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Guillermo Sapiro

James B. Duke Distinguished Professor of Electrical and Computer Engineering
Electrical and Computer Engineering
Office hours By appointment. Contact via e-mail.  

Research Interests


Image and video processing, computer vision, computer graphics, computational vision, biomedical imaging, brain imaging, cryo-tomography of viruses, computational tools in cryo-tomography, computational tools in early diagnosis of psychiatric disorders, differential geometry and differential equations, scientific computation, learning and high dimensional data analysis, sparse modeling and dictionary learning, applied mathematics.

Selected Grants


Caregiver Coaching to Improve Outcomes of Young Autistic Children in Africa

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027

Causality in the Real World: From Geometry to Privacy Foundations

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2024 - 2027

Accurate, low-cost, trackerless neuronavigation for transcranial magnetic stimulation

ResearchInvestigator · Awarded by National Institute of Mental Health · 2022 - 2027

Stratifying the Heterogeneity of Autism Spectrum Disorder: Impact of Co-Occurring Anxiety and ADHD

ResearchCollaborator · Awarded by National Institutes of Health · 2021 - 2026

Caregiver Coaching to Improve Outcomes of Young Autistic Children in Africa

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027

Causality in the Real World: From Geometry to Privacy Foundations

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2024 - 2027

Accurate, low-cost, trackerless neuronavigation for transcranial magnetic stimulation

ResearchInvestigator · Awarded by National Institute of Mental Health · 2022 - 2027

Stratifying the Heterogeneity of Autism Spectrum Disorder: Impact of Co-Occurring Anxiety and ADHD

ResearchCollaborator · Awarded by National Institutes of Health · 2021 - 2026

Collaborative Reseach: Transferable, Hierarchical, Expressive, Optimal, Robust, Interpretable NETworks (THEORINET)

ResearchPrincipal Investigator · Awarded by Simons Foundation · 2020 - 2025

Collaborative Reseach: Transferable, Hierarchical, Expressive, Optimal, Robust, Interpretable NETworks (THEORINET)

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2020 - 2025

CIF: Small: Foundations and Applications of Blind Subgroup Robustness

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2021 - 2024

Learning and Explaining Information Dynamics from Overhead Imagery

ResearchPrincipal Investigator · Awarded by National Geospatial-Intelligence Agency · 2019 - 2024

Apple Research Projects

ResearchPrincipal Investigator · Awarded by Apple Corporation · 2023 - 2024

Feeling and Body Investigators (FBI)-ARFID Division: Sensory and Somatic Exposure for Children with Avoidant Restrictive Food Intake Disorder

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2024

Novel Approaches to Infant Screening for ASD in Pediatric Primary Care

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2024

Scalable Computational Platform For Active Closed-Loop Behavioral Coding in Autism Spectrum Disorder

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2024

Novel see and treat strategies for cervical cancer prevention in low-resource settings

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2019 - 2024

HDR TRIPODS: Innovations in Data Science: Integrating Stochastic Modeling, Data Representation, and Algorithms

ResearchSenior Investigator · Awarded by National Science Foundation · 2019 - 2023

CIF: AF: Small: Foundations of Multimodal Information Integration

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2017 - 2023

Uncovering Population-Level Cellular Relationships to Behavior via Mesoscale Networks

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2023

Digital Behavioral Outcome Measures for Autism

ResearchPrincipal Investigator · Awarded by Simons Foundation Autism Research Initiative · 2019 - 2023

Learning Utility-Preserving Private, Fair, and Invariant Representations

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2020 - 2023

Fundamentals and Applications in Learned Information Representation

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2020 - 2023

Tailoring treatment targets for early autism intervention in Africa

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2023

Duke Expanded Access Protocol Proposal for the Cord Blood Association Foundation

ResearchCo Investigator · Awarded by Cord Blood Association Foundation · 2020 - 2022

Learning Privacy for the Internet of Visual Things

ResearchPrincipal Investigator · Awarded by Cisco Systems, Inc. · 2018 - 2022

Administrative Supplement: SCH: INT: Computational Tools for Avoidant/Restrictive Food Intake Disorder

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2022

The Foundations of Dynamic Drone-based Threat Detection

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2017 - 2022

Building a streamlined birth cohort to study autism risk factors and biomarkers

ResearchCo Investigator · Awarded by Drexel University · 2020 - 2022

REU Site for Meeting the Grand Challenges in Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Science Foundation · 2017 - 2022

GitPaper: A Networked Model of Scientific Review and Dissemination

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2017 - 2021

Learning and Privacy in a Closed Environment

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2018 - 2021

Training in Medical Imaging

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2020

Network Inference and Analysis of Big Dynamic Data

ResearchPrincipal Investigator · Awarded by National Geospatial-Intelligence Agency · 2016 - 2020

Modeling, Computations, and Applications in Multimodal Information Integration

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2016 - 2019

Multimodal Subspace Learning and Modeling of Complex Systems

ResearchPrincipal Investigator · Awarded by Army Research Laboratory · 2016 - 2019

Network motifs in cortical computation

ResearchCo-Principal Investigator · Awarded by University of California - Los Angeles · 2016 - 2019

Synaptomes of Mice and Men

ResearchPrincipal Investigator · Awarded by Allen Institute for Brain Science · 2014 - 2019

Nonparametric Bayes Methods for Big Data in Neuroscience

ResearchCo-Mentor · Awarded by National Institutes of Health · 2014 - 2019

Scalable Quantitative Video Analysis for Online Phenotyping, Early Screening, and Symptom Monitoring for Autism Spectrum Disorders

ResearchPrincipal Investigator · Awarded by Simons Foundation Autism Research Initiative · 2017 - 2018

Path Toward MRI with Direct Sensitivity to Neuro-Electro-Magnetic Oscillations

ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2018

Learning to Exploit Big Data

ResearchPrincipal Investigator · Awarded by National Geospatial-Intelligence Agency · 2013 - 2017

Precursors to the development of anxiety disorders in young children with autism spectrum disorder

ResearchCollaborator · Awarded by Department of Defense · 2014 - 2017

Precursors to the development of anxiety disorders in young children with autism spectrum disorder

ResearchCollaborator · Awarded by Department of Defense · 2014 - 2017

AF: Small: Learning to Parsimoniously Model and Compute with Big Data

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2013 - 2017

Visitors to the Information Initiative at Duke

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2015 - 2016

Informed Signal Models: Theory and Applications in Image Sciences

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2012 - 2016

MRI: Development of an Instrument that Monitors Behaviors with OCD and Schizophrenia

ResearchPrincipal Investigator · Awarded by University of Minnesota · 2013 - 2016

Information Acquisition, Analysis, and Integration

ResearchPrincipal Investigator · Awarded by University of Minnesota · 2012 - 2016

HARDI Mapping of Disease Effects on the Brain

ResearchPrincipal Investigator · Awarded by University of California - Los Angeles · 2012 - 2014

External Relationships


  • Apple Inc.
  • Surgical Information Sciences
  • Tanku

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.