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Heath Gasier

Associate Professor in Anesthesiology
Anesthesiology
DUMC 3823, 40 Medicine Circle, Durham, NC 27710
Center for Hyperbaric Medicine, & Environmental Physiology, DUMC 3823 Durham, NC 27710
Office hours Monday-Friday, 8:30 am - 5:00 pm  

Research Interests


I joined the Duke Center for Hyperbaric Medicine and Environmental Physiology in August 2019 after retiring from the US Navy. While my educational background is nutrition and exercise physiology, navy directed training and mission requirements resulted in conducting research in the following areas: bone health in submariners and obesity, performance nutrition for high altitude, mitochondrial physiology in heat stress and obesity, and diving safety. From these topics, I have gained an appreciation for the biological limitations imposed by exposure to increased or decreased ambient pressure, and the metabolic stress caused by nutrient excess. My new role within the Center for Hyperbaric Medicine and Environmental Physiology has afforded me the great opportunity to pursue more focused research questions with the overall goal of improving human health, performance and safety during exposure to hyper- and hypobaric environments.      

Selected Grants


Applied Physiology of CNS Oxygen Toxicity: Mechanisms in Humans

ResearchCo Investigator · Awarded by Office of Naval Research · 2023 - 2026

The Role of GABA in Susceptibility to Oxygen Toxicity with Repeated HBO2 Exposure

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2022 - 2025

Repair Mechanisms of Oxidative Tissue Damage

EquipmentPrincipal Investigator · Awarded by Office of Naval Research · 2024 - 2025

AQP5 as a Target for Prophylactic Countermeasures for Pulmonary Hyperbaric Oxygen Toxicity

ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2023 - 2024

Applied Physiology of CNS Oxygen Toxicity: Mechanisms in Humans

ResearchCo Investigator · Awarded by Office of Naval Research · 2023 - 2026

The Role of GABA in Susceptibility to Oxygen Toxicity with Repeated HBO2 Exposure

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2022 - 2025

Repair Mechanisms of Oxidative Tissue Damage

EquipmentPrincipal Investigator · Awarded by Office of Naval Research · 2024 - 2025

AQP5 as a Target for Prophylactic Countermeasures for Pulmonary Hyperbaric Oxygen Toxicity

ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2023 - 2024

Ketone Ester Supplement for CNSOT Mitigation

ResearchCo Investigator · Awarded by Naval Sea Systems Command · 2022 - 2024

Enhanced Assessment of Oxidative Tissue Damage

EquipmentPrincipal Investigator · Awarded by Office of Naval Research · 2022 - 2023

Perfluoromethane to Reduce Decompression Sickness

ResearchCo Investigator · Awarded by Naval Sea Systems Command · 2021 - 2023

METABOLIC SYSTEM FOR IN VIVO RODENT TESTING

EquipmentPrincipal Investigator · Awarded by Office of Naval Research · 2021 - 2022

Characterizing Hyperoxia-Induced Alterations in Muscular Physiology

ResearchPrincipal Investigator · Awarded by Navy Experimental Diving Unit · 2021 - 2022

Effects of HBO2 on skeletal muscle calcium regulation and mitochondrial function

ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2021 - 2022

Effects of Exercise on Skeletal Health in Iron Deficient Female Rats

ResearchPrincipal Investigator · Awarded by Henry M. Jackson Foundation · 2019 - 2021

Fellowships, Gifts, and Supported Research


Bone Health in US Submariners · 2010 - 2013 PI · Office of Naval Research · $828,000.00
Exhaled nitric oxide (NO) and carbon monoxide (CO) as noninvasive markers of hyperbaric oxidative stress in humans · 2010 - 2013 Co-I · Office of Naval Research · $435,000.00
The importance of nitrate-nitrite-NO pathway in regulating systemic blood flow under hypobaric and the impact of nitrate supplementation on exercise performance at high altitude · 2012 - 2013 Co-I · Office of Naval Research · $198,179.00
The role of nitric oxide in hyperbaric hyperbaric stress · 2010 - 2011 Co-I · Defense Health Medical Research and Development Program · $247,000.00
The effects of immediate post-resistance exercise protein ingestion on protein synthesis using 2H2O · 2006 - 2007 PI · Gatorade Sports Science Institute · $1,500.00
Bone Health in US Submariners · 2010 - 2013 PI · Office of Naval Research · $828,000.00
Exhaled nitric oxide (NO) and carbon monoxide (CO) as noninvasive markers of hyperbaric oxidative stress in humans · 2010 - 2013 Co-I · Office of Naval Research · $435,000.00
The importance of nitrate-nitrite-NO pathway in regulating systemic blood flow under hypobaric and the impact of nitrate supplementation on exercise performance at high altitude · 2012 - 2013 Co-I · Office of Naval Research · $198,179.00
The role of nitric oxide in hyperbaric hyperbaric stress · 2010 - 2011 Co-I · Defense Health Medical Research and Development Program · $247,000.00
The effects of immediate post-resistance exercise protein ingestion on protein synthesis using 2H2O · 2006 - 2007 PI · Gatorade Sports Science Institute · $1,500.00
The effects of a carbohydrate-protein drink on performance and mood in US pararescue trainees · 2005 - 2006 PI · USAF, 59th Clinical Research Squadron · $5,000.00
Oxidative tissue damage after HBO2 exposure using selected FDA-approved anti-epileptic drugs (AEDs) · 2020 - 2022 PI · Office of Naval Research · $287,000.00
Perfluoromethane toxicity study · 2021 - 2022 Co-I · Naval Sea Systems Command · $71,725.00
Heme oxygenase-1 regulation of skeletal muscle inflammation and mitochondrial fitness in sarcopenic obesity · 2020 - 2021 PI · Duke University · $30,000.00
REMM HITT-Covid19 · 2021 - 2026 Co-I · National Institutes of Health (NHLBI) · $4,174,449.00
Ketone Ester Supplement for CNSOT Mitigation · 2022 - 2024 Co-I · Naval Sea Systems Command · $825,248.00
Decrements in skeletal muscle performance and mitochondrial function following hypobaric exposure and enhancing oxyhemoglobin affinity to attenuate these effects in a rodent model · 2017 - 2019 Co-I · Office of Naval Research · $319,988.00
The Effects of Vitamin D on Upper Respiratory Tract Infections and Immune Function in Marine Corps Recruits · 2016 - 2018 PI · Defense Health Program · $470,000.00
Application of low dose inhaled carbon monoxide to attenuate diet induced obesity in rats · 2015 - 2018 PI · Uniformed Services University of the Health Sciences · $90,000.00