Scholars@Duke
John David Hamilton

John David Hamilton

Professor Emeritus of Medicine
Medicine, Infectious Diseases
hamil008@mc.duke.edu
Duke Box 102359, Durham, NC 27710
Division of Infectious Diseases, Room 185 Hanes House, Durham, NC 27710

Selected Publications

A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection.

Journal Article J Immunol · June 1, 2005 The importance of lymphotoxin (LT) betaR (LTbetaR) as a regulator of lymphoid organogenesis is well established, but its role in host defense has yet to be fully defined. In this study, we report that mice deficient in LTbetaR signaling were highly suscept ... Full text Link to item Cite

Nasal peptide vaccination elicits CD8 responses and reduces viral burden after challenge with virulent murine cytomegalovirus.

Journal Article Microbiol Immunol · 2005 Infection of BALB/c mice with murine cytomegalovirus (MCMV) leads to CD8 cell responses to an immunodominant epitope YPHFMPTNL. We presented this epitope as a nasal peptide vaccine in combination with cholera toxin adjuvant, and evaluated immune responses ... Full text Link to item Cite

Active or prior GB virus C infection does not protect against vertical transmission of HIV in coinfected women from Tanzania.

Journal Article Clin Infect Dis · March 15, 2004 To determine whether GB virus C (GBV-C) infection is associated with protection against vertical transmission of human immunodeficiency virus (HIV), we tested 186 HIV-positive pregnant women for GBV-C. Neither active nor prior GBV-C infection was associate ... Full text Link to item Cite

HIV-associated morbidity, mortality and diagnostic testing opportunities among inpatients at a referral hospital in northern Tanzania.

Journal Article Ann Trop Med Parasitol · March 2004 Hospitalized patients with HIV infection are among the most likely to benefit from the expanding availability of anti-retroviral therapy in sub-Saharan Africa. Between 1990 and 2000, 3667 people known to be HIV-infected were admitted to Kilimanjaro Christi ... Full text Link to item Cite

Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta.

Journal Article J Exp Med · April 7, 2003 Differentiation of dendritic cells (DCs) into particular subsets may act to shape innate and adaptive immune responses, but little is known about how this occurs during infections. Plasmacytoid dendritic cells (PDCs) are major producers of interferon (IFN) ... Full text Link to item Cite

Economic analysis of influenza vaccination and antiviral treatment for healthy working adults.

Journal Article Ann Intern Med · August 20, 2002 BACKGROUND: Physicians have several treatment options for influenza, including vaccination and various antiviral therapies. However, the optimal influenza prevention and treatment strategy is unknown. OBJECTIVE: To compare the relative health values of con ... Full text Link to item Cite

Role of clinical microbiology laboratories in the management and control of infectious diseases and the delivery of health care.

Journal Article Clin Infect Dis · February 15, 2001 Modern medicine has led to dramatic changes in infectious diseases practice. Vaccination and antibiotic therapy have benefited millions of persons. However, constrained resources now threaten our ability to adequately manage threats of infectious diseases ... Full text Link to item Cite

Enhanced green fluorescent protein as a marker for localizing murine cytomegalovirus in acute and latent infection.

Journal Article J Virol Methods · September 2000 A recombinant murine cytomegalovirus (mCMV) that expresses enhanced green fluorescent protein (EGFP) under control of the native immediate-early 1/3 promoter was constructed to detect directly sites of viral activity in latent and reactivated infections. T ... Full text Link to item Cite

Outcome at 6 months for 50 adolescents with major depression treated in a health maintenance organization.

Journal Article J Am Acad Child Adolesc Psychiatry · November 1999 OBJECTIVE: To examine the short-term outcome of adolescents with major depressive disorder treated in a health maintenance organization (HMO) setting. METHOD: Fifty consecutive adolescents meeting DSM-IV criteria for major depressive disorder at intake to ... Full text Link to item Cite

An analysis of the causes of adverse events from the Quality in Australian Health Care Study.

Journal Article Med J Aust · May 3, 1999 OBJECTIVE: To examine the causes of adverse events (AEs) resulting from healthcare to assist in developing strategies to minimise preventable patient injury. DESIGN: Descriptions of the 2353 AEs previously reported by the Quality in Australian Health Care ... Full text Link to item Cite

Persistence of combat-related posttraumatic stress symptoms for 75 years.

Journal Article J Trauma Stress · October 1998 Investigations of the duration of combat-related posttraumatic stress symptoms have focused mainly on survivors of World War II and the Vietnam War, with little attention to surviving veterans of World War I. The authors describe a case in which posttrauma ... Full text Link to item Cite

Race and stress in the incidence of herpes zoster in older adults.

Journal Article J Am Geriatr Soc · August 1998 OBJECTIVES: To examine the effect of black race and acute (negative life events) and chronic (lack of social support) psychological stress on the risk of herpes zoster in late life. DESIGN: A population-based, prospective cohort study. SETTING: Central Nor ... Full text Link to item Cite

A deanship at Newcastle.

Journal Article Med J Aust · January 5, 1998 Full text Link to item Cite

Resolution of fear of flying with fluoxetine treatment.

Journal Article J Anxiety Disord · 1998 Fear of flying is a common specific phobia usually treated with behavior therapy; the possibility of pharmacologic treatment has received very little study. The authors report two cases in which successful fluoxetine treatment of major depressive disorder ... Full text Link to item Cite

Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure. VA Cooperative Study Group on AIDS.

Journal Article Ann Intern Med · June 15, 1997 BACKGROUND: Markers are needed for assessing response to antiretroviral therapy over time. The CD4+ lymphocyte count is one such surrogate, but it is relatively weak. OBJECTIVE: To assess the association of changes in plasma human immunodeficiency virus (H ... Full text Link to item Cite

Outcome of psychiatric hospitalization for very low-functioning demented patients.

Journal Article J Geriatr Psychiatry Neurol · April 1997 The authors determined the outcome of geropsychiatric hospitalization for 73 very low-functioning demented patients (GAF score < 21). General psychiatric symptoms, depression, and agitation decreased significantly, and mean GAF scores increased significant ... Full text Link to item Cite

Why elderly veterans choose VA services.

Journal Article Psychiatr Serv · January 1997 Full text Link to item Cite

Hepatitis C.

Journal Article Ann Intern Med · October 15, 1996 OBJECTIVES: To review the virology, epidemiology, pathogenesis, natural history, clinical manifestations, and current treatment of hepatitis C virus (HCV) infection. DATA SOURCES: The MEDLINE database (1966 to 1996) was searched for English-language articl ... Full text Link to item Cite

Aquatic risk assessment of a polycarboxylate dispersant polymer used in laundry detergents.

Journal Article J Toxicol Environ Health · September 1996 Polycarboxylates enhance detergent soil removal properties and prevent encrustation of calcium salts on fabrics during washing. Laundry wastewater typically reaches wastewater treatment plants, which then discharge into aquatic environments. The yearly ave ... Full text Link to item Cite

Quality in Australian Health Care Study.

Journal Article Med J Aust · June 17, 1996 Full text Link to item Cite

Cytomegalovirus infection following liver transplantation: review of the literature.

Journal Article Clin Infect Dis · March 1996 Cytomegalovirus (CMV) remains a major cause of problems following solid organ transplantation, accounting for a significant increase in morbidity and affiliated costs. Infection with CMV following orthotopic liver transplantation (OLT) is commonly seen as ... Full text Link to item Cite

Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. Veterans Affairs Cooperative Study Group on AIDS.

Journal Article N Engl J Med · February 15, 1996 BACKGROUND: Clinical trials of antiretroviral drugs can take years to complete because the outcomes measured are progression to the acquired immunodeficiency syndrome (AIDS) or death. Trials could be accelerated by the use of end points such as changes in ... Full text Link to item Cite

Long-term follow-up of symptomatic HIV-infected patients originally randomized to early versus later zidovudine treatment; report of a Veterans Affairs Cooperative Study. VA Cooperative Study Group on AIDS Treatment.

Journal Article J Acquir Immune Defic Syndr Hum Retrovirol · February 1, 1996 Following a 4-year controlled trial comparing early and later zidovudine treatment, we conducted an additional 3-year follow-up. Of the original 338 patients, 275 participated. Clinical outcome measures were AIDS and death. In the early therapy group (n = ... Full text Link to item Cite

Review of international criteria and mixture rules for health hazard classification.

Journal Article Regul Toxicol Pharmacol · December 1995 The presentation of consistent hazard information in the face of conflicting inter- and intranational regulations and standards is a formidable task. The principal challenge arises from the varying definitions of what is and is not a hazardous chemical and ... Full text Link to item Cite

The Quality in Australian Health Care Study.

Journal Article Med J Aust · November 6, 1995 A review of the medical records of over 14,000 admissions to 28 hospitals in New South Wales and South Australia revealed that 16.6% of these admissions were associated with an "adverse event", which resulted in disability or a longer hospital stay for the ... Full text Link to item Cite

Mouse cytomegalovirus reactivation in severe combined immune deficient mice after implantation of latently infected salivary gland.

Journal Article J Infect Dis · August 1995 The hypothesis that replication-competent mouse cytomegalovirus (MCMV) is detectable in severe combined immunodeficient (scid) mice after implantation of latently infected tissue was examined. Sections of latently infected salivary gland from 5 BALB/c mice ... Full text Link to item Cite

Expression of a murine cytomegalovirus early-late protein in "latently" infected mice.

Journal Article J Infect Dis · August 1995 Monoclonal antibodies were isolated from the spleen of a latently infected mouse to identify possible antigenic markers for latent murine cytomegalovirus infection. One antibody, AM3, was selected for further study. Characterization of the antigen recogniz ... Full text Link to item Cite

Influence of lead on mineralization during bone growth.

Journal Article Fundam Appl Toxicol · July 1995 Lead will inhibit skeletal development and localize in areas of bone formation and resorption, but the mechanisms of lead toxicity in bone are largely unknown. This study used an ectopic bone (plaque) induction method to investigate the effect of lead on m ... Full text Link to item Cite

Establishing standards and measurement methods for medical education.

Journal Article Acad Med · July 1995 This paper focuses largely on describing the accreditation system recently instituted for medical schools in Australia. Features of the system include evaluation of medical schools in terms of their own objectives and emphasis on the accreditation process ... Full text Link to item Cite

External examiners.

Journal Article Lancet · April 29, 1995 Full text Link to item Cite

Racial differences in the occurrence of herpes zoster.

Journal Article J Infect Dis · March 1995 The purpose of this study was to determine if there are racial differences in the occurrence of herpes zoster (shingles). The study population was the Duke Established Populations for Epidemiologic Studies of the Elderly, a probability sample of community- ... Full text Link to item Cite

The accuracy of self-report of herpes zoster.

Journal Article J Clin Epidemiol · November 1994 The accuracy of self-report of herpes zoster was investigated in the Duke Established Populations for Epidemiological Studies of the Elderly, a longitudinal study of 4162 community-dwelling elderly persons residing in North Carolina, 1986-1993. The authors ... Full text Link to item Cite

Effects of lead exposure on skeletal development in rats.

Journal Article Fundam Appl Toxicol · May 1994 The effects of lead on growth in female rats and on growth and skeletal development in their offspring were investigated. No alteration in growth rate, compared to the growth rate in pair-fed controls, was observed in 48 weanling females continuously expos ... Full text Link to item Cite

Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression. Department of Veterans Affairs Cooperative Study Group.

Journal Article J Infect Dis · April 1994 Delayed-type hypersensitivity (DTH) testing was evaluated as a predictor of human immunodeficiency virus (HIV) disease progression in 336 symptomatic patients with baseline CD4 cell counts of 200-500/mm3 who were participating in a randomized trial of earl ... Full text Link to item Cite

Structural equation modeling and nested ANOVA: effects of lead exposure on maternal and fetal growth in rats.

Journal Article Environ Res · January 1994 This study provided an assessment of the effects of lead on early growth in rats based on structural equation modeling and nested analysis of variance (ANOVA). Structural equation modeling showed that lead in drinking water (250, 500, or 1000 ppm) had a di ... Full text Link to item Cite

Cost effectiveness analysis of early zidovudine treatment of HIV infected patients.

Journal Article BMJ · November 20, 1993 OBJECTIVE--To compare cost effectiveness of early and later treatment with zidovudine for patients infected with HIV. DESIGN--Markov chain analysis of cost effectiveness based on results of use of health care and efficacy from a trial of zidovudine treatme ... Full text Link to item Cite

Hepatitis B vaccination and booster in predialysis patients: a 4-year analysis.

Journal Article Vaccine · September 1993 Patients undergoing chronic haemodialysis are at increased risk for infection with hepatitis B virus (HBV), but response to currently available vaccines is suboptimal. We undertook a 4-year prospective study of the efficacy of hepatitis B vaccine in patien ... Full text Link to item Cite

Evaluation of a saliva alcohol test stick as a therapeutic adjunct in an alcoholism treatment program.

Journal Article J Stud Alcohol · September 1993 This study was designed to evaluate the clinical usefulness of a saliva alcohol dipstick by comparing dipstick saliva alcohol concentrations to simultaneous blood and urine alcohol concentrations. The sample consisted of 211 saliva tests and blood alcohol ... Full text Link to item Cite

Zidovudine resistance, syncytium-inducing phenotype, and HIV disease progression in a case-control study. The VA Cooperative Study Group.

Journal Article J Acquir Immune Defic Syndr (1988) · August 1993 A case-control study of patients with progressive (cases) or nonprogressive (controls) disease was designed to determine the association among disease progression, zidovudine sensitivity, and syncytium-inducing phenotype. Viral isolates were screened for s ... Link to item Cite

A cost-effectiveness analysis of hepatitis B vaccine in predialysis patients.

Journal Article Health Serv Res · April 1993 OBJECTIVE: Our objective was to assess the cost effectiveness of hepatitis B vaccine in predialysis patients. DATA SOURCES: Costs were calculated from estimated rates of health services use and unit costs of resource use. Efficacy data were based on probab ... Link to item Cite

Detection of murine cytomegalovirus immediate early 1 transcripts in the spleens of latently infected mice.

Journal Article J Infect Dis · April 1993 The spleens of mice latently infected with murine cytomegalovirus were examined by reverse transcription followed by the polymerase chain reaction to assay for transcriptional activity of the viral immediate early 1 gene. Transcripts were detected in 6 of ... Full text Link to item Cite

Ethical dilemmas in continuing a zidovudine trial after early termination of similar trials.

Journal Article Control Clin Trials · February 1993 Ethical dilemmas caused by external events and an interim subset analysis raised concerns about continuing a long-term VA clinical trial comparing early with later zidovudine therapy for symptomatic human immunodeficiency virus (HIV) infection. The first e ... Full text Link to item Cite

Quality assessment and improvement in group psychotherapy.

Journal Article Am J Psychiatry · February 1993 OBJECTIVE: The authors sought a practical means of monitoring and evaluating group psychotherapy, using existing clinical resources, for purposes of quality improvement and education on a large general hospital psychiatric service. METHOD: Monitoring indic ... Full text Link to item Cite

Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia.

Journal Article Schizophr Res · January 1993 There is growing evidence that some genetic predisposition is important in the etiology of schizophrenia. We have sought to implicate a major gene by performing a candidate gene association study comparing the allele frequencies of seven restriction fragme ... Full text Link to item Cite

Aging and reactivation of latent murine cytomegalovirus.

Journal Article J Infect Dis · December 1992 BALB/c mice were experimentally infected with murine cytomegalovirus (MCMV) to discover whether latent MCMV persisted in aging mice and to examine the effect of aging on MCMV reactivation. Latently infected mice received saline, cyclophosphamide, or alloge ... Full text Link to item Cite

Early zidovudine and survival in HIV infection.

Journal Article N Engl J Med · September 10, 1992 Full text Link to item Cite

Late treatment of HIV infection--is it better?

Journal Article Infect Agents Dis · June 1992 Link to item Cite

A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection. Results of the Veterans Affairs Cooperative Study.

Journal Article N Engl J Med · February 13, 1992 BACKGROUND: Zidovudine is recommended for asymptomatic and early symptomatic human immunodeficiency virus (HIV) infection. The best time to initiate zidovudine treatment remains uncertain, however, and whether early treatment improves survival has not been ... Full text Link to item Cite

Murine cytomegalovirus gene amplification and culture after submaxillary salivary gland biopsy.

Journal Article Lab Anim Sci · October 1991 An important target tissue for murine cytomegalovirus (CMV) infection is the submaxillary salivary gland. Submaxillary salivary gland biopsy specimens from BALB/c mice latently infected with murine CMV were examined for murine CMV DNA by in vitro enzymatic ... Link to item Cite

The accreditation of undergraduate medical education in Australia.

Journal Article Med J Aust · November 5, 1990 The Australian Medical Council was established in 1985 with one of its three functions being the accreditation of medical schools and of courses leading to basic medical qualifications. The Accreditation (Standing) Committee has developed guidelines for as ... Full text Link to item Cite

Persistence of antibody in healthcare workers vaccinated against hepatitis B.

Journal Article Infect Control Hosp Epidemiol · October 1990 A cross-sectional serological survey was undertaken in 82 randomly selected high-risk healthcare workers previously vaccinated with the hepatitis B vaccine. The study design allowed for the identification and testing for hepatitis B surface antibody in equ ... Full text Link to item Cite

Amplification of HIV-1 provirus from cerebrospinal fluid and its correlation with neurologic disease.

Journal Article J Infect Dis · June 1990 The polymerase chain reaction (PCR) was used to detect human immunodeficiency virus type 1 (HIV-1) proviral sequences (gag and env) in nucleated cells from the cerebrospinal fluid (CSF) of 31 HIV-1-positive patients, and the results were compared with clin ... Full text Link to item Cite

Detection of mouse cytomegalovirus nucleic acid in latently infected mice by in vitro enzymatic amplification.

Journal Article J Infect Dis · February 1990 Transmission of human and murine cytomegalovirus (CMV) with transfusions and organ transplantation suggests that the latent virus is located in multiple organs and perhaps multiple cell types. The direct identification and localization of the latent virus ... Full text Link to item Cite

Withholding medical treatment from the severely demented patient. Decisional processes and cost implications.

Journal Article Arch Intern Med · September 1988 We performed an observational study to determine the prevalence of severe dementia in a general medicine unit, the categories of acute medical care provided to these patients, the process by which treatment decisions are made, and their cost implications. ... Link to item Cite

Medical education in China for the 21st century: the context for change.

Journal Article Med Educ · July 1988 A national conference on Medical Education in China for the 21st Century was convened in Beijing in November 1986. Over 6 days, leading medical educators and Ministry of Public Health officials from across China presented China's future health service need ... Full text Link to item Cite

Determinants of the source of cytomegalovirus in murine renal allograft recipients.

Journal Article Transplantation · November 1987 Cytomegalovirus is present in a latent state in renal allografts and may be reactivated in recipients. While human and murine strains are alike in that a primary infection occurs in seronegative recipients of a kidney from a seropositive donor, they may di ... Full text Link to item Cite

Cytomegalovirus pneumonia.

Journal Article Semin Respir Infect · June 1987 Cytomegalovirus (CMV) is a common virus that asymptomatically infects the majority of the population by early adulthood. After initial infection, the virus remains in a latent state in the host and can be reactivated under a variety of conditions. In contr ... Link to item Cite

Posttraumatic stress disorder in World War II naval veterans.

Journal Article Hosp Community Psychiatry · February 1987 Full text Link to item Cite

Yersinia enterocolitica inguinal lymphadenitis.

Journal Article Diagn Microbiol Infect Dis · September 1986 Inguinal lymphadenitis is associated with a well-defined group of etiologic agents including many sexually transmitted diseases and nonvenereal agents including Yersinia pestis (bubonic plague). We report herein the first case of a second Yersinia species- ... Full text Link to item Cite

The manipulative patient.

Journal Article Am J Psychother · April 1986 "Manipulative" is a popular but often misused description of behavior seen in some patients who come to psychiatric attention. The authors suggest a definition of "manipulation" which can impart helpful information about symptoms, diagnosis, and treatment. ... Full text Link to item Cite

Reactivation of latent murine cytomegalovirus from kidney.

Journal Article Kidney Int · December 1985 Cytomegalovirus (CMV) is presumed to cause latent infection, but the sites of infection are incompletely known. We propose that latent murine cytomegalovirus is present in kidney and may be reactivated by explanation. Immunosuppressive agents and allogenei ... Full text Link to item Cite

The source of murine cytomegalovirus in mice receiving kidney allografts.

Journal Article J Infect Dis · December 1985 The sources of cytomegalovirus (CMV) infection in kidney transplant recipients include reactivation of latent endogenous virus in the recipient or reactivation of latent virus in donated blood or kidney. In the present study, kidneys from mice latently inf ... Full text Link to item Cite

The 1984 Hunter Oration.

Journal Article Med J Aust · September 2, 1985 Full text Link to item Cite

Pseudo-posttraumatic stress disorder.

Journal Article Mil Med · July 1985 Link to item Cite

Transmission of latent cytomegalovirus in a murine kidney tissue transplantation model.

Journal Article Transplantation · March 1985 This paper examines the hypothesis that latent murine cytomegalovirus (MCMV) may be transmitted in kidney tissue to transplant recipients. Balb/c mice were infected with MCMV, and at intervals of less than 1 week to greater than 1 year, transmission of the ... Full text Link to item Cite

Nonurban male homosexuals: epidemiologic, immunologic and virologic characteristics.

Journal Article Am J Med Sci · October 1984 Twenty asymptomatic male homosexuals living in North Carolina were evaluated looking at epidemiologic, immunologic and virologic characteristics. In ten subjects selected for inhalant nitrite use a significantly higher frequency of multiple drug abuse and ... Full text Link to item Cite

Non-A, non-B hepatitis and chronic dialysis--another dilemma.

Journal Article Am J Nephrol · 1984 To define the incidence of non-A, non-B (NANB) hepatitis and evaluate possible risk factors, we reviewed records of 163 patients on chronic dialysis during a 3-year period. 23 cases of NANB hepatitis occurred, 13 (27%) in 49 center dialysis, 8 (10%) in 77 ... Full text Link to item Cite

Hepatitis B virus vaccine. An analysis of its potential use in medical workers.

Journal Article JAMA · October 28, 1983 At the Duke University Medical Center, Durham, NC, there are approximately ten recognized hepatitis B virus (HBV) infections per year in employees. The hospital's hepatitis control program costs $91,995 per year, including costs for workman's compensation, ... Full text Link to item Cite

Brain abscess caused by a variety of cladosporium trichoides.

Journal Article Am J Clin Pathol · June 1983 A brain abscess caused by a new variety of Cladosporium trichoides occurred in a previously healthy man. A reversed T-suppressor/helper cell ratio was noted as the only immunologic abnormality. He required three surgical procedures, the last an occipital l ... Full text Link to item Cite

Cross-reaction to maprotiline.

Journal Article Am J Psychiatry · April 1983 Full text Link to item Cite

Esophageal tuberculosis: findings on barium swallow and computed tomography.

Journal Article Gastrointest Radiol · 1983 Esophageal tuberculosis secondary to tuberculous mediastinal lymphadenopathy is a very unusual presentation of adult tuberculosis. We report a patient presenting with fever of unknown origin and dysphagia. Barium swallow demonstrated esophageal displacemen ... Full text Link to item Cite

Possible tobramycin delirium.

Journal Article JAMA · October 22, 1982 Full text Link to item Cite

Inadequate sensitivity of tuberculin tine test for screening employee populations.

Journal Article J Occup Med · August 1982 Tuberculin Tine and Mantoux skin tests were simultaneously applied to opposite arms of 1,065 medical center employees during their usual preemployment and annual health examinations for the purpose of evaluating the Tine test sensitivity. Of 829 skin tests ... Full text Link to item Cite

Acquired cytomegalovirus retinitis. Four new cases and a review of the literature with implications for management.

Journal Article Am J Nephrol · 1982 49 cases of acquired cytomegalovirus retinitis were reviewed including three new cases in renal allograft recipients and one in a patient with Hodgkin's Disease. Diagnosis in over 90% of cases was based on the distinctive funduscopic appearance of cytomega ... Full text Link to item Cite

Hepatitis B in a medical center.

Journal Article J Occup Med · May 1981 The Employee Health Service of Duke University has been evaluating all employees with known blood product exposures through a standardized protocol since January 1977. All known cases of hepatitis B among employees were also evaluated. During the 40-month ... Link to item Cite

Anti-self HLA may be clonally expressed.

Journal Article J Exp Med · February 1, 1979 A monolayer absorption technique was used to test the hypothesis that killer cells directed to self HLA-associated minor histocompatibility antigens (H-Y) were divisible into subsets. The results showed that sensitized killer cells, which recognized two co ... Full text Link to item Cite

Effects of murine cytomegalovirus infection on the immune response to a tumor allograft.

Journal Article Rev Infect Dis · 1979 The purpose of this study was to compare the effects of murine cytomegalovirus infection introduced after an EL4 ascites tumor allograft with cytomegalovirus infection accompanying or preceding the allograft. Parameters that were measured included document ... Full text Link to item Cite

Viral infection-homograft interactions in a murine model.

Journal Article J Clin Invest · December 1978 The effects on some host defenses of murine cytomegalovirus (MCMV) and(or) EL(4), a mouse ascites homograft, were studied in mice. Assays of cellular and humoral immunity in response to either or both of these perturbations were carried out by quantitation ... Full text Link to item Cite

The clinical librarian and the patient: report of a project at McMaster University Medical Centre.

Journal Article Bull Med Libr Assoc · October 1978 In June 1975 a clinical librarian project was initiated in the Gastroenterology Programme of McMaster University Medical Centre. The objectives of the project were to assist patients in participating more knowledgeably in their own health care and to assis ... Link to item Cite

Small-bowel malabsorption and gastrointestinal malignancy.

Journal Article Radiology · March 1978 In addition to lymphoma, there is an increased incidence of gastrointestinal carcinoma in patients with malabsorption due to celiac disease. This is frequently manifested by a loss of response to gluten withdrawal. Four such cases are described: one patien ... Full text Link to item Cite

Hemolytic anemia in patients receiving sulfasalazine.

Journal Article Digestion · 1978 Hemolytic anemia is a well-recognized complication of sulfasalazine treatment. 17 of 40 (43%) patients with inflammatory bowel disease receiving sulfasalazine had evidence of hemolysis as detected by starch gel electrophoresis. Only 47% (8) of patients wit ... Full text Link to item Cite

A preparatory course for medical students who lack a conventional academic background.

Journal Article J Med Educ · May 1977 McMaster University School of Medicine admits students who may not have had an extensive education in physics, chemistry, and biology. For several years a short preliminary course was offered to those students. The course has since been discontinued, and i ... Full text Link to item Cite

Effects of cold exposure and dehydration on renal function in black-tailed prairie dogs.

Journal Article J Appl Physiol Respir Environ Exerc Physiol · February 1977 Black-tailed prairie dogs (Cynomys ludovicianus) were deprived of food and water for several weeks during the fall and winter in a cold-room hibernaculum (Ta 5-8 degrees C), and for several days at room temperature during the summer. Body temperatures (Tb) ... Full text Link to item Cite

"Blood and guts": one component of an integrated program in biologic sciences as applied to medicine.

Journal Article Can Med Assoc J · January 8, 1977 The 3-year medical school program at McMaster University encourages an approach to learning a physician can apply throughout his or her career. The program has four phases and provides early exposure to relevant clinical material. In phase 3, the basic sci ... Link to item Cite

Persistence of proctitis in 2 cases of clindamycin-associated colitis.

Journal Article Gastroenterology · January 1977 Two cases of persisting proctitis after an episode of clindamycin-associated colitis are reported. Both patients had fulminant colitis and required emergency operation. Severe proctitis persisted in the rectal stumps until their removal 8 months after the ... Link to item Cite

Transmission of hepatitis B by a human bite: an occupational hazard.

Journal Article Can Med Assoc J · September 4, 1976 Hepatitis B developed in a policeman 15 weeks after he was bitten on the hand. A few days after the bite hepatitis B developed in the assailant. The bite had drawn blood and this method of inoculation was presumed to be the route of transmission of the vir ... Link to item Cite

Role of gluten, prednisone, and azathioprine in non-responsive coeliac disease.

Journal Article Lancet · June 5, 1976 A case of severe "non-responsive" coeliac disease has been shown to be sensitive to gluten whilst under prednisone therapy, but not without prednisone. This adds an additional dimension to the criteria for diagnosis of coeliac disease. Cases of non-respons ... Full text Link to item Cite

The McMaster curriculum: a critique.

Journal Article Br Med J · May 15, 1976 Full text Link to item Cite

Paecilomyces varioti endocarditis on a prosthetic aortic valve.

Journal Article J Thorac Cardiovasc Surg · March 1976 Fungal endocarditis following prosthetic valve surgery has assumed increased importance as a cause of postoperative death. We present, to our knowledge, the first case of the fungus Paecilomyces varioti producing endocarditis on a prosthetic aortic valve. ... Link to item Cite

Letter: Esophageal hemorrhage due to pancreatitis.

Journal Article Can Med Assoc J · October 4, 1975 Link to item Cite

Fungal infection following renal transplantation.

Journal Article Arch Intern Med · September 1975 Twenty-seven deep fungal infections developed in 22 of 171 patients following renal transplantation. These infections included cryptococcosis (ten), nocardiosis (seven), candidiasis (four), aspergillosis (two), phycomycosis (two), chromomycosis (one), and ... Link to item Cite

Combined activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo in mice.

Journal Article J Infect Dis · February 1975 The in vitro and in vivo activities of amphotericin B and 5-fluorocytosine (5-FC) alone and in combination were studied to determine possible drug interactions against two strains of Cryptococcus neoformans, one sensitive to 5-FC and one resistant to 5-FC. ... Full text Link to item Cite

Amphotericin B therapy in an anephric patient.

Journal Article Antimicrob Agents Chemother · September 1973 Serum levels of amphotericin B were serially determined during and after a course of therapy in an anephric patient who developed systemic candidiasis after an unsuccessful renal transplantation. There was no progressive accumulation of drug in serum, and ... Full text Link to item Cite

Preprocessing cotton to prevent byssinosis.

Journal Article Br J Ind Med · July 1973 Merchant, J. A., Lumsden, J. C., Kilburn, K. H., Germino, V. H., Hamilton, J. D., Lynn, W. S., Byrd, H., and Baucom, D. (1973).British Journal of Industrial Medicine,30, 237-247. Preprocessing cotton to prevent byssinosis. A fundamental approach of cleanin ... Full text Link to item Cite

Byssinosis in a nontextile worker.

Journal Article Am Rev Respir Dis · March 1973 Full text Link to item Cite

Dose response studies in cotton textile workers.

Journal Article J Occup Med · March 1973 Link to item Cite

Differential aerosol challenge studies in byssinosis.

Journal Article Arch Environ Health · March 1973 Full text Link to item Cite

The selection of medical students at McMaster University.

Journal Article J R Coll Physicians Lond · July 1972 Link to item Cite

Experience with coeliac axis compression syndrome.

Journal Article Br Med J · February 7, 1970 Seven patients with "coeliac axis compression syndrome" are reported. Five were treated surgically, but only two did well. A survey of 200 healthy adults showed epigastric bruits in 6.5%; only one of these had dyspepsia, though dyspepsia was present in 12. ... Full text Link to item Cite

Neisseria meningitidis, a respiratory pathogen?

Journal Article J Infect Dis · January 1970 Full text Link to item Cite