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Guofang Zhang
Associate Professor in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
guofang.zhang@duke.edu
DUMC Box 104775, Durham, NC 27710
300 North Duke Street, Durham, NC 27701
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AT A GLANCE
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Credentials
Education
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Academic Experience
Current Appointments & Affiliations
Previous Appointments & Affiliations
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Expertise
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Research
Selected Grants
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Publications
Selected Publications
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Artistic Works / Events
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Teaching
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Advising & Mentoring
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Recognition
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Professional Activities
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Selected Grants
Mechanisms of lipid-induced bioenergetic stress in muscle
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2010 - 2028
Mechanisms linking the Branched-Chain alpha-Keto Acid regulatory network to the pathogenesis of NASH
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2023 - 2028
Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2022 - 2027
Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience
Research
Investigator ·
Awarded by National Institute of Diabetes and Digestive and Kidney Diseases ·
2022 - 2027
Engineered Glucose Metabolism in Insulin Secreting Cells
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2002 - 2026
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Mechanisms of lipid-induced bioenergetic stress in muscle
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2010 - 2028
Mechanisms linking the Branched-Chain alpha-Keto Acid regulatory network to the pathogenesis of NASH
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2023 - 2028
Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2022 - 2027
Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience
Research
Investigator ·
Awarded by National Institute of Diabetes and Digestive and Kidney Diseases ·
2022 - 2027
Engineered Glucose Metabolism in Insulin Secreting Cells
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2002 - 2026
NRF2-ACSS2 Axis in Alcohol-associated Metabolic Reprogramming and Esophageal Pathology
Research
Principal Investigator ·
Awarded by Coriell Institute for Medical Research ·
2023 - 2025
Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing Heart
Research
Co Investigator ·
Awarded by University of Pennsylvania ·
2021 - 2025
Role of Muscle Ketone Metabolism in Mediating the Metabolic Benefits of Weight Loss
Research
Collaborator ·
Awarded by National Institutes of Health ·
2020 - 2025
Propionyl-CoA and propionylcarnitine mediate cardiac complications in patients with propionic acidemia
Research
Principal Investigator ·
Awarded by Propionic Acidemia Foundation ·
2020 - 2024
NCDRC P&F
Research
Principal Investigator ·
Awarded by Wake Forest University Health Sciences ·
2023 - 2024
Glucagon and insulin act cooperatively in the regulation of prandial hepatic glycogen metabolism
Research
Co-Mentor ·
Awarded by National Institutes of Health ·
2021 - 2023
NCDRC P&F April 2022
Research
Collaborator ·
Awarded by Wake Forest University ·
2021 - 2023
Developing a clinical diagnostic tool for age-related cochlear synaptopathy
Research
Principal Investigator ·
Awarded by Gateway Biotechnology, Inc. ·
2023 - 2023
Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic disease
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2019 - 2023
Validation of a novel mass spectrometry-based method for measurement of muscle glucose uptake in mice
Research
Senior Research Scientist ·
Awarded by Augusta University ·
2020 - 2022
The Role of ChREBP in Fructose Induced Metabolic Disease
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2014 - 2022
Core Laboratory - Flux analysis of lipid oxidation
Research
Co-Principal Investigator ·
Awarded by Axcella Health ·
2020 - 2021
Organic Cations and Mitochondrial Efficiency
Research
Statistician ·
Awarded by East Carolina University ·
2016 - 2021
The role of proline metabolism during osteoblast differentiation and bone formation
Research
Co Investigator ·
Awarded by University of Texas Southwestern Medical Center ·
2021 - 2021
Role of Glutamine Metabolism during Osteoblast Differentiation and Bone Formation
Research
Investigator ·
Awarded by University of Texas Southwestern Medical Center ·
2021 - 2021
The role of proline metabolism during osteoblast differentiation and bone formation
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2020 - 2020
Role of Glutaminase activity during bone formation
Research
Investigator ·
Awarded by National Institutes of Health ·
2018 - 2020
13C-Metabolic Flux Analysis for Understanding Cardiac Energy Homeostasis
Fellowship
Collaborator ·
Awarded by National Institutes of Health ·
2017 - 2019
Validation of a Novel Mass Spectrometry-based Method for Muscle Glucose Flux Analysis in Mice
Research
Senior Research Scientist ·
Awarded by Augusta University ·
2018 - 2019
Manipulation of BCAA Metabolism for Therapy of Diabetes and its Co-morbidities
Research
Investigator ·
Awarded by Eli Lilly and Company ·
2017 - 2018
Organic Cations and Mitochondrial Efficiency
Research
Senior Research Scientist ·
Awarded by East Carolina University ·
2016 - 2018
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