Scholars@Duke
Andrew T. Huang

Andrew T. Huang

Professor of Medicine
Medicine, Hematologic Malignancies and Cellular Therapy
huang014@mc.duke.edu
Duke Box 3942, Durham, NC 27710
316 Sands Bldg, Durham, NC 27710

Overview

Our research at Duke parallels our research in Taiwan in breast cancer early-age onset population under the age of 40 years in comparison to late-onset population with age greater than 60. We are using comparative genomic hybridization (CGH), SKY and microarray techniques to evaluate and search for specific genetic mutation sites. We have found, by CGH, more gains in chromosome 8q, 1q and 17q, and losses in 16q,17p,11g and 8p in the early onset population as compared to late onset patients. In 13q, 16p and 8p, major differences are observed that distinguish between these two patient populations. The more advanced the disease is (e.g. stage 0 as compared to III and IV), the greater the frequencies of gain and losses seen. The greater the lymph node involvement (from 0 to $4 positive), the higher the frequencies of CGH changes. In the next phase of our experiments, we will look at methylation of BRCA1 and perform microarrays on p53 from these breast cancer tissues.

Current Appointments & Affiliations

Professor of Medicine · 1983 - Present Medicine, Hematologic Malignancies and Cellular Therapy, Medicine

Recent Publications

Association of a Bundled-Payment Program With Cost and Outcomes in Full-Cycle Breast Cancer Care.

Journal Article JAMA Oncol · March 1, 2017 IMPORTANCE: Value-driven payment system reform is a potential tool for aligning economic incentives with the improvement of quality and efficiency of health care and containment of cost. Such a payment system has not been researched satisfactorily in full- ... Full text Link to item Cite

A clinical clerkship collaborative program in Taiwan: Acquiring core clinical competencies through patient care responsibility.

Journal Article J Formos Med Assoc · June 2016 BACKGROUND/PURPOSE: Traditionally, clinical clerkship training in Taiwan does not provide medical students with sufficient patient care responsibilities and often results in inadequate clinical skills. METHODS: We implemented a pilot clerkship program at a ... Full text Link to item Cite

An Eighteen-Gene Classifier Predicts Locoregional Recurrence in Post-Mastectomy Breast Cancer Patients.

Journal Article EBioMedicine · March 2016 We previously identified 34 genes of interest (GOI) in 2006 to aid the oncologists to determine whether post-mastectomy radiotherapy (PMRT) is indicated for certain patients with breast cancer. At this time, an independent cohort of 135 patients having DNA ... Full text Link to item Cite
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Recent Grants

Treatment For Patients With Stage Iii & Iv Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1986 - 1987

Treatment For Patients With Stage Iii And Iv Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1986 - 1987

Treatment For Patients With Stage Iii And Iv Head And

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1985 - 1987

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Education, Training & Certifications

National Taiwan University (Taiwan) · 1964 M.D.