Our research at Duke parallels our research in Taiwan in breast cancer early-age onset population under the age of 40 years in comparison to late-onset population with age greater than 60. We are using comparative genomic hybridization (CGH), SKY and microarray techniques to evaluate and search for specific genetic mutation sites. We have found, by CGH, more gains in chromosome 8q, 1q and 17q, and losses in 16q,17p,11g and 8p in the early onset population as compared to late onset patients. In 13q, 16p and 8p, major differences are observed that distinguish between these two patient populations. The more advanced the disease is (e.g. stage 0 as compared to III and IV), the greater the frequencies of gain and losses seen. The greater the lymph node involvement (from 0 to $4 positive), the higher the frequencies of CGH changes. In the next phase of our experiments, we will look at methylation of BRCA1 and perform microarrays on p53 from these breast cancer tissues.
Current Appointments & Affiliations
Education, Training & Certifications
National Taiwan University (Taiwan) ·