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Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells.

Publication ,  Journal Article
Buckley, RH; Kremer, WB; Rowlands, DT; Huntley, CC; Amos, DB; Huang, AT
Published in: Clin Exp Immunol
September 1971

The clinical, immunologic and pathologic features of the first recorded examples of lymphopenic immunologic deficiency in twins are presented. Eleven-month-old male identical twin infants were found to be severely lymphopenic and lacked demonstrable cell-mediated immunity and antibody formation. Each first-degree relative differed from the probands by one chromosome at the major human histocompatibility locus, HL-A. Because of their rapidly deteriorating clinical conditions, allogeneic bone marrow transplantation was undertaken. Circumvention of graft-versus-host disease was attempted by separation of donor bone marrow cells on a discontinuous-albumin-gradient and administration of only 5×106 immature nucleated marrow cells per kilogram infant body weight. Additionally, immunologic enhancement was attempted by pretreating the infants with human isoantisera to identifiable infant HL-A antigens not present in the marrow donor. Paternal lymphocyte allografting occurred, as demonstrated by lymphocyte cytotoxicity testing, but both infants succumbed to graft-versus-host disease at the end of 3 weeks.

Duke Scholars

Published In

Clin Exp Immunol

ISSN

0009-9104

Publication Date

September 1971

Volume

9

Issue

3

Start / End Page

289 / 304

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Thymus Gland
  • Spleen
  • Skin Tests
  • Sheep
  • Serum Albumin, Bovine
  • Rabbits
  • Male
  • Lymphopenia
  • Lymphocytes
 

Citation

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Buckley, R. H., Kremer, W. B., Rowlands, D. T., Huntley, C. C., Amos, D. B., & Huang, A. T. (1971). Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells. Clin Exp Immunol, 9(3), 289–304.
Buckley, R. H., W. B. Kremer, D. T. Rowlands, C. C. Huntley, D. B. Amos, and A. T. Huang. “Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells.Clin Exp Immunol 9, no. 3 (September 1971): 289–304.
Journal cover image

Published In

Clin Exp Immunol

ISSN

0009-9104

Publication Date

September 1971

Volume

9

Issue

3

Start / End Page

289 / 304

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Thymus Gland
  • Spleen
  • Skin Tests
  • Sheep
  • Serum Albumin, Bovine
  • Rabbits
  • Male
  • Lymphopenia
  • Lymphocytes