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Guofang Zhang

Associate Professor in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
DUMC Box 104775, Durham, NC 27710
300 North Duke Street, Durham, NC 27701

Selected Grants


Mechanisms linking the Branched-Chain alpha-Keto Acid regulatory network to the pathogenesis of NASH

ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2028

Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027

Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience

ResearchInvestigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2022 - 2027

Engineered Glucose Metabolism in Insulin Secreting Cells

ResearchCo Investigator · Awarded by National Institutes of Health · 2002 - 2026

NRF2-ACSS2 Axis in Alcohol-associated Metabolic Reprogramming and Esophageal Pathology

ResearchPrincipal Investigator · Awarded by Coriell Institute for Medical Research · 2023 - 2025

Mechanisms linking the Branched-Chain alpha-Keto Acid regulatory network to the pathogenesis of NASH

ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2028

Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027

Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience

ResearchInvestigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2022 - 2027

Engineered Glucose Metabolism in Insulin Secreting Cells

ResearchCo Investigator · Awarded by National Institutes of Health · 2002 - 2026

NRF2-ACSS2 Axis in Alcohol-associated Metabolic Reprogramming and Esophageal Pathology

ResearchPrincipal Investigator · Awarded by Coriell Institute for Medical Research · 2023 - 2025

Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing Heart

ResearchCo Investigator · Awarded by University of Pennsylvania · 2021 - 2025

Role of Muscle Ketone Metabolism in Mediating the Metabolic Benefits of Weight Loss

ResearchCollaborator · Awarded by National Institutes of Health · 2020 - 2025

Propionyl-CoA and propionylcarnitine mediate cardiac complications in patients with propionic acidemia

ResearchPrincipal Investigator · Awarded by Propionic Acidemia Foundation · 2020 - 2024

NCDRC P&F

ResearchPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2023 - 2024

The Role of ChREBP in Fructose Induced Metabolic Disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2024

Glucagon and insulin act cooperatively in the regulation of prandial hepatic glycogen metabolism

ResearchCo-Mentor · Awarded by National Institutes of Health · 2021 - 2023

NCDRC P&F April 2022

ResearchCollaborator · Awarded by Wake Forest University · 2021 - 2023

Developing a clinical diagnostic tool for age-related cochlear synaptopathy

ResearchPrincipal Investigator · Awarded by Gateway Biotechnology, Inc. · 2023 - 2023

Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2023

Mechanisms of lipid-induced bioenergetic stress in muscle

ResearchCo Investigator · Awarded by National Institutes of Health · 2010 - 2023

Validation of a novel mass spectrometry-based method for measurement of muscle glucose uptake in mice

ResearchSenior Research Scientist · Awarded by Augusta University · 2020 - 2022

Core Laboratory - Flux analysis of lipid oxidation

ResearchCo-Principal Investigator · Awarded by Axcella Health · 2020 - 2021

Organic Cations and Mitochondrial Efficiency

ResearchStatistician · Awarded by East Carolina University · 2016 - 2021

The role of proline metabolism during osteoblast differentiation and bone formation

ResearchCo Investigator · Awarded by University of Texas Southwestern Medical Center · 2021 - 2021

Role of Glutamine Metabolism during Osteoblast Differentiation and Bone Formation

ResearchInvestigator · Awarded by University of Texas Southwestern Medical Center · 2021 - 2021

The role of proline metabolism during osteoblast differentiation and bone formation

ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2020

Role of Glutaminase activity during bone formation

ResearchInvestigator · Awarded by National Institutes of Health · 2018 - 2020

13C-Metabolic Flux Analysis for Understanding Cardiac Energy Homeostasis

FellowshipCollaborator · Awarded by National Institutes of Health · 2017 - 2019

Validation of a Novel Mass Spectrometry-based Method for Muscle Glucose Flux Analysis in Mice

ResearchSenior Research Scientist · Awarded by Augusta University · 2018 - 2019

Manipulation of BCAA Metabolism for Therapy of Diabetes and its Co-morbidities

ResearchInvestigator · Awarded by Eli Lilly and Company · 2017 - 2018

Organic Cations and Mitochondrial Efficiency

ResearchSenior Research Scientist · Awarded by East Carolina University · 2016 - 2018