Overview
My research involves identifying gene regulatory elements across the genome to help us understand how chromatin structure dictates cell function and fate. For the last 30 years, mapping chromatin accessible sites has been the gold standard method to identify the location of active regulatory elements, including promoters, enhancers, silencers, and locus control regions. I have developed technologies that can identify most DNase I hypersensitive sites from potentially any cell type from any species with a sequenced genome. We are combining this data with other wet-lab and computational data types to better understand how these regulatory regions control global gene expression in a set of diverse tissues (normal and diseased) representative of the human body.
Current Appointments & Affiliations
Professor in Pediatrics
·
2020 - Present
Pediatrics, Medical Genetics,
Pediatrics
Associate Professor in Molecular Genetics and Microbiology
·
2015 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Affiliate of the Duke Regeneration Center
·
2021 - Present
Regeneration Next Initiative,
Basic Science Departments
Education, Training & Certifications
University of Michigan, Ann Arbor ·
2001
Ph.D.