Scholars@Duke
Andrew T. Huang

Andrew T. Huang

Professor of Medicine
Medicine, Hematologic Malignancies and Cellular Therapy
huang014@mc.duke.edu
Duke Box 3942, Durham, NC 27710
316 Sands Bldg, Durham, NC 27710

Selected Publications

Association of a Bundled-Payment Program With Cost and Outcomes in Full-Cycle Breast Cancer Care.

Journal Article JAMA Oncol · March 1, 2017 IMPORTANCE: Value-driven payment system reform is a potential tool for aligning economic incentives with the improvement of quality and efficiency of health care and containment of cost. Such a payment system has not been researched satisfactorily in full- ... Full text Link to item Cite

A clinical clerkship collaborative program in Taiwan: Acquiring core clinical competencies through patient care responsibility.

Journal Article J Formos Med Assoc · June 2016 BACKGROUND/PURPOSE: Traditionally, clinical clerkship training in Taiwan does not provide medical students with sufficient patient care responsibilities and often results in inadequate clinical skills. METHODS: We implemented a pilot clerkship program at a ... Full text Link to item Cite

An Eighteen-Gene Classifier Predicts Locoregional Recurrence in Post-Mastectomy Breast Cancer Patients.

Journal Article EBioMedicine · March 2016 We previously identified 34 genes of interest (GOI) in 2006 to aid the oncologists to determine whether post-mastectomy radiotherapy (PMRT) is indicated for certain patients with breast cancer. At this time, an independent cohort of 135 patients having DNA ... Full text Link to item Cite

A General Cutoff Level Combined With Personalized Dynamic Change of Serum Carcinoembryonic Antigen Can Suggest Timely Use of FDG PET for Early Detection of Recurrent Colorectal Cancer.

Journal Article Clin Nucl Med · October 2015 PURPOSE: FDG PET that has been used is good for diagnosing asymptomatic colorectal cancer (CRC) recurrence in patients with elevated serum carcinoembryonic antigen (CEA) level. However, there is no reference level of CEA rise that would universally suggest ... Full text Link to item Cite

Validating a prognostic scoring system for postmastectomy locoregional recurrence in breast cancer.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2013 PURPOSE: This study is designed to validate a previously developed locoregional recurrence risk (LRR) scoring system and further define which groups of patients with breast cancer would benefit from postmastectomy radiation therapy (PMRT). METHODS AND MATE ... Full text Link to item Cite

Electronic health record technology - Reply

Journal Article JAMA · May 30, 2012 Full text Cite

A proposed framework for understanding the forces behind legislation of universal health insurance: lessons from ten countries.

Journal Article Health Serv Res · December 2011 OBJECTIVE: To understand the forces propelling countries to legislate universal health insurance. DATA SOURCE/STUDY DESIGN: Descriptive review and exploratory synthesis of historic data on economic, geographic, socio-demographic, and political factors. DAT ... Full text Link to item Cite

Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization.

Journal Article BMC Cancer · April 18, 2011 BACKGROUND: Optimizing treatment through microarray-based molecular subtyping is a promising method to address the problem of heterogeneity in breast cancer; however, current application is restricted to prediction of distant recurrence risk. This study in ... Full text Link to item Cite

Genomics in the Diagnosis and Management of Breast Cancer

Journal Article · December 1, 2010 Breast cancer is the second leading cause of death among females. As the most common cancer diagnosis in women, one out of every six American women will confront breast cancer during her lifetime. The disease is more common in industrialized Northern Ameri ... Full text Cite

Breast Cancer and Genomic Medicine

Journal Article · December 1, 2009 Full text Cite

Adherence to quality indicators and survival in patients with breast cancer.

Journal Article Med Care · February 2009 BACKGROUND: International initiatives increasingly advocate physician adherence to clinical protocols that have been shown to improve outcomes, yet the process-outcome relationship for adhering to breast cancer care protocol is unknown. OBJECTIVE: This stu ... Full text Link to item Cite

Breast Cancer and Genomic Medicine

Chapter · November 11, 2008 Full text Cite

Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents.

Journal Article J Infect Dis · March 1, 2008 BACKGROUND: Klebsiella pneumoniae causes serious, life-threatening infections in humans in endemic and epidemic settings. The objective of this study was to determine whether the incidence of K. pneumoniae bloodstream infection (BSI) was higher during warm ... Full text Link to item Cite

A prognostic scoring system for locoregional control in nasopharyngeal carcinoma following conformal radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2006 PURPOSE: This study established a prognostic scoring system for nasopharyngeal carcinoma (NPC), which estimates the probability of locoregional (LR) control following definitive conformal radiotherapy. METHODS AND MATERIALS: Patients with nondisseminated N ... Full text Link to item Cite

Multidisciplinary management of cancer pain: a longitudinal retrospective study on a cohort of end-stage cancer patients.

Journal Article J Pain Symptom Manage · November 2006 The epidemiology of cancer pain and the outcomes associated with pain treatments were investigated through a retrospective survey of 772 patients with advanced cancer. The cumulative prevalence of pain was 87%, including all types of cancer. Mean duration ... Full text Link to item Cite

Genomic prediction of locoregional recurrence after mastectomy in breast cancer.

Journal Article J Clin Oncol · October 1, 2006 PURPOSE: This study aims to explore gene expression profiles that are associated with locoregional (LR) recurrence in breast cancer after mastectomy. PATIENTS AND METHODS: A total of 94 breast cancer patients who underwent mastectomy between 1990 and 2001 ... Full text Link to item Cite

Prevertebral muscle involvement in nasopharyngeal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2006 PURPOSE: The purpose of this study is to evaluate the prevalence and prognostic significance of prevertebral muscle involvement in patients with nasopharyngeal carcinoma (NPC). METHODS AND MATERIALS: Between July 1990 and December 2001, 521 newly diagnosed ... Full text Link to item Cite

Patterns of diagnosis and treatment of hypertension in Taiwan

Journal Article Taiwan Journal of Public Health · June 1, 2006 Objectives: By using evidence-based practice guidelines developed in the United States, Great Britain and recommended by the World Health Organization (WHO) as references, this study attempted to analyze the pattern of ambulatory diagnosis and treatment of ... Cite

Embracing the complexity of genomic data for personalized medicine.

Journal Article Genome Res · May 2006 Numerous recent studies have demonstrated the use of genomic data, particularly gene expression signatures, as clinical prognostic factors in cancer and other complex diseases. Such studies herald the future of genomic medicine and the opportunity for pers ... Full text Link to item Cite

Rapid detection of submicroscopic chromosomal rearrangements in children with multiple congenital anomalies using high density oligonucleotide arrays.

Journal Article Hum Mutat · May 2006 Chromosomal rearrangements such as microdeletions and interstitial duplications are the underlying cause of many human genetic disorders. These disorders can manifest in the form of multiple congenital anomalies (MCA), which are a significant cause of morb ... Full text Link to item Cite

Prognostic index score and clinical prediction model of local regional recurrence after mastectomy in breast cancer patients.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2006 PURPOSE: To develop clinical prediction models for local regional recurrence (LRR) of breast carcinoma after mastectomy that will be superior to the conventional measures of tumor size and nodal status. METHODS AND MATERIALS: Clinical information from 1,01 ... Full text Link to item Cite

Breast cancer and dietary factors in Taiwanese women.

Journal Article Cancer Causes Control · October 2005 OBJECTIVES: To examine the effect of the consumption of dietary factors on the risk of breast cancer in a case-control study in Taiwan. METHODS: Two-hundred-and-fifty cases and 219 age-matched controls between the ages of 25 and 74 were interviewed in pers ... Full text Link to item Cite

Prognostic significance of parapharyngeal space venous plexus and marrow involvement: potential landmarks of dissemination for stage I-III nasopharyngeal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2005 PURPOSE: To determine whether the parapharyngeal space venous plexus and marrow of the skull base bones are anatomic landmarks of the potential routes for the spread of disease for Stage I-III (American Joint Commission on Cancer 1997 staging system) nasop ... Full text Link to item Cite

Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes.

Journal Article Proc Natl Acad Sci U S A · June 1, 2004 We describe a comprehensive modeling approach to combining genomic and clinical data for personalized prediction in disease outcome studies. This integrated clinicogenomic modeling framework is based on statistical classification tree models that evaluate ... Full text Link to item Cite

Excel in clinical teaching: Principles and strategies

Journal Article Journal of Internal Medicine of Taiwan · May 6, 2004 Clinical teaching plays an important role in the medical education effectively based on the principles of educational psychology. Through understanding of five major elements of adult learning and cognitive development, we will be able to apply them to cli ... Cite

Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutations.

Journal Article Cancer Genet Cytogenet · January 1, 2004 Nearly 30% of the breast cancer patients in the Taiwanese community have their diseases diagnosed before the age of 40. Their 5-year survival rate is poorer than that of their late-onset breast cancer counterparts. Genomic abnormalities between these two b ... Full text Link to item Cite

Towards integrated clinico-genomic models for personalized medicine: combining gene expression signatures and clinical factors in breast cancer outcomes prediction.

Journal Article Hum Mol Genet · October 15, 2003 Genomic data, particularly genome-scale measures of gene expression derived from DNA microarray studies, has the potential for adding enormous information to the analysis of biological phenotypes. Perhaps the most successful application of this data has be ... Full text Link to item Cite

Gene expression predictors of breast cancer outcomes.

Journal Article Lancet · May 10, 2003 BACKGROUND: Correlation of risk factors with genomic data promises to provide specific treatment for individual patients, and needs interpretation of complex, multivariate patterns in gene expression data, as well as assessment of their ability to improve ... Full text Link to item Cite

Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2003 PURPOSE: This study compares the difference in dose-volume data between three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for patients with hepatocellular carcinoma (HCC) and previously documented radiation-induc ... Full text Link to item Cite

The analysis of the resource utilization for patients with thyroid cancer and benign thyroid diseases with thyroidectomy case payment

Journal Article Taiwan Journal of Public Health · December 1, 2002 Objective: Based on the framework of HCFA DRGs, we conducted an analysis of the relationship between medical expenditures and the number of hospital days in patients who undergo thyroid surgery in Taiwan. It compares the differences in surgery for thyroid ... Cite

The quality issues in the diagnosis and treatment of breast cancer in Taiwan

Journal Article Taiwan Journal of Public Health · October 1, 2002 Objectives: The objectives of this study were two-fold, Using the guidelines based on evidence, we analyzed the patterns of diagnosis and treatment of breast cancer in Taiwan. The second objective was to determine whether the data generated from the analys ... Cite

Colorectal cancer screening in asymptomaic adults: comparison of colonoscopy, sigmoidoscopy and fecal occult blood tests.

Journal Article J Formos Med Assoc · October 2002 BACKGROUND AND PURPOSE: Fecal occult blood tests (FOBT) and flexible sigmoidoscopy have previously been recommended for colon cancer screening. More recently, studies have recommended colonoscopy due to the high rates of advanced neoplasm not detected by F ... Link to item Cite

Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: dosimetric analysis and implication.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2002 Featured Publication PURPOSE: To analyze the correlation of radiation-induced liver disease (RILD) with patient-related and treatment-related dose-volume factors and to describe the probability of RILD by a normal tissue complication probability (NTCP) model for patients with ... Full text Link to item Cite

The utilization of psychiatric services in cancer inpatients

Journal Article Taiwan Journal of Public Health · August 1, 2002 Objectives: This study attempts to examine the utilization and factors affecting the utilization of psychiatric services of cancer inpatients in Taiwan. Methods: The study was conducted by analyzing the utilization and factors affecting the utilization of ... Cite

Improvement of local control of T3 and T4 nasopharyngeal carcinoma by hyperfractionated radiotherapy and concomitant chemotherapy.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2002 Featured Publication PURPOSE: When the primary tumor of nasopharyngeal carcinoma (NPC) is treated at the base of skull and intracranium with conventional radiotherapy, the result is generally poor. In this report, we investigated whether hyperfractionated radiotherapy (HFRT) a ... Full text Link to item Cite

Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description.

Journal Article Radiother Oncol · April 2002 Twelve patients with hepatocellular carcinoma and chronic hepatitis developed radiation-induced liver disease (RILD) after three-dimensional conformal radiotherapy. Six patients died of RILD and six recovered. Mean prescribed dose was 50.6+/-4.3Gy, in a da ... Full text Link to item Cite

Locoregional failure of postmastectomy patients with 1-3 positive axillary lymph nodes without adjuvant radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2002 PURPOSE: To analyze the incidence and risk factors for locoregional recurrence (LRR) in patients with breast cancer who had T1 or T2 primary tumor and 1-3 histologically involved axillary lymph nodes treated with modified radical mastectomy without adjuvan ... Full text Link to item Cite

Medical consultation - The role of an internist

Journal Article Journal of Internal Medicine of Taiwan · January 1, 2002 Because modern medicine has become more sophisticated and specialized, a practicing physician often needs to consult other specialties or subspecialties in the care of their patients. Consultation is an important activity in medicine today. Internists are ... Cite

Proposal for colorectal cancer management algorithm

Journal Article Journal of Internal Medicine of Taiwan · December 1, 2001 The colorectal cancer was among the top ten cancers in Taiwan. The incidence of colorectal cancer ranked number three and the mortality ranked number three in 1997. There were 5472 people diagnosed with colorectal cancer and 2855 people died from colorecta ... Cite

Unresectable hepatocellular carcinoma treated with radiotherapy and/or chemoembolization.

Journal Article Int J Cancer · August 20, 2001 Featured Publication The purpose of our study was to evaluate the outcome, patterns of failure, and toxicity for patients with unresectable hepatocellular carcinoma (HCC) treated with radiotherapy, transcatheter arterial chemoembolization (TACE), or combined TACE and radiother ... Full text Link to item Cite

Examining prognostic factors and patterns of failure in nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy: impact on future clinical trials.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2001 Featured Publication PURPOSE: Concomitant chemotherapy and radiotherapy (CCRT), followed by adjuvant chemotherapy, has improved the outcome of nasopharyngeal carcinoma (NPC). However, the prognosis and patterns of failure after this combined-modality treatment are not yet clea ... Full text Link to item Cite

Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2000 Featured Publication PURPOSE: The purpose of this study is to demonstrate long-term survival of nasopharyngeal carcinoma treated with concomitant chemotherapy and radiotherapy (CCRT) followed by adjuvant chemotherapy. METHODS AND PATIENTS: One hundred and seven patients with S ... Full text Link to item Cite

Unique features of breast cancer in Taiwan.

Journal Article Breast Cancer Res Treat · October 2000 Featured Publication Between April 1990 and December 1997, 811 consecutive patients with 830 newly diagnosed breast cancers having their primary treatments in our institution were included in this study. Sixty three percent of breast cancer patients were premenopausal. The ear ... Full text Link to item Cite

Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma.

Journal Article J Clin Oncol · May 2000 Featured Publication PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. The purpose of this rep ... Full text Link to item Cite

Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2000 Featured Publication PURPOSE: To evaluate the treatment outcome, patterns of failure, and prognostic factors for patients with unresectable hepatocellular carcinoma (HCC) treated with local radiotherapy alone or as an adjunct to transcatheter arterial chemoembolization (TACE). ... Full text Link to item Cite

Adjuvant sequential chemotherapy with doxorubicin plus cyclophosphamide, methotrexate, and fluorouracil (ACMF) with concurrent radiotherapy in resectable advanced breast cancer.

Journal Article Am J Clin Oncol · April 2000 Featured Publication Doxorubicin (Adriamycin) is an anthracycline effective in breast cancer. Despite a worldwide acceptance of Adriamycin in the adjuvant chemotherapy to maximize the survival benefit in the higher risk patients with breast cancer with promising results, oncol ... Full text Link to item Cite

A pilot study of three-dimensional conformal radiotherapy in unresectable hepatocellular carcinoma.

Journal Article J Gastroenterol Hepatol · October 1999 BACKGROUND: The purpose of this study was to determine the potential role of three-dimensional (3-D) conformal radiotherapy (RT) in treatment of unresectable hepatocellular carcinoma (HCC). METHODS: Thirteen patients were included in this study, which was ... Full text Link to item Cite

A multi-centre randomized phase II study of nolatrexed versus doxorubicin in treatment of Chinese patients with advanced hepatocellular carcinoma.

Journal Article Cancer Chemother Pharmacol · 1999 PURPOSE: A multi-centre randomized phase II study of single agent nolatrexed dihydrochloride versus doxorubicin was undertaken in Chinese patients with advanced hepatocellular carcinoma (HCC) to study and compare the clinical efficacy of the two drugs. MET ... Full text Link to item Cite

Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal carcinoma following concurrent chemotherapy and radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 1998 PURPOSE: Concurrent chemotherapy and radiotherapy (CCRT) are effective in treatment of locoregionally advanced nasopharyngeal carcinoma (NPC). However, the prognostic factors after CCRT have not been evaluated. We therefore attempt to evaluate factors that ... Full text Link to item Cite

Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer.

Journal Article N Engl J Med · June 18, 1998 BACKGROUND: Radiotherapy is often the primary treatment for advanced head and neck cancer, but the rates of locoregional recurrence are high and survival is poor. We investigated whether hyperfractionated irradiation plus concurrent chemotherapy (combined ... Full text Link to item Cite

Diagnostic thoracic-computed tomography in radiotherapy for loco-regional recurrent breast carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 1998 PURPOSE: This study was initiated to evaluate whether pretreatment diagnostic thoracic CT scan was useful for patients with loco-regional recurrent breast carcinoma, and to assess its impact on the design of radiotherapeutic treatment. METHODS AND MATERIAL ... Full text Link to item Cite

T classification and clivus margin as risk factors for determining locoregional control by radiotherapy of nasopharyngeal carcinoma.

Journal Article Cancer · January 15, 1998 BACKGROUND: The purpose of this study was to determine risk factors that affect locoregional control of nasopharyngeal carcinoma (NPC) after radiotherapy. Computed tomography (CT) is utilized for radiotherapy planning and for identifying high risk anatomic ... Full text Link to item Cite

Preoperative concurrent chemotherapy and radiotherapy in rectal cancer patients.

Journal Article J Formos Med Assoc · January 1998 The management of rectal cancer has changed significantly in recent years. The key end-point is no longer survival but rather preservation of sphincter function with improved quality of life. Preoperative radiation can not only render a low-lying rectal tu ... Link to item Cite

Concurrent radiotherapy and chemotherapy for tonsillar carcinoma: Preliminary report

Journal Article Chinese Journal of Radiology · October 1, 1997 The purpose of this study is to test the toxicity of concurrent radiotherapy and chemotherapy and evaluate the treatment outcome of the patients with tonsillar carcinoma. From October 1990 to July 1996, 12 patients with squamous cell carcinoma of tonsillar ... Cite

Concomitant chemotherapy and radiotherapy for locally advanced nasopharyngeal carcinoma.

Journal Article Cancer J Sci Am · 1997 BACKGROUND: The prognosis of stage III and IV nasopharyngeal carcinoma treated with radiation therapy alone is poor. To improve outcome, concomitant chemotherapy was incorporated into the treatment of locally advanced nasopharyngeal carcinoma. METHODS AND ... Link to item Cite

A program for eradication of hepatitis B from Taiwan by a 10-year, four-dose vaccination program.

Journal Article Cancer Causes Control · May 1996 Approximately 15 percent of the Taiwanese population are chronic carriers of hepatitis B virus (HBV), among the highest rates in Asia. In July 1984, the Taiwanese government initiated a nationwide HBV-vaccination program. The program began with educational ... Full text Link to item Cite

Concomitant renal cell carcinoma and metastatic epithelioid angiosarcoma with microangiopathy.

Journal Article J Formos Med Assoc · 1995 Epithelioid angiosarcoma is an extremely rare clinical entity. Recognized only in recent years, epithelioid angiosarcoma mimicks epithelial tumors, both morphologically and immunohistochemically. It is very aggressive, assuming a rapid, metastatic and fata ... Link to item Cite

The role of CD45RO in antithymocyte globulin's stimulation of primitive haemopoietic cells.

Journal Article Br J Haematol · November 1994 We have found that antithymocyte globulin (ATG), an equine antibody with proven efficacy in aplastic anaemia (AA), has a direct stimulatory effect on primitive haemopoietic cells from normal donors. This growth stimulation may be mediated via anti-CD45RO a ... Full text Link to item Cite

Oral ondansetron pharmacokinetics: the effect of chemotherapy.

Journal Article J Clin Pharmacol · July 1994 The effect of a typical 5-day chemotherapy treatment with cisplatin (20-40 mg/m2 per day) and 5-fluorouracil (5-FU, 1 gm/m2 per day) on the pharmacokinetics of ondansetron was investigated. Twenty cancer patients received 8 mg of ondansetron in three perio ... Full text Link to item Cite

A phase I/II trial of twice daily irradiation and concurrent chemotherapy for locally advanced squamous cell carcinoma of the head and neck.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 1994 PURPOSE: This study was designed to test the toxicity and efficacy of a regimen of twice daily irradiation and concurrent multiagent chemotherapy for patients with locally advanced squamous cell carcinoma of the head and neck. METHODS AND MATERIALS: This w ... Full text Link to item Cite

Endoscopic Features of Duodenal Metastases from Breast Cancer

Journal Article Digestive Endoscopy · January 1, 1994 Abstract: The endoscopic appearance of gastrointestinal metastasis from breast cancer is demonstrated in this report. A patient with breast cancer was found by panendoscope examination to have duodenal metastases. The endoscopic characteristic was that of ... Full text Cite

Cancer epidemiology in the Far East--contrast with the United States.

Journal Article Oncology (Williston Park) · June 1993 Cancer incidence is rising rapidly in the Far East. Liver and lung cancers are the dominant neoplasms, but the incidence of breast and colorectal cancers has been increasing over the past 30 years, as Asians gradually adopt Western diet and lifestyle. Over ... Link to item Cite

A phase II study of piritrexim in patients with advanced squamous head and neck cancer.

Journal Article Cancer · February 15, 1992 Piritrexim (PTX) is a newly developed lipid-soluble folate antagonist that crosses the cell membrane by a simple, rapid, carrier-independent diffusion process. A Phase II study was conducted to evaluate the activity of PTX in 34 patients with previously ch ... Full text Link to item Cite

A randomized comparison of two doses of human lymphoblastoid interferon-alpha in hairy cell leukemia. Wellcome HCL Study Group.

Journal Article Blood · December 15, 1991 One hundred thirty-eight patients with hairy cell leukemia were randomized to receive either a dose of 2.0 megaunits (MU)/m2 or a 10-fold lower dose of 0.2 MU/m2 of a highly purified natural alpha-interferon, administered daily for 28 days followed by a th ... Link to item Cite

Polymorphism and altered methylation of the lactoferrin gene in normal leukocytes, leukemic cells, and breast cancer.

Journal Article Cancer Res · June 1, 1991 Human lactoferrin has been found to be decreased or absent in most breast cancer and leukemia cells. In order to examine the lactoferrin gene for both structural alterations and the degree of methylation, we isolated a 2117-kilobase complementary DNA from ... Link to item Cite

Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells.

Journal Article Antimicrob Agents Chemother · February 1991 The anti-human immunodeficiency virus (HIV) activity and hemopoietic toxicity of zidovudine (AZT) and didanosine (dideoxyinosine;ddI), alone and in combination, were assessed in a variety of cell types. AZT was more potent than ddI as an inhibitor of HIV i ... Full text Link to item Cite

Absence of phosphatidylinositol (PI)-linked proteins in a very early human multipotential haematopoietic marrow cell.

Journal Article Br J Haematol · February 1991 A very early human haematopoietic progenitor cell population which was negative for the major histocompatibility class II antigen (HLA-DR) and positive for the CD34 (MY10) antigen was separated into two subsets according to the expression of decay-accelera ... Full text Link to item Cite

Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis.

Journal Article Cancer Res · July 15, 1990 Anti-thymocyte globulin (ATG), a horse antiserum to human thymus tissue, has been shown to induce granulocytic differentiation of the HL-60 human leukemia cell line. In this paper we describe the effect of ATG on leukemic blasts and its effect on other hum ... Link to item Cite

Phase I studies of recombinant interferon-gamma.

Journal Article J Biol Response Mod · April 1990 A phase I study of the effects of intravenous administration of interferon-gamma on 31 patients was performed. The effects of dose, schedule, and chronic administration were studied. In the first phase of the study, a dose range of 0.01-500 MU/m2 (0.0002-2 ... Link to item Cite

Extranodal head and neck lymphoma. Prognosis and patterns of recurrence.

Journal Article Arch Otolaryngol Head Neck Surg · January 1990 Stages I and II extranodal head and neck lymphomas treated between 1969 and 1986 were reviewed to determine prognosis and recurrence patterns. Forty-four patients had low-grade lymphoma, with 57% remaining disease free (median survival, 7.2 years). Radioth ... Full text Link to item Cite

A multicenter trial of antithymocyte globulin in aplastic anemia and related diseases.

Journal Article Blood · December 1988 One hundred fifty patients with bone marrow failure were treated in three groups with antithymocyte globulin (ATG; Upjohn, Kalamazoo, MI) in a multicenter trial. Patients were assessed at 3, 6, and 12 months after initiation of treatment by three criteria: ... Link to item Cite

Antithymocyte globulin stimulates human hematopoietic progenitor cells.

Journal Article Proc Natl Acad Sci U S A · August 1987 Antithymocyte globulin (ATG), a horse antihuman thymus antiserum highly effective in the majority of patients with aplastic anemia, was studied for its in vitro effects on hematopoietic progenitor cells. Marrow cells isolated by an immunoadherence techniqu ... Full text Link to item Cite

A prospective study of squamous head and neck carcinoma. Immunologic aberrations in patients who develop recurrent disease.

Journal Article Cancer · May 15, 1987 In a prospective study of squamous head and neck cancer, the pretreatment peripheral blood of 125 patients was examined for lymphocyte subclass and in vitro immunologic function. After 4 years of follow-up, 49 recurrences of disease were observed. Lymphocy ... Full text Link to item Cite

Changes in hairy cells after alpha-interferon treatment as measured by flow cytometry.

Journal Article Leukemia · April 1987 Patients with hairy cell leukemia who responded to alpha-interferon (IFN-alpha) were compared to those who did not by examining their hairy cells throughout treatment. The examination of the cells by cytofluorography included the expression of surface anti ... Link to item Cite

Transformation of hairy cell leukemia to EBV genome-containing aggressive B cell lymphoma.

Journal Article Leukemia · April 1987 Hairy cell leukemia is a preplasmacytic B cell leukemia which is not EBV associated, although elevated titers of Epstein-Barr virus (EBV) antibodies have been seen in this leukemia and chronic lymphocytic leukemia. Hairy cells are not readily susceptible t ... Link to item Cite

5-Fluorouracil, cyclophosphamide, and vincristine for adenoid cystic carcinoma of the head and neck.

Journal Article Cancer · March 1, 1987 Twenty-one patients with adenoid cystic carcinoma of the head and neck were treated with intravenous boluses of cyclophosphamide and vincristine and 5-day continuous intravenous infusions of 5-fluorouracil (CVF) every 4 weeks. Eight patients received CVF a ... Full text Link to item Cite

The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA.

Journal Article Int J Cancer · January 15, 1987 Immunologic studies of Epstein-Barr virus (EBV) have implicated EBV in undifferentiated and partially differentiated, non-keratinizing nasopharyngeal carcinoma (NPC). Patients with the well-differentiated, keratinizing form of NPC have EBV serologic patter ... Full text Link to item Cite

Antithymocyte globulin: a realistic approach to therapy for severe aplastic anemia.

Journal Article South Med J · September 1986 Antithymocyte or antilymphocyte globulin (ATG or ALG) has emerged since 1978 as important therapy applicable to the majority of patients with aplastic anemia. On the basis of similarities of patient populations, nine clinical trials were selected among man ... Link to item Cite

Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation.

Journal Article J Immunol · April 1, 1986 Recent advances in the prevention of graft-vs-host disease (GVHD) have allowed the use of haploidentical bone marrow cells for correction of lethal genetic defects of the immune system. Sequential analyses of blood lymphocyte phenotypes and functions were ... Link to item Cite

Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations.

Journal Article Clin Pharmacol Ther · January 1986 The oral absorption of digoxin in tablet form has been reported to be reduced after cancer chemotherapy and radiation therapy because of cancer treatment-induced damage to the intestinal epithelium. We investigated possible differences in the effects of hi ... Full text Link to item Cite

Cutaneous T cell lymphoma. Lymphocyte phenotype analysis after anti-thymocyte globulin therapy.

Journal Article Am J Med · November 1985 In an attempt to explore new or alternative therapy for refractory cutaneous T cell lymphoma, a patient with advanced disease refractory to conventional chemotherapy was treated with anti-thymocyte globulin. The therapy was associated with tolerable and ma ... Full text Link to item Cite

Tolerance and interleukin 2 deficiency.

Journal Article Immunol Today · August 1985 Full text Link to item Cite

Predictive factors for response to anti-thymocyte globulin in acquired aplastic anemia.

Journal Article Am J Med · July 1985 Lymphocyte phenotype, bone marrow cellularity, in vitro marrow growth potential, and treatment responses were examined in 22 patients with acquired aplastic anemia who were given anti-thymocyte globulin. Eleven of 22 patients (50 percent) had a significant ... Full text Link to item Cite

Differentiation of normal marrow and HL60 cells induced by antithymocyte globulin.

Journal Article Proc Natl Acad Sci U S A · July 1985 Antithymocyte globulin (ATG) therapy is an important treatment alternative for patients with acquired aplastic anemia. The mechanism by which it exerts its effects on hematopoiesis is unknown. In this report, we describe the ability of horse ATG to induce ... Full text Link to item Cite

Adjuvant chemotherapy after surgery and radiation for stage III and IV head and neck cancer.

Journal Article Ann Surg · August 1984 Twenty consecutive patients with Stage III and IV squamous head and neck cancer were treated with surgery, radiation, and adjuvant multiagent chemotherapy. Eleven other patients who were referred for local recurrent disease were treated with second surgery ... Full text Link to item Cite

Antibody-dependent cellular cytotoxicity and disease course in North American patients with nasopharyngeal carcinoma: a prospective study.

Journal Article Int J Cancer · June 15, 1984 It has previously been reported that antibody-dependent cellular cytotoxicity (ADCC) levels determined at diagnosis against Epstein-Barr virus (EBV)-specific membrane antigens (MA) are predictive of disease course following therapy in patients with nasopha ... Full text Link to item Cite

Severe combined immunodeficiency with natural killer-cell predominance: abrogation of graft-versus-host disease and immunologic reconstitution with HLA-identical bone marrow cells.

Journal Article J Allergy Clin Immunol · June 1984 A 3 1/2-month-old infant with severe combined immunodeficiency was found to have an unusual blood lymphocyte phenotype. Thirty percent of her cells formed rosettes with sheep erythrocytes, but only 7.9% reacted with the pan T monoclonal antibody OKT3, and ... Full text Link to item Cite

Phase I study of pharmacological and immunological effects of human lymphoblastoid interferon given to patients with cancer.

Journal Article Cancer Res · September 1983 An extensive Phase I evaluation of human lymphoblastoid interferon has been completed which, in addition to describing its clinical and pharmacological effects, emphasized a broad-scale evaluation of the immune response as a function of interferon dosage. ... Link to item Cite

Application of Epstein-Barr virus serology to the diagnosis and staging of North American patients with nasopharyngeal carcinoma.

Journal Article Otolaryngol Head Neck Surg · June 1983 From 1978 to 1981, 151 patients with nasopharyngeal carcinoma (NPC) were enrolled in a prospective, collaborative study of North American patients, most of them white. Thirty-seven had World Health Organization (WHO) type 1 tumors, and 114 had WHO types 2 ... Full text Link to item Cite

Application of Epstein-Barr virus (EBV) serology to the diagnosis of North American nasopharyngeal carcinoma.

Journal Article Cancer · January 15, 1983 A cooperative study was established among a number of institutions in the USA to determine the clinical value of Epstein-Barr virus (EBV) serology for the diagnosis of different histopathological types of North American nasopharyngeal carcinoma (NPC) inclu ... Full text Link to item Cite

Conditions for an in vitro culture of murine mixed hematopoietic colonies and their putative cellular origin.

Journal Article Blood · July 1982 The supernatant fluid of stimulated spleen cells (PHA-SCM) supported in vitro colony growth of murine marrow. In the absence of exogenous erythropoietin, it stimulated the growth of (1) myeloid colonies and (2) distinct mixed colonies containing erythroid ... Link to item Cite

EFFECT OF MICROWAVE RADIATION (1. 0 GHz) ON THE BLOOD-BRAIN BARRIER IN DOGS.

Journal Article Radio Science · 1982 Utilizing an accepted pharmacological approach to the problem of evaluating the integrity of blood-brain barrier (BBB), the authors evaluated dogs following microwave radiation at 1. 0-GHz frequency and herein report their findings. The method involved can ... Cite

Lymphoblastoid interferon (Wellferon) trial in chronic lymphocytic leukemia in progressive phase

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1982 Cite

Immunopharmacology of human lymphoblastoid interferon (IF) in man

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1982 Cite

Microwave treatment of intracerebral L1210 leukemia: schedule-dependent partial reversal of the effects of methotrexate.

Journal Article Bioelectromagnetics · 1981 One-GHz microwave (MW) irradiation at a power density of 5 mW/cm2 was combined with methotrexate (MTX) in an attempt to treat more effectively central nervous system (CNS) L1210 leukemia in DBA/2J mice. When mice with CNS leukemia were treated with the com ... Full text Link to item Cite

Cisplatin-induced changes in sodium, chloride, and urea transport by the frog skin.

Journal Article Kidney Int · January 1981 Cisplatin is a platinum-containing antitumor agent whose usefulness is limited by nephrotoxicity. We examined the effects of cisplatin on a representative, transporting epithelium--the frog skin. Cisplatin (10(-3)M) from the mucosal surface increased the a ... Full text Link to item Cite

DTIC, CCNU, bleomycin and vincristine (BOLD) in metastatic melanoma.

Journal Article Cancer · December 1, 1980 Treatment of 91 consecutive patients having metastatic, Stage IV melanoma who had not received any previous chemotherapy was begun between January 1977 and April 1978. The therapy included bleomycin (B) at 7.5 units subcutaneously in the first course and 1 ... Full text Link to item Cite

Inhibitor of marrow thymidine incorporation from sera of patients with uremia.

Journal Article Kidney Int · December 1980 A low-molecular-weight fraction of serum samples from 14 patients with uremia inhibited tritiated thymidine incorporation (18 +/- 2%) by cultured rabbit marrow whereas an identical fraction from nonazotemic subjects did not. A similar effect on ferrous 59 ... Full text Link to item Cite

Anti-EBV serologic tests for nasopharyngeal carcinoma.

Journal Article Laryngoscope · December 1980 Sixty-three serum specimens from American patients with nasopharyngeal carcinoma were examined for antibodies to antigens associated with Epstein-Barr virus (EBV) and compared with 98 specimens from patients with other head and neck cancers, 133 from patie ... Full text Link to item Cite

Complement sensitivity of paroxysmal nocturnal hemoglobinuria bone marrow cells.

Journal Article Blood · June 1980 Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder in which erythrocytes, granulocytes, and platelets are defective, as shown by increased susceptibility of RBCs, WBCs, and platelets to complement-mediated lysis in vitro. The purpose of this ... Link to item Cite

A trial of outpatient chemotherapy for recurrent head and neck tumors.

Journal Article Cancer · April 15, 1980 A four-drug combination chemotherapy (bleomycin-methotrexate-vinblastine-CCNU) had been used in 38 evaluable patients with recurrent squamous cell carcinoma of the head and neck region on an outpatient basis. A large number of these patients had carcinoma ... Full text Link to item Cite

Inhibition of DNA synthesis and enhancement of the uptake and action of methotrexate by low-power-density microwave radiation in L1210 leukemia cells.

Journal Article Cancer Res · April 1980 We have studied the effects of low-power-density microwave (MW) radiation (continuous and pulsed wave with average power density of 10 milliwatts/sq cm and range of 5 to 50 milliwatts/sq cm; frequency, 1.0 GHz) on the uptake and action of methotrexate (MTX ... Link to item Cite

Immunologic and hematopoietic alterations by 2,450-MHz electromagnetic radiation.

Journal Article Bioelectromagnetics · 1980 A biphasic modulation of responsiveness of spleen lymphocytes to mitogens was observed in mice exposed to 2,450-MHz radiation at power densities of 5-15 mW/cm2 over various periods ranging between one and 17 days. This modulated phenomenon may be explained ... Full text Link to item Cite

The use of in vitro technics to study drug-induced pancytopenia.

Journal Article N Engl J Med · September 20, 1979 The confirmation of drug-induced marrow aplasia is difficult since rechallenging the patient can lead to serious morbidity. We used marrow-culture technics to challenge in vitro the bone marrow of a patient with marrow aplasia after ingestion of quinidine. ... Full text Link to item Cite

Leukopheresis therapy of leukemic reticuloendotheliosis (hairy cell leukemia).

Journal Article Blood · September 1979 Intensive leukopheresis has been valuable in the short-term palliation of chronic lymphocytic and granulocytic leukemias. A 47-yr-old man with refractory leukemic reticuloendotheliosis (hairy cell leukemia) manifested by anemia, thrombocytopenia, elevated ... Link to item Cite

Autologous marrow transplantation for patients with acute myelogenous leukemia--a preliminary report.

Journal Article Exp Hematol · 1979 Twelve consecutive adult patients with acute myelogenous leukemia have been entered on a treatment protocol which examines the role of "remission-intensification" during maintenance using high-dose chemoradiotherapy and autologous remission marrow transpla ... Link to item Cite

Binding specificity of non-nucleic acid myocardial anthracycline receptive substance

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1979 Cite

A phase II study of bleomycin, oncovin, lomustine and DTIC (BOLD) in stage IV metastatic melanoma

Journal Article Proceedings of the American Association for Cancer Research · 1979 Cite

Effects of cis-diamminedichloroplatinum on sodium transport by the frog skin

Journal Article Clinical Research · January 1, 1979 Cite

A phase II study of bleomycin, oncovin, lomustine and DTIC (BOLD) in stage IV metastatic melanoma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1979 Cite

Vinblastine-related pain in tumors.

Journal Article Cancer Treat Rep · December 1977 Link to item Cite

EFFECT OF MICROWAVE RADIATION (2450 MHz) ON THE MORPHOLOGY AND CHROMOSOMES OF LYMPHOCYTES.

Journal Article Radio Science · 1977 Effects of microwave radiation have been examined on blood lymphocytes from Chinese hamsters that were irradiated 15 minutes each day during five consecutive days by 2450-MHz (CW) energy at power densities from zero to 45 mW/cm**2. Measurements of absorbed ... Cite

The effect of microwave radiation (2450 MHz) on the morphology and chromosomes of lymphocytes

Journal Article Radio Science · January 1, 1977 Effects of microwave radiation have been examined on blood lymphocytes from Chinese hamsters that were irradiated 15 minutes each day during five consecutive days by 2450‐MHz (CW) energy at power densities from zero to 45 mW/cm2. Measurements of absorbed e ... Full text Cite

Two biochemical markers in lymphocyte subpopulations.

Journal Article Br J Haematol · December 1976 Human blood lymphocytes can be separated into two populations according to the presence of surface complement receptors. Lymphocytes containing complement receptors (CR+) were found to have a high rate of RNA synthesis or turnover accompanied by increased ... Full text Link to item Cite

Effects of nitrogen mustard and splenectomy on mouse bone marrow colony formation in vitro.

Journal Article Cancer · September 1976 Improved tolerance of splenectomized patients with Hodgkin's disease (HD) to radiotherapy and chemotherapy has been reported. The present study was undertaken to determine the effects of splenectomy and nitrogen mustard (NM) on colony-forming cells (CFC's) ... Full text Link to item Cite

Correction of severe combined immunodeficiency by fetal liver cells.

Journal Article N Engl J Med · May 13, 1976 As an alternative to bone-marrow transplantation, two infants with severe combined immunodeficiency who had no histocompatible donors were given intraperitoneal infusions of fresh liver cells from fetuses of eight and nine to 10 weeks. Transient graft-vers ... Full text Link to item Cite

Some properties of a DNA-unwinding protein unique to lymphocytes from chronic lymphocytic leukemia.

Journal Article Cancer Res · April 1975 Lymphocytes from a common human leukemia, chronic lymphocytic leukemia, chronic lymphocytic leukemia, have a greatly enhanced capability of DNA repair and a concomitantly prolonged survival in vitro after damage to DNA. From these lymphocytes, we isolated ... Link to item Cite

Effects of nitrogen mustard and splenectomy on mouse bone marrow colony formation in vitro

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1974 Cite

Impaired lymphocyte transformation in Hodgkin's disease. Evidence for depletion of circulating t-lymphocytes.

Journal Article J Clin Invest · August 1973 The kinetics of lymphocyte transformation induced by phytohemagglutinin (PHA) and pokeweed mitogen (PWM) were studied daily, with blood lymphocytes from normal individuals and from untreated patients in all stages of Hodgkin's disease (HD). In addition, sp ... Full text Link to item Cite

DNA repair synthesis after x-irradiation in E. coli.

Journal Article Experientia · December 15, 1972 Full text Link to item Cite

DNA repair in human leukaemic lymphocytes.

Journal Article Nat New Biol · November 22, 1972 Full text Link to item Cite

Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells.

Journal Article Clin Exp Immunol · September 1971 The clinical, immunologic and pathologic features of the first recorded examples of lymphopenic immunologic deficiency in twins are presented. Eleven-month-old male identical twin infants were found to be severely lymphopenic and lacked demonstrable cell-m ... Link to item Cite