Scholars@Duke
E. Hope Weissler

E. Hope Weissler

House Staff
Surgery

Selected Publications

Implementation of an acute care vascular surgery "Surgeon of the Week" model improves efficiency of inpatient care delivery.

Journal Article J Vasc Surg · June 7, 2025 OBJECTIVE: Acute care vascular surgery (ACVS) comprises a significant proportion of modern vascular surgery practice. Given the burden of ACVS at our institution, we have transitioned from a traditional "on call" model to a "Surgeon of the Week" (SOW) mode ... Full text Link to item Cite

Effectiveness of Negative Pressure Wound Therapy on Groin Surgical Site Infection After Lower Extremity Bypass for Chronic Limb-Threatening Ischemia.

Journal Article Ann Vasc Surg · February 2025 BACKGROUND: Surgical site infections (SSIs) are a common cause of patient morbidity, hospital readmission, and reoperation after lower extremity bypass (LEBs) surgery for chronic limb-threatening ischemia (CLTI). Recent studies on the use of incisional neg ... Full text Link to item Cite

Understanding the Scope of Acute Care Vascular Surgery at a Tertiary Academic Medical System.

Journal Article Ann Vasc Surg · January 2025 BACKGROUND: The restructuring of nonelective general surgery and nationwide implementation of the acute care surgery paradigm has improved patient outcomes and healthcare resource utilization. Although vascular surgery maintains one of the highest acuity r ... Full text Link to item Cite

Engaging patients and their caregivers in research to improve evidence-based, patient-centered and equitable care for chronic limb-threatening ischemia and advanced peripheral artery disease.

Journal Article JVS Vasc Insights · 2025 Chronic limb-threatening ischemia (CLTI) is the end stage of advanced peripheral artery disease (PAD), a condition that is estimated to affect more than 200 million individuals globally. CLTI poses significant risks to many patients, particularly those fro ... Full text Link to item Cite

Defining the Value of Vascular Surgery Service at a Tertiary Academic Medical Center.

Journal Article Ann Vasc Surg · December 2024 BACKGROUND: Vascular surgeons play a critical role in the functioning of a healthcare system. As a service line, vascular surgery not only performs its own complex operations but also provides support to other surgical specialties by assisting in the manag ... Full text Link to item Cite

Impact of Wound Closure Technique on Surgical Site Infection After Lower Extremity Bypass Surgery.

Journal Article Ann Vasc Surg · December 2024 BACKGROUND: Surgical site infections (SSIs) are among the most common complications after lower extremity bypass (LEB). Both patient and hospital-related factors have been associated with SSI after LEB; however, the impact of surgical closure technique on ... Full text Link to item Cite

Development and Validation of a Natural Language Processing Model to Identify Low-Risk Pulmonary Embolism in Real Time to Facilitate Safe Outpatient Management.

Journal Article Ann Emerg Med · August 2024 STUDY OBJECTIVE: This study aimed to (1) develop and validate a natural language processing model to identify the presence of pulmonary embolism (PE) based on real-time radiology reports and (2) identify low-risk PE patients based on previously validated r ... Full text Link to item Cite

Using Separate Single-Outcome Risk Presentations Instead of Integrated Multioutcome Formats Improves Comprehension in Discrete Choice Experiments.

Journal Article Med Decis Making · August 2024 INTRODUCTION: Despite decades of research on risk-communication approaches, questions remain about the optimal methods for conveying risks for different outcomes across multiple time points, which can be necessary in applications such as discrete choice ex ... Full text Link to item Cite

Leveraging Computational Fluid Dynamics for Next-Generation Preoperative Planning in Vascular Surgery.

Conference Annu Int Conf IEEE Eng Med Biol Soc · July 2024 Chronic limb-threatening ischemia (CLTI) is one of the leading causes of permanent disability and death in the United States and around the world. Surgical revascularization is the mainstay of treatment for CLTI, but patients still suffer high rates of lim ... Full text Link to item Cite

Long-term outcomes for hybrid aortic arch repair.

Journal Article J Vasc Surg · April 2024 OBJECTIVE: Since its inception in the early 2000s, hybrid arch repair (HAR) has evolved from novel approach to well-established treatment modality for aortic arch pathology in appropriately selected patients. Despite this nearly 20-year history of use, lon ... Full text Link to item Cite

Surgical Specialty Impacts Quality of Operative Training in Carotid Endarterectomy.

Journal Article Ann Vasc Surg · February 2024 BACKGROUND: Carotid endarterectomy (CEA) is currently performed by multiple surgical specialties. The impact of surgical specialty and operative volume on post-CEA outcomes has been well described. However, it is unclear whether trainees of different surgi ... Full text Link to item Cite

Failure-to-Salvage After Femoropopliteal Bypass Surgery is Associated With Nonmodifiable Risk Factors.

Journal Article J Surg Res · January 2024 INTRODUCTION: Bypass graft failure and major amputation are among the worst complications after femoropopliteal bypass surgery. In this large multicenter analysis, we examined our incidence and risk factors for failure-to-salvage (FTS) following either byp ... Full text Link to item Cite

Preoperative Anemia is Associated with Poorer Postoperative Outcomes in Patients Undergoing Infrainguinal Bypass Surgery.

Journal Article Ann Vasc Surg · November 2023 BACKGROUND: Preoperative anemia is an important, modifiable risk factor among surgical patients. However, data are scarce on the impact of preoperative anemia on postoperative outcomes after infrainguinal bypass. METHODS: In this multi-institutional analys ... Full text Link to item Cite

Sex-based differences in outcomes after lower extremity bypass for chronic limb-threatening ischemia.

Journal Article Atherosclerosis · November 2023 BACKGROUND AND AIMS: Lower extremity bypass surgery is an effective treatment option for patients with chronic limb-threatening ischemia (CLTI). Recent studies have suggested that sex-based differences may impact patient outcomes following lower extremity ... Full text Link to item Cite

Tailored approach and outcomes of aortic arch reconstruction after acute type A dissection repair.

Journal Article J Thorac Cardiovasc Surg · October 2023 OBJECTIVE: After limited root/ascending with or without hemiarch repair for acute type A aortic dissection (ATAAD), 20% to 30% of patients require distal reintervention, frequently for arch pathology. In this report, we describe an institutional algorithm ... Full text Link to item Cite

Development and Integration of Machine Learning Algorithm to Identify Peripheral Arterial Disease: Multistakeholder Qualitative Study.

Journal Article JMIR Form Res · September 21, 2023 BACKGROUND: Machine learning (ML)-driven clinical decision support (CDS) continues to draw wide interest and investment as a means of improving care quality and value, despite mixed real-world implementation outcomes. OBJECTIVE: This study aimed to explore ... Full text Link to item Cite

Internet Versus Noninternet Participation in a Decentralized Clinical Trial: Lessons From the ADAPTABLE Study.

Journal Article J Am Heart Assoc · July 4, 2023 Background Internet-based participation has the potential to enhance pragmatic and decentralized trials, where representative study populations and generalizability to clinical practice are key. We aimed to study the differences between internet and nonint ... Full text Link to item Cite

A Systematic Review of Clopidogrel Resistance in Vascular Surgery: Current Perspectives and Future Directions.

Journal Article Ann Vasc Surg · April 2023 BACKGROUND: Clopidogrel resistance is a well-described phenomenon that has been linked to adverse cardiovascular events in patients with coronary artery disease. The impact of clopidogrel resistance in patient outcomes after vascular and endovascular surge ... Full text Link to item Cite

Failing To See the Forest for the Trees.

Journal Article Eur J Vasc Endovasc Surg · April 2023 Full text Link to item Cite

Outcomes among patients with peripheral artery disease in the Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness (ADAPTABLE) study.

Journal Article Vasc Med · April 2023 BACKGROUND: We aimed to understand the effects of aspirin dose on outcomes in patients with peripheral artery disease (PAD) as well as their participation in a pragmatic randomized controlled trial. METHODS: In a subanalysis of the Aspirin Dosing: A Patien ... Full text Link to item Cite

Selective Sinus Replacement for Aortic Root Aneurysm: Durable Approach in Selected Patients.

Journal Article Ann Thorac Surg · February 2023 BACKGROUND: Selective sinus replacement (SSR) allows a tailored repair approach in patients with sinus of Valsalva or asymmetric aortic root aneurysm. SSR avoids the need for coronary reimplantation for nondiseased sinuses and shortens operative time, alth ... Full text Link to item Cite

Restoring Venous Patency with the ClotTriever Following Deep Vein Thrombosis.

Journal Article Ann Vasc Surg · January 2023 BACKGROUND: Although randomized data remain inconclusive, invasive endovenous therapy is increasingly favored in patients with extensive iliocaval or iliofemoral deep vein thrombosis (DVT) to reduce the rates of postthrombotic syndrome. Previously, pharmac ... Full text Link to item Cite

Association Between Device Type and Type IIIb Endoleaks Following Thoracic Endovascular Aortic Repair.

Journal Article Eur J Vasc Endovasc Surg · January 2023 OBJECTIVE: Endoleaks following thoracic endovascular aortic repair (TEVAR) can lead to the need for re-intervention and aortic rupture. Given the recent recall of a specific thoracic stent graft type due to concerns about type IIIb endoleak (T3bE), in whic ... Full text Link to item Cite

Initial Thoracic Endovascular Aortic Repair vs Medical Therapy for Acute Uncomplicated Type B Aortic Dissection.

Journal Article JAMA Cardiol · January 1, 2023 IMPORTANCE: Thoracic endovascular aortic repair (TEVAR) has increasingly been used for uncomplicated type B aortic dissection (uTBAD) despite limited supporting data. OBJECTIVE: To assess whether initial TEVAR following uTBAD is associated with reduced mor ... Full text Link to item Cite

Stent Graft-induced Aortic Wall Injury: Incidence, Risk Factors, and Outcomes.

Journal Article Ann Thorac Surg · September 2022 BACKGROUND: Stent graft-induced new entry has been described in thoracic endovascular aortic repair for aortic dissection. The incidence of stent graft-induced aortic wall injury (SAWI) related to iatrogenic injury in nondissections is incompletely describ ... Full text Link to item Cite

Impact of risk factor control on peripheral artery disease outcomes and health disparities.

Journal Article Vasc Med · August 2022 BACKGROUND: Peripheral artery disease (PAD) is associated with modifiable atherosclerotic risk factors like hypertension, diabetes, hyperlipidemia, and smoking. However, the effect of risk factor control on outcomes and disparities in achieving control is ... Full text Link to item Cite

Cardiovascular and Limb Events Following Endovascular Revascularization Among Patients ≥65 Years Old: An American College of Cardiology PVI Registry Analysis.

Journal Article J Am Heart Assoc · June 20, 2022 Background We aimed to characterize the occurrence of major adverse cardiovascular and limb events (MACE and MALE) among patients with peripheral artery disease (PAD) undergoing peripheral vascular intervention (PVI), as well as associated factors in patie ... Full text Link to item Cite

Vertebral artery transection with pseudoaneurysm and arteriovenous fistula requiring antegrade and retrograde embolization.

Conference J Vasc Surg Cases Innov Tech · June 2022 Traumatic vertebral artery injury is a rare, life-threatening injury that has been increasingly managed with endovascular intervention. However, an antegrade endovascular approach alone can fail to occlude traumatic pseudoaneurysms (PSAs) and arteriovenous ... Full text Link to item Cite

Clinician Specialty, Access to Care, and Outcomes Among Patients with Peripheral Artery Disease.

Journal Article Am J Med · February 2022 BACKGROUND: Understanding the relationship between patterns of peripheral artery disease and outcomes is an essential step toward improving care and outcomes. We hypothesized that clinician specialty would be associated with occurrence of major adverse vas ... Full text Link to item Cite

Percutaneous Coronary Intervention Following Diagnostic Angiography by Noninterventional Versus Interventional Cardiologists: Insights From the CathPCI Registry.

Journal Article Circulation. Cardiovascular interventions · January 2022 BackgroundThere are limited contemporary, national data describing diagnostic cardiac catheterization with subsequent percutaneous coronary intervention (ad hoc percutaneous coronary intervention [PCI]) performed by an invasive-diagnostic and inte ... Full text Cite

Understanding Study Drug Discontinuation Through EUCLID.

Journal Article Front Cardiovasc Med · 2022 INTRODUCTION: Disparities in the care and outcomes of peripheral artery disease (PAD) have been well-established. In part this is due to disparities in enrollment of PAD trial cohorts. However, less attention has been paid to non-random protocol non-adhere ... Full text Link to item Cite

Younger patients with chronic limb threatening ischemia face more frequent amputations.

Journal Article Am Heart J · December 2021 INTRODUCTION: Amputations among younger patients with chronic limb threatening ischemia (CLTI) may carry higher personal and societal costs, but younger patients are often not included in CLTI research because of dataset limitations. We aimed to characteri ... Full text Link to item Cite

Predicting major adverse limb events in individuals with type 2 diabetes: Insights from the EXSCEL trial.

Journal Article Diabet Med · October 2021 AIMS: Although models exist to predict amputation among people with type 2 diabetes with foot ulceration or infection, we aimed to develop a prediction model for a broader range of major adverse limb events (MALE)-including gangrene, revascularization and ... Full text Link to item Cite

The association of healthcare disparities and patient-specific factors on clinical outcomes in peripheral artery disease.

Journal Article Am Heart J · September 2021 BACKGROUND: PAD increases the risk of cardiovascular mortality and limb loss, and disparities in treatment and outcomes have been described. However, the association of patient-specific characteristics with variation in outcomes is less well known. METHODS ... Full text Link to item Cite

The role of machine learning in clinical research: transforming the future of evidence generation.

Journal Article Trials · August 16, 2021 BACKGROUND: Interest in the application of machine learning (ML) to the design, conduct, and analysis of clinical trials has grown, but the evidence base for such applications has not been surveyed. This manuscript reviews the proceedings of a multi-stakeh ... Full text Open Access Link to item Cite

National trends in repair for type B aortic dissection.

Journal Article Clin Cardiol · August 2021 BACKGROUND: Thoracic endovascular aortic repair (TEVAR) first gained in popularity for repair of type B aortic dissections (TBADs) in the early 2000's. We aimed to describe patients undergoing open repair, TEVAR, and no repair and analyze factors associate ... Full text Link to item Cite

Retrograde Transamputation Revascularization: A Case Report.

Journal Article Ann Vasc Surg · July 2021 Below-knee amputation remains the most common level of amputation in patients with lower extremity gangrene and critical limb ischemia. Failure to heal, requiring additional operative debridement or conversion to an above-knee amputation remains a signific ... Full text Link to item Cite

The Role for Combined Antithrombotic Therapy With Platelet and Coagulation Inhibition After Lower Extremity Revascularization.

Journal Article JACC Cardiovasc Interv · April 12, 2021 Evidence for antithrombotic treatment following lower extremity revascularization (LER) for peripheral artery disease (PAD) is limited, leading to weak and conflicting guideline recommendations and heterogeneous practice patterns. This variability in post- ... Full text Link to item Cite

Successful Peripheral Vascular Intervention in Patients with High-risk Comorbidities or Lesion Characteristics.

Journal Article Curr Cardiol Rep · March 5, 2021 PURPOSE OF REVIEW: Certain comorbidities and lesion characteristics are associated with increased risk for procedural complications, limb events, and cardiovascular events following peripheral vascular intervention (PVI) in patients with peripheral arteria ... Full text Link to item Cite

Paclitaxel-coated devices in the treatment of femoropopliteal stenosis among patients ≥65 years old: An ACC PVI Registry Analysis.

Journal Article Am Heart J · March 2021 BACKGROUND: The connection between paclitaxel-coated devices (PCD) use during peripheral vascular interventions (PVI) and mortality is debated. We aimed to analyze patterns of PCD use and the safety and effectiveness of PCD use in the superficial femoral a ... Full text Link to item Cite

Characteristics and Outcomes of Patients With Diabetes Mellitus Undergoing Peripheral Vascular Intervention for Infrainguinal Symptomatic Peripheral Artery Disease.

Journal Article Vasc Endovascular Surg · February 2021 PURPOSE: Patients with diabetes mellitus (DM) are known to be at higher risk for peripheral artery disease (PAD), amputations, and major adverse cardiovascular events, though it is unclear whether they are at any higher risk for repeat intervention. LIBERT ... Full text Link to item Cite

Association of Chronic Obstructive Pulmonary Disease with Morbidity and Mortality in Patients with Peripheral Artery Disease: Insights from the EUCLID Trial.

Journal Article Int J Chron Obstruct Pulmon Dis · 2021 BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of developing lower extremity peripheral artery disease (PAD) and suffering PAD-related morbidity and mortality. However, the effect and burden of COPD on patients ... Full text Link to item Cite

Preoperative Screening for COVID-19.

Journal Article North Carolina medical journal · January 2021 Cite

Polyvascular disease: A narrative review of current evidence and a consideration of the role of antithrombotic therapy.

Journal Article Atherosclerosis · December 2020 BACKGROUND AND AIMS: Polyvascular disease (PVD) affects approximately 20% of patients with atherosclerosis and is a strong independent risk factor for ischemic outcomes. However, guidelines do not address screening or treatment for PVD, and there have been ... Full text Link to item Cite

Permissive Hypertension and Collateral Revascularization May Allow Avoidance of Cerebrospinal Fluid Drainage in Thoracic Endovascular Aortic Repair.

Journal Article Ann Thorac Surg · November 2020 BACKGROUND: The utility of cerebrospinal fluid drainage (CSFD) for prevention of spinal cord ischemia (SCI) after thoracic endovascular aortic repair (TEVAR) remains unclear. We previously published our institutional algorithm restricting preoperative CSFD ... Full text Link to item Cite

The impact of chronic kidney disease on outcomes following peripheral vascular intervention.

Journal Article Clin Cardiol · November 2020 BACKGROUND: Patients with chronic kidney disease (CKD) have worsened clinical outcomes following percutaneous coronary intervention; however, limited evidence exists in patients undergoing peripheral vascular intervention (PVI). PURPOSE: We aimed to assess ... Full text Link to item Cite

Use of Natural Language Processing to Improve Identification of Patients With Peripheral Artery Disease.

Journal Article Circ Cardiovasc Interv · October 2020 BACKGROUND: Peripheral artery disease (PAD) is underrecognized, undertreated, and understudied: each of these endeavors requires efficient and accurate identification of patients with PAD. Currently, PAD patient identification relies on diagnosis/procedure ... Full text Link to item Cite

Model-Based Algorithms for Detecting Peripheral Artery Disease Using Administrative Data From an Electronic Health Record Data System: Algorithm Development Study.

Journal Article JMIR Med Inform · August 19, 2020 BACKGROUND: Peripheral artery disease (PAD) affects 8 to 10 million Americans, who face significantly elevated risks of both mortality and major limb events such as amputation. Unfortunately, PAD is relatively underdiagnosed, undertreated, and underresearc ... Full text Link to item Cite

Safety and Feasibility of Simultaneous Transcarotid Revascularization With Flow Reversal and Coronary Artery Bypass Grafting for Concomitant Carotid Artery Stenosis and Coronary Artery Disease.

Journal Article Vasc Endovascular Surg · July 2020 OBJECTIVE: The management of patients with combined severe carotid artery and coronary artery disease (CAD) is controversial. Transcarotid stenting with flow reversal (TCAR) is a novel hybrid technique for carotid revascularization. We sought to investigat ... Full text Link to item Cite

Aortic valve repair with a newly approved geometric annuloplasty ring in patients undergoing proximal aortic repair: early results from a single-centre experience.

Journal Article Eur J Cardiothorac Surg · June 1, 2020 OBJECTIVES: Aortic insufficiency (AI) is common in patients with proximal aortic disease, but limited options exist to facilitate aortic valve repair (AVr) in this population. This study reports 'real-world' early results of AVr using newly FDA-approved tr ... Full text Link to item Cite

A Hybrid Approach to Radiation-Induced Axillary Artery Hemorrhage.

Journal Article Vasc Endovascular Surg · February 2020 Axillary artery blowout is a rare life- and limb-threatening condition. The traditional surgical approach of ligation and extra-anatomic bypass is associated with a high morbidity and mortality. We present a case report of a 65-year-old male with axillary ... Full text Link to item Cite

Plastic Surgeon Closure of Index Spinal Cases: A Single-Institution Review of 928 Cases.

Journal Article Clinical spine surgery · November 2019 PurposeThe role of the plastic surgeon in wound management following complications from prior spinal surgeries is well established. The present study evaluates wound complications following plastic surgeon closure of the primary spinal surgery in ... Full text Cite

Patient-reported Outcome Instruments in Lower Extremity Trauma: A Systematic Review of the Literature.

Journal Article Plast Reconstr Surg Glob Open · May 2019 BACKGROUND: Advances in fracture fixation and soft tissue coverage continue to improve the care of patients after limb-threatening lower extremity (LE) trauma. However, debate continues regarding which treatment option-reconstruction or amputation-is most ... Full text Link to item Cite

An Evidence-Based Approach to Management of Pectus Excavatum and Carinatum.

Journal Article Annals of plastic surgery · March 2019 Pectus excavatum (PE) and pectus carinatum (PC) are the most common congenital chest wall anomalies. Current research suggests that PE and PC may result from overgrowth of the sternocostal cartilages. This can produce a deformation that displaces the stern ... Full text Cite

Preoperative breast size affects reconstruction status following mastectomy.

Journal Article The breast journal · November 2017 Much research has been devoted to why women choose not to be reconstructed following mastectomy. The effect of breast size has not been well explored. The authors aimed to assess the relationship between breast size and reconstructive choices. A single-cen ... Full text Cite

Reply: Alveolar Bone Grafting and Cleft Lip and Palate: A Review.

Journal Article Plastic and reconstructive surgery · August 2017 Full text Cite

The Necessity of the Nipple: Redefining Completeness in Breast Reconstruction.

Journal Article Annals of plastic surgery · June 2017 IntroductionSatisfaction with breast reconstruction is thought to be greatest among patients who complete nipple and areolar complex (NAC) reconstruction. Anecdotally, many patients are known to decline NAC reconstruction. The authors aimed to cha ... Full text Cite

The Association of Accessory Auricular Tissue With Solid Organ Abnormalities and Its Effect on Auditory and Vestibular Function.

Journal Article Annals of plastic surgery · April 2017 BackgroundAccessory auricular tissue is a common congenital anomaly ranging from an accessory skin appendage to a separate pinna. The association between auditory or vestibular dysfunction and accessory auricular tissue is debated, and little is k ... Full text Cite

Neonatal Micrognathia: National Trends in Early Mandibular Surgery.

Journal Article Annals of plastic surgery · March 2017 BackgroundMicrognathia is a congenital anomaly that may pose breathing and feeding limitations in newborns, sometimes necessitating invasive management. The present study aims to identify the complications associated with receiving mandibular surg ... Full text Cite

Alveolar Bone Grafting and Cleft Lip and Palate: A Review.

Journal Article Plastic and reconstructive surgery · December 2016 Alveolar bone grafting in the mixed dentition stage is an accepted step in the management of cleft alveoli, providing maxillary arch support for dentition and mastication. Points of contention regarding best practices remain, including specific timing, per ... Full text Cite

An Evidence-Based Approach to Nonsynostotic Plagiocephaly.

Journal Article Plastic and reconstructive surgery · October 2016 This article provides an evidence-based review of the literature concerning the cause, diagnosis, manifestations, and treatment of nonsynostotic plagiocephaly, with a particular focus on recently published studies of helmet therapy. It is designed to serve ... Full text Cite

Reconstructive Surgery in Times of Conflict.

Journal Article The Journal of craniofacial surgery · September 2016 BackgroundSmile Train is a charitable organization that partners with and trains surgeons in developing countries to provide surgical care to patients with cleft lip/palate deformities. The organization supports surgeries in several countries that ... Full text Cite