Scholars@Duke
John Palmer Grant

John Palmer Grant

Professor of Surgery
Surgery, Minimally Invasive Surgery
grant003@mc.duke.edu
Duke Box 3857, Durham, NC 27704
Duke North Hospital, Durham, NC 27704
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Selected Publications

Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study.

Journal Article Br J Anaesth · March 2020 BACKGROUND: The Duke Activity Status Index (DASI) questionnaire might help incorporate self-reported functional capacity into preoperative risk assessment. Nonetheless, prognostically important thresholds in DASI scores remain unclear. We conducted a neste ... Full text Link to item Cite

Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study.

Journal Article Br J Anaesth · August 2019 BACKGROUND: Preoperative anaemia is associated with elevated risks of postoperative complications. This association may be explained by confounding related to poor cardiopulmonary fitness. We conducted a pre-specified substudy of the Measurement of Exercis ... Full text Link to item Cite

Using the 6-minute walk test to predict disability-free survival after major surgery.

Journal Article Br J Anaesth · January 2019 BACKGROUND: The 6-min walk test (6MWT) is a common means of functional assessment. Its relationship to disability-free survival (DFS) is uncertain. METHODS: This sub-study of the Measurement of Exercise Tolerance for Surgery study had co-primary outcome me ... Full text Link to item Cite

Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study.

Journal Article Lancet · June 30, 2018 BACKGROUND: Functional capacity is an important component of risk assessment for major surgery. Doctors' clinical subjective assessment of patients' functional capacity has uncertain accuracy. We did a study to compare preoperative subjective assessment wi ... Full text Link to item Cite

Gastric Bypass Surgery Leads to Long-term Remission or Improvement of Type 2 Diabetes and Significant Decrease of Microvascular and Macrovascular Complications.

Journal Article Ann Surg · June 2016 OBJECTIVES: The aim of the study was to compare long-term outcomes of 2 groups of morbidly obese patients with type 2 diabetes mellitus-1 managed by Roux-en-Y gastric bypass surgery and a comparable group managed medically. METHODS: The present study was a ... Full text Link to item Cite

Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery.

Journal Article BMJ Open · March 11, 2016 INTRODUCTION: Preoperative functional capacity is considered an important risk factor for cardiovascular and other complications of major non-cardiac surgery. Nonetheless, the usual approach for estimating preoperative functional capacity, namely doctors' ... Full text Link to item Cite

A comparative analysis of Type 2 diabetes and binge eating disorder in a bariatric sample.

Journal Article Eat Behav · August 2011 An emerging literature has illuminated an important link between Type 2 diabetes mellitus (DM) and binge eating disorder (BED) within obese cohorts. However, prior work has not examined this relationship specifically in a weight loss surgery (WLS) sample o ... Full text Link to item Cite

Nutritional support in acute and chronic pancreatitis.

Journal Article Surg Clin North Am · August 2011 Nutritional support can have a significant beneficial impact on the course of moderate to severe acute pancreatitis. Enteral nutrition is preferred, with emphasis on establishment of jejunal access; however, parenteral nutrition can also be of value if int ... Full text Link to item Cite

Remission of type 2 diabetes after Roux-en-Y gastric bypass is associated with greater weight loss.

Journal Article Surg Obes Relat Dis · 2009 BACKGROUND: Physiologic studies in rodents and preliminary human studies have suggested that Roux-en-Y gastric bypass (RYGB) improves type 2 diabetes mellitus (T2DM) by way of metabolic changes, long before the bariatric or weight loss effects occur, leadi ... Full text Link to item Cite

Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial.

Journal Article Lancet · May 31, 2008 BACKGROUND: Trials of beta blockers in patients undergoing non-cardiac surgery have reported conflicting results. This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative beta blocker ... Full text Link to item Cite

Preoperative weight gain does not predict failure of weight loss or co-morbidity resolution of laparoscopic Roux-en-Y gastric bypass for morbid obesity.

Journal Article Surg Obes Relat Dis · 2008 BACKGROUND: Success with preoperative weight loss (PWL) is often mandated by the bariatric team to assess patient compliance and has been suggested to correlate with improved postoperative weight loss outcomes. METHODS: We performed a retrospective analysi ... Full text Link to item Cite

Validation of the obesity surgery mortality risk score in a multicenter study proves it stratifies mortality risk in patients undergoing gastric bypass for morbid obesity.

Journal Article Ann Surg · October 2007 BACKGROUND: A scoring system for clinical assessment of mortality risk has been previously proposed for bariatric surgery (Demaria EJ, Portenier D, Wolfe L, Surg Obes Relat Dis. 2007;3:34-40.). The Obesity Surgery Mortality Risk Score (OS-MRS) was develope ... Full text Link to item Cite

Psychological correlates of obese patients seeking surgical or residential behavioral weight loss treatment.

Journal Article Surg Obes Relat Dis · 2007 BACKGROUND: The purpose of this study was to gain a better understanding of the psychological factors related to obese individuals self-selecting for either a residential cognitive-behavioral-based program or surgical treatment program for weight loss. MET ... Full text Link to item Cite

Who is adherent with preoperative psychological treatment recommendations among weight loss surgery candidates?

Journal Article Surg Obes Relat Dis · 2007 BACKGROUND: Adherence to treatment regimens is critical for success with weight loss surgery. Weight loss surgery patients commonly undergo a psychological evaluation before surgery. When indicated, patients are provided with preoperative behavioral recomm ... Full text Link to item Cite

Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass.

Journal Article Surg Obes Relat Dis · 2007 BACKGROUND: Because of the claim that about one third of patients develop gallstones within 6 months of Roux-en-Y gastric bypass (RYGB), many have recommended preoperative ultrasonography for all patients and/or prophylactic cholecystectomy (CCY), or ursod ... Full text Link to item Cite

Surgical revision of loop ("mini") gastric bypass procedure: multicenter review of complications and conversions to Roux-en-Y gastric bypass.

Journal Article Surg Obes Relat Dis · 2007 BACKGROUND: The claim that the "mini"-gastric bypass (MGB) procedure with its loop gastrojejunostomy is safer and equally effective to the Roux-en-Y gastric bypass (RYGB) procedure has been promoted before validation. Rumors of unreported complications and ... Full text Link to item Cite

VersaStep trocar hernia rate in unclosed fascial defects in bariatric patients.

Journal Article Surg Endosc · October 2006 OBJECTIVE: Use of the VersaStep trocar system (US Surgical, Norwalk, CT) has the perceived advantage of minimal trocar-related hernias in patients undergoing Roux-en-Y gastric bypass surgery (RYGB). We performed a retrospective review of our last 747 conse ... Full text Link to item Cite

Anatomy and physiology of venous system vascular access: implications.

Journal Article JPEN J Parenter Enteral Nutr · 2006 Ideal characteristics for long-term vascular access that can be managed in the home environment include a large vascular lumen in a high-flow blood system to minimize risks of obstruction and phlebitis, ease of sterile dressing maintenance, patient comfort ... Full text Link to item Cite

Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study.

Journal Article Br J Anaesth · March 2020 BACKGROUND: The Duke Activity Status Index (DASI) questionnaire might help incorporate self-reported functional capacity into preoperative risk assessment. Nonetheless, prognostically important thresholds in DASI scores remain unclear. We conducted a neste ... Full text Link to item Cite

Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study.

Journal Article Br J Anaesth · August 2019 BACKGROUND: Preoperative anaemia is associated with elevated risks of postoperative complications. This association may be explained by confounding related to poor cardiopulmonary fitness. We conducted a pre-specified substudy of the Measurement of Exercis ... Full text Link to item Cite

Using the 6-minute walk test to predict disability-free survival after major surgery.

Journal Article Br J Anaesth · January 2019 BACKGROUND: The 6-min walk test (6MWT) is a common means of functional assessment. Its relationship to disability-free survival (DFS) is uncertain. METHODS: This sub-study of the Measurement of Exercise Tolerance for Surgery study had co-primary outcome me ... Full text Link to item Cite

Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study.

Journal Article Lancet · June 30, 2018 BACKGROUND: Functional capacity is an important component of risk assessment for major surgery. Doctors' clinical subjective assessment of patients' functional capacity has uncertain accuracy. We did a study to compare preoperative subjective assessment wi ... Full text Link to item Cite

Gastric Bypass Surgery Leads to Long-term Remission or Improvement of Type 2 Diabetes and Significant Decrease of Microvascular and Macrovascular Complications.

Journal Article Ann Surg · June 2016 OBJECTIVES: The aim of the study was to compare long-term outcomes of 2 groups of morbidly obese patients with type 2 diabetes mellitus-1 managed by Roux-en-Y gastric bypass surgery and a comparable group managed medically. METHODS: The present study was a ... Full text Link to item Cite

Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery.

Journal Article BMJ Open · March 11, 2016 INTRODUCTION: Preoperative functional capacity is considered an important risk factor for cardiovascular and other complications of major non-cardiac surgery. Nonetheless, the usual approach for estimating preoperative functional capacity, namely doctors' ... Full text Link to item Cite

A comparative analysis of Type 2 diabetes and binge eating disorder in a bariatric sample.

Journal Article Eat Behav · August 2011 An emerging literature has illuminated an important link between Type 2 diabetes mellitus (DM) and binge eating disorder (BED) within obese cohorts. However, prior work has not examined this relationship specifically in a weight loss surgery (WLS) sample o ... Full text Link to item Cite

Nutritional support in acute and chronic pancreatitis.

Journal Article Surg Clin North Am · August 2011 Nutritional support can have a significant beneficial impact on the course of moderate to severe acute pancreatitis. Enteral nutrition is preferred, with emphasis on establishment of jejunal access; however, parenteral nutrition can also be of value if int ... Full text Link to item Cite

Remission of type 2 diabetes after Roux-en-Y gastric bypass is associated with greater weight loss.

Journal Article Surg Obes Relat Dis · 2009 BACKGROUND: Physiologic studies in rodents and preliminary human studies have suggested that Roux-en-Y gastric bypass (RYGB) improves type 2 diabetes mellitus (T2DM) by way of metabolic changes, long before the bariatric or weight loss effects occur, leadi ... Full text Link to item Cite

Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial.

Journal Article Lancet · May 31, 2008 BACKGROUND: Trials of beta blockers in patients undergoing non-cardiac surgery have reported conflicting results. This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative beta blocker ... Full text Link to item Cite

Preoperative weight gain does not predict failure of weight loss or co-morbidity resolution of laparoscopic Roux-en-Y gastric bypass for morbid obesity.

Journal Article Surg Obes Relat Dis · 2008 BACKGROUND: Success with preoperative weight loss (PWL) is often mandated by the bariatric team to assess patient compliance and has been suggested to correlate with improved postoperative weight loss outcomes. METHODS: We performed a retrospective analysi ... Full text Link to item Cite

Validation of the obesity surgery mortality risk score in a multicenter study proves it stratifies mortality risk in patients undergoing gastric bypass for morbid obesity.

Journal Article Ann Surg · October 2007 BACKGROUND: A scoring system for clinical assessment of mortality risk has been previously proposed for bariatric surgery (Demaria EJ, Portenier D, Wolfe L, Surg Obes Relat Dis. 2007;3:34-40.). The Obesity Surgery Mortality Risk Score (OS-MRS) was develope ... Full text Link to item Cite

Psychological correlates of obese patients seeking surgical or residential behavioral weight loss treatment.

Journal Article Surg Obes Relat Dis · 2007 BACKGROUND: The purpose of this study was to gain a better understanding of the psychological factors related to obese individuals self-selecting for either a residential cognitive-behavioral-based program or surgical treatment program for weight loss. MET ... Full text Link to item Cite

Who is adherent with preoperative psychological treatment recommendations among weight loss surgery candidates?

Journal Article Surg Obes Relat Dis · 2007 BACKGROUND: Adherence to treatment regimens is critical for success with weight loss surgery. Weight loss surgery patients commonly undergo a psychological evaluation before surgery. When indicated, patients are provided with preoperative behavioral recomm ... Full text Link to item Cite

Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass.

Journal Article Surg Obes Relat Dis · 2007 BACKGROUND: Because of the claim that about one third of patients develop gallstones within 6 months of Roux-en-Y gastric bypass (RYGB), many have recommended preoperative ultrasonography for all patients and/or prophylactic cholecystectomy (CCY), or ursod ... Full text Link to item Cite

Surgical revision of loop ("mini") gastric bypass procedure: multicenter review of complications and conversions to Roux-en-Y gastric bypass.

Journal Article Surg Obes Relat Dis · 2007 BACKGROUND: The claim that the "mini"-gastric bypass (MGB) procedure with its loop gastrojejunostomy is safer and equally effective to the Roux-en-Y gastric bypass (RYGB) procedure has been promoted before validation. Rumors of unreported complications and ... Full text Link to item Cite

VersaStep trocar hernia rate in unclosed fascial defects in bariatric patients.

Journal Article Surg Endosc · October 2006 OBJECTIVE: Use of the VersaStep trocar system (US Surgical, Norwalk, CT) has the perceived advantage of minimal trocar-related hernias in patients undergoing Roux-en-Y gastric bypass surgery (RYGB). We performed a retrospective review of our last 747 conse ... Full text Link to item Cite

Anatomy and physiology of venous system vascular access: implications.

Journal Article JPEN J Parenter Enteral Nutr · 2006 Ideal characteristics for long-term vascular access that can be managed in the home environment include a large vascular lumen in a high-flow blood system to minimize risks of obstruction and phlebitis, ease of sterile dressing maintenance, patient comfort ... Full text Link to item Cite

Anatomy and physiology of the luminal gut: enteral access implications.

Journal Article JPEN J Parenter Enteral Nutr · 2006 Successful long-term enteral nutrition requires enteral access that is comfortable and easy to maintain. However, to be successful, the enteral access must also satisfy conditions of gut anatomy and physiology. ... Full text Link to item Cite

Use of interdisciplinary team approach in establishing esthetic restorative dentistry.

Journal Article The New York state dental journal · 2005 Managing crown lengthening in cases of attrition (wear or loss of tooth substance) and achieving desired esthetic outcomes, especially in the esthetic zone, is challenging. This case report presents an interdisciplinary approach to case management. Concomi ... Cite

Impact of race on psychosocial characteristics of female bariatric surgery applicants

Journal Article INTERNATIONAL JOURNAL OF EATING DISORDERS · May 1, 2004 Link to item Cite

Binge eating, quality of life and physical activity improve after Roux-en-Y gastric bypass for morbid obesity.

Journal Article Obes Surg · March 2004 BACKGROUND: Severe obesity has been associated with disordered eating, impaired quality of life (QoL), and decreased physical activity. This study examines changes in these variables 6 months after Roux-en-Y gastric bypass (RYGBP). METHODS: 40 morbidly obe ... Full text Link to item Cite

Effects of endplate removal on the structural properties of the lower lumbar vertebral bodies.

Journal Article Spine · April 2003 STUDY DESIGN: A biomechanical investigation using indentation tests in human cadaveric lumbar vertebrae. OBJECTIVES: To determine the effect of endplate removal on the structural properties across the lower lumbar vertebral bodies (L3-L5). SUMMARY OF BACKG ... Cite

The effects of bone density and disc degeneration on the structural property distributions in the lower lumbar vertebral endplates.

Journal Article J Orthop Res · September 2002 Featured Publication In this study, we hypothesized that vertebral bone density and disc degeneration would affect the structural property distributions of the lower lumbar vertebral endplates (L3-L5). The results may have implications for improving interbody implant designs t ... Full text Link to item Cite

Poor outcome and quality of life in female patients undergoing secondary surgery for recurrent peptic ulcer disease.

Journal Article J Gastrointest Surg · 2002 Featured Publication Secondary peptic ulcer surgery is uncommon given the success of a wide variety of medical therapies, plus the good outcome expected after primary peptic ulcer surgery. Early reports of secondary peptic ulcer surgery in the 1950s and 1960s suggested good lo ... Full text Link to item Cite

Recognition, prevention, and treatment of home total parenteral nutrition central venous access complications.

Journal Article JPEN J Parenter Enteral Nutr · 2002 Placement of central venous catheters for long-term administration of i.v. solutions in the home is associated with potential immediate and long-term complications. These complications can seriously threaten a patient's well-being and greatly increase cost ... Full text Link to item Cite

Mapping the structural properties of the lumbosacral vertebral endplates.

Journal Article Spine (Phila Pa 1976) · April 15, 2001 Featured Publication STUDY DESIGN: A biomechanical investigation using indentation tests in a human cadaveric model to seek variation in the structural properties across the lower lumbar and sacral endplates. OBJECTIVES: To determine 1) if there are regional differences in end ... Full text Link to item Cite

Metabolic occurrences in total parenteral nutrition patients managed by a nutrition support team

Journal Article Nutrition in Clinical Practice · January 1, 2001 Few reports have been published examining the impact of a nutrition support service on avoiding serious metabolic complications in hospitalized patients receiving total parenteral nutrition (TPN). We report a high frequency of metabolic abnormalities, with ... Full text Cite

Mortality with percutaneous endoscopic gastrostomy.

Journal Article Am J Gastroenterol · January 2000 Featured Publication Full text Link to item Cite

Total parenteral nutrition alters NPY/PYY receptor levels in the rat brain.

Journal Article Physiol Behav · December 1997 The regulation of appetite and satiety is complex and may involve peptide mediators such as cholecystokinin (CCK) and neuropeptide Y (NPY). Studies have indicated that calories administered enterally and parenterally impact on feeding, and possibly via the ... Full text Link to item Cite

Use of electrocardiogram to position right atrial catheters during surgery.

Journal Article Ann Surg · February 1997 OBJECTIVE: This study evaluated the accuracy of placing right atrial catheters using an electrocardiographic (ECG) technique. SUMMARY BACKGROUND DATA: Placement of right atrial catheters for vascular access is a common operative procedure. Accurate placeme ... Full text Link to item Cite

Management of Nutrition Support Cases Under “Unusual Circumstances”

Journal Article Nutrition in Clinical Practice · January 1, 1997 Full text Cite

Glutathione depletion: a risk factor for impaired glucose regulation

Journal Article FASEB Journal · December 1, 1996 A deficiency of the antioxidant glutathione (GSH) in various pathophysiologic conditions, is associated with impaired blood glucose regulation (IGR). AIM: To examine the possibility that GSH depletion is a cause of IGR. METHODS : Male Sprague-Dawley rats ( ... Cite

Malabsorption associated with surgical procedures and its treatment.

Journal Article Nutr Clin Pract · April 1996 Signs and symptoms of malabsorption after surgical procedures can be subtle and recognized late. This article reviews some of the more common surgical procedures potentially associated with malabsorption and suggests techniques of nutrition intervention. E ... Full text Link to item Cite

Prospective evaluation of the safety and efficacy of laparoscopic jejunostomy.

Journal Article West J Med · February 1995 We prospectively assessed the safety and efficacy of laparoscopic jejunostomy done by 11 surgeons in 8 medical centers using the T-fastener technique. In all, 23 men and 13 women aged 19 to 84 (mean, 59) years required enteral feeding, but could not underg ... Link to item Cite

Nutritional support in critically ill patients.

Journal Article Ann Surg · November 1994 OBJECTIVE: The author reviews the newer nutritional substrates in use or under investigation for enteral and parenteral nutrition. Management of the critically ill patient remains a significant challenge to clinicians, and it is hoped that dietary manipula ... Full text Link to item Cite

Effects of enteral feeding products on survival from Escherichia coli peritonitis.

Journal Article J Trauma · November 1994 Male Fischer 344 rats were orally fed one of four diets (Osmolite HN, Alitraq, Impact, and Purina rodent chow). After 6 days, jejunal mucosal nitrogen content and thickness were normal in all groups. After 7 days, challenge with Escherichia coli intraperit ... Full text Link to item Cite

Duke procedure for super obesity: preliminary report with 3.5-year follow-up.

Journal Article Surgery · June 1994 BACKGROUND: Super obese patients pose a major health care problem because their obesity is associated with high risks of morbidity and even death. Neither dietary programs nor surgery results in significant or lasting weight loss. Presented here is a new s ... Link to item Cite

Nutrition care of patients with acute and chronic respiratory failure.

Journal Article Nutr Clin Pract · February 1994 Nutrition is intimately linked to pulmonary function and an understanding of these relationships have therapeutic utility. Malnutrition is known to be associated with impaired mechanical function of the lung in both chronic and acute respiratory insufficie ... Full text Link to item Cite

A case of retrograde jejunoduodenal intussusception caused by a feeding gastrostomy tube.

Journal Article Nutr Clin Pract · February 1994 A case is presented of migration of a gastrostomy feeding tube (Foley type) through the pylorus with duodenal obstruction and subsequent retrograde intussusception. Although feeding tube migration is not uncommon, retrograde intussusception of the jejunum ... Full text Link to item Cite

World Bank's world development report.

Journal Article Lancet · August 14, 1993 Link to item Cite

Percutaneous endoscopic gastrostomy. Initial placement by single endoscopic technique and long-term follow-up.

Journal Article Ann Surg · February 1993 Of 598 patients, 595 underwent placement of a percutaneous endoscopic gastrostomy (PEG) tube using a single endoscopy technique and a polyurethane gastrostomy tube. Primary indications were altered mental status and dysphagia. All procedures were performed ... Full text Link to item Cite

[UNICEF--the vulnerable years].

Journal Article Sygeplejersken · January 6, 1993 Link to item Cite

Effect of glutamine-supplemented total parenteral nutrition on recovery of the small intestine after starvation atrophy.

Journal Article JPEN J Parenter Enteral Nutr · 1993 Intestinal atrophy was induced in rats by infusion of 5% dextrose for 7 days with only oral water allowed. Compared with control animals fed standard rat chow (Purina Mills, St. Louis), the starved animals lost 30.5% of their initial body weight, 34.7% muc ... Full text Link to item Cite

Effect of glutamine-supplemented intravenous nutrition on survival after Escherichia coli-induced peritonitis.

Journal Article JPEN J Parenter Enteral Nutr · 1993 Current solution formulations for total parenteral nutrition (TPN) do not contain glutamine (GLN). The purpose of this study was to examine whether GLN supplementation of TPN would improve survival in experimental Escherichia coli peritonitis in Fischer 34 ... Full text Link to item Cite

Effect of total parenteral nutrition on amino acid and glucose transport by the human small intestine

Journal Article Annals of Surgery · 1993 Objective: The effect of total parenteral nutrition (TPN) on small intestinal amino acid transport activity was studied in humans. Summary Background Data: Studies in humans receiving TPN indicate that a decrease in the activities of the dissacharidase enz ... Cite

Use of triple-lumen subclavian catheters for administration of total parenteral nutrition.

Journal Article JPEN J Parenter Enteral Nutr · 1992 This study evaluated the safety of triple vs single-lumen catheters in intravenous nutrition. Patients who were judged likely to benefit from a triple-lumen catheter were randomized to receive either a single-lumen catheter, with additional peripheral or c ... Full text Link to item Cite

[Vaccination of children. A resounding success from the 1980's].

Journal Article Soins Gynecol Obstet Pueric Pediatr · December 1991 Link to item Cite

A prospective analysis of 1518 laparoscopic cholecystectomies.

Other N Engl J Med · April 18, 1991 BACKGROUND AND METHODS: The Southern Surgeons Club conducted a prospective study of 1518 patients who underwent laparoscopic cholecystectomy for treatment of gallbladder disease in order to evaluate the safety of this procedure. RESULTS: Seven hundred fift ... Full text Link to item Cite

Reaching the unreached: a miracle in the making.

Journal Article Asia Pac J Public Health · 1991 The survival and well-being of children is identified as the primary frontier of international health. In this regard, 1990 is identified as the most historic year ever in world history for children, and the achievements of the Universal Child Immunization ... Full text Link to item Cite

Total parental nutrition

Journal Article Current Practice in Surgery · January 1, 1991 Cite

Proper use and recognized role of TPN in the cancer patient

Journal Article Nutrition · September 14, 1990 Cite

Use of enteral and parenteral nutrition in acute pancreatitis

Journal Article Nutritional support in organ failure: proceedings of the International Symposium. ICS836 · January 1, 1990 The application of nutritional support to patients with acute pancreatitis can help assure optimal patient outcome. Whether parenteral, enteral or a combination of therapies including oral intake is preferred depends upon the severity of the inflammatory p ... Cite

Invited commentary

Journal Article World Journal of Surgery · July 1, 1989 Full text Cite

Nutritional support in patients with systemic scleroderma.

Journal Article JPEN J Parenter Enteral Nutr · 1989 Systemic scleroderma often involves the gastrointestinal tract and can lead to significant malnutrition. Specialized home nutritional support was provided to five patients (one enteral and four parenteral) with restoration of adequate nutritional status, i ... Full text Link to item Cite

Teaching health professionals to teach.

Journal Article Asia Pac J Public Health · 1989 Full text Link to item Cite

Use of L-glutamine in total parenteral nutrition.

Journal Article J Surg Res · May 1988 Gut atrophy develops during prolonged total parenteral nutrition (TPN). TPN solutions do not contain glutamine, an energy substrate of the intestinal tract. This study evaluated the effect of addition of L-glutamine to TPN on gut nitrogen content, histolog ... Full text Link to item Cite

Comparison of percutaneous endoscopic gastrostomy with Stamm gastrostomy.

Journal Article Ann Surg · May 1988 In a review of 125 percutaneous endoscopic gastrostomies (PEG) and 88 Stamm gastrostomies performed at Duke University Medical Center since 1978, the average operating room time for PEG (50 +/- 20 min) was shorter than for Stamm (96 +/- 26 min) (p less tha ... Full text Link to item Cite

Total parenteral nutrition in poor prognosis gestational trophoblastic disease.

Journal Article Gynecol Oncol · November 1987 From 1978 through 1984, 35 women received therapy for poor prognosis gestational trophoblastic disease (GTD) at Duke University Medical Center. Total parenteral nutrition (TPN) was utilized in nine patients (26%) for reasons including inadequate oral intak ... Full text Link to item Cite

Invited Review: Intravenous lipid emulsions

Journal Article Nutrition in Clinical Practice · January 1, 1987 Full text Cite

Leadership in mobilising all for Health for All.

Journal Article Asia Pac J Public Health · 1987 Full text Link to item Cite

Effect of enteral nutrition on human pancreatic secretions.

Journal Article JPEN J Parenter Enteral Nutr · 1987 The influence on pancreatic secretion of four enteral feeding products was evaluated in a unique patient with an isolated duodenal fistula for whom enteral feeding access was obtained via a gastrostomy with a small Silastic catheter passed through the gast ... Full text Link to item Cite

The second decade: a new beginning.

Journal Article JPEN J Parenter Enteral Nutr · 1987 Full text Link to item Cite

Child survival and development revolution.

Journal Article Pediatr Rev · December 1986 Full text Link to item Cite

Invited commentary

Journal Article World Journal of Surgery · June 1, 1986 Full text Cite

Familial aggregation of melanoma, basal cell carcinoma, and gastric adenocarcinoma.

Journal Article Cancer · June 1, 1986 A family with four cases of melanoma, seven cases of basal cell carcinoma, and two cases of gastric adenocarcinoma, is described. The proband, who had three different primary tumors, died of gastric cancer, as did his father. Four of the proband's six sibl ... Full text Link to item Cite

Nutritional assessment in clinical practice

Journal Article Nutrition in Clinical Practice · January 1, 1986 John P. Grant, M.D., incoming president of A.S.P.E.N., is the featured author of the lead article in this first issue of Nutrition in Clinical Practice. Dr. Grant is Associate Professor of Surgery and Director of Nutritional Support Service at Duke Univers ... Full text Cite

The state of the world's children, 1985.

Journal Article Indian J Pediatr · 1985 Full text Link to item Cite

The effect of choline supplementation on hepatic steatosis in the parenterally fed rat.

Journal Article JPEN J Parenter Enteral Nutr · 1985 Information regarding hepatic function during total parenteral nutrition in rats is often extrapolated to the clinical situation, but the steatosis observed in that species may simply reflect choline deficiency and be irrelevant to man. The effect of choli ... Full text Link to item Cite

Pathogenesis of hepatic steatosis in the parenterally fed rat.

Journal Article J Clin Invest · November 1984 Hepatic steatosis frequently complicates total parenteral nutrition (TPN). Some of the mechanisms responsible were examined in rats receiving calories as dextrose (CHO-TPN) or dextrose plus lipid emulsion (Lipid-TPN). Hepatic triglyceride content increased ... Full text Link to item Cite

Total parenteral nutrition in pancreatic disease.

Journal Article Ann Surg · November 1984 Total parenteral nutrition (TPN) was given to 121 patients admitted with severe pancreatitis (73), chronic pancreatitis (23), or pancreatic malignancy (25) over 104 months. No adverse effects on the pancreas were detected from the TPN, including the provis ... Full text Link to item Cite

[Revolution for the benefit of the children?].

Journal Article Fortschr Med · January 26, 1984 Link to item Cite

Marketing child survival.

Journal Article Assignment Child · 1984 Link to item Cite

A simple method of obtaining repeated venous blood samples from the conscious rat.

Journal Article J Surg Res · January 1984 A method for repeated venous blood sampling from the conscious, unrestrained rat is described using a silastic femoral vein catheter buried within a scrotal pouch. ... Full text Link to item Cite

THE PATHOGENESIS OF HEPATIC STEATOSIS IN THE PARENTERALLY FED RAT

Journal Article BRITISH JOURNAL OF SURGERY · January 1, 1984 Link to item Cite

The pelvis after surgery for rectal carcinoma: serial CT observations with emphasis on nonneoplastic features.

Journal Article AJR Am J Roentgenol · November 1983 Ten asymptomatic patients who had undergone resection of rectal carcinoma were evaluated prospectively by at least three serial computed tomographic (CT) examinations of the pelvis within 24 months of surgery. Of the seven patients who had undergone abdomi ... Full text Link to item Cite

Rectosigmoid perforation and intestinal evisceration from transanal suction.

Journal Article J Pediatr Surg · February 1983 Transanal suction injuries were sustained in 1981 by five children when they sat upon uncovered swimming area drain sites. Tears of the rectosigmoid areas occurred in each with associated evisceration and loss of substantial amounts of small intestine beca ... Full text Link to item Cite

Fluoroscopic placement of nasojejunal feeding tubes with immediate feeding using a nonelemental diet.

Journal Article JPEN J Parenter Enteral Nutr · 1983 A method for fluoroscopic placement of an Erythrothane (8 French) feeding nasojejunostomy tube with a wire stylet is described. Two hundred thirty-eight feeding tubes were passed successfully to or beyond the Ligament of Treitz in 141 patients with an aver ... Full text Link to item Cite

Effect of D-L-carnitine on fat utilization in the parenterally fed rat

Journal Article Surgical Forum · January 1, 1983 Cite

Children in dark times: a year of silent emergency.

Journal Article Draper Fund Rep · December 1982 Link to item Cite

Enhanced mobilization of iron from body stores in malnourished patients during intravenous nutritional support.

Journal Article Surg Gynecol Obstet · March 1982 Abnormal iron metabolism, characterized by low serum iron concentration and diminished saturation of iron-binding capacity, is known to occur in patients with malignant or inflammatory diseases. In this study, serum iron concentration and iron-binding capa ... Link to item Cite

Vitamin E and total parenteral nutrition.

Journal Article Ann N Y Acad Sci · 1982 Vitamin E and essential fatty acid status were examined in two groups of patients, one receiving fat-free total parenteral nutrition (TPN) with intravenous all-rac-alpha-tocopherol for vitamin E deficiency and the other receiving routine intravenous fat (I ... Full text Link to item Cite

Degeneration of the central nervous system associated with celiac disease.

Journal Article J Neurol Sci · January 1982 The following report describes a 57-year-old man with celiac disease who developed a progressive and fatal neurologic disorder despite intensive medical and nutritional care. The clinical and pathological CNS findings in this patient are compared with thos ... Full text Link to item Cite

NMR rheotomography: feasibility and clinical potential.

Journal Article Med Phys · 1982 An investigation has been undertaken of the effect of flow on NMR images. We term the new technique of flow analysis examined here, NMR rheotomography. Images were acquired through use of a spin-echo technique. They were of doped water passing through a gl ... Full text Link to item Cite

Children in dark times.

Journal Article UNICEF News · December 1981 Link to item Cite

Current techniques of nutritional assessment.

Journal Article Surg Clin North Am · June 1981 This article has dealt with techniques of nutritional assessment as currently utilized in the hospital setting. Although the techniques are easily mastered and abundant data have been collected, we are only slightly closer to achieving an accurate and clin ... Full text Link to item Cite

The structure and function of pyruvate kinase.

Journal Article Biochem Soc Trans · June 1981 Full text Link to item Cite

Birth planning propaganda, incentives and peer pressure.

Journal Article Draper Fund Rep · March 1980 Link to item Cite

Health services and the family planning component.

Journal Article Draper Fund Rep · March 1980 Link to item Cite

IMMEDIATE POSTOPERATIVE ENTERAL NUTRITION

Journal Article SURGICAL FORUM · January 1, 1980 Link to item Cite

A safer system for percutaneous subclavian venous catheterization in newborn infants.

Journal Article J Pediatr Surg · October 1979 Percutaneous infraclavicular cannulation of the subclavian vein in even the tiniest infants can be performed with safety and ease using a plastic cannula metal needle stylet and following plastic catheter. This route for achieving superior vena caval cathe ... Full text Link to item Cite

Serum hepatic enzyme and bilirubin elevations during parenteral nutrition.

Journal Article Surg Gynecol Obstet · October 1977 Serial liver enzyme and bilirubin concentrations were measured in 100 patients undergoing total parenteral nutrition. Between the eighth and tenth days, serum glutamic-pyruvic transaminase levels rose to 5.4 times pretotal parenteral nutrition levels; seru ... Link to item Cite

Urologic sepsis/shock.

Journal Article J Am Geriatr Soc · July 1976 At Columbia-Presbyterian Medical Center during the six-year period 1968-1973, there were 1236 cases of sepsis from Gram-negative pathogens; 124 of these originated in the urinary tract. Of these 124 patients, 19 died-a mortality rate of 15.3 percent. There ... Full text Link to item Cite

The changing pattern of bacterial sepsis since the introduction of antibiotic therapy.

Journal Article J Am Geriatr Soc · April 1976 During the six-year period, 1968-1973, sepsis developed in 1 of every 80 patients admitted to the Presbyterian Hospital, New York. In 1 of 133 patients the sepsis was due to Gram-positive organisms, and in 1 of 188 patients to Gram-negative organisms. The ... Full text Link to item Cite

Humoral antibody response and tumor transplantation resistance elicited by fetal tissues in mice.

Journal Article J Natl Cancer Inst · February 1976 Immune responses to fetal antigen immunization were studied in C57BL/6 (B6), C3H/HeN (C3H), and BALB/c (BALB) mice. In tests by the isotopic antiglobulin technique, the mice could be grouped in three classes according to their antibody responses: good resp ... Full text Link to item Cite

Gram-negative sepsis and endotoxic shock (lecture).

Journal Article Antibiot Chemother (1971) · 1976 Full text Link to item Cite

Chemotherapy.

Journal Article Antibiot Chemother (1971) · 1976 Full text Link to item Cite

Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms.

Journal Article J Am Geriatr Soc · November 1975 A review of the literature reveals that glucocorticoids have: 1) a protective effect both in vitro and in vivo against bacterial endotoxins and exotoxins, and 2) a protective or therapeutic effect in sepsis/shock caused by Gram-negative microorganisms. At ... Full text Link to item Cite

Nitrogen-sparing intravenous fluids in postoperative patients.

Journal Article N Engl J Med · July 24, 1975 Improved nitrogen sparing was demonstrated in 20 patients undergoing either head-and-neck operations or abdominal explorations, who were randomized to receive intravenously either 3 per cent amino acids or 5 per cent dextrose. Infusions were started immedi ... Full text Link to item Cite

Expression of murine leukemia virus structural antigens on the surface of chemically induced murine sarcomas.

Journal Article Proc Natl Acad Sci U S A · December 1974 Cultured cells of different chemically-induced C57BL/6N murine sarcomas produced variable amounts of infectious murine leukemia virus (MuLV) and contained proportional amounts of MuLV structural components as determined by radioimmunoassay. Monospecific an ... Full text Link to item Cite