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Gregory E. Crawford

Professor in Pediatrics
Pediatrics, Medical Genetics
Box 3382 Med Ctr, Durham, NC 27710
Room 2111 CIEMAS, Durham, NC 27708

Overview


My primary research interest is understanding how the genome is regulated.  The human genome contains approximately 25,000 genes, which are encoded in ~2% of the genome. The overarching goal of my research program is to identify and characterize how these genes are turned on and off in different cell types, tissues, development states, environmental responses, diseases, and individuals. By understanding where all gene regulatory elements are located, how they work to regulate gene expression, and how non-coding variants within these regions affect function, my research program can address a number of important basic and clinical questions.

Current Appointments & Affiliations


Professor in Pediatrics · 2020 - Present Pediatrics, Medical Genetics, Pediatrics
Associate Professor in Molecular Genetics and Microbiology · 2015 - Present Molecular Genetics and Microbiology, Basic Science Departments
Affiliate of the Duke Regeneration Center · 2021 - Present Duke Regeneration Center, Basic Science Departments

In the News


Published March 25, 2025
Duke Honors 31 New Distinguished Professors
Published October 3, 2018
From Innovation to Impact
Published April 9, 2018
Faculty Startup Sold to Belgian Pharma for $30 Million

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Recent Publications


Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases.

Journal Article Alzheimers Dement · May 2025 INTRODUCTION: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease (PD) represent a spectrum of neurodegenerative diseases (NDDs). Here, we performed the first direct comparison of their transcriptomic landscapes. METHODS: We ... Full text Link to item Cite

Massively parallel assessment of gene regulatory activity at human cortical structure associated variants.

Journal Article bioRxiv · February 13, 2025 Genetic association studies have identified hundreds of largely non-coding loci associated with inter-individual differences in the structure of the human cortex, though the specific genetic variants that impact regulatory activity are unknown. We implemen ... Full text Link to item Cite
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Recent Grants


Leveraging novel mouse models to investigate toxic metal exposures on brain aging and Alzheimer's disease

ResearchPrincipal Investigator · Awarded by Boston University · 2024 - 2029

Epigenetic Programming of T Cells for Enhanced Cellular Immunotherapy

ResearchCo Investigator · Awarded by National Cancer Institute · 2024 - 2029

To support research on the development of CRISPR-based epigenome editing tools to refine genome wide association studies

ResearchCo Investigator · Awarded by Open Philanthropy Project · 2018 - 2027

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Education, Training & Certifications


University of Michigan, Ann Arbor · 2001 Ph.D.

External Links


Crawford Lab Website