Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Primary Board Certification, Physical Medicine And Rehabilitation, American Board of Physical Medicine and Rehabilitation 2008 - 2028
  • Fellow in Pain Management, Anesthesiology, University of Virginia School of Medicine 2005 - 2006
  • Chief Resident, Physical Medicine And Rehabilitation, University of Virginia School of Medicine 2004 - 2005
  • Intern and Resident Physician, Physical Medication And Rehab, University of Virginia School of Medicine 2001 - 2005
  • M.D., University of Kentucky, College of Medicine 2001
  • Ph.D., University of Kentucky 1997
• 

  Medical Licensure

  • NC 2006-01250. North Carolina. 2006
• 

  Previous Appointments & Affiliations

  • Associate Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2017 - 2020
• 

  Academic Positions Outside Duke

  • Associate Professor, Wake Forest University, SOM. 2016 - 2017
  • Assistant Professor, Wake Forest University, SOM. 2006 - 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Gao, Chengjiang, Hongtao Guo, Junping Wei, Zhiyong Mi, Philip Wai, and Paul C. Kuo. “S-Nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages.” J Biol Chem 292, no. 8 (February 24, 2017): 3542. https://doi.org/10.1074/jbc.A117.313385.
       Full Text  Link to Item
    • Guo, Hongtao, Charles Q. Cai, and Paul C. Kuo. “Hepatocyte nuclear factor-4α mediates redox sensitivity of inducible nitric-oxide synthase gene transcription.” J Biol Chem 292, no. 3 (January 20, 2017): 1143. https://doi.org/10.1074/jbc.A116.109017.
       Full Text  Link to Item
    • Guo, Hongtao, Zhiyong Mi, Dawn E. Bowles, Syamal D. Bhattacharya, and Paul C. Kuo. “Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.” J Biol Chem 292, no. 3 (January 20, 2017): 1142. https://doi.org/10.1074/jbc.A110.161869.
       Full Text  Link to Item
    • Guo, Hongtao, Zhiyong Mi, and Paul C. Kuo. “Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene.” J Biol Chem 292, no. 3 (January 20, 2017): 1144. https://doi.org/10.1074/jbc.A116.804062.
       Full Text  Link to Item
    • Osada, Takuya, Michael A. Morse, Amy Hobeika, Marcio A. Diniz, William R. Gwin, Zachary Hartman, Junping Wei, et al. “Vaccination targeting human HER3 alters the phenotype of infiltrating T cells and responses to immune checkpoint inhibition.” Oncoimmunology 6, no. 6 (2017): e1315495. https://doi.org/10.1080/2162402X.2017.1315495.
       Full Text  Link to Item
    • Osada, Takuya, Koji Nagaoka, Masashi Takahara, Xiao Yi Yang, Cong-Xiao Liu, Hongtao Guo, Kingshuk Roy Choudhury, et al. “Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors.” J Immunother 38, no. 4 (May 2015): 155–64. https://doi.org/10.1097/CJI.0000000000000075.
       Full Text  Link to Item
    • Guo, H., C. Gao, Z. Mi, P. Y. Wai, and P. C. Kuo. “Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4a transcriptional activity.” Biochem J 461, no. 2 (July 15, 2014): 347. https://doi.org/10.1042/bj4610347.
       Full Text  Link to Item
    • Bhattacharya, Syamal D., Zhiyong Mi, Lindsay J. Talbot, Hongtao Guo, and Paul C. Kuo. “Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers.” Surgery 152, no. 3 (September 2012): 449–54. https://doi.org/10.1016/j.surg.2012.06.011.
       Full Text  Link to Item
    • Bhattacharya, Syamal D., Zhiyong Mi, Victoria M. Kim, Hongtao Guo, Lindsay J. Talbot, and Paul C. Kuo. “Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model.” Ann Surg 255, no. 2 (February 2012): 319–25. https://doi.org/10.1097/SLA.0b013e31823e3a1c.
       Full Text  Link to Item
    • Hartman, Zachary C., Junping Wei, Oliver K. Glass, Hongtao Guo, Gangjun Lei, Xiao-Yi Yang, Takuya Osada, et al. “Increasing vaccine potency through exosome antigen targeting.” Vaccine 29, no. 50 (November 21, 2011): 9361–67. https://doi.org/10.1016/j.vaccine.2011.09.133.
       Full Text  Link to Item
    • Talbot, Lindsay Jones, Zhiyong Mi, Syamal Dave Bhattacharya, Victoria Kim, Hongtao Guo, and Paul C. Kuo. “Pharmacokinetic characterization of an RNA aptamer against osteopontin and demonstration of in vivo efficacy in reversing growth of human breast cancer cells.” Surgery 150, no. 2 (August 2011): 224–30. https://doi.org/10.1016/j.surg.2011.05.015.
       Full Text  Link to Item
    • Mi, Zhiyong, Syamal D. Bhattacharya, Victoria M. Kim, Hongtao Guo, Lindsay J. Talbot, and Paul C. Kuo. “Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis.” Carcinogenesis 32, no. 4 (April 2011): 477–87. https://doi.org/10.1093/carcin/bgr009.
       Full Text  Link to Item
    • Guo, Hongtao, Zhiyong Mi, Dawn E. Bowles, Syamal D. Bhattacharya, and Paul C. Kuo. “Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.” J Biol Chem 285, no. 48 (November 26, 2010): 37787–96. https://doi.org/10.1074/jbc.M110.161869.
       Full Text  Link to Item
    • Bhattacharya, Syamal D., Juline Garrison, Hongtao Guo, Zhiyong Mi, Jovan Markovic, Victoria M. Kim, and Paul C. Kuo. “Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines.” Surgery 148, no. 2 (August 2010): 291–97. https://doi.org/10.1016/j.surg.2010.05.007.
       Full Text  Link to Item
    • Mi, Zhiyong, Hongtao Guo, and Paul C. Kuo. “Identification of osteopontin-dependent signaling pathways in a mouse model of human breast cancer.” Bmc Res Notes 2 (July 1, 2009): 119. https://doi.org/10.1186/1756-0500-2-119.
       Full Text  Link to Item
    • Zhang, Jinping, Hongtao Guo, Zhiyong Mi, Chengjiang Gao, Syamal Bhattacharya, Jiansheng Li, and Paul C. Kuo. “EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells.” Exp Cell Res 315, no. 2 (January 15, 2009): 304–12. https://doi.org/10.1016/j.yexcr.2008.10.042.
       Full Text  Link to Item
    • Mi, Zhiyong, Hongtao Guo, M Benjamin Russell, Yingmiao Liu, Bruce A. Sullenger, and Paul C. Kuo. “RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells.” Mol Ther 17, no. 1 (January 2009): 153–61. https://doi.org/10.1038/mt.2008.235.
       Full Text  Link to Item
    • Guo, Hongtao, Zhiyong Mi, and Paul C. Kuo. “Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene.” J Biol Chem 283, no. 37 (September 12, 2008): 25209–17. https://doi.org/10.1074/jbc.M804062200.
       Full Text  Link to Item
    • Guo, Hongtao, Philip Y. Wai, Zhiyong Mi, Chengjiang Gao, Jinping Zhang, and Paul C. Kuo. “Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis.” Surgery 144, no. 2 (August 2008): 182–88. https://doi.org/10.1016/j.surg.2008.03.007.
       Full Text  Link to Item
    • Emani, Sirisha, Jinping Zhang, Lucie Guo, Hongtao Guo, and Paul C. Kuo. “RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer.” Surgery 143, no. 6 (June 2008): 803–12. https://doi.org/10.1016/j.surg.2008.02.005.
       Full Text  Link to Item
    • Gao, Chengjiang, Zhiyong Mi, Hongtao Guo, and Paul C. Kuo. “Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.” Neoplasia 9, no. 9 (September 2007): 699–706. https://doi.org/10.1593/neo.07463.
       Full Text  Link to Item
    • Guo, Lucie, Hongtao Guo, Chengjiang Gao, Zhiyong Mi, William B. Russell, and Paul C. Kuo. “Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages.” Surgery 142, no. 2 (August 2007): 156–62. https://doi.org/10.1016/j.surg.2007.02.016.
       Full Text  Link to Item
    • Takami, Yoji, Michael B. Russell, Chengjiang Gao, Zhiyong Mi, Hongtao Guo, Christopher R. Mantyh, and Paul C. Kuo. “Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells.” Surgery 142, no. 2 (August 2007): 163–69. https://doi.org/10.1016/j.surg.2007.02.015.
       Full Text  Link to Item
    • Guo, Hongtao, Chengjiang Gao, Zhiyong Mi, Jinping Zhang, and Paul C. Kuo. “Characterization of the PC4 binding domain and its interactions with HNF4alpha.” J Biochem 141, no. 5 (May 2007): 635–40. https://doi.org/10.1093/jb/mvm066.
       Full Text  Link to Item
    • Mi, Zhiyong, Tim Oliver, Hongtao Guo, Chengjiang Gao, and Paul C. Kuo. “Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells.” Cancer Res 67, no. 9 (May 1, 2007): 4088–97. https://doi.org/10.1158/0008-5472.CAN-06-4066.
       Full Text  Link to Item
    • Gao, Chengjiang, Hongtao Guo, Zhiyong Mi, Michael J. Grusby, and Paul C. Kuo. “Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages.” J Immunol 178, no. 3 (February 1, 2007): 1870–81. https://doi.org/10.4049/jimmunol.178.3.1870.
       Full Text  Link to Item
    • Wai, Philip Y., Luci Guo, Chenjiang Gao, Zhiyong Mi, Hongtao Guo, and Paul C. Kuo. “Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation.” Surgery 140, no. 2 (August 2006): 132–40. https://doi.org/10.1016/j.surg.2006.02.005.
       Full Text  Link to Item
    • Wai, Philip Y., Zhiyong Mi, Chengjiang Gao, Hongtao Guo, Carlos Marroquin, and Paul C. Kuo. “Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells.” J Biol Chem 281, no. 28 (July 14, 2006): 18973–82. https://doi.org/10.1074/jbc.M511962200.
       Full Text  Link to Item
    • Mi, Zhiyong, Hongtao Guo, Philip Y. Wai, Chengjiang Gao, and Paul C. Kuo. “Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells.” Carcinogenesis 27, no. 6 (June 2006): 1134–45. https://doi.org/10.1093/carcin/bgi352.
       Full Text  Link to Item
    • Guo, Hongtao, Chengjiang Gao, Zhiyong Mi, Philip Y. Wai, and Paul C. Kuo. “Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.” Biochem J 394, no. Pt 2 (March 1, 2006): 379–87. https://doi.org/10.1042/BJ20051730.
       Full Text  Link to Item
    • Gao, Chengjiang, Hongtao Guo, Zhiyong Mi, Philip Y. Wai, and Paul C. Kuo. “Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin.” J Immunol 175, no. 1 (July 1, 2005): 523–30. https://doi.org/10.4049/jimmunol.175.1.523.
       Full Text  Link to Item
    • Marroquin, Carlos E., Philip Y. Wai, Paul C. Kuo, and Hongtao Guo. “Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4.” Surgery 138, no. 1 (July 2005): 93–99. https://doi.org/10.1016/j.surg.2005.03.014.
       Full Text  Link to Item
    • Guo, Hongtao, Carlos E. Marroquin, Philip Y. Wai, and Paul C. Kuo. “Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells.” Dig Dis Sci 50, no. 7 (July 2005): 1288–98. https://doi.org/10.1007/s10620-005-2775-6.
       Full Text  Link to Item
    • Wai, Philip Y., Zhiyong Mi, Hongtao Guo, Shiva Sarraf-Yazdi, Chengjiang Gao, Junping Wei, Carlos E. Marroquin, Bryan Clary, and Paul C. Kuo. “Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis.” Carcinogenesis 26, no. 4 (April 2005): 741–51. https://doi.org/10.1093/carcin/bgi027.
       Full Text  Link to Item
    • Gao, Chengjiang, Hongtao Guo, Junping Wei, Zhiyong Mi, Philip Y. Wai, and Paul C. Kuo. “Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages.” Nitric Oxide 12, no. 2 (March 2005): 121–26. https://doi.org/10.1016/j.niox.2004.11.006.
       Full Text  Link to Item
    • Mi, Zhiyong, Hongtao Guo, Philip Y. Wai, Chengjiang Gao, Junping Wei, and Paul C. Kuo. “Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.” J Biol Chem 279, no. 45 (November 5, 2004): 46659–67. https://doi.org/10.1074/jbc.M407952200.
       Full Text  Link to Item
    • Gao, Chengjiang, Zhiyong Mi, Hongtao Guo, Junping Wei, Philip Y. Wai, and Paul C. Kuo. “A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line.” Biochem Biophys Res Commun 321, no. 4 (September 3, 2004): 1010–16. https://doi.org/10.1016/j.bbrc.2004.07.063.
       Full Text  Link to Item
    • Marroquin, Carlos E., Laura Downey, Hongtao Guo, and Paul C. Kuo. “Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells.” Immunol Lett 95, no. 1 (August 15, 2004): 109–12. https://doi.org/10.1016/j.imlet.2004.06.001.
       Full Text  Link to Item
    • Gao, Chengjiang, Hongtao Guo, Junping Wei, Zhiyong Mi, Philip Wai, and Paul C. Kuo. “S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages.” J Biol Chem 279, no. 12 (March 19, 2004): 11236–43. https://doi.org/10.1074/jbc.M313385200.
       Full Text  Link to Item
    • Wei, Junping, Hongtao Guo, Chengjiang Gao, and Paul C. Kuo. “Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter.” Biochem J 377, no. Pt 3 (February 1, 2004): 809–18. https://doi.org/10.1042/BJ20031235.
       Full Text  Link to Item
    • Gao, Chengjiang, Hongtao Guo, Laura Downey, Carlos Marroquin, Junping Wei, and Paul C. Kuo. “Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells.” Carcinogenesis 24, no. 12 (December 2003): 1871–78. https://doi.org/10.1093/carcin/bgg139.
       Full Text  Link to Item
    • Gao, Chengjiang, Hongtao Guo, Junping Wei, and Paul C. Kuo. “Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages.” Biochem Biophys Res Commun 309, no. 1 (September 12, 2003): 120–25. https://doi.org/10.1016/s0006-291x(03)01534-1.
       Full Text  Link to Item
    • Guo, Hongtao, Junping Wei, Yusuke Inoue, Frank J. Gonzalez, and Paul C. Kuo. “Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes.” Am J Physiol Cell Physiol 284, no. 4 (April 2003): C1090–99. https://doi.org/10.1152/ajpcell.00394.2002.
       Full Text  Link to Item
    • Gao, Chun, Sewite Negash, Hong Tao Guo, Dolena Ledee, Hwai-Shi Wang, and Peggy Zelenka. “CDK5 regulates cell adhesion and migration in corneal epithelial cells.” Mol Cancer Res 1, no. 1 (November 2002): 12–24.
       Link to Item
    • Wei, Junping, Hongtao Guo, and Paul C. Kuo. “Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages.” J Immunol 168, no. 9 (May 1, 2002): 4721–27. https://doi.org/10.4049/jimmunol.168.9.4721.
       Full Text  Link to Item
    • Guo, Hongtao, Charles Q. Cai, and Paul C. Kuo. “Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription.” J Biol Chem 277, no. 7 (February 15, 2002): 5054–60. https://doi.org/10.1074/jbc.M109017200.
       Full Text  Link to Item
    • Guo, Hong T., Charles Q. Cai, Rebecca A. Schroeder, and Paul C. Kuo. “Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages.” Immunol Lett 80, no. 1 (January 1, 2002): 21–26. https://doi.org/10.1016/s0165-2478(01)00284-x.
       Full Text  Link to Item
    • Guo, H., J. Wei, and P. C. Kuo. “Nitric oxide inhibits expression of cytochrome B in endotoxin-stimulated murine macrophages.” Biochem Biophys Res Commun 289, no. 5 (December 21, 2001): 993–97. https://doi.org/10.1006/bbrc.2001.6107.
       Full Text  Link to Item
    • Guo, H., Z. Li, F. Zhang, Z. Zhang, L. Xu, W. Li, W. Wang, and M. Wu. “Surgical treatment of malignant esophageal tumors in PUMC Hospital.” Chin Med Sci J 16, no. 4 (December 2001): 214–17.
       Link to Item
    • Gao, C., S. Negash, H. S. Wang, D. Ledee, H. Guo, P. Russell, and P. Zelenka. “Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock.” J Cell Sci 114, no. Pt 6 (March 2001): 1145–53. https://doi.org/10.1242/jcs.114.6.1145.
       Full Text  Link to Item
    • Guo, H., C. Q. Cai, R. A. Schroeder, and P. C. Kuo. “Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages.” J Immunol 166, no. 2 (January 15, 2001): 1079–86. https://doi.org/10.4049/jimmunol.166.2.1079.
       Full Text  Link to Item
    • Guo, H., Z. Li, Z. Zhang, C. Sun, L. Xu, W. Li, S. Wang, and M. Wu. “[Surgical treatment of malignant esophageal tumors in PUMC Hospital].” Zhongguo Yi Xue Ke Xue Yuan Xue Bao 22, no. 6 (December 2000): 548–50.
       Link to Item
    • Guo, H. T., C. Q. Cai, and P. C. Kuo. “Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages.” Biochem Biophys Res Commun 277, no. 3 (November 2, 2000): 617–21. https://doi.org/10.1006/bbrc.2000.3718.
       Full Text  Link to Item
    • Cai, C. Q., H. Guo, R. A. Schroeder, C. Punzalan, and P. C. Kuo. “Nitric oxide-dependent ribosomal RNA cleavage is associated with inhibition of ribosomal peptidyl transferase activity in ANA-1 murine macrophages.” J Immunol 165, no. 7 (October 1, 2000): 3978–84. https://doi.org/10.4049/jimmunol.165.7.3978.
       Full Text  Link to Item
    • Pan, G., S. Lu, M. Ke, S. Han, H. Guo, and X. Fang. “[An epidemiologic study of irritable bowel syndrome in Beijing - a stratified randomized study by clustering sampling].” Zhonghua Liu Xing Bing Xue Za Zhi 21, no. 1 (February 2000): 26–29.
       Link to Item
    • Guo, H., T. Liu, and J. Gao. “[Murine Doube Minute 2 oncogene inhibited apoptosis induced by retroviral-mediated wild-type p53].” Zhongguo Yi Xue Ke Xue Yuan Xue Bao 20, no. 6 (December 1998): 401–6.
       Link to Item
    • Guo, H., T. Liu, and J. Gao. “Inhibiting effect of murine double minute-2 oncogene on apoptosis induced by retroviral-mediated wild-type p53.” Chin Med J (Engl) 111, no. 12 (December 1998): 1102–6.
       Link to Item
    • Guo, H., T. Liu, and J. Gao. “[The effect of adenovirus-mediated wild-type p53 expression on the growth of human pancreatic carcinoma cell line cells].” Zhongguo Yi Xue Ke Xue Yuan Xue Bao 20, no. 5 (October 1998): 345–50.
       Link to Item
    • Guo, H., T. Liu, and J. Gao. “[Apoptosis induced by adenovirus-mediated wild-type p53 expression in human pancreatic cancer cells].” Zhonghua Bing Li Xue Za Zhi 27, no. 3 (June 1998): 194–97.
       Link to Item
    • Guo, H., Z. Li, Z. Zhang, H. Ren, H. Yu, F. Ge, C. Sun, and L. Xu. “Diagnosis and treatment of stage-III peripheral squamous cell carcinoma of right upper lung.” Chin Med Sci J 12, no. 4 (December 1997): 236–39.
       Link to Item
    • Zhang, L., H. Guo, and T. Liu. “[The inhibitory effect of combined treatment of TNF alpha and antisense oligodeoxynucleotides on the growth of human pancreatic carcinoma cell line cells].” Zhonghua Bing Li Xue Za Zhi 26, no. 5 (October 1997): 281–84.
       Link to Item
    • Zhang, H., X. Xu, and H. Guo. “[Systemic manifestations of myasthenia gravis and its putative pathogenesis].” Zhonghua Nei Ke Za Zhi 36, no. 6 (June 1997): 368–71.
       Link to Item
    • Aziz, S. M., M. Toborek, B. Hennig, M. P. Mattson, H. Guo, and D. W. Lipke. “Oxidative stress mediates monocrotaline-induced alterations in tenascin expression in pulmonary artery endothelial cells.” Int J Biochem Cell Biol 29, no. 5 (May 1997): 775–87. https://doi.org/10.1016/s1357-2725(97)00010-1.
       Full Text  Link to Item
    • Lipke, D. W., P. S. Newman, S. Tofiq, H. Guo, S. S. Arcot, S. M. Aziz, J. W. Olson, and E. E. Soltis. “Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension.” Clin Exp Hypertens 19, no. 3 (April 1997): 269–95. https://doi.org/10.3109/10641969709080819.
       Full Text  Link to Item
    • Guo, H., G. DeWitt, M. Wu, and P. Ashton. “Ion-paired codrug for increased ocular absorption.” Proceedings of the Controlled Release Society, no. 24 (January 1, 1997): 617–18.
    • Guo, H., T. Liu, and J. Gao. “[Studies on MDM2 oncogene expression and its effect on pancreatic carcinoma cells].” Zhonghua Bing Li Xue Za Zhi 25, no. 4 (August 1996): 232–35.
       Link to Item
    • Guo, H., G. DeWitt, and P. Ashton. “Antibiotic/nonsteroidal anti-inflammatory codrugs for topical application.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
    • Kasahara, N., H. Wu, H. Guo, and P. Ashton. “Sustained release ciprofloxacin and diclofenac from a disposable contact lens.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
    • Ramasamy, S., D. W. Lipke, G. A. Boissonneault, H. Guo, and B. Hennig. “Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells.” Atherosclerosis 120, no. 1–2 (February 1996): 199–208. https://doi.org/10.1016/0021-9150(95)05702-1.
       Full Text  Link to Item
    • Guo, H. Y., R. R. Lorenz, and P. M. Vanhoutte. “Anisodamine at higher concentrations in inhibiting alpha-adrenergic responses in isolated canine blood vessels.” Chin Med J (Engl) 106, no. 6 (June 1993): 452–57.
       Link to Item

  • Book Sections

    • Guo, H. M., J. J. Hawes, and M. K. Childers. “Botulinum Toxin Injections in Myofascial Pain Disorders.” In Pain Procedures in Clinical Practice, 97–110, 2011. https://doi.org/10.1016/B978-1-4160-3779-8.10014-4.
       Full Text

  • Conference Papers

    • Guo, H., T. Cynkowski, G. Cynkowska, P. A. Crooks, G. J. Jaffe, and P. Ashton. “"Smart" co-drugs. Rapid intravitreal delivery of 5-FU and prolonged delivery of steroid from the same erodible device.” In Investigative Ophthalmology and Visual Science, Vol. 38, 1997.
    • Yang, D. C. S., J. A. Khawly, D. P. Hainsworth, S. Chen, P. Ashton, H. Guo, and G. J. Jaffe. “Efficacy and pharmacokinetics of intravitreal sustained release triamcinolone/5-FU codrug suspension in the treatment of experimental PVR.” In Investigative Ophthalmology and Visual Science, Vol. 37, 1996.
    • Ashton, P., H. Guo, G. Cynkowska, T. Cynkowski, and P. A. Crooks. “Disease enhanced delivery from erodible implants.” In Proceedings of the Controlled Release Society, 163–64, 1995.
    • Guo, H., T. Cynkowski, G. Cynkowska, P. A. Crooks, and P. Ashton. “Sustained release of synergistic agents.” In Proceedings of the Controlled Release Society, 326–27, 1995.
• Teaching & Mentoring
• 

  Recent Courses

  • ORTHO 221C: Physical Medicine and Rehabilitation 2022
  • ORTHO 221C: Physical Medicine and Rehabilitation 2021

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.