Current Appointments & Affiliations
Associate Professor in Medicine
·
2023 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Member of Duke Molecular Physiology Institute
·
2015 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Metabolic flux analysis in hiPSC-CMs reveals insights into cardiac dysfunction in propionic acidemia.
Journal Article Cell Mol Life Sci · April 2, 2025 Propionic acidemia is an inborn error of metabolism caused by mutations in either the PCCA or PCCB genes. Patients with propionic acidemia experience a range of complications, including life-threatening cardiac dysfunctions. However, the pathological mecha ... Full text Link to item CiteEffect of in utero metformin exposure in gestational diabetes mellitus on infant mesenchymal stem cell metabolism.
Journal Article Am J Physiol Endocrinol Metab · April 1, 2025 Offspring exposed to metformin treatment for gestational diabetes mellitus (GDM) experience altered growth patterns that increase the risk for developing cardiometabolic diseases later in life. The adaptive cellular mechanisms underlying these patterns rem ... Full text Link to item CiteIntegration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism.
Journal Article Cell Rep · February 25, 2025 The transcription factor carbohydrate response element binding protein (ChREBP) activates genes of glucose, fructose, and lipid metabolism in response to carbohydrate feeding. Integrated transcriptomic and metabolomic analyses in rats with GalNac-siRNA-med ... Full text Link to item CiteRecent Grants
Mechanisms of lipid-induced bioenergetic stress in muscle
ResearchCo Investigator · Awarded by National Institutes of Health · 2010 - 2028Mechanisms linking the Branched-Chain alpha-Keto Acid regulatory network to the pathogenesis of NASH
ResearchCo Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2023 - 2028Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction
ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027View All Grants
Education, Training & Certifications
Vrije Universiteit Brussel (Belgium) ·
2004
M.S.
Nanjing University (China) ·
2001
Ph.D.