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Guofang Zhang

Associate Professor in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
DUMC Box 104775, Durham, NC 27710
300 North Duke Street, Durham, NC 27701

Current Appointments & Affiliations


Associate Professor in Medicine · 2023 - Present Medicine, Endocrinology, Metabolism, and Nutrition, Medicine
Member of Duke Molecular Physiology Institute · 2015 - Present Duke Molecular Physiology Institute, Institutes and Centers

Recent Publications


Metabolic flux analysis in hiPSC-CMs reveals insights into cardiac dysfunction in propionic acidemia.

Journal Article Cell Mol Life Sci · April 2, 2025 Propionic acidemia is an inborn error of metabolism caused by mutations in either the PCCA or PCCB genes. Patients with propionic acidemia experience a range of complications, including life-threatening cardiac dysfunctions. However, the pathological mecha ... Full text Link to item Cite

Effect of in utero metformin exposure in gestational diabetes mellitus on infant mesenchymal stem cell metabolism.

Journal Article Am J Physiol Endocrinol Metab · April 1, 2025 Offspring exposed to metformin treatment for gestational diabetes mellitus (GDM) experience altered growth patterns that increase the risk for developing cardiometabolic diseases later in life. The adaptive cellular mechanisms underlying these patterns rem ... Full text Link to item Cite

Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism.

Journal Article Cell Rep · February 25, 2025 The transcription factor carbohydrate response element binding protein (ChREBP) activates genes of glucose, fructose, and lipid metabolism in response to carbohydrate feeding. Integrated transcriptomic and metabolomic analyses in rats with GalNac-siRNA-med ... Full text Link to item Cite
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Recent Grants


Mechanisms of lipid-induced bioenergetic stress in muscle

ResearchCo Investigator · Awarded by National Institutes of Health · 2010 - 2028

Mechanisms linking the Branched-Chain alpha-Keto Acid regulatory network to the pathogenesis of NASH

ResearchCo Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2023 - 2028

Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027

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Education, Training & Certifications


Vrije Universiteit Brussel (Belgium) · 2004 M.S.
Nanjing University (China) · 2001 Ph.D.