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Correction of severe combined immunodeficiency by fetal liver cells.

Publication ,  Journal Article
Buckley, RH; Whisnant, KJ; Schiff, RI; Gilbertsen, RB; Huang, AT; Platt, MS
Published in: N Engl J Med
May 13, 1976

As an alternative to bone-marrow transplantation, two infants with severe combined immunodeficiency who had no histocompatible donors were given intraperitoneal infusions of fresh liver cells from fetuses of eight and nine to 10 weeks. Transient graft-versus-host disease began at 42 and 52 days, respectively. Both infants had rises in T cells and declines in B cells by three months. No functional immunologic improvement occurred in the first infant, who died of pulmonary disease 10 months later. Clinical and functional immunologic improvement occurred in the other, who is now 19 months after transplantation. Lymphocyte responses to phytohemagglutinin and pokeweed mitogen were noted by three months, to concanavalin A by five months, and to allogeneic cells by eight months. Delayed cutaneous responsiveness to candida developed and IgM became norma. IgA and IgG remained low. Chimerism was demonstrated by a donor marker chromosome in metaphases from recipient lymphocytes. Fetal liver cells therefore reversed the immunodeficiency.

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Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

May 13, 1976

Volume

294

Issue

20

Start / End Page

1076 / 1081

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • T-Lymphocytes
  • Male
  • Lymphocytes
  • Liver Transplantation
  • Liver
  • Leukocyte Count
  • Infant
  • Immunologic Deficiency Syndromes
  • Immunoglobulin G
 

Citation

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Buckley, R. H., Whisnant, K. J., Schiff, R. I., Gilbertsen, R. B., Huang, A. T., & Platt, M. S. (1976). Correction of severe combined immunodeficiency by fetal liver cells. N Engl J Med, 294(20), 1076–1081. https://doi.org/10.1056/NEJM197605132942002
Buckley, R. H., K. J. Whisnant, R. I. Schiff, R. B. Gilbertsen, A. T. Huang, and M. S. Platt. “Correction of severe combined immunodeficiency by fetal liver cells.N Engl J Med 294, no. 20 (May 13, 1976): 1076–81. https://doi.org/10.1056/NEJM197605132942002.
Buckley RH, Whisnant KJ, Schiff RI, Gilbertsen RB, Huang AT, Platt MS. Correction of severe combined immunodeficiency by fetal liver cells. N Engl J Med. 1976 May 13;294(20):1076–81.
Buckley, R. H., et al. “Correction of severe combined immunodeficiency by fetal liver cells.N Engl J Med, vol. 294, no. 20, May 1976, pp. 1076–81. Pubmed, doi:10.1056/NEJM197605132942002.
Buckley RH, Whisnant KJ, Schiff RI, Gilbertsen RB, Huang AT, Platt MS. Correction of severe combined immunodeficiency by fetal liver cells. N Engl J Med. 1976 May 13;294(20):1076–1081.
Journal cover image

Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

May 13, 1976

Volume

294

Issue

20

Start / End Page

1076 / 1081

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • T-Lymphocytes
  • Male
  • Lymphocytes
  • Liver Transplantation
  • Liver
  • Leukocyte Count
  • Infant
  • Immunologic Deficiency Syndromes
  • Immunoglobulin G