Scholars@Duke
Hiroshi Date

Selected Publications

Lung transplantation from donation after circulatory death donors over 55 years old: A national analysis of outcomes and utilization.

Journal Article JHLT Open · February 2026 BACKGROUND: Lungs from older donation after circulatory death (DCD) donors are underutilized; however, these organs may represent an opportunity to expand the donor pool. Herein, we evaluated utilization and outcomes of lung transplants using lungs from ol ... Full text Open Access Link to item Cite

Active aldehydes accelerate CD8+ T cell exhaustion by metabolic alteration in the tumor microenvironment.

Journal Article Nat Immunol · January 7, 2026 Glycolysis and mitochondrial fatty acid oxidation (FAO) regulate CD8+ T cell differentiation, but how this metabolic balance regulates T cell exhaustion is unclear. PD-1 signaling inhibits glycolysis and enhances FAO. Here, we show that CD8+ T cells in tum ... Full text Link to item Cite

Microglia Display Heterogeneous Initial Responses to Disseminated Tumor Cells.

Journal Article Cancer Res · December 10, 2025 Brain metastases are frequent and often lethal complications of advanced cancers. Microglia, resident immune cells of the brain, are known to exert both anti-tumor and pro-tumor functions in late-stage metastases; however, their response during the initial ... Full text Link to item Cite

Pharmacological inhibition of toll-like receptor 4 suppresses ischemia-reperfusion injury-induced inflammation and improves lung allograft function after transplantation

Journal Article Jhlt Open · November 1, 2025 Ischemia reperfusion injury (IRI) is a significant risk factor for primary graft dysfunction following lung transplantation. Toll-like receptor 4 (TLR4) signaling plays an important role not only in IRI but also in the development of acute and chronic allo ... Full text Cite

The effect of CTLA4-Ig on fibrotic progression in a murine model of chronic lung allograft dysfunction.

Journal Article J Heart Lung Transplant · September 2025 Co-stimulatory blockade has emerged as a promising strategy for preventing acute and chronic rejection in solid organ transplantation. This study investigates the efficacy of cytotoxic T-lymphocyte-associated protein-4-Ig (CTLA4-Ig), a T-cell co-stimulatio ... Full text Link to item Cite

Impact of Severe Skeletal Muscle Loss During the Waiting Period on Prognosis in Lung Transplantation for Interstitial Lung Disease.

Journal Article Eur J Cardiothorac Surg · August 2, 2025 OBJECTIVES: This study aimed to evaluate the impact of skeletal muscle loss during the waiting period on postoperative outcomes following lung transplantation for interstitial lung disease. METHODS: This retrospective analysis included adult patients with ... Full text Link to item Cite

Pharmacokinetics of ganciclovir for prevention of cytomegalovirus infection in a lung transplant recipient on veno-arterial extracorporeal membrane oxygenation: A case report and literature review.

Journal Article J Infect Chemother · August 2025 Ganciclovir (GCV) plays an important role in preventing cytomegalovirus (CMV) infection after lung transplantation. Because of the large inter-individual and intra-individual variabilities in GCV pharmacokinetics, it has been suggested that individualized ... Full text Link to item Cite

Epidemiology and clinical course of large cell neuroendocrine carcinoma of the lung: The Japanese lung cancer registry study.

Journal Article Lung Cancer · June 2025 BACKGROUND: This study aimed to investigate the characteristics and clinical courses of patients with pulmonary large cell neuroendocrine carcinoma (LCNEC) and compare the differences across lung cancer types. METHODS: This prospective study included 11,31 ... Full text Link to item Cite

Diffusing capacity and alveolar attachments to small airways in smokers with and without COPD.

Journal Article ERJ Open Res · May 2025 The number of alveolar attachments to the small airways correlates with D LCO in smokers, both with and without COPD. Early smoking-related lung pathology is reflected in impaired D LCO. https://bit.ly/4fY3QUr. ... Full text Link to item Cite

Optimizing cytomegalovirus treatment through therapeutic drug monitoring in a ganciclovir-unresponsive lung transplant recipient.

Journal Article J Infect Chemother · April 2025 Ganciclovir and valganciclovir are utilized in the treatment of cytomegalovirus infection and its reactivation following lung transplantation. However, treatment complexity arises due to the development of resistant viruses. Recently, therapeutic drug moni ... Full text Link to item Cite

The 2024 American Association for Thoracic Surgery expert consensus document: Current standards in donor lung procurement and preservation.

Journal Article J Thorac Cardiovasc Surg · February 2025 BACKGROUND: Donor lung procurement and preservation is critical for lung transplantation success. Unfortunately, the large variability in techniques impacts organ utilization rates and transplantation outcomes. Compounding this variation, recent developmen ... Full text Link to item Cite

Investigation of severe acute respiratory syndrome coronavirus 2 infection status in solid organ transplant recipients treated with tixagevimab/cilgavimab.

Journal Article J Infect Chemother · December 2024 INTRODUCTION: Tixagevimab and cilgavimab (T/C) are neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be used to prevent SARS-CoV-2 infection in solid organ transplant (SOT) recipients. However, their neut ... Full text Link to item Cite

Adult living-donor lobar lung transplant using a small-for-size graft.

Journal Article Eur J Cardiothorac Surg · November 28, 2024 OBJECTIVES: This study was designed to examine the outcomes of adult living-donor lobar lung transplants (LDLLTs) using small-for-size grafts. METHODS: A calculated graft forced vital capacity of <50% of the predicted forced vital capacity of the recipient ... Full text Link to item Cite

Pulmonary metastasectomy after immune checkpoint inhibitors in malignant melanoma.

Journal Article Asian Cardiovasc Thorac Ann · September 2024 The management of malignant melanoma with pulmonary metastases is controversial and occasionally requires multimodality management, including pulmonary metastasectomy after immune checkpoint inhibitors (ICIs). However, limited data are available on these p ... Full text Link to item Cite

Clinicopathological Features and Survival Outcomes of Resected Lung Adenosquamous Carcinoma: Results From a Nationwide Japanese Registry Data.

Journal Article Clin Lung Cancer · September 2024 OBJECTIVES: The objective of this study was to clarify the clinicopathological features and prognostic factors of resected lung adenosquamous carcinoma (ASC) using a nationwide multi-institutional database. METHODS: We retrospectively reviewed the records ... Full text Link to item Cite

Promoting successful healing of artificial trachea by intratracheal administration of basic fibroblast growth factor†.

Journal Article Eur J Cardiothorac Surg · August 2, 2024 OBJECTIVES: This study evaluated the effect of intratracheal administration of basic fibroblast growth factor (bFGF) on tracheal healing following implantation of a novel layered polyglycolic acid (PGA) material to replace a critical-size defect in rat tra ... Full text Link to item Cite

Practical guide for the diagnosis and management of primary ciliary dyskinesia.

Journal Article Auris Nasus Larynx · June 2024 OBJECTIVE: Primary ciliary dyskinesia (PCD) is a relatively rare genetic disorder that affects approximately 1 in 20,000 people. Approximately 50 genes are currently known to cause PCD. In light of differences in causative genes and the medical system in J ... Full text Link to item Cite

Fibrotic progression from acute cellular rejection is dependent on secondary lymphoid organs in a mouse model of chronic lung allograft dysfunction.

Journal Article Am J Transplant · June 2024 Chronic lung allograft dysfunction (CLAD) remains one of the major limitations to long-term survival after lung transplantation. We modified a murine model of CLAD and transplanted left lungs from BALB/c donors into B6 recipients that were treated with int ... Full text Link to item Cite

Acute exacerbation predicting poor outcomes in idiopathic interstitial pneumonia and advanced lung cancer patients undergoing cytotoxic chemotherapy.

Journal Article Sci Rep · May 3, 2024 Effective treatment for advanced lung cancer and idiopathic interstitial pneumonia (IIP) remains an unmet medical need. The relationship between chemotherapy's effectiveness in advanced lung cancer and the risk of acute exacerbation of IIP is poorly invest ... Full text Link to item Cite

Beneficial effects of extracorporeal membrane oxygenation over cardiopulmonary bypass in living-donor lobar lung transplantation

Journal Article Jhlt Open · May 1, 2024 Background: Extracorporeal membrane oxygenation (ECMO) has been frequently used instead of cardiopulmonary bypass (CPB) as extracorporeal circulatory support during cadaveric lung transplantation. This study compared the outcomes of intraoperative CPB or E ... Full text Cite

Complex situations in lung cancer: multifocal disease, oligoprogression and oligorecurrence.

Journal Article Eur Respir Rev · April 30, 2024 With the emergence of lung cancer screening programmes and newly detected localised and multifocal disease, novel treatment compounds and multimodal treatment approaches, the treatment landscape of non-small cell lung cancer is becoming increasingly comple ... Full text Link to item Cite

Combination Therapy with EGFR Tyrosine Kinase Inhibitors and TEAD Inhibitor Increases Tumor Suppression Effects in EGFR Mutation-positive Lung Cancer.

Journal Article Mol Cancer Ther · April 2, 2024 EGFR-tyrosine kinase inhibitors (TKI) are the first-line therapies for EGFR mutation-positive lung cancer. EGFR-TKIs have favorable therapeutic effects. However, a large proportion of patients with EGFR mutation-positive lung cancer subsequently relapse. S ... Full text Link to item Cite

Effect of epoprostenol-induced thrombocytopaenia on lung transplantation for pulmonary arterial hypertension.

Journal Article Eur J Cardiothorac Surg · March 29, 2024 OBJECTIVES: Preoperative intravenous epoprostenol therapy can cause thrombocytopaenia, which may increase the risk of perioperative bleeding during lung transplantation. This study aimed to determine whether lung transplantation can be safely performed in ... Full text Link to item Cite

Immune checkpoint inhibitors in patients with lung cancer having chronic interstitial pneumonia.

Journal Article ERJ Open Res · March 2024 BACKGROUND: In interstitial pneumonia (IP)-associated lung cancer, immune checkpoint inhibitor pneumonitis (ICIP) is common with immune checkpoint inhibitor (ICI) treatment. The purpose of the present study was to clarify the safety and efficacy of ICI tre ... Full text Link to item Cite

The impact of vascular division sequence and epithelial-mesenchymal transition status on postoperative recurrence in lung adenocarcinoma.

Journal Article Asian Cardiovasc Thorac Ann · March 2024 BACKGROUND: The vascular division sequence in video-assisted thoracic surgery (VATS) lung resection is usually determined by the handling difficulty due to the limited surgical view through the scope. However, upfront pulmonary vein division is theoretical ... Full text Link to item Cite

Various combinations of living and deceased donors for lung retransplantation-a single institutional retrospective study.

Journal Article Interdiscip Cardiovasc Thorac Surg · January 2, 2024 OBJECTIVES: Lung retransplantation has been performed as a treatment option mainly for chronic lung allograft dysfunction; however, the outcomes of lung retransplantation have been reported to be worse than those of primary lung transplantation. Because of ... Full text Link to item Cite

Living-donor lobar lung transplantation.

Journal Article J Heart Lung Transplant · January 2024 Living-donor lobar lung transplantation (LDLLT) is indicated for critically ill patients who would not survive the waiting period in the case of severe brain-dead donor shortage. It is essential to confirm that potential donors are willing to donate withou ... Full text Link to item Cite

Favorable effect of CD26/DPP-4 inhibitors on postoperative outcomes after lung transplantation: A propensity-weighted analysis.

Journal Article J Heart Lung Transplant · January 2024 BACKGROUND: We have shown the efficacy of CD26/dipeptidyl peptidase 4 (CD26/DPP-4) inhibitors, antidiabetic agents, in allograft protection after experimental lung transplantation (LTx). We aimed to elucidate whether CD26/DPP-4 inhibitors effectively impro ... Full text Link to item Cite

Five-Year Overall Survival Analysis of the JIPANG Study: Pemetrexed or Vinorelbine Plus Cisplatin for Resected Stage II-IIIA Nonsquamous Non-Small-Cell Lung Cancer.

Journal Article J Clin Oncol · December 1, 2023 Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Up ... Full text Link to item Cite

Association between blood eosinophil count and small airway eosinophils in smokers with and without COPD.

Journal Article ERJ Open Res · September 2023 INTRODUCTION: Airway eosinophilic inflammation is a pathological feature in a subgroup of patients with COPD and in some smokers with a high COPD risk. Although blood eosinophil count is used to define eosinophilic COPD, the association between blood eosin ... Full text Link to item Cite

The first successful case of ABO-incompatible living-donor lobar lung transplantation following desensitization therapy.

Journal Article Am J Transplant · September 2023 ABO-incompatible (ABO-I) living-donor lobar lung transplantation (LDLLT) was successfully performed in a 14-year-old girl who suffered from bronchiolitis obliterans due to graft-versus-host disease following hematopoietic stem cell transplantation. In the ... Full text Link to item Cite

Development of novel layered polyglycolic acid sheet for regeneration of critical-size defect in rat trachea.

Journal Article Eur J Cardiothorac Surg · May 2, 2023 OBJECTIVES: Polyglycolic acid (PGA) sheets are difficult to adapt to the central airway because of poor durability against high air pressure. Therefore, we developed a novel layered PGA material to cover the central airway and examined its morphologic trai ... Full text Link to item Cite

Right transmanubrial approach to the cervicothoracic spine with venous reconstruction.

Journal Article Asian Cardiovasc Thorac Ann · May 2023 The transmanubrial approach first reported by Grunenwald in 1997 is well-known for superior sulcus lung malignancies involving the thoracic inlet. Because an anterior approach to levels below Th2 is difficult without removing the manubrium, we used the tra ... Full text Link to item Cite

Outcome and growth of lobar graft after pediatric living-donor lobar lung transplantation.

Journal Article J Heart Lung Transplant · May 2023 BACKGROUND: Living-donor lobar lung transplantation (LDLLT) remains a life-saving option for pediatric patients with respiratory failure. However, the long-term survival and post-transplant quality of adult lobar grafts transplanted into children are unkno ... Full text Link to item Cite

Comparison of living-donor lobar lung transplantation and cadaveric lung transplantation for pulmonary hypertension.

Journal Article Eur J Cardiothorac Surg · April 3, 2023 OBJECTIVES: Living-donor lobar lung transplantation (LDLLT) is a life-saving procedure for critically ill patients with various lung diseases, including pulmonary hypertension (PH). However, there are concerns regarding the development of heart failure wit ... Full text Link to item Cite

Chemotherapy versus best supportive care in advanced lung cancer and idiopathic interstitial pneumonias: A retrospective multi-centre cohort study.

Journal Article Respir Investig · March 2023 BACKGROUND: The clinical questions of whether chemotherapy as initial treatment, compared with best supportive care (BSC), improves overall survival (OS) and whether it increases the occurrence risk of acute exacerbation of idiopathic interstitial pneumoni ... Full text Link to item Cite

Right-to-Left Inverted Living-Donor Lobar Lung Transplantation

Journal Article Operative Techniques in Thoracic and Cardiovascular Surgery · March 1, 2023 In standard bilateral living-donor lobar lung transplantation (LDLLT), right and left lower lobes donated by 2 healthy donors are implanted into a recipient after right and left pneumonectomies. Because only 2 lobes are implanted, the grafts may be too sma ... Full text Cite

Robot-assisted segmentectomy for small lung cancer using a radiofrequency identification marker.

Journal Article Asian Cardiovasc Thorac Ann · February 2023 Owing to the prevalence of robot-assisted thoracoscopic surgery and the increase in the number of small lung cancer cases, robot-assisted thoracoscopic segmentectomy cases have also been increasing. For small lung cancers, such as ground-glass opacity lesi ... Full text Link to item Cite

Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis.

Journal Article Blood Adv · January 10, 2023 Patients with pulmonary graft-versus-host disease (pGVHD) have a poor prognosis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, pGVHD pathogenesis is not fully elucidated in humans, and currently available immunosuppressa ... Full text Link to item Cite

The American Association for Thoracic Surgery (AATS) 2022 Expert Consensus Document: The use of mechanical circulatory support in lung transplantation.

Journal Article J Thorac Cardiovasc Surg · January 2023 OBJECTIVE: The use of mechanical circulatory support (MCS) in lung transplantation has been steadily increasing over the prior decade, with evolving strategies for incorporating support in the preoperative, intraoperative, and postoperative settings. There ... Full text Link to item Cite

Electromagnetic navigation bronchoscopy-guided radiofrequency identification marking in wedge resection for fluoroscopically invisible small lung lesions.

Journal Article Eur J Cardiothorac Surg · December 2, 2022 OBJECTIVES: We developed a novel wireless localization technique after electromagnetic navigation bronchoscopy-guided radiofrequency identification marker placement for fluoroscopically invisible small lung lesions. We conducted an observational study to i ... Full text Link to item Cite

Pulmonary cancers across different histotypes share hybrid tuft cell/ionocyte-like molecular features and potentially druggable vulnerabilities.

Journal Article Cell Death Dis · November 19, 2022 Tuft cells are chemosensory epithelial cells in the respiratory tract and several other organs. Recent studies revealed tuft cell-like gene expression signatures in some pulmonary adenocarcinomas, squamous cell carcinomas (SQCC), small cell carcinomas (SCL ... Full text Link to item Cite

Epidermal growth factor receptor tyrosine kinase inhibitors as first-line treatment for postoperative recurrent EGFR-mutated lung adenocarcinoma: a multi-institutional retrospective study.

Journal Article Eur J Cardiothorac Surg · October 4, 2022 OBJECTIVES: The aim of this study was to analyse the long-term survival outcomes and prognostic factors of patients receiving epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) as first-line treatment for postoperative recurrent EGFR-m ... Full text Link to item Cite

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

Journal Article Sci Adv · September 23, 2022 In the initial process of coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects respiratory epithelial cells and then transfers to other organs the blood vessels. It is believed that SARS-CoV-2 can pass t ... Full text Link to item Cite

Intraoperative Diagnosis of Bronchovenous Fistula During Lung Transplantation Using Transesophageal Echocardiography.

Journal Article J Cardiothorac Vasc Anesth · August 2022 Bronchovenous fistula (BVF) is a rare complication and can cause arterial gas embolism in vital organs, including the heart and the brain, resulting in a high mortality rate. A 51-year-old man developed a BVF during pneumonectomy for lung transplantation, ... Full text Link to item Cite

Strategy for lung parenchyma-sparing bronchial resection: a case series report.

Journal Article Interact Cardiovasc Thorac Surg · July 9, 2022 Lung parenchyma-sparing bronchial resection is uncommon, and the operative procedure depends on the cause and location of the stenosis. We present 6 cases and discuss the different surgical strategies for sleeve resection of the central airway without lung ... Full text Link to item Cite

Limited resection for stage IA radiologically invasive lung cancer: a real-world nationwide database study.

Journal Article Eur J Cardiothorac Surg · June 15, 2022 OBJECTIVES: Radiologically invasive non-small-cell lung cancer, defined as consolidation size to maximum tumour diameter ratio of over 0.5, is associated with pathological invasiveness and worse prognosis. However, there are no real-world, nationwide datab ... Full text Link to item Cite

Perioperative diabetes mellitus affects the outcomes of lung transplant recipients.

Journal Article Eur J Cardiothorac Surg · June 15, 2022 OBJECTIVES: Identifying the risks for chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is beneficial to the patient. We hypothesized that diabetes mellitus (DM) is relevant to CLAD development. Our study aimed to clarify if DM is ... Full text Link to item Cite

Creation of a video library for education and virtual simulation of anatomical lung resection.

Journal Article Interact Cardiovasc Thorac Surg · May 2, 2022 OBJECTIVES: Recently, preoperative and intraoperative simulation using three-dimensional computed tomography (CT) has attracted much attention in thoracic surgery. However, because conventional three-dimensional CT only shows static images, dynamic simulat ... Full text Link to item Cite

Virtual-assisted lung mapping in sublobar resection of small pulmonary nodules, long-term results.

Journal Article Eur J Cardiothorac Surg · March 24, 2022 OBJECTIVES: The short-term efficacy of virtual-assisted lung mapping (VAL-MAP), a preoperative bronchoscopic multi-spot lung-marking technique, has been confirmed in 2 prospective multicentre studies. The objectives of this study were to analyse the local ... Full text Link to item Cite

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors as a first-line treatment for postoperative recurrent and EGFR-mutated non-small-cell lung cancer.

Journal Article Interact Cardiovasc Thorac Surg · February 21, 2022 OBJECTIVES: To clarify survival outcomes and prognostic factors of patients receiving epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitors (TKIs) as first-line treatment for postoperative recurrence. METHODS: A retrospective chart review wa ... Full text Link to item Cite

Changes in the health-related quality of life and social reintegration status after lung transplantation following hematopoietic stem cell transplantation.

Journal Article Support Care Cancer · February 2022 PURPOSE: Late-onset non-infectious pulmonary complications (LONIPCs) after allogeneic hematopoietic stem cell transplantation are fatal; however, lung transplantation might achieve good survival. Nevertheless, improving the health-related quality of life ( ... Full text Link to item Cite

Risk factors of breakthrough aspergillosis in lung transplant recipients receiving itraconazole prophylaxis.

Journal Article J Infect Chemother · January 2022 INTRODUCTION: Invasive Aspergillus infection (IA) in lung transplantation can result in poor outcomes. Itraconazole has been shown to be effective for fungal prophylaxis in lung transplant recipients. However, IA remains a major cause of death after lung t ... Full text Link to item Cite

The importance of central airway dilatation in patients with bronchiolitis obliterans.

Journal Article ERJ Open Res · October 2021 BACKGROUND: Bronchiolitis obliterans (BO) is a clinical syndrome characterised by progressive small airway obstruction, causing significant morbidity and mortality. Central airway dilatation is one of its radiological characteristics, but little is known a ... Full text Link to item Cite

Lymph node dissection in thymic carcinomas and neuroendocrine carcinomas.

Journal Article Interact Cardiovasc Thorac Surg · July 26, 2021 OBJECTIVES: Although lymph node (LN) metastases are not uncommon in thymic carcinomas, preoperative LN evaluation, intraoperative lymph node dissection (LND) and postoperative outcomes remain unknown. The aim of this study was to elucidate the characterist ... Full text Link to item Cite

T-cell chimerism prior to graft-versus-host disease.

Journal Article Eur J Cardiothorac Surg · July 14, 2021 Graft-versus-host disease (GVHD), a serious complication of haematopoietic stem cell transplantation, can occur following solid organ transplantation. However, diagnosing solid organ transplantation-associated GVHD is difficult, and its risk factors are no ... Full text Link to item Cite

Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology.

Journal Article Sci Transl Med · July 7, 2021 Mucociliary clearance is an essential lung function that facilitates the removal of inhaled pathogens and foreign matter unidirectionally from the airway tract and is innately achieved by coordinated ciliary beating of multiciliated cells. Should ciliary f ... Full text Link to item Cite

Postoperative outcomes of lung transplant recipients with preformed donor-specific antibodies.

Journal Article Interact Cardiovasc Thorac Surg · April 19, 2021 OBJECTIVES: Few studies have evaluated the outcomes of lung transplantation (LTx) in recipients with preformed donor-specific antibodies (DSAs). This study investigated the postoperative changes in preformed DSAs based on prospectively collected data of DS ... Full text Link to item Cite

Updated long-term outcomes of salvage surgery after stereotactic body radiotherapy for early-stage non-small-cell lung cancer.

Journal Article Interact Cardiovasc Thorac Surg · December 7, 2020 There is dearth of data regarding the long-term survival outcomes of salvage surgery after stereotactic body radiotherapy for early-stage non-small-cell lung cancer, as previous studies have included a short follow-up period. There is also scarce informati ... Full text Link to item Cite

Left upper lobectomy is a risk factor for cerebral infarction after pulmonary resection: a multicentre, retrospective, case-control study in Japan.

Journal Article Surg Today · November 2020 PURPOSE: The anatomical site of resected lobes may influence postoperative cerebral infarction. The objective of the current study was to determine if left upper pulmonary lobectomy is a risk factor for postoperative cerebral infarction. METHODS: This was ... Full text Link to item Cite

Beneficial effects of perioperative low-dose inhaled carbon monoxide on pulmonary allograft survival in MHC-inbred CLAWN miniature swine.

Journal Article Transplantation · December 27, 2010 BACKGROUND: We have recently reported that perioperative low-dose carbon monoxide (CO) inhalation decreases lung ischemia-reperfusion injury in miniature swine. The aims of this study were to establish a large animal model of pulmonary allograft rejection ... Full text Link to item Cite