Scholars@Duke
Heather Stuart Shaw

Heather Stuart Shaw

Assistant Professor of Medicine
Medicine, General Internal Medicine
heather.shaw@duke.edu
N/A, Durham, NC 27710
508 Fulton St, C5020, Durham, NC 27705

Selected Publications

Contribution of cancer symptoms, dysfunctional sleep related thoughts, and sleep inhibitory behaviors to the insomnia process in breast cancer survivors: a daily process analysis.

Journal Article Sleep · November 2010 STUDY OBJECTIVES: using a comprehensive cognitive-behavioral model of insomnia and a daily process approach, this study was conducted to examine the contribution of cancer symptoms and dysfunctional sleep related thoughts and behaviors to the process of in ... Full text Link to item Cite

A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer.

Journal Article Breast Cancer Res Treat · February 2010 The purpose of this study was to determine the safety and maximum tolerated dose (MTD) of BZL101 (FDA IND# 59,521), an orally delivered aqueous extract from the herb Scutellaria barbata, in women with metastatic breast cancer (MBC). The trial was an open-l ... Full text Link to item Cite

Feasibility and acceptability to patients of a longitudinal system for evaluating cancer-related symptoms and quality of life: pilot study of an e/Tablet data-collection system in academic oncology.

Journal Article J Pain Symptom Manage · June 2009 Programmed, notebook-style, personal computers ("e/Tablets") can collect symptom and quality-of-life (QOL) data at the point of care. Patients use an e/Tablet in the clinic waiting area to complete electronic surveys. Information then travels wirelessly to ... Full text Link to item Cite

Use of tablet personal computers for sensitive patient-reported information.

Journal Article J Support Oncol · 2009 Notebook-style computers (e/Tablets) are increasingly replacing paper methods for collecting patient-reported information. Discrepancies in data between these methods have been found in oncology for sexuality-related questions. A study was performed to for ... Link to item Cite

Improving health care efficiency and quality using tablet personal computers to collect research-quality, patient-reported data.

Journal Article Health Serv Res · December 2008 OBJECTIVE: To determine whether e/Tablets (wireless tablet computers used in community oncology clinics to collect review of systems information at point of care) are feasible, acceptable, and valid for collecting research-quality data in academic oncology ... Full text Link to item Cite

Effect of exercise on biomarkers, fatigue, sleep disturbances, and depressive symptoms in older women with breast cancer receiving hormonal therapy.

Journal Article Oncol Nurs Forum · July 2008 PURPOSE/OBJECTIVES: To compare the effectiveness of a prescribed home-based walking exercise intervention with usual care in older women receiving hormonal treatment for breast cancer, and to examine relationships among levels of the cortisol, serotonin, i ... Full text Link to item Cite

A phase I trial of scutellaria barbata (BZL101) for metastatic breast cancer.

Journal Article J Clin Oncol · May 20, 2008 1099 Background: BZL101 is an aqueous extract from herba Scutellaria Barbata. BZL101 demonstrates in vitro growth inhibitory effects on human breast cancer cell lines and does not inhibit the growth of normal human mammary epithelium. In a murine xenograft ... Link to item Cite

A pilot study of predictive markers of chemotherapy-related amenorrhea among premenopausal women with early stage breast cancer.

Journal Article Cancer Invest · 2008 BACKGROUND: Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed. PATIENTS AND METHODS: Premenopausal women with ESBC and plann ... Full text Link to item Cite

Actaea/Cimicifuga racemosa (black cohosh) extract and breast cancer recurrence risk: Commentary

Journal Article Focus on Alternative and Complementary Therapies · September 1, 2007 Cite

E-tablets to collect research-quality patient-reported data

Conference JOURNAL OF CLINICAL ONCOLOGY · June 20, 2007 Link to item Cite

Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies.

Journal Article Integr Cancer Ther · June 2007 Extracts of milk thistle have been recognized for centuries as "liver tonics" and are well-known to prevent or reverse hepatotoxicity of reactive drug metabolites or naturally occurring toxins. Milk thistle extracts are now under intense study in the exper ... Full text Link to item Cite

Yoga for women with metastatic breast cancer: results from a pilot study.

Journal Article J Pain Symptom Manage · March 2007 Metastatic breast cancer (MBC) remains a terminal illness for which major treatment advances are slow to appear, and hence it is crucial that effective palliative interventions be developed to reduce the cancer-related symptoms of women with this condition ... Full text Link to item Cite

Simple and inexpensive methods to prevent botanical misfortune

Journal Article Acta Horticulturae · January 1, 2006 Botanical dietary supplements are often targeted by the mainstream media and scientific/medical communities as being unscientific and unsafe relative to prescription pharmaceuticals and over-the counter drugs. However, the relative risk of botanical medici ... Full text Cite

Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer.

Journal Article J Clin Oncol · November 1, 2005 PURPOSE: ABI-007, the first biologically interactive albumin-bound paclitaxel in a nanameter particle, free of solvents, was compared with polyethylated castor oil-based standard paclitaxel in patients with metastatic breast cancer (MBC). This phase III st ... Full text Link to item Cite

Erratum

Journal Article Journal of Clinical Oncology · February 20, 2005 Full text Cite

Letrozole in the treatment of breast cancer.

Journal Article Expert Opin Pharmacother · May 2002 Over the last 30 years the role of tamoxifen in breast cancer treatment has been progressively expanded by clinical investigation to encompass the entire spectrum of disease from cancer chemoprevention to palliation of advanced disease. The primacy of tamo ... Full text Link to item Cite

Effects of chemotherapy and tamoxifen on cervical and vaginal smears in bone marrow transplant recipients.

Journal Article Acta Cytol · 1999 OBJECTIVE: To clarify the importance of squamous and glandular atypia in the genital tracts of women undergoing high-dose chemotherapy and receiving tamoxifen. STUDY DESIGN: The pathology records of 769 female bone marrow transplant recipients from a five- ... Full text Link to item Cite

Mutations in the PTEN tumor suppressor gene in cervical carcinomas

Journal Article International Journal of Gynecological Cancer · December 1, 1998 To elucidate further the molecular pathogenesis of cervical cancer we sought to determine whether mutations in the PTEN tumor suppressor gene are a feature of these cancers. Genomic DNA was extracted from 67 primary cervical cancers and 9 immortalized cerv ... Full text Cite

Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.

Journal Article Gynecol Oncol · July 1998 OBJECTIVE: The PTEN tumor suppressor gene on chromosome 10q23 undergoes inactivating mutations in several types of malignancies including glioblastomas and prostate and endometrial carcinomas. The aim of this study was to determine if mutation of the PTEN ... Full text Link to item Cite

Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.

Journal Article Cancer Res · June 15, 1998 Mutation and deletion of the PTEN tumor suppressor gene occurs in about 40% of endometrial carcinomas. The purpose of this study was to determine whether PTEN mutations also are present in endometrial hyperplasias, which are premalignant precursors of inva ... Link to item Cite