for treatment of HIV infection.” In Jaids Journal of Acquired Immune Deficiency Syndromes, 77:33–33. Ovid Technologies (Wolters Kluwer Health), 2018. https://doi.org/10.1097/01.qai.0000532483.69631.d6.
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  - Buchbinder, Susan, Nicole Grunenberg, Brittany Sanchez, Kelly Seaton, Guido Ferrari, M Anthony Moody, Nicole Frahm, et al. “DNA/MVA HIV Vaccine Producing Virus-like Particles (VLPs) Is Well-tolerated and Induces Durable Functional Antibodies (Abs) in HVTN 094.” In Aids Research and Human Retroviruses, 32:99–99. MARY ANN LIEBERT, INC, 2016.
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  - Huang, Ying, Georgia Tomaras, Erica Andersen-Nissen, One Dintwe, Lynn Morris, Nicole Grunenberg, Abby Issacs, et al. “The Relationship between Immune Responses to Tetanus Vaccine, Hepatitis B Vaccine and a Pox-protein HIV Vaccine Regimen.” In Aids Research and Human Retroviruses, 32:76–76. MARY ANN LIEBERT, INC, 2016.
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  - Shen, Xiaoying, Rahul Basu, Suefen Kwa, Celia Labranche, David Beaumont, Guido Ferrari, Linda Wyatt, et al. “MVA-expressed gp140 Boosts More Durable V1/V2 and gp120 Antibody Responses than gp120 Protein in Alum.” In Aids Research and Human Retroviruses, 32:59–59. MARY ANN LIEBERT, INC, 2016.
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  - Clutton, Genevieve Tyndale, Yinyan Xu, Maria Abad Fernandez, Amanda Crooks, Blair Turner, Nicole Maponga, Anna Cope, et al. “Effects of different treatment regimens on T cell function in acute HIV infection.” In Journal of Immunology, Vol. 196. AMER ASSOC IMMUNOLOGISTS, 2016.
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  - Prentice, Heather, Georgia Tomaras, Daniel Geraghty, Richard Apps, Youyi Fong, Philip Ehrenberg, Morgane Rolland, et al. “HIV-1-specific IgG antibody levels correlate with the presence of a specific HLA class II allele to impact acquisition and vaccine efficacy.” In Journal of the International Aids Society, Vol. 18. JOHN WILEY & SONS LTD, 2015. https://doi.org/10.7448/IAS.18.5.20541.
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  - Swiderska-Syn, M., S. Choi, A. Lan, G. Ferrari, A. M. Diehl, and S. Naggie. “P0469 : Markers of tissue repair and cellular aging are increased in liver tissue of patients with dual chronic HIV/HCV infections.” In Journal of Hepatology, 62:S489–S489. Elsevier BV, 2015. https://doi.org/10.1016/s0168-8278(15)30677-2.
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  - Fourati, S., M. Vaccari, S. N. Gordon, L. Schifanella, M. Cameron, B. F. Keele, X. Shen, et al. “Modulation of RAS Pathways as a Biomarker of Protection against HIV and as a Means to Improve Vaccine Efficacy.” In Aids Res Hum Retroviruses, 30 Suppl 1:A99, 2014. https://doi.org/10.1089/aid.2014.5182b.abstract.
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  - Vaccari, M., S. N. Gordon, S. Fourati, L. Schifanella, M. Cameron, B. F. Keele, X. Shen, et al. “Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine Induced Protection from SIVmac251 Acquisition.” In Aids Res Hum Retroviruses, 30 Suppl 1:A64–65, 2014. https://doi.org/10.1089/aid.2014.5117.abstract.
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  - Fouda, G., J. Pollara, E. McGuire, W. Rountree, G. Overman, G. Tegha, D. Kamwendo, et al. “Association of HIV-1 Env Antibody Responses with Postnatal Mother-to-Child Transmission of HIV-1 via Breastfeeding.” In Aids Res Hum Retroviruses, 30 Suppl 1:A99–100, 2014. https://doi.org/10.1089/aid.2014.5182c.abstract.
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  - Moody, M. A., D. Easterhoff, T. C. Gurley, J. F. Whitesides, D. J. Marshall, A. Foulger, K. E. Lloyd, et al. “Induction of Antibodies with Long Variable Heavy Third Complementarity Determining Regions by Repetitive Boosting with AIDSVAX® B/E in RV144 Vaccinees.” In Aids Res Hum Retroviruses, 30 Suppl 1:A36, 2014. https://doi.org/10.1089/aid.2014.5057a.abstract.
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  - Ackerman, M. E., Y. Huang, G. Alter, G. Ferrari, D. Forthal, J. Kappes, G. Lewis, et al. “Comparative Evaluation of Assays for Fc Receptor-Mediated Antibody Effector Functions Targeting HIV-1.” In Aids Research and Human Retroviruses, 29:A169–A169. MARY ANN LIEBERT, INC, 2013.
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  - Chege, G. K., D. C. Montefiori, S. Barnett, C. M. Gray, W. A. Burgers, T. L. Muller, E. G. Shephard, C. Williamson, G. Ferrari, and A. Williamson. “A Combined Saavi MVA-C and Novartis Gp140 Env Protein Vaccine Boost Elicits Robust HIV Cellular and Humoral Responses in a Nonhuman Primate Model.” In Aids Research and Human Retroviruses, 29:A39–A39. MARY ANN LIEBERT, INC, 2013.
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  - Gao, F., M. Bonsignori, H. Liao, A. Kumar, S. Xia, F. Cai, X. Lu, et al. “Multiple Pathways of HIV-1 Autologous Neutralizing Antibodies Cooperate to Drive CD4 Binding Site Broadly Neutralizing Antibody Responses.” In Aids Research and Human Retroviruses, 29:A186–A186. MARY ANN LIEBERT, INC, 2013.
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  - Gordon, S. N., M. Vaccari, M. N. Doster, N. P. Liyanage, P. Pegu, L. Schifanella, F. Caccuri, et al. “Priming with Adenovirus26 Vaccines Affects ALVAC-SIV/gp120 Vaccine Efficacy Tested in a SIVmac251 Challenge Model Performed One-Month Post-Vaccination.” In Aids Research and Human Retroviruses, 29:A39–A39. MARY ANN LIEBERT, INC, 2013.
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  - Joachim, A., P. Munseri, C. Nilsson, M. Bakari, S. Aboud, E. F. Lyamuya, C. Moshiro, et al. “A Late Third HIV-MVA Vaccination Boosted Strong and Potent Immune Responses in Tanzanian Volunteers Previously Immunized with HIV-DNA and HIV-MVA.” In Aids Research and Human Retroviruses, 29:A174–A174. MARY ANN LIEBERT, INC, 2013.
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  - Li, S. S., P. B. Gilbert, G. D. Tomaras, G. Kijak, G. Ferrari, R. Thomas, S. Zolla-Pazner, et al. “Association of Fc gamma RIIC Polymorphism with Vaccine Efficacy and Correlates of HIV-1 Infection Risk in RV144.” In Aids Research and Human Retroviruses, 29:A178–79. MARY ANN LIEBERT, INC, 2013.
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  - Pollara, J., M. Bonsignori, M. Moody, S. Alam, K. Hwang, T. C. Gurley, D. M. Kozink, et al. “Heterogeneity of Anti-V2 ADCC Ab Responses and Implications for Vaccine Development.” In Aids Research and Human Retroviruses, 29:A41–A41. MARY ANN LIEBERT, INC, 2013.
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  - Schifanella, L., S. Gordon, M. Vaccari, N. Binello, F. Caccuri, M. Blackburn, C. Fenizia, et al. “MF59 and ALUM, in Combination with an ALVAC-SIV/gp120 Vaccine, Induce Plasmablasts that Differ in the Expression of Homing Markers.” In Aids Research and Human Retroviruses, 29:A13–A13. MARY ANN LIEBERT, INC, 2013.
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  - Vaccari, M., S. N. Gordon, M. Doster, N. Liynage, P. Pegu, L. Schifanella, B. F. Keele, et al. “Protection from SIVmac251 Acquisition by an ALVAC/SIV/gp120 Regimen Is Not Improved by the Increase of Anti-Envelope Antibodies and T Cell Responses.” In Aids Research and Human Retroviruses, 29:A34–A34. MARY ANN LIEBERT, INC, 2013.
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  - Wise, M., N. Hutnick, J. Pollara, D. Myles, A. Khan, S. Barnette, G. Ferrari, D. Montefiori, N. Sardesai, and D. Weiner. “Multiclade E-DNA Prime Enhances the Functional Antibody Response Induced by a Recombinant gp120 Boost in Non-human Primates.” In Aids Research and Human Retroviruses, 29:A38–A38. MARY ANN LIEBERT, INC, 2013.
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  - Blasi, M., D. Negri, S. Santra, R. Parks, X. Shen, G. Tomaras, S. Permar, et al. “A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys.” In Aids Research and Human Retroviruses, 29:A161–A161. MARY ANN LIEBERT, INC, 2013.
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  - Bonsignori, M., J. Pollara, M. A. Moody, T. B. Kepler, X. Chen, T. C. Gurley, D. M. Kozink, et al. “Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial preferentially use the VH1 gene family.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-p78.
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  - Franchini, G., P. Pegu, S. Gordon, B. Keele, M. Doster, Y. Guan, G. Ferrari, et al. “Antibodies to the envelope protein protect macaques from SIVmac251 acquisition in an immunization regimen that mimics the RV-144 Thai trial.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-o2.
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  - Hutnick, N. A., M. Karuppiah, J. Pollara, J. Yan, D. J. Myles, K. Broderick, M. Morrow, et al. “E-DNA IM or ID delivery prime enhances antibody and T cell responses following recombinant gp120 env boost.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-p364.
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  - Joachim, A., C. Nilsson, S. Aboud, E. F. Lyamuya, M. Robb, M. Marovich, C. Ochsenbauer, et al. “Antibody-mediated inhibition of HIV-1 elicited by HIV-I DNA priming and boosting with heterologous HIV-1 recombinant MVA in healthy Tanzanian adults.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-o53.
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  - Pollara, J., M. Bonsignori, M. Moody, M. Alam, H. Liao, K. Hwang, J. Pickeral, et al. “Vaccine-induced ADCC-mediating antibodies target unique and overlapping envelope epitopes.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-o39.
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  - Williams, W. B., K. Jones, A. Krambrink, D. Grove, P. Liu, N. L. Yates, M. A. Moody, et al. “Multiple antibody specificities (gp41, V1V2, and V3) elicited in the phase II multiclade (A, B, C) HIV-1 DNA prime, rAd5 boost vaccine trial.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-o55.
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  - Ferrari, G., J. Cox, A. Garcia, W. Rountree, C. DeCastro, R. Louzao, B. Liebl, et al. “Development of CAVD/EQAPOL Long-Term PBMC Repository ('07-'10) @ DUMC; T-Cell Functionality as Measured by ELISpot and Flow Cytometry Is Maintained Ov.” In Aids Research and Human Retroviruses, 27:A55–A55. MARY ANN LIEBERT INC, 2011.
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  - Fouda, G., N. Yates, J. Pollara, G. Overman, T. Mahlokozera, A. Wilks, H. Kang, et al. “HIV Neutralization in Breast Milk Mirrors that of Plasma and Is Mainly Mediated by IgG Antibodies.” In Aids Research and Human Retroviruses, 27:A72–A72. MARY ANN LIEBERT INC, 2011.
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  - Franchini, G., M. Vaccari, B. Keele, M. Doster, Z. Ma, A. Hryniewicz, T. Morgan, et al. “Efficacy of HIV Vaccine Candidate in Macaques Dependent on the Dose of SIVmac251 Challenge Exposure: Immune Correlates of Vaccine Efficacy.” In Aids Research and Human Retroviruses, 27:A111–A111. MARY ANN LIEBERT INC, 2011.
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  - Franchini, G., P. Pegu, M. Vaccari, S. Gordon, B. Keele, M. Doster, Y. Guan, et al. “Titered Mucosal Challenge of Rhesus Macaques with SIVmac251 Recapitulates HIV Vaccine Efficacy in Humans.” In Aids Research and Human Retroviruses, 27:A4–A4. MARY ANN LIEBERT INC, 2011.
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  - Pollara, J., L. Morris, N. Meguid, J. Pickeral, J. Hoxie, J. Kappes, C. Ochsenbauer, et al. “Ontogeny, Breadth, and Specificity of Circulating ADCC-Mediating Antibodies in HIV-1 Infected Individuals.” In Aids Research and Human Retroviruses, 27:A66–67. MARY ANN LIEBERT INC, 2011.
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  - Ferrari, G., J. Pollara, D. Kozink, T. Harms, M. Drinker, S. Freel, M. A. Moody, et al. “Mapping of ADCC Activity: The A32 Conformational C1 Epitope is a Dominant Target for ADCC Antibodies in Chronically HIV-1 Infected Subjects.” In Aids Research and Human Retroviruses, 27:A66–A66. MARY ANN LIEBERT INC, 2011.
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  - Freel, S. A., R. A. Picking, G. Ferrari, C. Ochsenbauer, J. C. Kappes, J. Kirchherr, K. J. Weinhold, et al. “Ontogeny of CD8+T Cells in Acute HIV-1 that Inhibit Autologous and Heterologous Transmitted/Founder (T/F) Viruses.” In Aids Research and Human Retroviruses, 27:A13–A13. MARY ANN LIEBERT INC, 2011.
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  - Ferrari, G., B. Korber, E. Turnbull, M. K. Liu, N. Goonetilleke, J. Salazar, M. Betts, et al. “High magnitude and multifunctionality epitope-specific CD8+T-cell responses are associated are associated with selection of escape mutants in acute HIV infection.” In Aids Research and Human Retroviruses, 26:A5–6. MARY ANN LIEBERT INC, 2010.
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  - Pollara, J., G. Landucci, C. Trac, C. White, N. Yates, J. Kappes, C. Ochsenbauer, et al. “Early Appearance of ADCC- and ADCVI-mediating Antibody Responses Against Autologous HIV-1 Transmitted/Founder Virus.” In Aids Research and Human Retroviruses, 26:A12–A12. MARY ANN LIEBERT INC, 2010.
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  - Pollara, J., L. Hart, J. Hoxie, J. Kappes, C. Ochsenbauer, L. Morris, K. Soderberg, et al. “High titers of cross-clade ADCC-mediating antibodies are detectable in plasma samples collected from individuals with broadly neutralizing antibodies.” In Aids Research and Human Retroviruses, 26:A20–21. MARY ANN LIEBERT INC, 2010.
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  - Yates, N., X. Shen, P. Liu, S. Barnett, P. Spearman, S. Lu, G. Ferrari, et al. “Vaccine-Elicited IgG Subclasses and Functional Antibodies.” In Aids Research and Human Retroviruses, 26:A157–A157. MARY ANN LIEBERT INC, 2010.
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  - Cristillo, A. D., G. Ferrari, L. Hudacik, D. Thompson, B. Bowen, B. Lewis, L. Galmin, et al. “P11-21. Induction of persistent mucosal humoral and cellular responses following immunization of mice with HIV-1 envelope protein in inulin-derived adjuvants.” In Retrovirology, 6:P166–P166, 2009. https://doi.org/10.1186/1742-4690-6-S3-P166.
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  - Ferrari, G., A. Garcia-Louzao, J. Cox, A. Sambor, P. D’Souza, C. Gray, M. Jaimes, et al. “Establishing PBMC Repository for T Cell Assays Optimization and Proficiency Testing in CTC-VIMC Laboratories.” In Aids Research and Human Retroviruses, 24:127–28. MARY ANN LIEBERT INC, 2008.
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  - Ferrari, G., M. Liu, C. Marking, N. Goonetilleke, M. Betts, C. Gray, B. Haynes, A. McMichael, and K. Weinhold. “Lack of Highly Poly-Functional Epitope-Specific CD8+Memory T Cell Responses during Spontaneous Control of Viremia.” In Aids Research and Human Retroviruses, 24:20–20. MARY ANN LIEBERT INC, 2008.
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  - Liu, M. K., G. Ferrari, J. Salazar, B. Keele, R. L. Tanner, E. Turnbull, M. Mlotshwa, et al. “T Cell Escape in Subjects with Acute HIV-1 Infection.” In Aids Research and Human Retroviruses, 24:6–7. MARY ANN LIEBERT INC, 2008.
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  - Sichangi, M. W., J. Bartlett, G. Ferrari, J. Crump, A. Muisyo, J. Puleo, T. Moody, B. Haynes, and J. Shao. “Detection of Cross-Clade T- and B-Cell-Mediated Immune Responses among HIV-1 Infected Individuals in Northern Tanzania.” In Aids Research and Human Retroviruses, 24:92–92. MARY ANN LIEBERT INC, 2008.
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  - Lathey, Janet, Neal Oden, Scott Gregory, Josephine Cox, Guido Ferrari, Susan Zimmermann, Richard Koup, M. Patricia D’Souza, and Isaac Rodriguez-Chavez. “Sa.133. ELISpot Proficiency Testing for International Laboratories Participating in HIV Vaccine Trials.” In Clinical Immunology, 119:S152–S152. Elsevier BV, 2006. https://doi.org/10.1016/j.clim.2006.04.365.
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  - Sempowski, G. D., C. Hicks, L. Edwards, G. Ferrari, J. Eron, and B. F. Haynes. “Naive T cells are maintained in the periphery during acute HIV infection.” In Faseb Journal, 16:A297–A297. FEDERATION AMER SOC EXP BIOL, 2002.
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  - Demarest, J. F., S. B. Jones, G. Ferrari, C. J. Johnson, M. Greenberg, T. O. O’Brien, W. Blattner, et al. “Natural history of HIV-specific CTL activity during acute HIV infection: envelope CTL impact subsequent plasma viremia.” In Faseb Journal, 13:A294–A294. WILEY, 1999.
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  - Weinhold, K. J., W. Humphrey, K. Corr, J. Johnson, M. West, C. Wiggins, S. Jones, J. Ottinger, M. Blanks, and G. Ferrari. “Cellular immune responses to candidate AIDS vaccines.” In 11e Colloque Des Cent Gardes, edited by M. Girard and B. Dodet, 167–75. EDITIONS SCIENTIFIQUES ET MEDICALES ELSEVIER, 1998.
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  - Stranford, S., J. Skurnick, D. Louria, D. Osmond, S. Y. Chang, J. Sninsky, G. Ferrari, K. Weinhold, C. Lindquist, and J. Levy. “The CD8+ cell non-cytotoxic, anti-HIV response is associated with protection in HIV-exposed, uninfected individuals.” In Faseb Journal, 12:A295, 1998.
  - Laughlin, M. J., J. Kurtzberg, K. Weinhold, G. Ferrari, A. Pilgrim, C. Gelber, S. Nair, et al. “Generation of T lymphocyte clones specific for acute lymphoblastic leukemia (ALL) via dendritic cell (DC) presentation.” In Blood, 88:1487–1487. W B SAUNDERS CO, 1996.
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  - FERRARI, G., C. PLACE, J. BARTLETT, D. MOODY, J. TARTAGLIA, E. PAOLETTI, and K. WEINHOLD. “ANTIGEN-SPECIFIC ACTIVATION/EXPANSION OF HUMAN ANTI-HIV CTL USING RECOMBINANT ALVAC (CANARYPOX)-BASED VECTORS.” In Journal of Cellular Biochemistry, 219–219. WILEY-LISS, 1995.
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  - FERRARI, G., K. KING, M. PACKARD, J. A. BARTLETT, J. TARTAGLIA, J. TOSO, and K. J. WEINHOLD. “THE EFFECT OF INTERLEUKIN-7 ON FUNCTIONAL AND PHENOTYPIC PROPERTIES OF ANTIGEN-DRIVEN CTL.” In Journal of Cellular Biochemistry, 354–354. WILEY-LISS, 1994.
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  - WEINHOLD, K. J., K. T. RATHBUN, C. A. PLACE, G. FERRARI, and D. P. BOLOGNESI. “CYTOTOXIC T-LYMPHOCYTE REACTIVITIES AMONG HIV-1 VACCINE RECIPIENTS IN THE AIDS VACCINE EVALUATION NETWORK.” In Aids Research and Human Retroviruses, 10:S89–S89. MARY ANN LIEBERT INC PUBL, 1994.
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  - FERRARI, G., M. V. PACKARD, J. A. BARTLETT, and K. J. WEINHOLD. “TH1 AND TH2 CD4 SUBSET RESPONSES IN HIV-1 INFECTED INDIVIDUALS AT VARIOUS STAGES OF DISEASE.” In Journal of Cellular Biochemistry, 78–78. WILEY-LISS, 1993.
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  - WEINHOLD, K. J., G. FERRARI, and L. O. ARTHUR. “COMPARISON OF CELLULAR ANTIVIRAL CYTOTOXICITIES PRESENT IN HIV-1 INFECTED HUMANS AND CHIMPANZEES.” In Aids Research and Human Retroviruses, 8:938–938. MARY ANN LIEBERT INC PUBL, 1992.
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  - TAGLIAFERRO, L., M. CORBELLI, P. GRIMA, S. REINA, F. LILLO, E. BOERI, G. FERRARI, and O. E. VARNIER. “HTLV REACTIVITY IN NORMAL POPULATION OF SOUTHERN APULIA (ITALY).” In Aids Research and Human Retroviruses, 6:141–141. MARY ANN LIEBERT INC PUBL, 1990.
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Teaching & Mentoring
Recent Courses
Advising & Mentoring
- I have been involved in teaching and training new researchers in several capacities. Since 2001, as part of consulting work for the World Health Organization and United Nation AIDS program (WHO/UNAIDS), I have organized and taught in 8 international ELISpot and Flow Cytometry workshops in South America (1), Asia (1), and Africa (6) to developing international sites that can perform vaccine clinical trials. In this capacity, I have taught more than 150 young investigators around the world. In 2002 and 2003, I taught the HIV-1 Vaccine development lecture for the IMM291 Comprehensive Immunology Course in the Duke Department of Immunology. Starting in 2007, I have also been awarded two R13 grants from the NIH to organize a series of International Symposia in South Africa that fosters interactions between young African scientists selected among those working in the HIV, TB, and malaria fields and senior international faculty. We have currently provided career development opportunity to more than 52 young investigators and facilitated the forum for a network of young investigators within the African continents.
  Moreover, I was one of the Co-Investigators for the MEPI project directed by Dr. J. Bartlett that collaborates with the Faculty at the Kilimanjaro Christian Medical College to develop a new curriculum of study for the students and to improve the teaching curriculum for the faculty members within the Basic Science fields. I consider this teaching as an integral part of my mandate as a scientist interested in Global Health to promote the education and interaction of the generation of young investigators, with particular focus on the African community.Mentoring has also been an important aspect of my career. Since joining the faculty in 2001, I have mentored 6 undergraduate students during their junior and senior year to perform independent research projects in my laboratory. Of them, 2 have already achieved their medical degree (Dr. Kolappa from John Hopkins University in 2009, Dr. Chaudhry from Brown University in 2009). Ms Hofmair is completing her medical degree at Duke University while achieving a MBA in medical science and a MPH in women health. Mr. Laithi graduated in 2010 and applying to Medical School for 2012. Ms. DiMarco who has recently graduated in May 2012 and has been accepted in Medical School at he University of Virginia. Mr. Hickey has completed his junior year project and we rejoin the lab after a summer internship at the University of KwaZulu-Natal (Durban, South Africa).
  
  In 2006, Marc Frahm joined my laboratory as graduate students for the Molecular Genetics and Microbiology Department. He has currently achieved the necessary requirements to defend his thesis and will graduate in August 2012.
  
  I have been a faculty mentor for the AIDS Training Grant starting in 2005 (Department of Medicine, T32). I have directly mentored two post-doctoral fellows Dr. Jie Yu (2007-2010) and Dr, Justin Pollara (2010-currently). Dr Yu is currently a Research Associate at Duke University with Dr. Chen after completing 3 years of training in my laboratory. Dr. Pollara is still in my laboratory and has already published 19 manuscripts, of which four as first author, and has five more manuscripts in preparation, two of those as first author. Dr. Pollara has been awarded a CHAVI Young Investigator for his work on fundamental insights into the HIV-1 ADCC antibody response. My career goals since joining the Duke faculty in September 2001 have been to make an impact on young investigators through basic research and teaching and mentoring undergraduate, graduate and medical students, and postdoctoral fellows at Duke University.
Available to mentor:
- PhD
- Post-Doc
- Undergraduate
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Advising & Mentoring

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