Overview
Dr. Gasier is a physiologist and nutritionist. His research is focused on understanding how breathing altered PO2 impacts cell physiology in the lung, brain, and skeletal muscle. Emphasis is placed on mitochondrial quality control (dynamics, mitophagy, and biogenesis) and bioenergetics. He uses in vivo and in vitro models, and employs an array of methods (e.g., confocal and electron microscopy, Seahorse respiration, immunoblotting, RT-qPCR, ELISA’s, isotope tracers, and 10X genomics) for hypothesis testing. The goal of his research is to improve the operational capacity of divers and safety of hyperoxia in hyperbaric and critical care medicine. Dr. Gasier believes in a hands-on mentoring approach and individualized training plans based on mentee’s aspirations. He is committed to lifetime learning and contributing to knowledge advancement.
Current Duke Appointments & Affiliations
Recent Scholarly Works
Impact of Sarcopenic Obesity on Pulmonary Responses to Hyperoxia
Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractBackground: Sarcopenic obesity (SO) is the coexistence of reduced muscle mass and function that occurs in aging and excess body fat. SO is linked to a higher incidence of lung disease than obesity ... Full text CiteRepeated hyperbaric oxygen exposure accelerates fatigue and impairs SR-calcium release in mice.
Journal article J Appl Physiol (1985) · February 1, 2025 Breathing hyperoxic gas is common in diving and accelerates fatigue after prolonged and repeated exposure. The mechanism(s) remain unknown but may be related to increased oxidants that interfere with skeletal muscle calcium trafficking or impaired aerobic ... Full text Open Access Link to item CiteRole of Paraoxonase 2 in Airway Epithelial Response to Oxidant Stress.
Journal article Antioxidants (Basel) · October 31, 2024 Asthma is a widespread chronic lung disease characterized by airway inflammation and hyperresponsiveness. This airway inflammation is classified by either the presence (T2-high) or absence (T2-low) of high levels of eosinophils. Because most therapies for ... Full text Open Access Link to item CiteRecent Grants
Integrated Training in Anesthesiology Research
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1996 - 2031Perfluoromethane as a Decompression Gas for Human Diving (CLIN 2001)
ResearchCo Investigator · Awarded by Naval Sea Systems Command · 2025 - 2030Perfluoromethane as a Decompression Gas for Human Diving (CLIN 1003)
ResearchCo Investigator · Awarded by Naval Sea Systems Command · 2025 - 2030View All Grants