Grace Prakalapakorn

Journal Article Ophthalmology · November 6, 2024 PURPOSE: To review the published literature assessing the efficacy of multifocal soft contact lenses for the treatment of myopia progression in children 18 years of age and younger. METHODS: A literature search of the PubMed database was conducted last in ... Full text Link to item Cite

Complications, Visual Acuity, and Refractive Error 3 Years after Secondary Intraocular Lens Implantation for Pediatric Aphakia.

Journal Article Ophthalmology · October 2024 PURPOSE: To report the cumulative incidence of complications and to describe refractive error and visual acuity (VA) outcomes in children undergoing secondary intraocular lens (IOL) implantation after previous surgery for nontraumatic cataract. DESIGN: Ped ... Full text Link to item Cite

Impact of Vision Impairment and Ocular Morbidity and Their Treatment on Quality of Life in Children: A Systematic Review.

Journal Article Ophthalmology · February 2024 TOPIC: This review summarizes existing evidence of the impact of vision impairment and ocular morbidity and their treatment on children's quality of life (QoL). CLINICAL RELEVANCE: Myopia and strabismus are associated with reduced QoL among children. Surgi ... Full text Link to item Cite

A pilot optical coherence tomography angiography classification of retinal neovascularization in retinopathy of prematurity.

Journal Article Sci Rep · January 4, 2024 Extraretinal neovascularization is a hallmark of treatment-requiring retinopathy of prematurity (ROP). Optical coherence tomography angiography (OCTA) offers vascular flow and depth information not available from indirect ophthalmoscopy and structural OCT, ... Full text Link to item Cite

Longitudinal Choroidal Development in Preterm Infants.

Journal Article Ophthalmol Sci · 2024 PURPOSE: To characterize changes in subfoveal choroidal thickness in preterm infants from 30 to 60 weeks' postmenstrual age (PMA). DESIGN: The prospective, observational Study of Eye Imaging in Preterm infantS (BabySTEPS) enrolled infants eligible for reti ... Full text Link to item Cite

Computer versus human-expert ranking of posterior pole vascular tortuosity and dilation using retinal vessel maps generated from bedside optical coherence tomography: a proof-of-concept study.

Journal Article J AAPOS · December 2023 Semiautomated computer software (ie, ROPtool) can trace and analyze optical coherence tomography (OCT)-generated retinal vessel maps for plus/pre-plus disease with high reliability and accuracy. This proof-of-concept study found that ROPtool can reliably r ... Full text Link to item Cite

Correlation between tear levels of vascular endothelial growth factor and vitamin D at retinopathy of prematurity stages in preterm infants.

Journal Article Sci Rep · September 27, 2023 Deregulation of vascular endothelial growth factor (VEGF) levels leads to retinopathy of prematurity (ROP). Vitamin D (VIT-D) is known to regulate VEGF in an oxygen dependent manner. The purpose of this study was to correlate tear levels of VEGF and VIT-D ... Full text Link to item Cite

Refractive Accuracy and Visual Outcome by Self-Refraction Using Adjustable-Focus Spectacles in Young Children: A Randomized Clinical Trial.

Journal Article JAMA Ophthalmol · September 1, 2023 IMPORTANCE: Uncorrected refractive error is the most common cause of vision impairment in children. Most children 12 years or older can achieve visual acuity (VA) of 20/25 or better by self-refraction using adjustable-focus spectacles, but data on younger ... Full text Open Access Link to item Cite

Ocular Pigmentation Impact on Retinal Versus Choroidal Optical Coherence Tomography Imaging in Preterm Infants.

Journal Article Transl Vis Sci Technol · July 3, 2023 PURPOSE: To evaluate the association of fundus pigmentation with the visibility of retinal versus choroidal layers on optical coherence tomography (OCT) in preterm infants. METHODS: For infants enrolled in BabySTEPS, ophthalmologists recorded fundus pigmen ... Full text Link to item Cite

The effect of sex on retinopathy of prematurity severity among premature mixed-sex multiple gestation infants.

Journal Article J AAPOS · June 2023 This retrospective study of 68 premature infants examined whether there was a difference between male and female mixed-sex multiple gestation infants with regard to stage of retinopathy of prematurity (ROP) developed or need for ROP treatment. We found tha ... Full text Link to item Cite

2021 U.S. Virgin Islands Zika health brigade: Providing recommended pediatric health screenings for children born to mothers with laboratory evidence of possible Zika virus infection during pregnancy.

Journal Article Birth Defects Res · March 15, 2023 BACKGROUND: The United States Virgin Islands (USVI) Department of Health (DOH) conducted a second Zika health brigade (ZHB) in 2021 to provide recommended Zika-related pediatric health screenings, including vision, hearing, neurologic, and developmental sc ... Full text Link to item Cite

Retinopathy of Prematurity in the 21st Century and the Complex Impact of Supplemental Oxygen.

Journal Article J Clin Med · February 3, 2023 Retinopathy of prematurity (ROP) is a leading cause of childhood blindness. Not only do the epidemiologic determinants and distributions of patients with ROP vary worldwide, but clinical differences have also been described. The Third Edition of the Intern ... Full text Link to item Cite

Safety and efficacy of avalglucosidase alfa in individuals with infantile-onset Pompe disease enrolled in the phase 2, open-label Mini-COMET study: The 6-month primary analysis report.

Journal Article Genet Med · February 2023 PURPOSE: Mini-COMET (NCT03019406; Sanofi) is a phase 2, open-label, ascending-dose, 3-cohort study, evaluating avalglucosidase alfa safety, pharmacokinetics, and efficacy in individuals with infantile-onset Pompe disease aged <18 years who previously recei ... Full text Link to item Cite

Quantitative comparison of blood vessel changes after treatment of retinopathy of prematurity with laser versus bevacizumab.

Journal Article J AAPOS · December 2022 Current therapies for treatment-indicated (type 1) retinopathy of prematurity mainly consist of laser photocoagulation and intravitreal anti-vascular endothelial growth factor (eg, bevacizumab) injection. The first visible signs of acute-phase regression a ... Full text Link to item Cite

Low- and Very Low-Dose Bevacizumab for Retinopathy of Prematurity: Reactivations, Additional Treatments, and 12-Month Outcomes.

Journal Article Ophthalmology · October 2022 PURPOSE: Low-dose and very low-dose intravitreal bevacizumab (IVB) have been reported to be successful in short-term treatment of type 1 retinopathy of prematurity (ROP), down to an initial dose of 0.004 mg. We now report 12-month outcomes for these infant ... Full text Link to item Cite

Impact of Vision Impairment and Ocular Morbidity and Their Treatment on Depression and Anxiety in Children: A Systematic Review.

Journal Article Ophthalmology · October 2022 TOPIC: This systematic review and meta-analysis summarizes existing evidence to establish whether vision impairment, ocular morbidity, and their treatment are associated with depression and anxiety in children. CLINICAL RELEVANCE: Understanding and quantif ... Full text Link to item Cite

Semi-automated vessel analysis of en face posterior pole vessel maps generated from optical coherence tomography for diagnosis of plus or pre-plus disease.

Journal Article J AAPOS · August 2022 En face retinal vessel maps generated from bedside optical coherence tomography (OCT) can show posterior pole vascular tortuosity and dilation (ie, plus/pre-plus disease). In this proof-of-concept study, we found that ROPtool could trace OCT-generated reti ... Full text Link to item Cite

Integrated Visualization Highlighting Retinal Changes in Retinopathy of Prematurity From 3-Dimensional Optical Coherence Tomography Data.

Journal Article JAMA Ophthalmol · July 1, 2022 IMPORTANCE: Early diagnosis of plus disease is critical in the management of retinopathy of prematurity (ROP). However, there is substantial interexpert disagreement in the diagnosis of plus disease based on vascular changes alone. Information derived from ... Full text Link to item Cite

Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity.

Journal Article JAMA Ophthalmol · July 1, 2022 IMPORTANCE: Preterm infants are at risk for poor visual acuity (VA) outcomes, even without retinal problems on ophthalmoscopy. Infant retinal microanatomy may provide insight as to potential causes. OBJECTIVE: To evaluate the association between preterm in ... Full text Link to item Cite

Cost comparison of using reusable versus disposable equipment for retinopathy of prematurity screening rounds.

Conference J AAPOS · April 2022 Retinopathy of prematurity (ROP) screening rounds have been linked to pathogen transmission and serious adverse outcomes in neonatal intensive care units (NICUs). Using Monte Carlo simulations, we found that it is more likely less expensive to use reusable ... Full text Link to item Cite

Plasma Levels of Bevacizumab and Vascular Endothelial Growth Factor After Low-Dose Bevacizumab Treatment for Retinopathy of Prematurity in Infants.

Journal Article JAMA Ophthalmol · April 1, 2022 IMPORTANCE: Intravitreal bevacizumab effectively treats severe retinopathy of prematurity (ROP), but it enters the bloodstream and may reduce serum vascular endothelial growth factor (VEGF), potentially causing detrimental effects on developing organs in t ... Full text Link to item Cite

Association Between Strabismus and Children's Mental Health.

Journal Article JAMA Ophthalmol · April 1, 2022 Full text Link to item Cite

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Journal Article JAMA Ophthalmology · April 1, 2022 Full text Cite

OP016: Mini-COMET: Safety and efficacy of ≥97 weeks’ avalglucosidase alfa in infantile-onset Pompe disease participants previously treated with alglucosidase alfa

Conference Genetics in Medicine · March 2022 Full text Cite

Mini-COMET study: Safety, biomarker, and efficacy data after avalglucosidase alfa dosing for ≥ 97 weeks in participants with infantile-onset pompe disease (IOPD) previously treated with alglucosidase alfa who had demonstrated clinical decline

Conference Molecular Genetics and Metabolism · February 2022 Full text Cite

Quantitative comparison of retinal vascular changes by quadrants after treatment of retinopathy of prematurity

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

Short-term treatment effects on retinal microanatomy in preterm infants with severe retinopathy of prematurity

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

Photographic assessment of eyelid position using a simple measurement tool paired with cell phone photography in a pediatric population.

Journal Article J AAPOS · October 2021 PURPOSE: This proof-of-concept study evaluates the ability to assess eyelid measurements and the reproducibility of eyelid measurements using a simple measurement tool paired with digital cell phone photography in children. METHODS: Seventy consecutive pat ... Full text Link to item Cite

Evaluating the association of clinical factors and optical coherence tomography retinal imaging with axial length and axial length growth among preterm infants.

Journal Article Graefes Arch Clin Exp Ophthalmol · September 2021 PURPOSE: To study the association of clinical factors and optical coherence tomography (OCT) retinal imaging with axial length (AL) and AL growth in preterm infants METHODS: Among a subgroup of infants from the prospective BabySTEPS study who were screened ... Full text Link to item Cite

Prophylactic laser versus continued surveillance after initial bevacizumab treatment for retinopathy of prematurity.

Journal Article J AAPOS · June 2021 Guidelines on managing infants after initial anti-vascular endothelial growth factor (VEGF) treatment (eg, bevacizumab) for retinopathy of prematurity (ROP) are limited. We found that following initial bevacizumab treatment for ROP, prophylactically laseri ... Full text Link to item Cite

Trends in Retinopathy of Prematurity Screening and Treatment: 2008-2018.

Journal Article Pediatrics · June 2021 BACKGROUND AND OBJECTIVES: Retinopathy of prematurity (ROP) is the leading avoidable and treatable cause of childhood blindness in the United States. The objective of this study was to evaluate trends of ROP screening, incidence, and treatment in US NICUs ... Full text Link to item Cite

Preterm Infant Stress During Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity.

Journal Article JAMA Ophthalmol · May 1, 2021 IMPORTANCE: Binocular indirect ophthalmoscopy (BIO) examination for retinopathy of prematurity (ROP) is a well-known cause of repeated preterm infant stress. OBJECTIVE: To compare stress during investigational optical coherence tomography (OCT) imaging to ... Full text Link to item Cite

Ocular Findings and Visual Function in Children Examined during the Zika Health Brigade in the US Virgin Islands, March 2018.

Journal Article Trop Med Infect Dis · April 29, 2021 Among children born with laboratory-confirmed Zika virus (ZIKV) infection, visual impairment (VI) can occur despite normal ocular structure. The objective of this report is to describe ocular findings and visual function among children examined during the ... Full text Link to item Cite

Quantitatively comparing weekly changes in retinal vascular characteristics of eyes eventually treated versus not treated for retinopathy of prematurity.

Journal Article J AAPOS · February 2021 PURPOSE: To quantitatively compare retinal vascular characteristics over time in eyes eventually treated versus not treated for retinopathy of prematurity (ROP), using ROPtool analysis of narrow-field retinal images. METHODS: This longitudinal study used p ... Full text Link to item Cite

Mini-COMET study: Effects of repeat avalglucosidase alfa dosing on ptosis in participants with infantile-onset Pompe disease (IOPD) who were previously treated with alglucosidase alfa

Conference Molecular Genetics and Metabolism · February 2021 Full text Cite

Characterization of Ebola Virus-Associated Eye Disease.

Journal Article JAMA Netw Open · January 4, 2021 IMPORTANCE: Survivors of Ebola virus disease (EVD) may experience ocular sequelae. Comparison with antibody-negative individuals from the local population is required to characterize the disease. OBJECTIVE: To assess features of ophthalmic disease specific ... Full text Link to item Cite

Development, Validation, and Innovation in Ophthalmic Laser-Based Imaging: Report From a US Food and Drug Administration-Cosponsored Forum.

Journal Article JAMA Ophthalmol · January 1, 2021 In April 2019, the US Food and Drug Administration, in conjunction with 11 professional ophthalmic, vision science, and optometric societies, convened a forum on laser-based imaging. The forum brought together the Food and Drug Administration, clinicians, ... Full text Link to item Cite

Efficacy and Safety Outcomes of Cataract Surgery in Survivors of Ebola Virus Disease: 12-Month Results From the PREVAIL VII Study.

Journal Article Transl Vis Sci Technol · January 2021 PURPOSE: In survivors of Ebola virus disease (EVD), intraocular viral persistence raises questions about the timing and safety of cataract surgery. To the best of our knowledge, this is the first controlled study evaluating Ebola virus persistence and cata ... Full text Link to item Cite

Mini-COMET: effects of avalglucosidase alfa on ptosis in participants with infantile-onset Pompe disease previously treated with alglucosidase alfa

Conference MOLECULAR GENETICS AND METABOLISM · 2021 Cite

Quantitative comparison of changes in vessel characteristics post retinopathy of prematurity treatment with bevacizumab versus laser

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Slow progressive perifoveal vascular formation in an infant with aggressive posterior retinopathy of prematurity.

Journal Article J AAPOS · October 2020 Aggressive posterior retinopathy of prematurity (AP-ROP) is a severe form of ROP occurring in preterm infants that is characterized by rapid progression and prominent vascularity. We report the use of investigational bedside noninvasive optical coherence t ... Full text Link to item Cite

Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity.

Journal Article Transl Vis Sci Technol · August 2020 PURPOSE: To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (RO ... Full text Link to item Cite

ROPtool analysis of plus and pre-plus disease in narrow-field images: a multi-image quadrant-level approach.

Journal Article J AAPOS · April 2020 BACKGROUND: The presence of plus disease is important in determining when to treat retinopathy of prematurity (ROP), but the diagnosis of plus disease is subjective. Semiautomated computer programs (eg, ROPtool) can objectively measure retinal vascular cha ... Full text Link to item Cite

Differentiating Retinal Detachment and Retinoschisis Using Handheld Optical Coherence Tomography in Stage 4 Retinopathy of Prematurity.

Conference JAMA Ophthalmol · January 1, 2020 IMPORTANCE: Progression of retinopathy of prematurity (ROP) to stage 4 may require surgical intervention. The partial retinal detachment of stage 4 ROP may involve the fovea (stage 4B ROP) or may not (stage 4A ROP). This determination has heretofore been b ... Full text Link to item Cite

Secondary 12-Month Ocular Outcomes of a Phase 1 Dosing Study of Bevacizumab for Retinopathy of Prematurity.

Journal Article JAMA Ophthalmol · January 1, 2020 IMPORTANCE: Lower bevacizumab dosages are being used for type 1 retinopathy of prematurity, but there are limited data on long-term ocular outcomes with lower doses. OBJECTIVE: To evaluate ocular outcomes at 12 months' corrected age for eyes that received ... Full text Link to item Cite

Impact and Trends in Global Ophthalmology.

Journal Article Curr Ophthalmol Rep · 2020 PURPOSE OF REVIEW: Our goal is to provide a review of the impact, global estimates, and projection of vision impairment as well as ongoing systems for eye care delivery. RECENT FINDINGS: Many of the blinding diseases in developing countries are preventable ... Full text Link to item Cite