Journal ArticleJ Breast Imaging · December 13, 2025
The initial method of detection (MOD) refers to the first imaging examination, physical symptom, or clinical sign that prompts further investigation and ultimately leads to a new breast cancer diagnosis. The MOD is assigned at the patient level and falls i ...
Full textLink to itemCite
Journal ArticleJ Breast Imaging · November 11, 2025
OBJECTIVE: To determine the outcome and malignancy rate of BI-RADS 3 masses during follow-up at 6, 12, and 24 months. METHODS: This retrospective cohort study identified female patients <35 years of age with an oval, parallel, circumscribed mass assigned a ...
Full textLink to itemCite
Journal ArticleJ Imaging Inform Med · June 2025
This work aims to perform a cross-site validation of automated segmentation for breast cancers in MRI and to compare the performance to radiologists. A three-dimensional (3D) U-Net was trained to segment cancers in dynamic contrast-enhanced axial MRIs usin ...
Full textLink to itemCite
Journal ArticleJ Am Coll Radiol · July 2024
OBJECTIVE: To determine the feasibility of standardized, prospective assignment of initial method of detection (MOD) of breast cancer by radiologists in diverse practice settings. METHODS: This multicenter, retrospective study analyzed the rate of assignme ...
Full textLink to itemCite
Journal ArticleJ Breast Imaging · May 27, 2024
OBJECTIVE: To determine cancer visualization utility and radiation dose for non-implant-displaced (ID) views using standard protocol with digital breast tomosynthesis (DBT) vs alternative protocol with 2D only when screening women with implant augmentation ...
Full textLink to itemCite
Journal ArticleJ Breast Imaging · July 28, 2023
Myeloid sarcoma (MS) is a rare extramedullary solid tumor arising most often in patients with current or subsequent acute myeloid leukemia (AML). Patients of all ages may present with involvement of the skin, lymph nodes, intestinal tract, bone, and/or cen ...
Full textLink to itemCite
Journal ArticleJournal of Breast Imaging · July 1, 2022
Research from randomized controlled trials initiated up to 60 years ago consistently confirms that regular screening with mammography significantly reduces breast cancer mortality. Despite this success, there is ongoing debate regarding the efficacy of scr ...
Full textCite
Journal ArticleJAMA Netw Open · August 2, 2021
IMPORTANCE: Breast cancer screening is among the most common radiological tasks, with more than 39 million examinations performed each year. While it has been among the most studied medical imaging applications of artificial intelligence, the development a ...
Full textLink to itemCite
Journal ArticleAJR Am J Roentgenol · April 2021
BACKGROUND. The incidence of ductal carcinoma in situ (DCIS) has steadily increased, as have concerns regarding overtreatment. Active surveillance is a novel treatment strategy that avoids surgical excision, but identifying patients with occult invasive di ...
Full textLink to itemCite
Journal ArticleJ Am Coll Radiol · January 2021
Current descriptions of ultrasound evaluations, including use of the term "point-of-care ultrasound" (POCUS), are imprecise because they are predicated on distinctions based on the device used to obtain images, the location where the images were obtained, ...
Full textLink to itemCite
Journal ArticleJAMA Netw Open. 2021;4(8):e2119100 · November 13, 2020
Breast cancer screening is one of the most common radiological tasks with
over 39 million exams performed each year. While breast cancer screening has
been one of the most studied medical imaging applications of artificial
intelligence, the development and ...
Link to itemCite
Journal ArticleAcad Radiol · November 2020
RATIONALE AND OBJECTIVES: The purpose of this study is to quantify breast radiologists' performance at predicting occult invasive disease when ductal carcinoma in situ (DCIS) presents as calcifications on mammography and to identify imaging and histopathol ...
Full textLink to itemCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020
Deep learning has achieved great success in image analysis and decision making in radiology. However, a large amount of annotated imaging data is needed to construct well-performing deep learning models. A particular challenge in the context of breast canc ...
Full textCite
Journal ArticleRadiographics · 2020
Fetal central nervous system (CNS) abnormalities are second only to cardiac malformations in their frequency of occurrence. Early and accurate diagnosis at prenatal US is therefore essential, allowing improved prenatal counseling and facilitating appropria ...
Full textLink to itemCite
Journal ArticleJ Magn Reson Imaging · August 2019
BACKGROUND: Preliminary work has demonstrated that background parenchymal enhancement (BPE) assessed by radiologists is predictive of future breast cancer in women undergoing high-risk screening MRI. Algorithmically assessed measures of BPE offer a more pr ...
Full textLink to itemCite
Journal ArticleJ Breast Imaging · March 13, 2019
OBJECTIVE: The purpose of this study was to determine the malignancy rate of solitary MRI masses with benign BI-RADS descriptors. METHODS: A retrospective review was conducted of all breast MRI reports that described a mass with a final BI-RADS assessment ...
Full textLink to itemCite
Journal ArticleAcad Radiol · January 2019
RATIONALE AND OBJECTIVES: To determine if background parenchymal enhancement (BPE) on screening breast magnetic resonance imaging (MRI) in high-risk women correlates with future cancer. MATERIALS AND METHODS: All screening breast MRIs (n = 1039) in high-ri ...
Full textLink to itemCite
Journal ArticleClin Imaging · 2019
PURPOSE: The purpose of this study is to identify predictors of tumor-positive surgical margins after breast-conserving surgery on dynamic contrast-enhanced (DCE) MRI. MATERIALS AND METHODS: We conducted a retrospective study of consecutive women who under ...
Full textLink to itemCite
Journal ArticleBr J Cancer · August 2018
BACKGROUND: Recent studies showed preliminary data on associations of MRI-based imaging phenotypes of breast tumours with breast cancer molecular, genomic, and related characteristics. In this study, we present a comprehensive analysis of this relationship ...
Full textLink to itemCite
Journal ArticleMenopause · March 2018
This Practice Pearl describes an approach to screening mammography for average-risk women that encourages the use of shared decision-making that addresses benefits (early diagnosis and decreased mortality) and potential harms (false positives and overdiagn ...
Full textLink to itemCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018
Digital breast tomosynthesis (DBT) is a relatively new modality for breast imaging that can provide detailed assessment of dense tissue within the breast. In the domains of cancer diagnosis, radiogenomics, and resident education, it is important to accurat ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018
One of the methods widely used to measure the proliferative activity of cells in breast cancer patients is the immunohistochemical (IHC) measurement of the percentage of cells stained for nuclear antigen Ki-67. Use of Ki-67 expression as a prognostic marke ...
Full textCite
Journal ArticleAcad Radiol · November 2017
RATIONALE AND OBJECTIVES: The aim of this study was to describe the imaging appearance of patients undergoing active surveillance for ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: We retrospectively identified 29 patients undergoing active survei ...
Full textLink to itemCite
Journal ArticleEur Radiol · June 2017
OBJECTIVES: To determine the malignancy rate overall and for specific BI-RADS descriptors in women ≥70 years who undergo stereotactic biopsy for calcifications. METHODS: We retrospectively reviewed 14,577 consecutive mammogram reports in 6839 women ≥70 yea ...
Full textLink to itemCite
Journal ArticleExpert Systems with Applications · September 1, 2016
Purpose Digital breast tomosynthesis (DBT) can improve lesion visibility in comparison to mammography by eliminating breast tissue superimposition. While the benefits of DBT in breast cancer screening rely on well trained radiologists, the optimal training ...
Full textCite
Journal ArticleRadiology · September 2016
Purpose To evaluate the impact of breast density notification legislation on breast density reporting by radiologists nationally. Materials and Methods The institutional review board exempted this HIPAA-compliant retrospective study from the requirement fo ...
Full textLink to itemCite
Journal ArticleJ Am Coll Surg · August 2016
BACKGROUND: Nipple-areola complex (NAC) and skin flap ischemia and necrosis can occur after nipple-sparing mastectomy (NSM). The purpose of this study was to correlate vascular findings on MRI with outcomes in patients who underwent NSM. STUDY DESIGN: Fema ...
Full textLink to itemCite
Journal ArticleMed Phys · August 2016
PURPOSE: To assess the interobserver variability of readers when outlining breast tumors in MRI, study the reasons behind the variability, and quantify the effect of the variability on algorithmic imaging features extracted from breast MRI. METHODS: Four r ...
Full textLink to itemCite
Journal ArticleJ Med Imaging (Bellingham) · July 2016
This study aims to characterize the effect of background tissue density and heterogeneity on the detection of irregular masses in breast tomosynthesis, while demonstrating the capability of the sophisticated tools that can be used in the design, implementa ...
Full textLink to itemCite
Journal ArticleJ Am Coll Radiol · February 2016
PURPOSE: The aim of this study was to better understand the relationship between digital breast tomosynthesis (DBT) difficulty and radiology trainee performance. METHODS: Twenty-seven radiology residents and fellows and three expert breast imagers reviewed ...
Full textLink to itemCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2016
Digital breast tomosynthesis (DBT) can improve lesion visibility by eliminating the issue of overlapping breast tissue present in mammography. However, this new modality likely requires new approaches to training. The issue of training in DBT is not well e ...
Full textCite
Journal ArticleAnn Surg Oncol · December 2015
PURPOSE: To determine the diagnostic value of magnetic resonance imaging (MRI) for the evaluation of patients with pathologic nipple discharge. METHODS: We performed a retrospective review of women with nipple discharge who underwent breast MRI between Jan ...
Full textLink to itemCite
Journal ArticleAJR Am J Roentgenol · December 2015
OBJECTIVE: The objective of our study was to determine the risk of malignancy associated with architectural distortion and to evaluate the imaging and clinical features that may contribute to the prediction of malignancy in the setting of architectural dis ...
Full textLink to itemCite
Journal ArticleEur J Radiol · November 2015
PURPOSE: The purpose of this study is to investigate the association between breast cancer recurrence-free survival and breast magnetic resonance imaging (MRI) tumor enhancement dynamics which are quantified semi-automatically using computer algorithms. ME ...
Full textLink to itemCite
Journal ArticleJAMA · October 20, 2015
IMPORTANCE: Patients need to consider both benefits and harms of breast cancer screening. OBJECTIVE: To systematically synthesize available evidence on the association of mammographic screening and clinical breast examination (CBE) at different ages and in ...
Full textLink to itemCite
Journal ArticleAcad Radiol · September 2015
RATIONALE AND OBJECTIVES: To compare the performance of two shortened breast magnetic resonance imaging (MRI) protocols to a standard MRI protocol for breast cancer screening. MATERIALS AND METHODS: In this Health Insurance Portability and Accountability A ...
Full textLink to itemCite
Journal ArticleAJR Am J Roentgenol · August 2015
OBJECTIVE: The purposes of this study were to evaluate the frequency, follow-up compliance, and cancer rate of MRI BI-RADS category 3 lesions and to determine the cancer rate for individual BI-RADS descriptors. MATERIALS AND METHODS: A retrospective review ...
Full textLink to itemCite
Journal ArticleAJR Am J Roentgenol · July 2015
OBJECTIVE: The purpose of this study was to assess the contribution of ultrasound to the evaluation of patients with pathologic nipple discharge. MATERIALS AND METHODS: A retrospective review was conducted of the records of females who presented with nippl ...
Full textLink to itemCite
Journal ArticleMed Phys · July 2015
PURPOSE: Physical phantoms are essential for the development, optimization, and evaluation of x-ray breast imaging systems. Recognizing the major effect of anatomy on image quality and clinical performance, such phantoms should ideally reflect the three-di ...
Full textLink to itemCite
Journal ArticleJ Am Coll Radiol · July 2015
PURPOSE: To determine the initial digital breast tomosynthesis (DBT) performance of radiology trainees with varying degrees of breast imaging experience. METHODS: To test trainee performance with DBT, we performed a reader study, after obtaining IRB approv ...
Full textLink to itemCite
Journal ArticleAJR Am J Roentgenol · May 2015
OBJECTIVE: The purpose of this study was to assess the interobserver variability of users of the MRI lexicon in the fifth edition of the BI-RADS atlas. MATERIALS AND METHODS: Three breast imaging specialists reviewed 280 routine clinical breast MRI finding ...
Full textLink to itemCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2015
Virtual clinical trials (VCT) can be carefully designed to inform, orient, or potentially replace clinical trials. The focus of this study was to demonstrate the capability of the sophisticated tools that can be used in the design, implementation, and perf ...
Full textCite
Journal Article · October 1, 2014
The state of maternal-fetal health in the developing world remains appalling despite growing global attention. Since the adoption of the Millennium Development goals, there has been increased deployment of resources towards this issue with little improveme ...
Full textCite
Journal ArticleMed Phys · September 2014
PURPOSE: Mammography is the most widely accepted and utilized screening modality for early breast cancer detection. Providing high quality mammography education to radiology trainees is essential, since excellent interpretation skills are needed to ensure ...
Full textLink to itemCite
Journal ArticleIEEE Trans Med Imaging · July 2014
Mammography is currently the most widely utilized tool for detection and diagnosis of breast cancer. However, in women with dense breast tissue, tissue overlap may obscure lesions. Digital breast tomosynthesis can reduce tissue overlap. Furthermore, imagin ...
Full textLink to itemCite
Journal ArticleAcad Radiol · July 2014
RATIONALE AND OBJECTIVES: The purpose of this study was to better understand the concept of mammography difficulty and how it affects radiology resident performance. MATERIALS AND METHODS: Seven radiology residents and three expert breast imagers reviewed ...
Full textLink to itemCite
ConferenceMed Phys · June 2014
PURPOSE: The use of contrast agents in breast imaging has the capability of enhancing nodule detectability and providing physiological information. Accordingly, there has been a growing trend toward using iodine as a contrast medium in digital mammography ...
Full textLink to itemCite
Journal ArticleMed Phys · March 2014
PURPOSE: The purpose of this study is to explore Breast Imaging-Reporting and Data System (BI-RADS) features as predictors of individual errors made by trainees when detecting masses in mammograms. METHODS: Ten radiology trainees and three expert breast im ...
Full textLink to itemCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2014
Providing high quality mammography education to radiology trainees is essential, as good interpretation skills potentially ensure the highest benefit of screening mammography for patients. We have previously proposed a computer-aided education system that ...
Full textCite
Journal ArticleLecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics · August 15, 2012
We previously developed a dynamic 4D anthropomorphic breast phantom, which can be used to optimize contrast-based breast imaging systems, accounting for patient variability and contrast kinetics [1]. In this study we aim to compare the performance of contr ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · May 4, 2012
Mammography is currently the most widely accepted tool for detection and diagnosis of breast cancer. However, the sensitivity of mammography is reduced in women with dense breast tissue due to tissue overlap, which may obscure lesions. Digital breast tomos ...
Full textCite
ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · May 4, 2012
Accurately targeting of small lesions for success is crucial in breast biopsy. In this paper, we proposed a new 3D tomobased biopsy, which is characterized in being more accurate, easier to perform, lower in dose, and free of metal artifact. In the scout p ...
Full textCite
Journal ArticleAJR Am J Roentgenol · April 2012
OBJECTIVE: The purpose of this article is to determine the potential reduction in screening recall rates by strictly following standardized BI-RADS lexicon for lesions seen on screening mammography. MATERIALS AND METHODS: Of 3084 consecutive mammograms per ...
Full textLink to itemCite
Journal ArticleAcad Radiol · June 2011
RATIONALE AND OBJECTIVES: Spectroscopy signal of a breast lesion may be disrupted by the presence of metal from a biopsy marking clip. This study compares the size of magnetic resonance (MR) susceptibility artifacts and degree of local spectroscopy signal ...
Full textLink to itemCite
Journal ArticleMed Phys · April 2011
PURPOSE: Mammography is known to be one of the most difficult radiographic exams to interpret. Mammography has important limitations, including the superposition of normal tissue that can obscure a mass, chance alignment of normal tissue to mimic a true le ...
Full textLink to itemCite
Journal ArticleAcad Radiol · May 2010
RATIONALE AND OBJECTIVES: The aim of this study was to determine if core biopsy-proven benign papillomas of the breast need to be surgically excised. MATERIALS AND METHODS: Mammographic and pathologic database review from January 1994 to January 2004 revea ...
Full textLink to itemCite
Journal ArticleAm J Surg · October 2009
BACKGROUND: The value of breast self-examination (BSE) to detect early breast cancer is controversial. METHODS: Within an institutional review board-approved prospective study, 147 high-risk women were enrolled from 2004 to 2007. Yearly clinical examinatio ...
Full textLink to itemCite
Journal ArticleAcad Radiol · March 2009
RATIONALE AND OBJECTIVES: Recent research has provided evidence that in reading rooms equipped with liquid crystal displays (LCDs), a measured increase of ambient lighting may improve clinicians' detection performance. In agreement with this research, the ...
Full textLink to itemCite
Journal ArticleAJR Am J Roentgenol · April 2008
OBJECTIVE: The purpose of this study was to retrospectively determine the value of adding 3D multiplanar sonography to 2D sonohysterography. MATERIALS AND METHODS: Between September 2003 and April 2005, 80 women (mean age, 43.5 years; range, 26-78 years) u ...
Full textLink to itemCite
Journal ArticleAJR Am J Roentgenol · June 2006
OBJECTIVE: The purpose of this study was to evaluate a compact portable 10-gauge handheld battery-operated vacuum-assisted biopsy system for MRI-guided breast biopsy. CONCLUSION: The compact portable battery-operated biopsy system can be used successfully ...
Full textLink to itemCite
Journal ArticleAJR Am J Roentgenol · May 2006
OBJECTIVE: Streaming detection is a novel sonography technique that uses ultrasonic energy to induce movement in cyst fluid that is detected on Doppler sonography. This pilot study evaluates the utility of streaming detection for differentiating cysts from ...
Full textLink to itemCite
Journal ArticleRadiology · April 2005
PURPOSE: To retrospectively compare recall and cancer detection rates between immediate and subsequent batch methods for interpretation of screening mammograms. MATERIALS AND METHODS: Institutional review board approval was obtained, and informed consent w ...
Full textLink to itemCite
Journal ArticleAJR Am J Roentgenol · March 2005
OBJECTIVE: Computer-aided detection (CAD) systems have been used successfully to detect malignant calcifications on mammography, with sensitivities ranging from 86% to 99%. Amorphous calcifications are a subset of small indistinct calcifications of interme ...
Full textLink to itemCite
Journal ArticleClin Imaging · 2005
A decision model was used to compare the relative costs of the 14-gauge automated gun technique to the 14-gauge and 11-gauge vacuum-assisted techniques for stereotactic biopsy of noncalcified breast lesions. Probability and cost variables were estimated fr ...
Full textLink to itemCite
Journal ArticleJ Ultrasound Med · September 1999
The purpose of this study was to evaluate the use of extended field-of-view two-dimensional ultrasonographic imaging for improvement in overall breast lesion documentation. Sonographic images of 59 patients with breast lesions or silicone implants were eva ...
Full textLink to itemCite
Journal ArticleClin Imaging · 1999
The purpose of this study was to evaluate the stereotactic 14-gauge, vacuum-assisted biopsy technique in diagnosing noncalcified breast lesions. Stereotactic biopsy of 116 noncalcified breast lesions was performed with either 14-gauge, vacuum-assisted tech ...
Full textLink to itemCite
Journal ArticleAcad Radiol · December 1995
RATIONALE AND OBJECTIVES: We assessed the follow-up behavior of women who had abnormal results of screening mammograms taken on a mobile van. METHODS: A retrospective cohort study was conducted between 1988 and 1991 of all women served by a mobile mammogra ...
Full textLink to itemCite
Journal ArticleJ Biol Chem · May 25, 1992
Although DNA helicases play important roles in the processing of DNA, little is known about the effects of DNA-interacting ligands on these helicases. Therefore, the effects of a wide variety of DNA-binding ligands on the unwinding and ATPase reactions cat ...
Link to itemCite