Current Appointments & Affiliations
Associate Professor in Medicine
·
2023 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Member of Duke Molecular Physiology Institute
·
2015 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Glucagon promotes net hepatic glycogen repletion following meal ingestion.
Journal Article JCI Insight · April 22, 2026 Insulin and glucagon are described as having opposing actions on hepatic glycogen metabolism. However, here we showed that their coordinated action promoted glycogen turnover and meal glucose storage. In mice, pharmacological doses of insulin or glucagon f ... Full text Link to item CiteGeneration of an isogenic human induced pluripotent stem cell line with a mutant propionyl-CoA carboxylase α subunit.
Journal Article Orphanet J Rare Dis · January 23, 2026 BACKGROUND: Propionic acidemia (PA) is a rare autosomal recessive metabolic disorder caused by defects in propionyl-CoA carboxylase (PCC), a mitochondrial enzyme composed of six alpha (PCCA) and six beta (PCCB) subunits. Mutations in PCCA/PCCB genes disrup ... Full text Link to item CiteCoenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductase.
Journal Article J Clin Invest · October 1, 2025 The cystine-xCT transporter/glutathione/GPX4 axis is the canonical pathway protecting cells from ferroptosis. Whereas GPX4-targeting ferroptosis-inducing compounds (FINs) act independently of mitochondria, xCT-targeting FINs require mitochondrial lipid per ... Full text Link to item CiteRecent Grants
Metabolic Actions of Glucagon
ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2030The role of branched-chain hydroxy acids in interorgan metabolic homeostasis
FellowshipCo-Mentor · Awarded by American Diabetes Association · 2026 - 2028Mechanisms of lipid-induced bioenergetic stress in muscle
ResearchCo Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2010 - 2028View All Grants
Education
Vrije Universiteit Brussel (Belgium) ·
2004
M.S.
Nanjing University (China) ·
2001
Ph.D.