Journal ArticleJournal of the Optical Society of America A · November 1, 2024
Understanding cellular responses to mechanical environmental stimuli is important for cellular mechanotransduction studies. While fluorescence microscopy has been used for aiding mechanotransduction research due to its molecular sensitivity, the ab ...
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Journal ArticleBiophysical journal · April 2023
Optical methods for examining cellular structure based on endogenous contrast rely on analysis of refractive index changes to discriminate cell phenotype. These changes can be visualized using techniques such as phase contrast microscopy, detected by light ...
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Chapter · February 1, 2023
Holographic cytometry (HC) has been developed as an ultra-high throughput implementation of quantitative phase microscopy (QPM). While QPM has been well developed for studying cells based on endogenous contrast, few implementations have imaged cell ...
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ConferenceNovel Techniques in Microscopy, NTM 2023 · January 1, 2023
We demonstrate a novel technique for calculating the fractal dimension of adherent cells using multiscale Quantitative Phase Imaging information. We examine the relationship between this measurement and disorder strength across different cell lines. ...
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ConferenceOptics InfoBase Conference Papers · January 1, 2022
Demonstration of quantitative phase microscopy and Förster resonance energy transfer for analyzing molecular and structural information simultaneously. We focus on signaling pathways and sub-cellular structure for endothelial cells exposed to various flows ...
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Journal ArticleBiomedical optics express · December 2021
For many clinical applications, such as dermatology, optical coherence tomography (OCT) suffers from limited penetration depth due primarily to the highly scattering nature of biological tissues. Here, we present a novel implementation of dual-axis optical ...
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Journal ArticleFrontiers in Physics · November 30, 2021
Holographic cytometry is an ultra-high throughput quantitative phase imaging modality that is capable of extracting subcellular information from millions of cells flowing through parallel microfluidic channels. In this study, we present our findings on the ...
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Journal ArticleCells · September 17, 2021
Holographic cytometry is introduced as an ultra-high throughput implementation of quantitative phase imaging of single cells flowing through parallel microfluidic channels. Here, the approach was applied for characterizing the morphology of individual red ...
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Journal ArticleIEEE transactions on bio-medical engineering · August 2021
Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. He ...
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ConferenceOptics InfoBase Conference Papers · January 1, 2021
We demonstrate the use of quantitative phase microscopy and Förster resonance energy transfer for analyzing molecular and structural information simultaneously. Specifically, we focus on effects of ion channel modulation on signaling pathways and sub-cellu ...
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Journal ArticleOptics express · June 2019
We describe an elastographic method to circumferentially-resolve airway wall compliance using endoscopic, anatomic optical coherence tomography (aOCT) combined with an intraluminal pressure catheter. The method was first demonstrated on notched silicone ph ...
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Journal ArticleIEEE transactions on medical imaging · April 2019
Identification and treatment of obstructive airway disorders (OADs) are greatly aided by imaging of the geometry of the airway lumen. Anatomical optical coherence tomography (aOCT) is a promising high-speed and minimally invasive endoscopic imaging modalit ...
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Journal ArticleJournal of biomedical optics · October 2018
It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-sour ...
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Journal ArticleBiomedical optics express · April 2017
Quantification of airway compliance can aid in the diagnosis and treatment of obstructive airway disorders by detecting regions vulnerable to collapse. Here we evaluate the ability of a swept-source anatomic optical coherence tomography (SSaOCT) system to ...
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ConferenceProceedings of SPIE--the International Society for Optical Engineering · February 2017
We describe a novel, multi-modal imaging protocol for validating quantitative dynamic airway imaging performed using anatomical Optical Coherence Tomography (aOCT). The aOCT system consists of a catheter-based aOCT probe that is deployed via a bronchoscope ...
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ConferenceProgress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017
To aid in diagnosis and treatment of upper airway obstructive disorders (UAOD), we propose anatomic Optical Coherence Tomography (aOCT) for endoscopic imaging of the upper airway lumen with high speed and resolution. aOCT and CT scans are performed sequent ...
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ConferenceProceedings of SPIE--the International Society for Optical Engineering · January 2016
Quantitative endoscopic imaging is at the vanguard of novel techniques in the assessment upper airway obstruction. Anatomic optical coherence tomography (aOCT) has the potential to provide the geometry of the airway lumen with high-resolution and in 4 dime ...
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Journal ArticleBiomedical optics express · March 2014
Minimally invasive imaging of upper airway obstructions in children and adults is needed to improve clinical decision-making. Toward this goal, we demonstrate an anatomical optical coherence tomography (aOCT) system delivered via a small-bore, flexible end ...
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Journal ArticleMethods (San Diego, Calif.) · February 2012
Noble metal nanoparticles hold great potential as optical contrast agents due to a unique feature, known as the plasmon resonance, which produces enhanced scattering and absorption at specific frequencies. The plasmon resonance also provides a spectral tun ...
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