Guofang Zhang
Associate Professor in Medicine
Current Appointments & Affiliations
- Associate Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2023
- Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2015
Contact Information
- 300 North Duke Street, Durham, NC 27701
- DUMC Box 104775, Durham, NC 27710
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guofang.zhang@duke.edu
(919) 668-2368
- Background
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Education, Training, & Certifications
- M.S., Vrije Universiteit Brussel (Belgium) 2004
- Ph.D., Nanjing University (China) 2001
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Previous Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2021 - 2023
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2015 - 2020
- Research
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Selected Grants
- Mechanisms linking the Branched-Chain alpha-Keto Acid regulatory network to the pathogenesis of NASH awarded by National Institutes of Health 2023 - 2028
- Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction awarded by National Institutes of Health 2022 - 2027
- Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience awarded by National Institutes of Health 2022 - 2027
- Glucagon and insulin act cooperatively in the regulation of prandial hepatic glycogen metabolism awarded by National Institutes of Health 2021 - 2026
- Engineered Glucose Metabolism in Insulin Secreting Cells awarded by National Institutes of Health 2002 - 2026
- Role of Muscle Ketone Metabolism in Mediating the Metabolic Benefits of Weight Loss awarded by National Institutes of Health 2020 - 2024
- Propionyl-CoA and propionylcarnitine mediate cardiac complications in patients with propionic acidemia awarded by Propionic Acidemia Foundation 2020 - 2024
- The Role of ChREBP in Fructose Induced Metabolic Disease awarded by National Institutes of Health 2014 - 2024
- Developing a clinical diagnostic tool for age-related cochlear synaptopathy awarded by Gateway Biotechnology, Inc. 2023
- Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic disease awarded by National Institutes of Health 2019 - 2023
- Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing Heart awarded by University of Pennsylvania 2021 - 2023
- Mechanisms of lipid-induced bioenergetic stress in muscle awarded by National Institutes of Health 2010 - 2023
- NCDRC P&F April 2022 awarded by Wake Forest University 2021 - 2023
- Validation of a novel mass spectrometry-based method for measurement of muscle glucose uptake in mice awarded by Augusta University 2020 - 2022
- Core Laboratory - Flux analysis of lipid oxidation awarded by Axcella Health 2020 - 2021
- Organic Cations and Mitochondrial Efficiency awarded by East Carolina University 2016 - 2021
- The role of proline metabolism during osteoblast differentiation and bone formation awarded by University of Texas Southwestern Medical Center 2021
- Role of Glutamine Metabolism during Osteoblast Differentiation and Bone Formation awarded by University of Texas Southwestern Medical Center 2021
- The role of proline metabolism during osteoblast differentiation and bone formation awarded by National Institutes of Health 2020
- Role of Glutaminase activity during bone formation awarded by National Institutes of Health 2018 - 2020
- 13C-Metabolic Flux Analysis for Understanding Cardiac Energy Homeostasis awarded by National Institutes of Health 2017 - 2019
- Validation of a Novel Mass Spectrometry-based Method for Muscle Glucose Flux Analysis in Mice awarded by Augusta University 2018 - 2019
- Manipulation of BCAA Metabolism for Therapy of Diabetes and its Co-morbidities awarded by Eli Lilly and Company 2017 - 2018
- Organic Cations and Mitochondrial Efficiency awarded by East Carolina University 2016 - 2018
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External Relationships
- Duke -National Univeristy of Singapore
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Koves, Timothy R., Guo-Fang Zhang, Michael T. Davidson, Alec B. Chaves, Scott B. Crown, Jordan M. Johnson, Dorothy H. Slentz, Paul A. Grimsrud, and Deborah M. Muoio. “Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles.” Cell Metab, April 11, 2023. https://doi.org/10.1016/j.cmet.2023.03.016.Full Text Link to Item
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He, Wentao, Jessica M. Berthiaume, Stephen Previs, Takhar Kasumov, and Guo-Fang Zhang. “Ischemia promotes acyl-CoAs dephosphorylation and propionyl-CoA accumulation.” Metabolomics 19, no. 2 (February 7, 2023): 12. https://doi.org/10.1007/s11306-023-01975-2.Full Text Link to Item
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Samms, Ricardo J., GuoFang Zhang, Wentao He, Olga Ilkayeva, Brian A. Droz, Steven M. Bauer, Cynthia Stutsman, et al. “Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue.” Mol Metab 64 (October 2022): 101550. https://doi.org/10.1016/j.molmet.2022.101550.Full Text Link to Item
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Tong, Wenxin, Sarah A. Hannou, You Wang, Inna Astapova, Ashot Sargsyan, Ruby Monn, Venkataramana Thiriveedi, et al. “The intestine is a major contributor to circulating succinate in mice.” Faseb J 36, no. 10 (October 2022): e22546. https://doi.org/10.1096/fj.202200135RR.Full Text Link to Item
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Yenilmez, Batuhan, Mark Kelly, Guo-Fang Zhang, Nicole Wetoska, Olga R. Ilkayeva, Kyounghee Min, Leslie Rowland, et al. “Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice.” J Biol Chem 298, no. 10 (October 2022): 102401. https://doi.org/10.1016/j.jbc.2022.102401.Full Text Link to Item
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Trub, Alec G., Gregory R. Wagner, Kristin A. Anderson, Scott B. Crown, Guo-Fang Zhang, J Will Thompson, Olga R. Ilkayeva, et al. “Statin therapy inhibits fatty acid synthase via dynamic protein modifications.” Nat Commun 13, no. 1 (May 10, 2022): 2542. https://doi.org/10.1038/s41467-022-30060-w.Full Text Link to Item
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Zhang, Hongyuan, Vijitha Puviindran, Puviindran Nadesan, Xiruo Ding, Leyao Shen, Yuning J. Tang, Hidetoshi Tsushima, et al. “Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations.” J Bone Miner Res 37, no. 5 (May 2022): 983–96. https://doi.org/10.1002/jbmr.4532.Full Text Link to Item
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Shen, Leyao, Yilin Yu, Yunji Zhou, Shondra M. Pruett-Miller, Guo-Fang Zhang, and Courtney M. Karner. “SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation.” Elife 11 (March 9, 2022). https://doi.org/10.7554/eLife.76963.Full Text Link to Item
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Hala, David, Lene H. Petersen, Duane B. Huggett, Michelle A. Puchowicz, Henri Brunengraber, and Guo-Fang Zhang. “Overcompensation of CoA Trapping by Di(2-ethylhexyl) Phthalate (DEHP) Metabolites in Livers of Wistar Rats.” Int J Mol Sci 22, no. 24 (December 16, 2021). https://doi.org/10.3390/ijms222413489.Full Text Link to Item
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He, Wentao, You Wang, Erik J. Xie, Michael A. Barry, and Guo-Fang Zhang. “Metabolic perturbations mediated by propionyl-CoA accumulation in organs of mouse model of propionic acidemia.” Mol Genet Metab 134, no. 3 (November 2021): 257–66. https://doi.org/10.1016/j.ymgme.2021.09.009.Full Text Link to Item
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Sharma, Deepika, Yilin Yu, Leyao Shen, Guo-Fang Zhang, and Courtney M. Karner. “SLC1A5 provides glutamine and asparagine necessary for bone development in mice.” Elife 10 (October 14, 2021). https://doi.org/10.7554/eLife.71595.Full Text Link to Item
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Zhang, Hongyuan, Vijitha Puviindran, Puviindran Nadesan, Xiruo Ding, Leyao Shen, Yuning J. Tang, Hidetoshi Tsushima, et al. “Distinct roles of glutamine metabolism in benign and malignant cartilage tumors with IDH mutations,” September 13, 2021. https://doi.org/10.1101/2021.09.12.459996.Full Text
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Zhang, Guo-Fang, Mette V. Jensen, Sarah M. Gray, Kimberley El, You Wang, Danhong Lu, Thomas C. Becker, Jonathan E. Campbell, and Christopher B. Newgard. “Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion.” Cell Metab 33, no. 4 (April 6, 2021): 804-817.e5. https://doi.org/10.1016/j.cmet.2020.11.020.Full Text Link to Item
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Walejko, Jacquelyn M., Bridgette A. Christopher, Scott B. Crown, Guo-Fang Zhang, Adrian Pickar-Oliver, Takeshi Yoneshiro, Matthew W. Foster, et al. “Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart.” Nat Commun 12, no. 1 (March 15, 2021): 1680. https://doi.org/10.1038/s41467-021-21962-2.Full Text Link to Item
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Arias-Alvarado, Andrea, Mirjavid Aghayev, Serguei Ilchenko, Nadia Rachdaoui, Josephine Lepp, Tsung-Heng Tsai, Guo-Fang Zhang, Stephen Previs, and Takhar Kasumov. “Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet.” Anal Biochem 615 (February 15, 2021): 114067. https://doi.org/10.1016/j.ab.2020.114067.Full Text Link to Item
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Bryant, Kirsten L., Clint A. Stalnecker, Daniel Zeitouni, Jennifer E. Klomp, Sen Peng, Andrey P. Tikunov, Venugopal Gunda, et al. “Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.” Nat Med 26, no. 6 (June 2020): 982. https://doi.org/10.1038/s41591-020-0947-8.Full Text Link to Item
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McGarrah, Robert W., Guo-Fang Zhang, Bridgette A. Christopher, Yann Deleye, Jacquelyn M. Walejko, Stephani Page, Olga Ilkayeva, Phillip J. White, and Christopher B. Newgard. “Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats.” Am J Physiol Endocrinol Metab 318, no. 2 (February 1, 2020): E216–23. https://doi.org/10.1152/ajpendo.00334.2019.Full Text Link to Item
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Yu, Yilin, Hunter Newman, Leyao Shen, Deepika Sharma, Guoli Hu, Anthony J. Mirando, Hongyuan Zhang, et al. “Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells.” Cell Metab 29, no. 4 (April 2, 2019): 966-978.e4. https://doi.org/10.1016/j.cmet.2019.01.016.Full Text Link to Item
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Bryant, Kirsten L., Clint A. Stalnecker, Daniel Zeitouni, Jennifer E. Klomp, Sen Peng, Andrey P. Tikunov, Venugopal Gunda, et al. “Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.” Nat Med 25, no. 4 (April 2019): 628–40. https://doi.org/10.1038/s41591-019-0368-8.Full Text Link to Item
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Wang, Yingxue, Bridgette A. Christopher, Kirkland A. Wilson, Deborah Muoio, Robert W. McGarrah, Henri Brunengraber, and Guo-Fang Zhang. “Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l-carnitine.” Am J Physiol Endocrinol Metab 315, no. 4 (October 1, 2018): E622–33. https://doi.org/10.1152/ajpendo.00081.2018.Full Text Link to Item
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Chen, Ying, Olga Berejnaia, Jinqi Liu, Sheng-Ping Wang, Natalie A. Daurio, Wu Yin, Rafael Mayoral, et al. “Quantifying ceramide kinetics in vivo using stable isotope tracers and LC-MS/MS.” Am J Physiol Endocrinol Metab 315, no. 3 (September 1, 2018): E416–24. https://doi.org/10.1152/ajpendo.00457.2017.Full Text Link to Item
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Bu, Pengcheng, Kai-Yuan Chen, Kun Xiang, Christelle Johnson, Scott B. Crown, Nikolai Rakhilin, Yiwei Ai, et al. “Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.” Cell Metab 27, no. 6 (June 5, 2018): 1249-1262.e4. https://doi.org/10.1016/j.cmet.2018.04.003.Full Text Link to Item
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White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.Full Text Link to Item
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McGarrah, Robert W., Scott B. Crown, Guo-Fang Zhang, Svati H. Shah, and Christopher B. Newgard. “Cardiovascular Metabolomics.” Circ Res 122, no. 9 (April 27, 2018): 1238–58. https://doi.org/10.1161/CIRCRESAHA.117.311002.Full Text Link to Item
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Wilson, Kirkland A., Yong Han, Miaoqi Zhang, Jeremy P. Hess, Kimberly A. Chapman, Gary W. Cline, Gregory P. Tochtrop, Henri Brunengraber, and Guo-Fang Zhang. “Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism.” Am J Physiol Endocrinol Metab 313, no. 4 (October 1, 2017): E413–28. https://doi.org/10.1152/ajpendo.00105.2017.Full Text Link to Item
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Sanabria, Juan R., Rajan S. Kombu, Guo-Fang Zhang, Yana Sandlers, Jizhou Ai, Rafael A. Ibarra, Rime Abbas, Kush Goyal, and Henri Brunengraber. “Glutathione species and metabolomic prints in subjects with liver disease as biological markers for the detection of hepatocellular carcinoma.” Hpb (Oxford) 18, no. 12 (December 2016): 979–90. https://doi.org/10.1016/j.hpb.2016.09.007.Full Text Link to Item
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Guzzo, Marissa B., Hoa T. Nguyen, Thanh H. Pham, Monika Wyszczelska-Rokiel, Hieronim Jakubowski, Kerstin A. Wolff, Sam Ogwang, et al. “Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs.” Plos Pathog 12, no. 10 (October 2016): e1005949. https://doi.org/10.1371/journal.ppat.1005949.Full Text Link to Item
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Marsboom, Glenn, Guo-Fang Zhang, Nicole Pohl-Avila, Yanmin Zhang, Yang Yuan, Hojin Kang, Bo Hao, Henri Brunengraber, Asrar B. Malik, and Jalees Rehman. “Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4.” Cell Rep 16, no. 2 (July 12, 2016): 323–32. https://doi.org/10.1016/j.celrep.2016.05.089.Full Text Link to Item
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Li, Ling, Guo-Fang Zhang, Kwangwon Lee, Rocio Lopez, Stephen F. Previs, Belinda Willard, Arthur McCullough, and Takhar Kasumov. “A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis.” Free Radic Biol Med 96 (July 2016): 13–21. https://doi.org/10.1016/j.freeradbiomed.2016.03.032.Full Text Link to Item
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Hao, Yujun, Yardena Samuels, Qingling Li, Dawid Krokowski, Bo-Jhih Guan, Chao Wang, Zhicheng Jin, et al. “Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.” Nat Commun 7 (June 20, 2016): 11971. https://doi.org/10.1038/ncomms11971.Full Text Link to Item
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Jin, Zhicheng, Fang Bian, Kristyen Tomcik, Joanne K. Kelleher, Guo-Fang Zhang, and Henri Brunengraber. “Compartmentation of Metabolism of the C12-, C9-, and C5-n-dicarboxylates in Rat Liver, Investigated by Mass Isotopomer Analysis: ANAPLEROSIS FROM DODECANEDIOATE.” J Biol Chem 290, no. 30 (July 24, 2015): 18671–77. https://doi.org/10.1074/jbc.M115.651737.Full Text Link to Item
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Li, Qingling, Shuang Deng, Rafael A. Ibarra, Vernon E. Anderson, Henri Brunengraber, and Guo-Fang Zhang. “Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase.” J Biol Chem 290, no. 13 (March 27, 2015): 8121–32. https://doi.org/10.1074/jbc.M114.631549.Full Text Link to Item
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Anand, Puneet, Alfred Hausladen, Ya-Juan Wang, Guo-Fang Zhang, Colin Stomberski, Henri Brunengraber, Douglas T. Hess, and Jonathan S. Stamler. “Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation.” Proc Natl Acad Sci U S A 111, no. 52 (December 30, 2014): 18572–77. https://doi.org/10.1073/pnas.1417816112.Full Text Link to Item
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Jin, Zhicheng, Jessica M. Berthiaume, Qingling Li, Fabrice Henry, Zhong Huang, Sushabhan Sadhukhan, Peng Gao, Gregory P. Tochtrop, Michelle A. Puchowicz, and Guo-Fang Zhang. “Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet.” J Biol Chem 289, no. 46 (November 14, 2014): 32327–38. https://doi.org/10.1074/jbc.M114.602458.Full Text Link to Item
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Sadhukhan, Sushabhan, Guo-Fang Zhang, and Gregory P. Tochtrop. “Modular isotopomer synthesis of γ-hydroxybutyric acid for a quantitative analysis of metabolic fates.” Acs Chem Biol 9, no. 8 (August 15, 2014): 1706–11. https://doi.org/10.1021/cb500380b.Full Text Link to Item
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Sadhukhan, Sushabhan, Yong Han, Zhicheng Jin, Gregory P. Tochtrop, and Guo-Fang Zhang. “Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver.” Free Radic Biol Med 70 (May 2014): 78–85. https://doi.org/10.1016/j.freeradbiomed.2014.02.008.Full Text Link to Item
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Li, Qingling, Shenghui Zhang, Jessica M. Berthiaume, Brigitte Simons, and Guo-Fang Zhang. “Novel approach in LC-MS/MS using MRM to generate a full profile of acyl-CoAs: discovery of acyl-dephospho-CoAs.” J Lipid Res 55, no. 3 (March 2014): 592–602. https://doi.org/10.1194/jlr.D045112.Full Text Link to Item
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Ibarra, R., J. E. Dazard, Y. Sandlers, F. Rehman, R. Abbas, R. Kombu, G. F. Zhang, H. Brunengraber, and J. Sanabria. “Metabolomic analysis of liver tissue from the vx2 rabbit model of secondary liver tumors.” Hpb Surgery 2014 (January 1, 2014). https://doi.org/10.1155/2014/310372.Full Text
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Gatbonton-Schwager, Tonibelle N., Sushabhan Sadhukhan, Guo-Fang Zhang, John J. Letterio, and Gregory P. Tochtrop. “Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal.” Redox Biol 2 (2014): 755–63. https://doi.org/10.1016/j.redox.2014.04.009.Full Text Link to Item
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Li, Qingling, Sushabhan Sadhukhan, Jessica M. Berthiaume, Rafael A. Ibarra, Hui Tang, Shuang Deng, Eric Hamilton, Laura E. Nagy, Gregory P. Tochtrop, and Guo-Fang Zhang. “4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart.” Free Radic Biol Med 58 (May 2013): 35–44. https://doi.org/10.1016/j.freeradbiomed.2013.01.005.Full Text Link to Item
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Harris, Stephanie R., Guo-Fang Zhang, Sushabhan Sadhukhan, Hua Wang, Chuan Shi, Michelle A. Puchowicz, Vernon E. Anderson, Robert G. Salomon, Gregory P. Tochtrop, and Henri Brunengraber. “Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.” Chem Res Toxicol 26, no. 2 (February 18, 2013): 213–20. https://doi.org/10.1021/tx3003643.Full Text Link to Item
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Li, Qingling, and Guo-Fang Zhang. “Identification of n-hydroxy acid metabolites in electron impact ionization mass spectrometry.” Rapid Commun Mass Spectrom 26, no. 11 (June 15, 2012): 1355–62. https://doi.org/10.1002/rcm.6233.Full Text Link to Item
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Zhang, Guo-Fang, Sushabhan Sadhukhan, Rafael A. Ibarra, Stephanie M. Lauden, Chia-Ying Chuang, Sophia Sushailo, Priya Chatterjee, Vernon E. Anderson, Gregory P. Tochtrop, and Henri Brunengraber. “Metabolism of γ-hydroxybutyrate in perfused rat livers.” Biochem J 444, no. 2 (June 1, 2012): 333–41. https://doi.org/10.1042/BJ20112046.Full Text Link to Item
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Li, Qingling, Kristyen Tomcik, Shenghui Zhang, Michelle A. Puchowicz, and Guo-Fang Zhang. “Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver.” Free Radic Biol Med 52, no. 6 (March 15, 2012): 1043–53. https://doi.org/10.1016/j.freeradbiomed.2011.12.022.Full Text Link to Item
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Andres Ibarra, R., R. Abbas, R. S. Kombu, G. F. Zhang, G. Jacobs, Z. Lee, H. Brunengraber, and J. R. Sanabria. “Disturbances in the glutathione/ophthalmate redox buffer system in the woodchuck model of hepatitis virus-induced hepatocellular carcinoma.” Hpb Surgery 2011 (November 25, 2011). https://doi.org/10.1155/2011/789323.Full Text
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Zhang, Guo-Fang, Sushabhan Sadhukhan, Gregory P. Tochtrop, and Henri Brunengraber. “Metabolomics, pathway regulation, and pathway discovery.” J Biol Chem 286, no. 27 (July 8, 2011): 23631–35. https://doi.org/10.1074/jbc.R110.171405.Full Text Link to Item
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Ogwang, Sam, Hoa T. Nguyen, Marissa Sherman, Saralee Bajaksouzian, Michael R. Jacobs, W Henry Boom, Guo-Fang Zhang, and Liem Nguyen. “Bacterial conversion of folinic acid is required for antifolate resistance.” J Biol Chem 286, no. 17 (April 29, 2011): 15377–90. https://doi.org/10.1074/jbc.M111.231076.Full Text Link to Item
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Tomcik, Kristyen, Rafael A. Ibarra, Sushabhan Sadhukhan, Yong Han, Gregory P. Tochtrop, and Guo-Fang Zhang. “Isotopomer enrichment assay for very short chain fatty acids and its metabolic applications.” Anal Biochem 410, no. 1 (March 1, 2011): 110–17. https://doi.org/10.1016/j.ab.2010.11.030.Full Text Link to Item
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Harris, Stephanie R., Guo-Fang Zhang, Sushabhan Sadhukhan, Anne M. Murphy, Kristyen A. Tomcik, Edwin J. Vazquez, Vernon E. Anderson, Gregory P. Tochtrop, and Henri Brunengraber. “Metabolism of levulinate in perfused rat livers and live rats: conversion to the drug of abuse 4-hydroxypentanoate.” J Biol Chem 286, no. 7 (February 18, 2011): 5895–5904. https://doi.org/10.1074/jbc.M110.196808.Full Text Link to Item
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Sadhukhan, Sushabhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P. Tochtrop. “Using isotopic tools to dissect and quantitate parallel metabolic pathways.” J Am Chem Soc 132, no. 18 (May 12, 2010): 6309–11. https://doi.org/10.1021/ja100399m.Full Text Link to Item
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Gu, Lei, Guo-Fang Zhang, Rajan S. Kombu, Frederick Allen, Gerd Kutz, Wolf-Ulrich Brewer, Charles R. Roe, and Henri Brunengraber. “Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. II. Effects on lipolysis, glucose production, and liver acyl-CoA profile.” Am J Physiol Endocrinol Metab 298, no. 2 (February 2010): E362–71. https://doi.org/10.1152/ajpendo.00384.2009.Full Text Link to Item
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Zhang, Guo-Fang, Rajan S. Kombu, Takhar Kasumov, Yong Han, Sushabhan Sadhukhan, Jianye Zhang, Lawrence M. Sayre, et al. “Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs.” J Biol Chem 284, no. 48 (November 27, 2009): 33521–34. https://doi.org/10.1074/jbc.M109.055665.Full Text Link to Item
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Deng, Shuang, Guo-Fang Zhang, Takhar Kasumov, Charles R. Roe, and Henri Brunengraber. “Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver.” J Biol Chem 284, no. 41 (October 9, 2009): 27799–807. https://doi.org/10.1074/jbc.M109.048744.Full Text Link to Item
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Kombu, Rajan S., Guo-Fang Zhang, Rime Abbas, John J. Mieyal, Vernon E. Anderson, Joanne K. Kelleher, Juan R. Sanabria, and Henri Brunengraber. “Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans.” Am J Physiol Endocrinol Metab 297, no. 1 (July 2009): E260–69. https://doi.org/10.1152/ajpendo.00080.2009.Full Text Link to Item
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Storozhenko, Sergei, Veerle De Brouwer, Maarten Volckaert, Oscar Navarrete, Dieter Blancquaert, Guo-Fang Zhang, Willy Lambert, and Dominique Van Der Straeten. “Folate fortification of rice by metabolic engineering.” Nat Biotechnol 25, no. 11 (November 2007): 1277–79. https://doi.org/10.1038/nbt1351.Full Text Link to Item
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Loizeau, Karen, Bernadette Gambonnet, Guo-Fang Zhang, Gilles Curien, Samuel Jabrin, Dominique Van Der Straeten, Willy E. Lambert, Fabrice Rébeillé, and Stéphane Ravanel. “Regulation of one-carbon metabolism in Arabidopsis: the N-terminal regulatory domain of cystathionine gamma-synthase is cleaved in response to folate starvation.” Plant Physiol 145, no. 2 (October 2007): 491–503. https://doi.org/10.1104/pp.107.105379.Full Text Link to Item
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Storozhenko, Sergei, Oscar Navarrete, Stéphane Ravanel, Veerle De Brouwer, Peter Chaerle, Guo-Fang Zhang, Olivier Bastien, Willy Lambert, Fabrice Rébeillé, and Dominique Van Der Straeten. “Cytosolic hydroxymethyldihydropterin pyrophosphokinase/dihydropteroate synthase from Arabidopsis thaliana: a specific role in early development and stress response.” J Biol Chem 282, no. 14 (April 6, 2007): 10749–61. https://doi.org/10.1074/jbc.M701158200.Full Text Link to Item
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De Brouwer, Veerle, Guo-Fang Zhang, Sergei Storozhenko, Dominique Van Der Straeten, and Willy E. Lambert. “pH stability of individual folates during critical sample preparation steps in prevision of the analysis of plant folates.” Phytochem Anal 18, no. 6 (2007): 496–508. https://doi.org/10.1002/pca.1006.Full Text Link to Item
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Zhang, Guo-Fang, Sergei Storozhenko, Dominique Van Der Straeten, and Willy E. Lambert. “Investigation of the extraction behavior of the main monoglutamate folates from spinach by liquid chromatography-electrospray ionization tandem mass spectrometry.” J Chromatogr A 1078, no. 1–2 (June 17, 2005): 59–66. https://doi.org/10.1016/j.chroma.2005.04.085.Full Text Link to Item
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Storozhenko, S., S. Ravanel, G. F. Zhang, F. Rébeillé, W. Lambert, and D. Van Der Straeten. “Folate enhancement in staple crops by metabolic engineering.” Trends in Food Science and Technology 16, no. 6–7 (January 1, 2005): 271–81. https://doi.org/10.1016/j.tifs.2005.03.007.Full Text
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Zhang, Guo-Fang, Kjell A. Mortier, Sergei Storozhenko, Jet Van De Steene, Dominique Van Der Straeten, and Willy E. Lambert. “Free and total para-aminobenzoic acid analysis in plants with high-performance liquid chromatography/tandem mass spectrometry.” Rapid Commun Mass Spectrom 19, no. 8 (2005): 963–69. https://doi.org/10.1002/rcm.1878.Full Text Link to Item
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Maudens, Kristof E., Guo-Fang Zhang, and Willy E. Lambert. “Quantitative analysis of twelve sulfonamides in honey after acidic hydrolysis by high-performance liquid chromatography with post-column derivatization and fluorescence detection.” J Chromatogr A 1047, no. 1 (August 20, 2004): 85–92. https://doi.org/10.1016/j.chroma.2004.07.007.Full Text Link to Item
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Mortier, Kjell A., Alain G. Verstraete, Guo-Fang Zhang, and Willy E. Lambert. “Enhanced method performance due to a shorter chromatographic run-time in a liquid chromatography-tandem mass spectrometry assay for paclitaxel.” J Chromatogr A 1041, no. 1–2 (July 2, 2004): 235–38. https://doi.org/10.1016/j.chroma.2004.04.026.Full Text Link to Item
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Mortier, Kjell A., Guo-Fang Zhang, Carlos H. van Peteghem, and Willy E. Lambert. “Adduct formation in quantitative bioanalysis: effect of ionization conditions on paclitaxel.” J Am Soc Mass Spectrom 15, no. 4 (April 2004): 585–92. https://doi.org/10.1016/j.jasms.2003.12.013.Full Text Link to Item
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Zhang, Guo-Fang, Kristof E. Maudens, Sergei Storozhenko, Kjell A. Mortier, Dominique Van Der Straeten, and Willy E. Lambert. “Determination of total folate in plant material by chemical conversion into para-aminobenzoic acid followed by high performance liquid chromatography combined with on-line postcolumn derivatization and fluorescence detection.” J Agric Food Chem 51, no. 27 (December 31, 2003): 7872–78. https://doi.org/10.1021/jf034808p.Full Text Link to Item
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Zhou, G. J., G. F. Zhang, and H. Y. Chen. “Development of integrated chemiluminescence flow sensor for the determination of adrenaline and isoprenaline.” Analytica Chimica Acta 463, no. 2 (July 22, 2002): 257–63. https://doi.org/10.1016/S0003-2670(02)00418-X.Full Text
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Zhang, G. F., and H. Y. Chen. “Studies of polyluminol modified electrode and its application in electrochemiluminescence analysis with flow system.” Analytica Chimica Acta 419, no. 1 (August 15, 2000): 25–31. https://doi.org/10.1016/S0003-2670(00)00983-1.Full Text
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Zhang, G. F., and H. Y. Chen. “Studies of micelle and trace non-polar organic solvent on a new chemiluminescence system and its application to flow injection analysis.” Analytica Chimica Acta 409, no. 1–2 (March 23, 2000): 75–81. https://doi.org/10.1016/S0003-2670(99)00856-9.Full Text
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Ye, L., G. F. Zhang, and H. Y. Chen. “Studies of the New Chemiluminescence System-NaIO4-H2O2-Trace Cyclohexane-Polyhydrophenols and Its Application.” Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities 21, no. 1 (January 10, 2000): 61.
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Zhang, G. F., and H. Y. Chen. “A sensitive photoinduced chemiluminescence method for the determination of riboflavin with flow injection analysis.” Analytical Letters 33, no. 15 (January 1, 2000): 3285–3302. https://doi.org/10.1080/00032719.2000.10399501.Full Text
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Zhang, G. F., and H. Y. Chen. “Chemiluminescence studies of the oxidation of ascorbic acid with copper(II) catalyzed by halide anions and its application to the determination of halide anions and ascorbic acid.” Analytical Sciences 16, no. 12 (January 1, 2000): 1317–21. https://doi.org/10.2116/analsci.16.1317.Full Text
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Feng, M., G. Zhang, and Z. Zhang. “FIA determination of pyruvate in serum based on direct chemiluminescence oxidation.” Fresenius’ Journal of Analytical Chemistry 363, no. 3 (January 1, 1999): 320–22. https://doi.org/10.1007/s002160051197.Full Text
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Feng, M., G. Zhang, and Z. Zhang. “Chemiluminescence method for cinchona alkaloids.” Analytical Letters 31, no. 14 (January 1, 1998): 2537–48. https://doi.org/10.1080/00032719808005323.Full Text
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Conference Papers
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Russell, Matthew, Christopher Newgard, Guofang Zhang, Arianna Nitzel, Michael Hamill, and Karim Azer. “LIVRQNac increases fatty acid oxidization in a primary human hepatocyte model of non-alcoholic steatohepatitis.” In Journal of Hepatology, 77:S718–S718, 2022.Link to Item
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Zhang, Hongyuan, Vijitha Puviindran, Puviindran Nadesan, Hidetoshi Tsushima, Yuning Tang, Leyao Shen, Guofang Zhang, Courtney Karner, and Benjamin Alman. “Glutamine Metabolism in Cartilage Tumors.” In Journal of Bone and Mineral Research, 35:106–106, 2020.Link to Item
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Wilson, Kirkland, Jeremy Hess, Guofang Zhang, Henri Brunengraber, and Gregory Tochtrop. “Metabolism of Beta-Alanine in Rat Liver: Degradation to Acetyl-CoA and Carboxylation to 2-(aminomethyl)-malonate.” In Faseb Journal, Vol. 31. FEDERATION AMER SOC EXP BIOL, 2017.Link to Item
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Fan, X., G. Zhang, and C. Zhu. “Synthesis of 2-[2-(5-methylbenzothiazolyl)azo]-5-dimethylaminobenzoic acid and its application to the spectrophotometric determination of nickel.” In Analyst, 123:109–12, 1998. https://doi.org/10.1039/a705268e.Full Text
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